Design, synthesis and antibacterial activity of fluoroquinolones containing bulky arenesulfonyl fragment: 2D-QSAR and docking study

European Journal of Medicinal Chemistry

Volumn 46, Issue 11, 2011, Pages 5487-5497

  Abdel Aziz, Alaa A M ^a,b   Asiri, Yousif A ^a   Al Agamy, Mohamed H M ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b MANSOURA UNIVERSITY   (Egypt)

Author keywords

2D QSAR; Antibacterial; Arenesulfonamido; Fluoroquinolones; Molecular docking

Indexed keywords

1 CYCLOPROPYL 6 FLUORO 4 OXO 7 (4 ((2,3,4,5,6 PENTAMETHYLPHENYL)SULFONYL)PIPERAZIN 1 YL) 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 6 FLUORO 4 OXO 7 (4 ((2,4,6 TRI ISOPROPYLPHENYL)SULFONYL)PIPERAZIN 1 YL) 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 6 FLUORO 4 OXO 7 (4 ((2,4,6 TRICHLOROPHENYL)SULFONYL)PIPERAZIN 1 YL) 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 6 FLUORO 7 (4 (MESITYLSULFONYL)PIPERAZIN 1 YL) 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 6 FLUORO 7 (4 (NAPHTHALEN 1 YLSULFONYL)PIPERAZIN 1 YL) 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 6 FLUORO 7 (4 (NAPHTHALEN 2 YLSULFONYL)PIPERAZIN 1 YL) 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 7 (4 ((2,4 DICHLOROPHENYL)SULFONYL)PIPERAZIN 1 YL) 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 7 (4 ((2,4 DIFLUOROPHENYL)SULFONYL)PIPERAZIN 1 YL) 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 7 (4 ((2,4 DIMETHOXYPHENYL)SULFONYL)PIPERAZIN 1 YL) 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 7 (4 ((3,4 DICHLOROPHENYL)SULFONYL)PIPERAZIN 1 YL) 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 7 (4 ((3,4 DIMETHOXYPHENYL)SULFONYL)PIPERAZIN 1 YL) 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 ETHYL 6 FLUORO 4 OXO 7 (4 ((2,3,4,5,6 PENTAMETHYLPHENYL)SULFONYL)PIPERAZIN 1 YL) 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 ETHYL 6 FLUORO 4 OXO 7 (4 ((2,4,6 TRI ISOPROPYLPHENYL)SULFONYL)PIPERAZIN 1 YL) 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 ETHYL 6 FLUORO 4 OXO 7 (4 ((2,4,6 TRICHLOROPHENYL)SULFONYL)PIPERAZIN 1 YL) 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 ETHYL 6 FLUORO 7 (4 (MESITYLSULFONYL)PIPERAZIN 1 YL) 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 ETHYL 6 FLUORO 7 (4 (NAPHTHALEN 1 YLSULFONYL)PIPERAZIN 1 YL) 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 ETHYL 6 FLUORO 7 (4 (NAPHTHALEN 2 YLSULFONYL)PIPERAZIN 1 YL) 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 (4 ((2,4 DICHLOROPHENYL)SULFONYL)PIPERAZIN 1 YL) 1 ETHYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 (4 ((2,4 DIFLUOROPHENYL)SULFONYL)PIPERAZIN 1 YL) 1 ETHYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 (4 ((2,4 DIMETHOXYPHENYL)SULFONYL)PIPERAZIN 1 YL) 1 ETHYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 (4 ((3,4 DICHLOROPHENYL)SULFONYL)PIPERAZIN 1 YL) 1 ETHYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 (4 ((3,4 DIMETHOXYPHENYL)SULFONYL)PIPERAZIN 1 YL) 1 ETHYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; ANTIBIOTIC AGENT; CIPROFLOXACIN; NORFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL STRAIN; DRUG DESIGN; DRUG SYNTHESIS; ESCHERICHIA COLI; HYDROGEN BOND; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; PSEUDOMONAS AERUGINOSA; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; BACTERIA; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; FLUOROQUINOLONES; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES;

EID: 80054964636     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.09.011     Document Type: Article

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