The pyrrole moiety as a template for COX-1/COX-2 inhibitors

European Journal of Medicinal Chemistry

Volumn 35, Issue 5, 2000, Pages 499-510

  Dannhardt, Gerd ^a   Kiefer, Werner ^a   Krämer, Godehard ^a,b   Maehrlein, Sabine ^a   Nowe, Ulrike ^a   Fiebich, Bernd ^c  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b ROCHE INNOVATION CENTER MUNICH   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

COX 1 COX 2 inhibition; Enzyme selectivity; Pyrrole derivatives; Structure activity relationship

Indexed keywords

ARACHIDONIC ACID DERIVATIVE; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; INDOMETACIN; LIPOPOLYSACCHARIDE; PYRROLE DERIVATIVE; THIOPHENE DERIVATIVE;

ANIMAL CELL; ARACHIDONIC ACID METABOLISM; ARTICLE; CATTLE; CONTROLLED STUDY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INDUCTION; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MONOCYTE; NEUTROPHIL; NONHUMAN; RADIOIMMUNOASSAY; STRUCTURE ACTIVITY RELATION;

EID: 0034123510     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(00)00150-1     Document Type: Article

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