메뉴 건너뛰기




Volumn 5, Issue 15, 2011, Pages 3359-3366

Thymoquinone rich fraction from Nigella sativa and thymoquinone are cytotoxic towards colon and leukemic carcinoma cell lines

Author keywords

Cell cycle; Colon cancer; Lymphoblastic leukemia; Nigella sativa; Promyelocytic leukemia; Supercritical fluid extraction system; Thymoquinone

Indexed keywords

ANTINEOPLASTIC AGENT; THYMOQUINONE; THYMOQUINONE RICH FRACTION; UNCLASSIFIED DRUG;

EID: 84860410277     PISSN: None     EISSN: 19960875     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (29)

References (37)
  • 2
    • 0038559976 scopus 로고    scopus 로고
    • Pharmacological and toxicological properties of Nigella sativa
    • Ali BH, Blunden G (2003). Pharmacological and toxicological properties of Nigella sativa. Phytother. Res., 17: 299-305.
    • (2003) Phytother. Res , vol.17 , pp. 299-305
    • Ali, B.H.1    Blunden, G.2
  • 4
    • 65649111745 scopus 로고    scopus 로고
    • Regulation of apolipoprotien A-1 and apolipoprotien B100 genes by thymoquinone rich fraction and thymoquinone in Hepg2 cells
    • Al NG, Ismail M (2009). Regulation of apolipoprotien A-1 and apolipoprotien B100 genes by thymoquinone rich fraction and thymoquinone in Hepg2 cells. J. Food Lipids, 16: 245-258.
    • (2009) J. Food Lipids , vol.16 , pp. 245-258
    • Al, N.G.1    Ismail, M.2
  • 5
    • 68149170016 scopus 로고    scopus 로고
    • Effects of thymoquinone rich fraction and thymoquinone on plasma lipoprotein levels and hepatic low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase genes expression
    • Al NG, Ismail M, Latifah SY (2009). Effects of thymoquinone rich fraction and thymoquinone on plasma lipoprotein levels and hepatic low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase genes expression. J. Funct. Foods, 1: 298-303.
    • (2009) J. Funct. Foods , vol.1 , pp. 298-303
    • Al, N.G.1    Ismail, M.2    Latifah, S.Y.3
  • 6
    • 34547699662 scopus 로고    scopus 로고
    • In vitro hypoglycemic activity of methanolic extract of some indigenous plants
    • Arayne MS, Sultana N, Mirza AZ, Zuberi MH, Siddiqui FA (2007). In vitro hypoglycemic activity of methanolic extract of some indigenous plants. Pak. J. Pharm. Sci., 20(4): 261-268.
    • (2007) Pak. J. Pharm. Sci , vol.20 , Issue.4 , pp. 261-268
    • Arayne, M.S.1    Sultana, N.2    Mirza, A.Z.3    Zuberi, M.H.4    Siddiqui, F.A.5
  • 7
    • 24344496959 scopus 로고    scopus 로고
    • The protective effect of thymoquinone on ethanol-induced acute gastric damage in the rat
    • Arslan SO, Gelir E, Armutcu F, Coskun O, Gurel A, Sayan H, Celik IL (2005). The protective effect of thymoquinone on ethanol-induced acute gastric damage in the rat. Nutr. Res., 25: 673-680.
    • (2005) Nutr. Res , vol.25 , pp. 673-680
    • Arslan, S.O.1    Gelir, E.2    Armutcu, F.3    Coskun, O.4    Gurel, A.5    Sayan, H.6    Celik, I.L.7
  • 8
    • 67650466020 scopus 로고    scopus 로고
    • Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer
    • Banerjee S, Kaseb AO, Wang Z, Kong D, Mohammad M, Padhye S, Sarkar FH, Mohammad RM (2009). Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer. Cancer Res., 69(13): 5575-5583.
    • (2009) Cancer Res , vol.69 , Issue.13 , pp. 5575-5583
    • Banerjee, S.1    Kaseb, A.O.2    Wang, Z.3    Kong, D.4    Mohammad, M.5    Padhye, S.6    Sarkar, F.H.7    Mohammad, R.M.8
  • 9
    • 79151470509 scopus 로고    scopus 로고
    • Antiasthmatic effect of Nigella sativa in airways of asthmatic patients
    • Boskabady MH, Mohsenpoor N, Takaloo L (2010). Antiasthmatic effect of Nigella sativa in airways of asthmatic patients. Phytomed., 17(10): 707-713.
    • (2010) Phytomed , vol.17 , Issue.10 , pp. 707-713
    • Boskabady, M.H.1    Mohsenpoor, N.2    Takaloo, L.3
  • 10
    • 79954440155 scopus 로고    scopus 로고
    • Combinatorial effects of thymoquinone on the anti-cancer activity of doxorubicin
    • DOI 10.1007/s00280-010-1386-x
    • Effenberger NK, Schobert R (2010). Combinatorial effects of thymoquinone on the anti-cancer activity of doxorubicin. Cancer Chemother. Pharmacol. DOI 10.1007/s00280-010-1386-x.
    • (2010) Cancer Chemother. Pharmacol
    • Effenberger, N.K.1    Schobert, R.2
  • 11
    • 26444457920 scopus 로고    scopus 로고
    • Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells
    • El M MA, Zhu Q, Wang QE, Wani G, Wani AA (2005). Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells. Int. J. Cancer, 117: 409-417.
    • (2005) Int. J. Cancer , vol.117 , pp. 409-417
    • El, M.M.A.1    Zhu, Q.2    Wang, Q.E.3    Wani, G.4    Wani, A.A.5
  • 13
    • 48649088554 scopus 로고    scopus 로고
    • Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells
    • Gali MH, Kuester D, Mawrin C (2008a). Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells. Cancer Res., 68: 5609-5618.
    • (2008) Cancer Res , vol.68 , pp. 5609-5618
    • Gali, M.H.1    Kuester, D.2    Mawrin, C.3
  • 14
    • 41149137253 scopus 로고    scopus 로고
    • Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models
    • Gali MH, Ocker M, Kuester D (2008b). Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models. J. Cell Mol. Med., 12: 330-342.
    • (2008) J. Cell Mol. Med , vol.12 , pp. 330-342
    • Gali, M.H.1    Ocker, M.2    Kuester, D.3
  • 15
    • 0023019005 scopus 로고
    • Use of MTT colorimetric assay to measure cell activation
    • Gerlier D, Thomasset N (1986). Use of MTT colorimetric assay to measure cell activation. J. Immunol. Methods, 94: 57-63.
    • (1986) J. Immunol. Methods , vol.94 , pp. 57-63
    • Gerlier, D.1    Thomasset, N.2
  • 17
    • 68149122167 scopus 로고    scopus 로고
    • Apoptosis and cell cycle arrest of human colorectal cancer cell line HT-29 induced by vanillin
    • Ho KL, Yazan LS, Ismail N, Ismail M (2009). Apoptosis and cell cycle arrest of human colorectal cancer cell line HT-29 induced by vanillin. Cancer Epidemiol., 33: 155-160.
    • (2009) Cancer Epidemiol , vol.33 , pp. 155-160
    • Ho, K.L.1    Yazan, L.S.2    Ismail, N.3    Ismail, M.4
  • 18
    • 55349088274 scopus 로고    scopus 로고
    • Black cumin seed (Nigella sativa Linn.) oil and its fractions protect against beta amyloid peptide-induced toxicity in primary cerebellar granule neurons
    • Ismail N, Ismail M A., Latiff L, Mazlan M, Mariod AA (2008). Black cumin seed (Nigella sativa Linn.) oil and its fractions protect against beta amyloid peptide-induced toxicity in primary cerebellar granule neurons. J. Food Lipids, 15: 519-533.
    • (2008) J. Food Lipids , vol.15 , pp. 519-533
    • Ismail, N.1    Ismail, M.A.2    Latiff, L.3    Mazlan, M.4    Mariod, A.A.5
  • 19
    • 34249939643 scopus 로고    scopus 로고
    • Chemotherapy through mitochondrial apoptosis using nutritional supplements and herbs: A brief overview
    • Kwon KB, Park BH, Ryu DG (2007). Chemotherapy through mitochondrial apoptosis using nutritional supplements and herbs: A brief overview. J. Bioenerg. Biomembr., 39: 31-34.
    • (2007) J. Bioenerg. Biomembr , vol.39 , pp. 31-34
    • Kwon, K.B.1    Park, B.H.2    Ryu, D.G.3
  • 20
    • 17944382048 scopus 로고    scopus 로고
    • Extraction of Nigella sativa L. Using Supercritical CO2: A study of antioxidant activity of the extract
    • Machmudah S, Shiramizu Y, Goto M, Sasaki M, Hirose T (2005). Extraction of Nigella sativa L. Using Supercritical CO2: A study of antioxidant activity of the extract. Separation Sci. Tech., 40: 1267- 1275.
    • (2005) Separation Sci. Tech , vol.40 , pp. 1267-1275
    • Machmudah, S.1    Shiramizu, Y.2    Goto, M.3    Sasaki, M.4    Hirose, T.5
  • 21
    • 64449083439 scopus 로고    scopus 로고
    • Antioxidant activity and phenolic content of phenolic rich fractions obtained from black cumin (Nigella sativa) seedcake
    • Mariod AA, Ibrahim RM, Ismail M, Ismail N (2009). Antioxidant activity and phenolic content of phenolic rich fractions obtained from black cumin (Nigella sativa) seedcake. Food Chem., 116(1): 306-312.
    • (2009) Food Chem , vol.116 , Issue.1 , pp. 306-312
    • Mariod, A.A.1    Ibrahim, R.M.2    Ismail, M.3    Ismail, N.4
  • 23
    • 77956268772 scopus 로고    scopus 로고
    • Protective effect of Nigella sativa extract and thymoquinone on serum/glucose deprivation-induced PC12 cells death
    • Mousavi SH, Tayarani-Najaran Z, Asghari M, Sadeghnia HR (2010). Protective effect of Nigella sativa extract and thymoquinone on serum/glucose deprivation-induced PC12 cells death. Cell. Mol. Neurobiol., 30(4): 591-598.
    • (2010) Cell. Mol. Neurobiol , vol.30 , Issue.4 , pp. 591-598
    • Mousavi, S.H.1    Tayarani-Najaran, Z.2    Asghari, M.3    Sadeghnia, H.R.4
  • 24
  • 25
    • 70449089588 scopus 로고    scopus 로고
    • Comparison of potential chemotherapeutic agents, 5-fluoruracil, green tea, and thymoquinone on colon cancer cells
    • Norwood AA, Tan M, May M, Tucci M, Benghuzzi H (2006). Comparison of potential chemotherapeutic agents, 5-fluoruracil, green tea, and thymoquinone on colon cancer cells. Biomed. Sci. Instrum., 42: 350-356.
    • (2006) Biomed. Sci. Instrum , vol.42 , pp. 350-356
    • Norwood, A.A.1    Tan, M.2    May, M.3    Tucci, M.4    Benghuzzi, H.5
  • 27
    • 77950796292 scopus 로고    scopus 로고
    • The protective effect of thymoquinone, an anti-oxidant and anti-inflammatory agent, against renal injury: A review. Saudi
    • Ragheb A, Attia A, Eldin WS, Elbarbry F, Gazarin S, Shoker A (2009). The protective effect of thymoquinone, an anti-oxidant and anti-inflammatory agent, against renal injury: A review. Saudi J. Kidney Dis. Transpl., 20(5): 741-752.
    • (2009) J. Kidney Dis. Transpl , vol.20 , Issue.5 , pp. 741-752
    • Ragheb, A.1    Attia, A.2    Eldin, W.S.3    Elbarbry, F.4    Gazarin, S.5    Shoker, A.6
  • 29
    • 50349098189 scopus 로고    scopus 로고
    • Targeting nuclear factor-κb activation pathway by thymoquinone: Role in suppression of antiapoptotic gene products and enhancement of apoptosis
    • Sethi G, Ahn KS, Aggarwal BB (2008). Targeting nuclear factor-κb activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis. Mol. Cancer Res., 6(6): 1059-1070.
    • (2008) Mol. Cancer Res , vol.6 , Issue.6 , pp. 1059-1070
    • Sethi, G.1    Ahn, K.S.2    Aggarwal, B.B.3
  • 30
    • 0035098984 scopus 로고    scopus 로고
    • Extraction, isolation and characterization of anti-tumor principle, alpha-hederin, from the seeds of Nigella sativa
    • Swamy SMK, Tan BKH (2001). Extraction, isolation and characterization of anti-tumor principle, alpha-hederin, from the seeds of Nigella sativa. Planta Medica, 67: 29-32.
    • (2001) Planta Medica , vol.67 , pp. 29-32
    • Swamy, S.M.K.1    Tan, B.K.H.2
  • 31
    • 77949543599 scopus 로고    scopus 로고
    • Protective effects of Nigella sativa on intestinal ischemia-reperfusion injury in rats
    • Terzi A, Coban S, Yildiz F, Ates M, Bitiren M, Taskin A, Aksoy N (2010). Protective effects of Nigella sativa on intestinal ischemia-reperfusion injury in rats. J. Investig. Surg., 23(1): 21-27.
    • (2010) J. Investig. Surg , vol.23 , Issue.1 , pp. 21-27
    • Terzi, A.1    Coban, S.2    Yildiz, F.3    Ates, M.4    Bitiren, M.5    Taskin, A.6    Aksoy, N.7
  • 32
    • 21744456053 scopus 로고    scopus 로고
    • Cytotoxic effects of a decoction of Nigella sativa, Hemidesmus indicus and Smilax glabra on human hepatoma HepG2 cells
    • Thabrew MI, Ragai RM, Mohammed AM, Robin DH (2005). Cytotoxic effects of a decoction of Nigella sativa, Hemidesmus indicus and Smilax glabra on human hepatoma HepG2 cells. J. Life Sci., 77: 1319-1330.
    • (2005) J. Life Sci , vol.77 , pp. 1319-1330
    • Thabrew, M.I.1    Ragai, R.M.2    Mohammed, A.M.3    Robin, D.H.4
  • 33
    • 77952140698 scopus 로고    scopus 로고
    • Effects of thymoquinone in the expression of mucin 4 in pancreatic cancer cells: Implications for the development of novel cancer therapies
    • Torres MP, Ponnusamy MP, Chakraborty S, Smith LM, Das S, Arafat HA, Batra SK (2010). Effects of thymoquinone in the expression of mucin 4 in pancreatic cancer cells: implications for the development of novel cancer therapies. Mol. Cancer Ther., pp. 1535-7163.
    • (2010) Mol. Cancer Ther , pp. 1535-7163
    • Torres, M.P.1    Ponnusamy, M.P.2    Chakraborty, S.3    Smith, L.M.4    Das, S.5    Arafat, H.A.6    Batra, S.K.7
  • 34
    • 0037051507 scopus 로고    scopus 로고
    • Recovery of pigments from Origanum majorana L. by extraction with supercritical carbon dioxide
    • Vagi E, Simándi B, Daood HG, Deak A, Sawinsky J (2002). Recovery of pigments from Origanum majorana L. by extraction with supercritical carbon dioxide. J. Agric. Food Chem., 50: 2297-2301.
    • (2002) J. Agric. Food Chem , vol.50 , pp. 2297-2301
    • Vagi, E.1    Simándi, B.2    Daood, H.G.3    Deak, A.4    Sawinsky, J.5
  • 35
    • 0037107560 scopus 로고    scopus 로고
    • A flow cytometry-based assay for quantitative analysis of cellular proliferation and cytotoxicity in vitro
    • Wang YY, Zheng XX (2002). A flow cytometry-based assay for quantitative analysis of cellular proliferation and cytotoxicity in vitro. J. Immunol. Methods, 268: 179-188.
    • (2002) J. Immunol. Methods , vol.268 , pp. 179-188
    • Wang, Y.Y.1    Zheng, X.X.2
  • 36
    • 75949108454 scopus 로고    scopus 로고
    • Protective effects of Nigella sativa against gentamicin induced nephrotoxicity in rats
    • Yaman I, Balikci E (2010). Protective effects of Nigella sativa against gentamicin induced nephrotoxicity in rats. Exp. Toxicologic Pathol., 62(2): 183-190.
    • (2010) Exp. Toxicologic Pathol , vol.62 , Issue.2 , pp. 183-190
    • Yaman, I.1    Balikci, E.2
  • 37
    • 80051830921 scopus 로고    scopus 로고
    • Cytotoxicity of thymoquinone (TQ) from Nigella sativa towards human cervical carcinoma cells (HeLa)
    • Yazan LS, Ng WK, Al-Naqeeb G, Ismail M (2009). Cytotoxicity of thymoquinone (TQ) from Nigella sativa towards human cervical carcinoma cells (HeLa). J. Pharm. Res., 2(4): 585-589.
    • (2009) J. Pharm. Res , vol.2 , Issue.4 , pp. 585-589
    • Yazan, L.S.1    Ng, W.K.2    Al-Naqeeb, G.3    Ismail, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.