-
1
-
-
0034680102
-
Molecular portraits of human breast tumours
-
10.1038/35021093, 10963602
-
Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, Fluge O, Pergamenschikov A, Williams C, Zhu SX, Lonning PE, Borresen-Dale AL, Brown PO, Botstein D. Molecular portraits of human breast tumours. Nature 2000, 406:747-752. 10.1038/35021093, 10963602.
-
(2000)
Nature
, vol.406
, pp. 747-752
-
-
Perou, C.M.1
Sorlie, T.2
Eisen, M.B.3
van de Rijn, M.4
Jeffrey, S.S.5
Rees, C.A.6
Pollack, J.R.7
Ross, D.T.8
Johnsen, H.9
Akslen, L.A.10
Fluge, O.11
Pergamenschikov, A.12
Williams, C.13
Zhu, S.X.14
Lonning, P.E.15
Borresen-Dale, A.L.16
Brown, P.O.17
Botstein, D.18
-
2
-
-
3142512612
-
Molecular characterization of the tumor microenvironment in breast cancer
-
10.1016/j.ccr.2004.06.010, 15261139
-
Allinen M, Beroukhim R, Cai L, Brennan C, Lahti-Domenici J, Huang H, Porter D, Hu M, Chin L, Richardson A, Schnitt S, Sellers WR, Polyak K. Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell 2004, 6:17-32. 10.1016/j.ccr.2004.06.010, 15261139.
-
(2004)
Cancer Cell
, vol.6
, pp. 17-32
-
-
Allinen, M.1
Beroukhim, R.2
Cai, L.3
Brennan, C.4
Lahti-Domenici, J.5
Huang, H.6
Porter, D.7
Hu, M.8
Chin, L.9
Richardson, A.10
Schnitt, S.11
Sellers, W.R.12
Polyak, K.13
-
3
-
-
33845191779
-
Genomic and transcriptional aberrations linked to breast cancer pathophysiologies
-
10.1016/j.ccr.2006.10.009, 17157792
-
Chin K, DeVries S, Fridlyand J, Spellman PT, Roydasgupta R, Kuo WL, Lapuk A, Neve RM, Qian Z, Ryder T, Chen F, Feiler H, Tokuyasu T, Kingsley C, Dairkee S, Meng Z, Chew K, Pinkel D, Jain A, Ljung BM, Esserman L, Albertson DG, Waldman FM, Gray JW. Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell 2006, 10:529-541. 10.1016/j.ccr.2006.10.009, 17157792.
-
(2006)
Cancer Cell
, vol.10
, pp. 529-541
-
-
Chin, K.1
DeVries, S.2
Fridlyand, J.3
Spellman, P.T.4
Roydasgupta, R.5
Kuo, W.L.6
Lapuk, A.7
Neve, R.M.8
Qian, Z.9
Ryder, T.10
Chen, F.11
Feiler, H.12
Tokuyasu, T.13
Kingsley, C.14
Dairkee, S.15
Meng, Z.16
Chew, K.17
Pinkel, D.18
Jain, A.19
Ljung, B.M.20
Esserman, L.21
Albertson, D.G.22
Waldman, F.M.23
Gray, J.W.24
more..
-
4
-
-
33845209913
-
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
-
10.1016/j.ccr.2006.10.008, 2730521, 17157791
-
Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, Fevr T, Clark L, Bayani N, Coppe JP, Tong F, Speed T, Spellman PT, DeVries S, Lapuk A, Wang NJ, Kuo WL, Stilwell JL, Pinkel D, Albertson DG, Waldman FM, McCormick F, Dickson RB, Johnson MD, Lippman M, Ethier S, Gazdar A, Gray JW. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell 2006, 10:515-527. 10.1016/j.ccr.2006.10.008, 2730521, 17157791.
-
(2006)
Cancer Cell
, vol.10
, pp. 515-527
-
-
Neve, R.M.1
Chin, K.2
Fridlyand, J.3
Yeh, J.4
Baehner, F.L.5
Fevr, T.6
Clark, L.7
Bayani, N.8
Coppe, J.P.9
Tong, F.10
Speed, T.11
Spellman, P.T.12
DeVries, S.13
Lapuk, A.14
Wang, N.J.15
Kuo, W.L.16
Stilwell, J.L.17
Pinkel, D.18
Albertson, D.G.19
Waldman, F.M.20
McCormick, F.21
Dickson, R.B.22
Johnson, M.D.23
Lippman, M.24
Ethier, S.25
Gazdar, A.26
Gray, J.W.27
more..
-
5
-
-
72749103664
-
Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis
-
10.1101/gad.1849509, 2779757, 19933147
-
Visvader JE. Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. Genes Dev 2009, 23:2563-2577. 10.1101/gad.1849509, 2779757, 19933147.
-
(2009)
Genes Dev
, vol.23
, pp. 2563-2577
-
-
Visvader, J.E.1
-
6
-
-
37049183697
-
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene
-
10.1126/science.3798106, 3798106
-
Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987, 235:177-182. 10.1126/science.3798106, 3798106.
-
(1987)
Science
, vol.235
, pp. 177-182
-
-
Slamon, D.J.1
Clark, G.M.2
Wong, S.G.3
Levin, W.J.4
Ullrich, A.5
McGuire, W.L.6
-
7
-
-
0032823487
-
Phase II study of weekly intravenous trastuzumab (Herceptin) in patients with HER2/neu-overexpressing metastatic breast cancer
-
Baselga J, Tripathy D, Mendelsohn J, Baughman S, Benz CC, Dantis L, Sklarin NT, Seidman AD, Hudis CA, Moore J, Rosen PP, Twaddell T, Henderson IC, Norton L. Phase II study of weekly intravenous trastuzumab (Herceptin) in patients with HER2/neu-overexpressing metastatic breast cancer. Semin Oncol 1999, 26:(4 Suppl 12):78-83.
-
(1999)
Semin Oncol
, vol.26
, Issue.4 SUPPL. 12
, pp. 78-83
-
-
Baselga, J.1
Tripathy, D.2
Mendelsohn, J.3
Baughman, S.4
Benz, C.C.5
Dantis, L.6
Sklarin, N.T.7
Seidman, A.D.8
Hudis, C.A.9
Moore, J.10
Rosen, P.P.11
Twaddell, T.12
Henderson, I.C.13
Norton, L.14
-
8
-
-
26844503270
-
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
-
10.1056/NEJMoa052306, 16236737
-
Piccart-Gebhart MJ, Procter M, Leyland-Jones B, Goldhirsch A, Untch M, Smith I, Gianni L, Baselga J, Bell R, Jackisch C, Cameron D, Dowsett M, Barrios CH, Steger G, Huang CS, Andersson M, Inbar M, Lichinitser M, Láng I, Nitz U, Iwata H, Thomssen C, Lohrisch C, Suter TM, Rüschoff J, Suto T, Greatorex V, Ward C, Straehle C, McFadden E, et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 2005, 353:1659-1672. 10.1056/NEJMoa052306, 16236737.
-
(2005)
N Engl J Med
, vol.353
, pp. 1659-1672
-
-
Piccart-Gebhart, M.J.1
Procter, M.2
Leyland-Jones, B.3
Goldhirsch, A.4
Untch, M.5
Smith, I.6
Gianni, L.7
Baselga, J.8
Bell, R.9
Jackisch, C.10
Cameron, D.11
Dowsett, M.12
Barrios, C.H.13
Steger, G.14
Huang, C.S.15
Andersson, M.16
Inbar, M.17
Lichinitser, M.18
Láng, I.19
Nitz, U.20
Iwata, H.21
Thomssen, C.22
Lohrisch, C.23
Suter, T.M.24
Rüschoff, J.25
Suto, T.26
Greatorex, V.27
Ward, C.28
Straehle, C.29
McFadden, E.30
more..
-
9
-
-
26844536978
-
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
-
10.1056/NEJMoa052122, 16236738
-
Romond EH, Perez EA, Bryant J, Suman VJ, Geyer CE, Davidson NE, Tan-Chiu E, Martino S, Paik S, Kaufman PA, Swain SM, Pisansky TM, Fehrenbacher L, Kutteh LA, Vogel VG, Visscher DW, Yothers G, Jenkins RB, Brown AM, Dakhil SR, Mamounas EP, Lingle WL, Klein PM, Ingle JN, Wolmark N. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 2005, 353:1673-1684. 10.1056/NEJMoa052122, 16236738.
-
(2005)
N Engl J Med
, vol.353
, pp. 1673-1684
-
-
Romond, E.H.1
Perez, E.A.2
Bryant, J.3
Suman, V.J.4
Geyer, C.E.5
Davidson, N.E.6
Tan-Chiu, E.7
Martino, S.8
Paik, S.9
Kaufman, P.A.10
Swain, S.M.11
Pisansky, T.M.12
Fehrenbacher, L.13
Kutteh, L.A.14
Vogel, V.G.15
Visscher, D.W.16
Yothers, G.17
Jenkins, R.B.18
Brown, A.M.19
Dakhil, S.R.20
Mamounas, E.P.21
Lingle, W.L.22
Klein, P.M.23
Ingle, J.N.24
Wolmark, N.25
more..
-
10
-
-
0037036949
-
New drugs for breast cancer
-
10.1016/S0140-6736(02)09903-8, 12241842
-
Smith IE. New drugs for breast cancer. Lancet 2002, 360:790-792. 10.1016/S0140-6736(02)09903-8, 12241842.
-
(2002)
Lancet
, vol.360
, pp. 790-792
-
-
Smith, I.E.1
-
11
-
-
77957940993
-
High-resolution genomic and expression analyses of copy number alterations in HER2-amplified breast cancer
-
10.1186/bcr2568, 2917012, 20459607
-
Staaf J, Jonsson G, Ringner M, Vallon-Christersson J, Grabau D, Arason A, Gunnarsson H, Agnarsson BA, Malmstrom PO, Johannsson OT, Loman N, Barkardottir RB, Borg A. High-resolution genomic and expression analyses of copy number alterations in HER2-amplified breast cancer. Breast Cancer Res 2010, 12:R25. 10.1186/bcr2568, 2917012, 20459607.
-
(2010)
Breast Cancer Res
, vol.12
-
-
Staaf, J.1
Jonsson, G.2
Ringner, M.3
Vallon-Christersson, J.4
Grabau, D.5
Arason, A.6
Gunnarsson, H.7
Agnarsson, B.A.8
Malmstrom, P.O.9
Johannsson, O.T.10
Loman, N.11
Barkardottir, R.B.12
Borg, A.13
-
12
-
-
77958540564
-
Molecular subtypes of breast cancer are associated with characteristic DNA methylation patterns
-
10.1186/bcr2590, 2917031, 20565864
-
Holm K, Hegardt C, Staaf J, Vallon-Christersson J, Jonsson G, Olsson H, Borg A, Ringner M. Molecular subtypes of breast cancer are associated with characteristic DNA methylation patterns. Breast Cancer Res 2010, 12:R36. 10.1186/bcr2590, 2917031, 20565864.
-
(2010)
Breast Cancer Res
, vol.12
-
-
Holm, K.1
Hegardt, C.2
Staaf, J.3
Vallon-Christersson, J.4
Jonsson, G.5
Olsson, H.6
Borg, A.7
Ringner, M.8
-
13
-
-
77951641554
-
Identification of subtypes in human epidermal growth factor receptor 2--positive breast cancer reveals a gene signature prognostic of outcome
-
10.1200/JCO.2009.22.8775, 20231686
-
Staaf J, Ringner M, Vallon-Christersson J, Jonsson G, Bendahl PO, Holm K, Arason A, Gunnarsson H, Hegardt C, Agnarsson BA, Luts L, Grabau D, Ferno M, Malmstrom PO, Johannsson OT, Loman N, Barkardottir RB, Borg A. Identification of subtypes in human epidermal growth factor receptor 2--positive breast cancer reveals a gene signature prognostic of outcome. J Clin Oncol 2010, 28:1813-1820. 10.1200/JCO.2009.22.8775, 20231686.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1813-1820
-
-
Staaf, J.1
Ringner, M.2
Vallon-Christersson, J.3
Jonsson, G.4
Bendahl, P.O.5
Holm, K.6
Arason, A.7
Gunnarsson, H.8
Hegardt, C.9
Agnarsson, B.A.10
Luts, L.11
Grabau, D.12
Ferno, M.13
Malmstrom, P.O.14
Johannsson, O.T.15
Loman, N.16
Barkardottir, R.B.17
Borg, A.18
-
14
-
-
77951083686
-
A pathway-based classification of human breast cancer
-
10.1073/pnas.0912708107, 2872436, 20335537
-
Gatza ML, Lucas JE, Barry WT, Kim JW, Wang Q, Crawford MD, Datto MB, Kelley M, Mathey-Prevot B, Potti A, Nevins JR. A pathway-based classification of human breast cancer. Proc Natl Acad Sci USA 2010, 107:6994-6999. 10.1073/pnas.0912708107, 2872436, 20335537.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 6994-6999
-
-
Gatza, M.L.1
Lucas, J.E.2
Barry, W.T.3
Kim, J.W.4
Wang, Q.5
Crawford, M.D.6
Datto, M.B.7
Kelley, M.8
Mathey-Prevot, B.9
Potti, A.10
Nevins, J.R.11
-
15
-
-
3142587028
-
Tumor microenvironmental physiology and its implications for radiation oncology
-
10.1016/j.semradonc.2004.04.008, 15254862
-
Vaupel P. Tumor microenvironmental physiology and its implications for radiation oncology. Semin Radiat Oncol 2004, 14:198-206. 10.1016/j.semradonc.2004.04.008, 15254862.
-
(2004)
Semin Radiat Oncol
, vol.14
, pp. 198-206
-
-
Vaupel, P.1
-
16
-
-
0034321578
-
Blood supply, oxygenation status and metabolic micromilieu of breast cancers: characterization and therapeutic relevance
-
Vaupel P, Hockel M. Blood supply, oxygenation status and metabolic micromilieu of breast cancers: characterization and therapeutic relevance. Int J Oncol 2000, 17:869-879.
-
(2000)
Int J Oncol
, vol.17
, pp. 869-879
-
-
Vaupel, P.1
Hockel, M.2
-
17
-
-
37549013776
-
A microenvironmental model of carcinogenesis
-
10.1038/nrc2255, 18059462
-
Gatenby RA, Gillies RJ. A microenvironmental model of carcinogenesis. Nat Rev Cancer 2008, 8:56-61. 10.1038/nrc2255, 18059462.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 56-61
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
18
-
-
0036359548
-
Hypoxia--a key regulatory factor in tumour growth
-
10.1038/nrc704, 11902584
-
Harris AL. Hypoxia--a key regulatory factor in tumour growth. Nat Rev Cancer 2002, 2:38-47. 10.1038/nrc704, 11902584.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
19
-
-
0030593729
-
Renal-cell carcinoma
-
10.1056/NEJM199609193351207, 8778606
-
Motzer RJ, Bander NH, Nanus DM. Renal-cell carcinoma. N Engl J Med 1996, 335:865-875. 10.1056/NEJM199609193351207, 8778606.
-
(1996)
N Engl J Med
, vol.335
, pp. 865-875
-
-
Motzer, R.J.1
Bander, N.H.2
Nanus, D.M.3
-
20
-
-
0032524285
-
P53 inhibits hypoxia-inducible factor-stimulated transcription
-
10.1074/jbc.273.20.11995, 9575138
-
Blagosklonny MV, An WG, Romanova LY, Trepel J, Fojo T, Neckers L. p53 inhibits hypoxia-inducible factor-stimulated transcription. J Biol Chem 1998, 273:11995-11998. 10.1074/jbc.273.20.11995, 9575138.
-
(1998)
J Biol Chem
, vol.273
, pp. 11995-11998
-
-
Blagosklonny, M.V.1
An, W.G.2
Romanova, L.Y.3
Trepel, J.4
Fojo, T.5
Neckers, L.6
-
21
-
-
0034050050
-
Loss of PTEN facilitates HIF-1-mediated gene expression
-
316386, 10691731
-
Zundel W, Schindler C, Haas-Kogan D, Koong A, Kaper F, Chen E, Gottschalk AR, Ryan HE, Johnson RS, Jefferson AB, Stokoe D, Giaccia AJ. Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev 2000, 14:391-396. 316386, 10691731.
-
(2000)
Genes Dev
, vol.14
, pp. 391-396
-
-
Zundel, W.1
Schindler, C.2
Haas-Kogan, D.3
Koong, A.4
Kaper, F.5
Chen, E.6
Gottschalk, A.R.7
Ryan, H.E.8
Johnson, R.S.9
Jefferson, A.B.10
Stokoe, D.11
Giaccia, A.J.12
-
22
-
-
0034654174
-
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics
-
Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu MM, Simons JW, Semenza GL. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 2000, 60:1541-1545.
-
(2000)
Cancer Res
, vol.60
, pp. 1541-1545
-
-
Zhong, H.1
Chiles, K.2
Feldser, D.3
Laughner, E.4
Hanrahan, C.5
Georgescu, M.M.6
Simons, J.W.7
Semenza, G.L.8
-
23
-
-
0035012605
-
HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
-
10.1128/MCB.21.12.3995-4004.2001, 87062, 11359907
-
Laughner E, Taghavi P, Chiles K, Mahon PC, Semenza GL. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol 2001, 21:3995-4004. 10.1128/MCB.21.12.3995-4004.2001, 87062, 11359907.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3995-4004
-
-
Laughner, E.1
Taghavi, P.2
Chiles, K.3
Mahon, P.C.4
Semenza, G.L.5
-
24
-
-
33644551073
-
Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers
-
10.1371/journal.pmed.0030047, 1334226, 16417408
-
Chi JT, Wang Z, Nuyten DS, Rodriguez EH, Schaner ME, Salim A, Wang Y, Kristensen GB, Helland A, Borresen-Dale AL, Giaccia A, Longaker MT, Hastie T, Yang GP, van de Vijver MJ, Brown PO. Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers. PLoS Med 2006, 3:e47. 10.1371/journal.pmed.0030047, 1334226, 16417408.
-
(2006)
PLoS Med
, vol.3
-
-
Chi, J.T.1
Wang, Z.2
Nuyten, D.S.3
Rodriguez, E.H.4
Schaner, M.E.5
Salim, A.6
Wang, Y.7
Kristensen, G.B.8
Helland, A.9
Borresen-Dale, A.L.10
Giaccia, A.11
Longaker, M.T.12
Hastie, T.13
Yang, G.P.14
van de Vijver, M.J.15
Brown, P.O.16
-
25
-
-
65749106405
-
Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
-
10.1016/j.ccr.2009.03.018, 2693960, 19477429
-
Li Z, Bao S, Wu Q, Wang H, Eyler C, Sathornsumetee S, Shi Q, Cao Y, Lathia J, McLendon RE, Hjelmeland AB, Rich JN. Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell 2009, 15:501-513. 10.1016/j.ccr.2009.03.018, 2693960, 19477429.
-
(2009)
Cancer Cell
, vol.15
, pp. 501-513
-
-
Li, Z.1
Bao, S.2
Wu, Q.3
Wang, H.4
Eyler, C.5
Sathornsumetee, S.6
Shi, Q.7
Cao, Y.8
Lathia, J.9
McLendon, R.E.10
Hjelmeland, A.B.11
Rich, J.N.12
-
26
-
-
20444490000
-
Spatial heterogeneity and oxygen dependence of glucose consumption in R3230Ac and fibrosarcomas of the Fischer 344 rat
-
10.1158/0008-5472.CAN-04-3900, 15958560
-
Schroeder T, Yuan H, Viglianti BL, Peltz C, Asopa S, Vujaskovic Z, Dewhirst MW. Spatial heterogeneity and oxygen dependence of glucose consumption in R3230Ac and fibrosarcomas of the Fischer 344 rat. Cancer Res 2005, 65:5163-5171. 10.1158/0008-5472.CAN-04-3900, 15958560.
-
(2005)
Cancer Res
, vol.65
, pp. 5163-5171
-
-
Schroeder, T.1
Yuan, H.2
Viglianti, B.L.3
Peltz, C.4
Asopa, S.5
Vujaskovic, Z.6
Dewhirst, M.W.7
-
27
-
-
57449097020
-
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
-
2582933, 19033663
-
Sonveaux P, Vegran F, Schroeder T, Wergin MC, Verrax J, Rabbani ZN, De Saedeleer CJ, Kennedy KM, Diepart C, Jordan BF, Kelley MJ, Gallez B, Wahl ML, Feron O, Dewhirst MW. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest 2008, 118:3930-3942. 2582933, 19033663.
-
(2008)
J Clin Invest
, vol.118
, pp. 3930-3942
-
-
Sonveaux, P.1
Vegran, F.2
Schroeder, T.3
Wergin, M.C.4
Verrax, J.5
Rabbani, Z.N.6
De Saedeleer, C.J.7
Kennedy, K.M.8
Diepart, C.9
Jordan, B.F.10
Kelley, M.J.11
Gallez, B.12
Wahl, M.L.13
Feron, O.14
Dewhirst, M.W.15
-
28
-
-
1542618348
-
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
-
10.1073/pnas.0308061100, 373461, 14985505
-
Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci USA 2004, 101:3329-3335. 10.1073/pnas.0308061100, 373461, 14985505.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 3329-3335
-
-
Shaw, R.J.1
Kosmatka, M.2
Bardeesy, N.3
Hurley, R.L.4
Witters, L.A.5
DePinho, R.A.6
Cantley, L.C.7
-
29
-
-
70349331678
-
Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells
-
10.1126/science.1174229, 2820374, 19661383
-
Yun J, Rago C, Cheong I, Pagliarini R, Angenendt P, Rajagopalan H, Schmidt K, Willson JK, Markowitz S, Zhou S, Diaz LA, Velculescu VE, Lengauer C, Kinzler KW, Vogelstein B, Papadopoulos N. Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. Science 2009, 325:1555-1559. 10.1126/science.1174229, 2820374, 19661383.
-
(2009)
Science
, vol.325
, pp. 1555-1559
-
-
Yun, J.1
Rago, C.2
Cheong, I.3
Pagliarini, R.4
Angenendt, P.5
Rajagopalan, H.6
Schmidt, K.7
Willson, J.K.8
Markowitz, S.9
Zhou, S.10
Diaz, L.A.11
Velculescu, V.E.12
Lengauer, C.13
Kinzler, K.W.14
Vogelstein, B.15
Papadopoulos, N.16
-
30
-
-
0027162708
-
Geographical mapping of metabolites in biological tissue with quantitative bioluminescence and single photon imaging
-
10.1007/BF00157805, 7689547
-
Mueller-Klieser W, Walenta S. Geographical mapping of metabolites in biological tissue with quantitative bioluminescence and single photon imaging. Histochem J 1993, 25:407-420. 10.1007/BF00157805, 7689547.
-
(1993)
Histochem J
, vol.25
, pp. 407-420
-
-
Mueller-Klieser, W.1
Walenta, S.2
-
31
-
-
0024311944
-
Blood flow, metabolism, cellular microenvironment, and growth rate of human tumor xenografts
-
Kallinowski F, Schlenger KH, Runkel S, Kloes M, Stohrer M, Okunieff P, Vaupel P. Blood flow, metabolism, cellular microenvironment, and growth rate of human tumor xenografts. Cancer Res 1989, 49:3759-3764.
-
(1989)
Cancer Res
, vol.49
, pp. 3759-3764
-
-
Kallinowski, F.1
Schlenger, K.H.2
Runkel, S.3
Kloes, M.4
Stohrer, M.5
Okunieff, P.6
Vaupel, P.7
-
32
-
-
0033764353
-
Review of methods used to study oxygen transport at the microcirculatory level
-
10.1002/1097-0215(20001020)90:5<237::AID-IJC1>3.0.CO;2-T, 11091348
-
Dewhirst MW, Klitzman B, Braun RD, Brizel DM, Haroon ZA, Secomb TW. Review of methods used to study oxygen transport at the microcirculatory level. Int J Cancer 2000, 90:237-255. 10.1002/1097-0215(20001020)90:5<237::AID-IJC1>3.0.CO;2-T, 11091348.
-
(2000)
Int J Cancer
, vol.90
, pp. 237-255
-
-
Dewhirst, M.W.1
Klitzman, B.2
Braun, R.D.3
Brizel, D.M.4
Haroon, Z.A.5
Secomb, T.W.6
-
33
-
-
0141429084
-
Ultrasound guided pO2 measurement of breast cancer reoxygenation after neoadjuvant chemotherapy and hyperthermia treatment
-
10.1080/0265673031000121517, 12944165
-
Vujaskovic Z, Rosen EL, Blackwell KL, Jones EL, Brizel DM, Prosnitz LR, Samulski TV, Dewhirst MW. Ultrasound guided pO2 measurement of breast cancer reoxygenation after neoadjuvant chemotherapy and hyperthermia treatment. Int J Hyperthermia 2003, 19:498-506. 10.1080/0265673031000121517, 12944165.
-
(2003)
Int J Hyperthermia
, vol.19
, pp. 498-506
-
-
Vujaskovic, Z.1
Rosen, E.L.2
Blackwell, K.L.3
Jones, E.L.4
Brizel, D.M.5
Prosnitz, L.R.6
Samulski, T.V.7
Dewhirst, M.W.8
-
34
-
-
0035479076
-
Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer
-
Brizel DM, Schroeder T, Scher RL, Walenta S, Clough RW, Dewhirst MW, Mueller-Klieser W. Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer. Int J Radiat Oncol Biol Phys 2001, 51:349-353.
-
(2001)
Int J Radiat Oncol Biol Phys
, vol.51
, pp. 349-353
-
-
Brizel, D.M.1
Schroeder, T.2
Scher, R.L.3
Walenta, S.4
Clough, R.W.5
Dewhirst, M.W.6
Mueller-Klieser, W.7
-
35
-
-
0028784650
-
Correlation of high lactate levels in human cervical cancer with incidence of metastasis
-
Schwickert G, Walenta S, Sundfor K, Rofstad EK, Mueller-Klieser W. Correlation of high lactate levels in human cervical cancer with incidence of metastasis. Cancer Res 1995, 55:4757-4759.
-
(1995)
Cancer Res
, vol.55
, pp. 4757-4759
-
-
Schwickert, G.1
Walenta, S.2
Sundfor, K.3
Rofstad, E.K.4
Mueller-Klieser, W.5
-
36
-
-
0031029634
-
Correlation of high lactate levels in head and neck tumors with incidence of metastasis
-
1858285, 9033256
-
Walenta S, Salameh A, Lyng H, Evensen JF, Mitze M, Rofstad EK, Mueller-Klieser W. Correlation of high lactate levels in head and neck tumors with incidence of metastasis. Am J Pathol 1997, 150:409-415. 1858285, 9033256.
-
(1997)
Am J Pathol
, vol.150
, pp. 409-415
-
-
Walenta, S.1
Salameh, A.2
Lyng, H.3
Evensen, J.F.4
Mitze, M.5
Rofstad, E.K.6
Mueller-Klieser, W.7
-
37
-
-
0034652620
-
High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers
-
Walenta S, Wetterling M, Lehrke M, Schwickert G, Sundfor K, Rofstad EK, Mueller-Klieser W. High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Res 2000, 60:916-921.
-
(2000)
Cancer Res
, vol.60
, pp. 916-921
-
-
Walenta, S.1
Wetterling, M.2
Lehrke, M.3
Schwickert, G.4
Sundfor, K.5
Rofstad, E.K.6
Mueller-Klieser, W.7
-
38
-
-
3142588858
-
Lactate: mirror and motor of tumor malignancy
-
10.1016/j.semradonc.2004.04.004, 15254870
-
Walenta S, Mueller-Klieser WF. Lactate: mirror and motor of tumor malignancy. Semin Radiat Oncol 2004, 14:267-274. 10.1016/j.semradonc.2004.04.004, 15254870.
-
(2004)
Semin Radiat Oncol
, vol.14
, pp. 267-274
-
-
Walenta, S.1
Mueller-Klieser, W.F.2
-
39
-
-
0035181306
-
Hypoxia-regulated carbonic anhydrase-9 (CA9) relates to poor vascularization and resistance of squamous cell head and neck cancer to chemoradiotherapy
-
Koukourakis MI, Giatromanolaki A, Sivridis E, Simopoulos K, Pastorek J, Wykoff CC, Gatter KC, Harris AL. Hypoxia-regulated carbonic anhydrase-9 (CA9) relates to poor vascularization and resistance of squamous cell head and neck cancer to chemoradiotherapy. Clin Cancer Res 2001, 7:3399-3403.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 3399-3403
-
-
Koukourakis, M.I.1
Giatromanolaki, A.2
Sivridis, E.3
Simopoulos, K.4
Pastorek, J.5
Wykoff, C.C.6
Gatter, K.C.7
Harris, A.L.8
-
40
-
-
34248172298
-
Relation of a hypoxia metagene derived from head and neck cancer to prognosis of multiple cancers
-
10.1158/0008-5472.CAN-06-3322, 17409455
-
Winter SC, Buffa FM, Silva P, Miller C, Valentine HR, Turley H, Shah KA, Cox GJ, Corbridge RJ, Homer JJ, Musgrove B, Slevin N, Sloan P, Price P, West CM, Harris AL. Relation of a hypoxia metagene derived from head and neck cancer to prognosis of multiple cancers. Cancer Res 2007, 67:3441-3449. 10.1158/0008-5472.CAN-06-3322, 17409455.
-
(2007)
Cancer Res
, vol.67
, pp. 3441-3449
-
-
Winter, S.C.1
Buffa, F.M.2
Silva, P.3
Miller, C.4
Valentine, H.R.5
Turley, H.6
Shah, K.A.7
Cox, G.J.8
Corbridge, R.J.9
Homer, J.J.10
Musgrove, B.11
Slevin, N.12
Sloan, P.13
Price, P.14
West, C.M.15
Harris, A.L.16
-
41
-
-
31144459985
-
Oncogenic pathway signatures in human cancers as a guide to targeted therapies
-
10.1038/nature04296, 16273092
-
Bild AH, Yao G, Chang JT, Wang Q, Potti A, Chasse D, Joshi MB, Harpole D, Lancaster JM, Berchuck A, Olson JA, Marks JR, Dressman HK, West M, Nevins JR. Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature 2006, 439:353-357. 10.1038/nature04296, 16273092.
-
(2006)
Nature
, vol.439
, pp. 353-357
-
-
Bild, A.H.1
Yao, G.2
Chang, J.T.3
Wang, Q.4
Potti, A.5
Chasse, D.6
Joshi, M.B.7
Harpole, D.8
Lancaster, J.M.9
Berchuck, A.10
Olson, J.A.11
Marks, J.R.12
Dressman, H.K.13
West, M.14
Nevins, J.R.15
-
42
-
-
58149157900
-
The genomic analysis of lactic acidosis and acidosis response in human cancers
-
10.1371/journal.pgen.1000293, 2585811, 19057672
-
Chen JL, Lucas JE, Schroeder T, Mori S, Wu J, Nevins J, Dewhirst M, West M, Chi JT. The genomic analysis of lactic acidosis and acidosis response in human cancers. PLoS Genet 2008, 4:e1000293. 10.1371/journal.pgen.1000293, 2585811, 19057672.
-
(2008)
PLoS Genet
, vol.4
-
-
Chen, J.L.1
Lucas, J.E.2
Schroeder, T.3
Mori, S.4
Wu, J.5
Nevins, J.6
Dewhirst, M.7
West, M.8
Chi, J.T.9
-
43
-
-
34848815630
-
Gene expression programs of human smooth muscle cells: tissue-specific differentiation and prognostic significance in breast cancers
-
1994710, 17907811
-
Chi JT, Rodriguez EH, Wang Z, Nuyten DS, Mukherjee S, van de Rijn M, van de Vijver MJ, Hastie T, Brown PO. Gene expression programs of human smooth muscle cells: tissue-specific differentiation and prognostic significance in breast cancers. PLoS Genet 2007, 3:1770-1784. 1994710, 17907811.
-
(2007)
PLoS Genet
, vol.3
, pp. 1770-1784
-
-
Chi, J.T.1
Rodriguez, E.H.2
Wang, Z.3
Nuyten, D.S.4
Mukherjee, S.5
van de Rijn, M.6
van de Vijver, M.J.7
Hastie, T.8
Brown, P.O.9
-
44
-
-
78049415422
-
Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA
-
10.1371/journal.pgen.1001093, 2937306, 20844768
-
Chen JL, Merl D, Peterson CW, Wu J, Liu PY, Yin H, Muoio DM, Ayer DE, West M, Chi JT. Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA. PLoS Genet 2010, 6:e1001093. 10.1371/journal.pgen.1001093, 2937306, 20844768.
-
(2010)
PLoS Genet
, vol.6
-
-
Chen, J.L.1
Merl, D.2
Peterson, C.W.3
Wu, J.4
Liu, P.Y.5
Yin, H.6
Muoio, D.M.7
Ayer, D.E.8
West, M.9
Chi, J.T.10
-
45
-
-
78049422909
-
Latent factor analysis to discover pathway-associated putative segmental aneuploidies in human cancers
-
10.1371/journal.pcbi.1000920, 2932681, 20824128
-
Lucas JE, Kung HN, Chi JT. Latent factor analysis to discover pathway-associated putative segmental aneuploidies in human cancers. PLoS Comput Biol 2010, 6:e1000920. 10.1371/journal.pcbi.1000920, 2932681, 20824128.
-
(2010)
PLoS Comput Biol
, vol.6
-
-
Lucas, J.E.1
Kung, H.N.2
Chi, J.T.3
-
46
-
-
0035845511
-
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
-
10.1073/pnas.191367098, 58566, 11553815
-
Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, Thorsen T, Quist H, Matese JC, Brown PO, Botstein D, Eystein Lonning P, Borresen-Dale AL. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 2001, 98:10869-10874. 10.1073/pnas.191367098, 58566, 11553815.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10869-10874
-
-
Sorlie, T.1
Perou, C.M.2
Tibshirani, R.3
Aas, T.4
Geisler, S.5
Johnsen, H.6
Hastie, T.7
Eisen, M.B.8
van de Rijn, M.9
Jeffrey, S.S.10
Thorsen, T.11
Quist, H.12
Matese, J.C.13
Brown, P.O.14
Botstein, D.15
Eystein Lonning, P.16
Borresen-Dale, A.L.17
-
47
-
-
34248233109
-
Isogenic normal basal and luminal mammary epithelial isolated by a novel method show a differential response to ionizing radiation
-
10.1158/0008-5472.CAN-06-4065, 17409405
-
Huper G, Marks JR. Isogenic normal basal and luminal mammary epithelial isolated by a novel method show a differential response to ionizing radiation. Cancer Res 2007, 67:2990-3001. 10.1158/0008-5472.CAN-06-4065, 17409405.
-
(2007)
Cancer Res
, vol.67
, pp. 2990-3001
-
-
Huper, G.1
Marks, J.R.2
-
48
-
-
66249092010
-
Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation
-
10.1158/0008-5472.CAN-08-2689, 19435925
-
Saito S, Furuno A, Sakurai J, Sakamoto A, Park HR, Shin-Ya K, Tsuruo T, Tomida A. Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation. Cancer Res 2009, 69:4225-4234. 10.1158/0008-5472.CAN-08-2689, 19435925.
-
(2009)
Cancer Res
, vol.69
, pp. 4225-4234
-
-
Saito, S.1
Furuno, A.2
Sakurai, J.3
Sakamoto, A.4
Park, H.R.5
Shin-Ya, K.6
Tsuruo, T.7
Tomida, A.8
-
49
-
-
0023631608
-
Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo
-
10.1016/0092-8674(87)90449-1, 3032456
-
Sinn E, Muller W, Pattengale P, Tepler I, Wallace R, Leder P. Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo. Cell 1987, 49:465-475. 10.1016/0092-8674(87)90449-1, 3032456.
-
(1987)
Cell
, vol.49
, pp. 465-475
-
-
Sinn, E.1
Muller, W.2
Pattengale, P.3
Tepler, I.4
Wallace, R.5
Leder, P.6
-
50
-
-
4143150688
-
Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma
-
10.1158/1078-0432.CCR-04-0220, 15328174
-
Nielsen TO, Hsu FD, Jensen K, Cheang M, Karaca G, Hu Z, Hernandez-Boussard T, Livasy C, Cowan D, Dressler L, Akslen LA, Ragaz J, Gown AM, Gilks CB, van de Rijn M, Perou CM. Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin Cancer Res 2004, 10:5367-5374. 10.1158/1078-0432.CCR-04-0220, 15328174.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 5367-5374
-
-
Nielsen, T.O.1
Hsu, F.D.2
Jensen, K.3
Cheang, M.4
Karaca, G.5
Hu, Z.6
Hernandez-Boussard, T.7
Livasy, C.8
Cowan, D.9
Dressler, L.10
Akslen, L.A.11
Ragaz, J.12
Gown, A.M.13
Gilks, C.B.14
van de Rijn, M.15
Perou, C.M.16
-
51
-
-
0035126052
-
C-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations
-
10.1038/84691, 11175856
-
D'Cruz CM, Gunther EJ, Boxer RB, Hartman JL, Sintasath L, Moody SE, Cox JD, Ha SI, Belka GK, Golant A, Cardiff RD, Chodosh LA. c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations. Nat Med 2001, 7:235-239. 10.1038/84691, 11175856.
-
(2001)
Nat Med
, vol.7
, pp. 235-239
-
-
D'Cruz, C.M.1
Gunther, E.J.2
Boxer, R.B.3
Hartman, J.L.4
Sintasath, L.5
Moody, S.E.6
Cox, J.D.7
Ha, S.I.8
Belka, G.K.9
Golant, A.10
Cardiff, R.D.11
Chodosh, L.A.12
-
52
-
-
34548803430
-
Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer
-
10.1073/pnas.0702387104, 1941796, 17670948
-
Franovic A, Gunaratnam L, Smith K, Robert I, Patten D, Lee S. Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer. Proc Natl Acad Sci USA 2007, 104:13092-13097. 10.1073/pnas.0702387104, 1941796, 17670948.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 13092-13097
-
-
Franovic, A.1
Gunaratnam, L.2
Smith, K.3
Robert, I.4
Patten, D.5
Lee, S.6
-
53
-
-
51649096739
-
Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells
-
10.1158/1541-7786.MCR-07-2177, 2775817, 18644974
-
Niu G, Briggs J, Deng J, Ma Y, Lee H, Kortylewski M, Kujawski M, Kay H, Cress WD, Jove R, Yu H. Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells. Mol Cancer Res 2008, 6:1099-1105. 10.1158/1541-7786.MCR-07-2177, 2775817, 18644974.
-
(2008)
Mol Cancer Res
, vol.6
, pp. 1099-1105
-
-
Niu, G.1
Briggs, J.2
Deng, J.3
Ma, Y.4
Lee, H.5
Kortylewski, M.6
Kujawski, M.7
Kay, H.8
Cress, W.D.9
Jove, R.10
Yu, H.11
-
54
-
-
46949094778
-
Hypoxia-inducible factor 1alpha is closely linked to an aggressive phenotype in breast cancer
-
10.1007/s10549-007-9742-1, 17805961
-
Yamamoto Y, Ibusuki M, Okumura Y, Kawasoe T, Kai K, Iyama K, Iwase H. Hypoxia-inducible factor 1alpha is closely linked to an aggressive phenotype in breast cancer. Breast Cancer Res Treat 2008, 110:465-475. 10.1007/s10549-007-9742-1, 17805961.
-
(2008)
Breast Cancer Res Treat
, vol.110
, pp. 465-475
-
-
Yamamoto, Y.1
Ibusuki, M.2
Okumura, Y.3
Kawasoe, T.4
Kai, K.5
Iyama, K.6
Iwase, H.7
-
55
-
-
58749090733
-
The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy
-
10.1038/sj.bjc.6604844, 2634728, 19165203
-
Tan EY, Yan M, Campo L, Han C, Takano E, Turley H, Candiloro I, Pezzella F, Gatter KC, Millar EK, O'Toole SA, McNeil CM, Crea P, Segara D, Sutherland RL, Harris AL, Fox SB. The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy. Br J Cancer 2009, 100:405-411. 10.1038/sj.bjc.6604844, 2634728, 19165203.
-
(2009)
Br J Cancer
, vol.100
, pp. 405-411
-
-
Tan, E.Y.1
Yan, M.2
Campo, L.3
Han, C.4
Takano, E.5
Turley, H.6
Candiloro, I.7
Pezzella, F.8
Gatter, K.C.9
Millar, E.K.10
O'Toole, S.A.11
McNeil, C.M.12
Crea, P.13
Segara, D.14
Sutherland, R.L.15
Harris, A.L.16
Fox, S.B.17
-
56
-
-
0033618371
-
Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines
-
10.1074/jbc.274.31.21528, 10419456
-
Nakatani K, Thompson DA, Barthel A, Sakaue H, Liu W, Weigel RJ, Roth RA. Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines. J Biol Chem 1999, 274:21528-21532. 10.1074/jbc.274.31.21528, 10419456.
-
(1999)
J Biol Chem
, vol.274
, pp. 21528-21532
-
-
Nakatani, K.1
Thompson, D.A.2
Barthel, A.3
Sakaue, H.4
Liu, W.5
Weigel, R.J.6
Roth, R.A.7
-
57
-
-
31044441241
-
Gene expression profiling of breast cell lines identifies potential new basal markers
-
10.1038/sj.onc.1209254, 16288205
-
Charafe-Jauffret E, Ginestier C, Monville F, Finetti P, Adelaide J, Cervera N, Fekairi S, Xerri L, Jacquemier J, Birnbaum D, Bertucci F. Gene expression profiling of breast cell lines identifies potential new basal markers. Oncogene 2006, 25:2273-2284. 10.1038/sj.onc.1209254, 16288205.
-
(2006)
Oncogene
, vol.25
, pp. 2273-2284
-
-
Charafe-Jauffret, E.1
Ginestier, C.2
Monville, F.3
Finetti, P.4
Adelaide, J.5
Cervera, N.6
Fekairi, S.7
Xerri, L.8
Jacquemier, J.9
Birnbaum, D.10
Bertucci, F.11
-
58
-
-
0023950817
-
Expression of basal and luminal epithelium-specific keratins in normal, benign, and malignant breast tissue
-
10.1093/jnci/80.9.691, 2453676
-
Dairkee SH, Puett L, Hackett AJ. Expression of basal and luminal epithelium-specific keratins in normal, benign, and malignant breast tissue. J Natl Cancer Inst 1988, 80:691-695. 10.1093/jnci/80.9.691, 2453676.
-
(1988)
J Natl Cancer Inst
, vol.80
, pp. 691-695
-
-
Dairkee, S.H.1
Puett, L.2
Hackett, A.J.3
-
59
-
-
35148885729
-
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
-
10.1016/j.ccr.2007.08.030, 17936563
-
Berns K, Horlings HM, Hennessy BT, Madiredjo M, Hijmans EM, Beelen K, Linn SC, Gonzalez-Angulo AM, Stemke-Hale K, Hauptmann M, Beijersbergen RL, Mills GB, van de Vijver MJ, Bernards R. A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell 2007, 12:395-402. 10.1016/j.ccr.2007.08.030, 17936563.
-
(2007)
Cancer Cell
, vol.12
, pp. 395-402
-
-
Berns, K.1
Horlings, H.M.2
Hennessy, B.T.3
Madiredjo, M.4
Hijmans, E.M.5
Beelen, K.6
Linn, S.C.7
Gonzalez-Angulo, A.M.8
Stemke-Hale, K.9
Hauptmann, M.10
Beijersbergen, R.L.11
Mills, G.B.12
van de Vijver, M.J.13
Bernards, R.14
-
60
-
-
30944450821
-
Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma
-
10.1038/modpathol.3800528, 16341146
-
Livasy CA, Karaca G, Nanda R, Tretiakova MS, Olopade OI, Moore DT, Perou CM. Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma. Mod Pathol 2006, 19:264-271. 10.1038/modpathol.3800528, 16341146.
-
(2006)
Mod Pathol
, vol.19
, pp. 264-271
-
-
Livasy, C.A.1
Karaca, G.2
Nanda, R.3
Tretiakova, M.S.4
Olopade, O.I.5
Moore, D.T.6
Perou, C.M.7
-
61
-
-
33847126689
-
Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation
-
10.1038/ncb1530, 17187062
-
Asselin-Labat ML, Sutherland KD, Barker H, Thomas R, Shackleton M, Forrest NC, Hartley L, Robb L, Grosveld FG, van der Wees J, Lindeman GJ, Visvader JE. Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation. Nat Cell Biol 2007, 9:201-209. 10.1038/ncb1530, 17187062.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 201-209
-
-
Asselin-Labat, M.L.1
Sutherland, K.D.2
Barker, H.3
Thomas, R.4
Shackleton, M.5
Forrest, N.C.6
Hartley, L.7
Robb, L.8
Grosveld, F.G.9
van der Wees, J.10
Lindeman, G.J.11
Visvader, J.E.12
-
62
-
-
33751202983
-
GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland
-
10.1016/j.cell.2006.09.048, 2646406, 17129787
-
Kouros-Mehr H, Slorach EM, Sternlicht MD, Werb Z. GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland. Cell 2006, 127:1041-1055. 10.1016/j.cell.2006.09.048, 2646406, 17129787.
-
(2006)
Cell
, vol.127
, pp. 1041-1055
-
-
Kouros-Mehr, H.1
Slorach, E.M.2
Sternlicht, M.D.3
Werb, Z.4
-
63
-
-
77957555408
-
Genome profiling of ERBB2-amplified breast cancers
-
10.1186/1471-2407-10-539, 2958950, 20932292
-
Sircoulomb F, Bekhouche I, Finetti P, Adelaide J, Ben Hamida A, Bonansea J, Raynaud S, Innocenti C, Charafe-Jauffret E, Tarpin C, Ben Ayed F, Viens P, Jacquemier J, Bertucci F, Birnbaum D, Chaffanet M. Genome profiling of ERBB2-amplified breast cancers. BMC Cancer 2010, 10:539. 10.1186/1471-2407-10-539, 2958950, 20932292.
-
(2010)
BMC Cancer
, vol.10
, pp. 539
-
-
Sircoulomb, F.1
Bekhouche, I.2
Finetti, P.3
Adelaide, J.4
Ben Hamida, A.5
Bonansea, J.6
Raynaud, S.7
Innocenti, C.8
Charafe-Jauffret, E.9
Tarpin, C.10
Ben Ayed, F.11
Viens, P.12
Jacquemier, J.13
Bertucci, F.14
Birnbaum, D.15
Chaffanet, M.16
-
64
-
-
67650252530
-
Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery
-
10.1371/journal.pone.0006146, 2702084, 19582160
-
Kao J, Salari K, Bocanegra M, Choi YL, Girard L, Gandhi J, Kwei KA, Hernandez-Boussard T, Wang P, Gazdar AF, Minna JD, Pollack JR. Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery. PLoS One 2009, 4:e6146. 10.1371/journal.pone.0006146, 2702084, 19582160.
-
(2009)
PLoS One
, vol.4
-
-
Kao, J.1
Salari, K.2
Bocanegra, M.3
Choi, Y.L.4
Girard, L.5
Gandhi, J.6
Kwei, K.A.7
Hernandez-Boussard, T.8
Wang, P.9
Gazdar, A.F.10
Minna, J.D.11
Pollack, J.R.12
-
65
-
-
18644366801
-
Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors
-
10.1593/neo.04430, 1501147, 15967109
-
Robey IF, Lien AD, Welsh SJ, Baggett BK, Gillies RJ. Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors. Neoplasia 2005, 7:324-330. 10.1593/neo.04430, 1501147, 15967109.
-
(2005)
Neoplasia
, vol.7
, pp. 324-330
-
-
Robey, I.F.1
Lien, A.D.2
Welsh, S.J.3
Baggett, B.K.4
Gillies, R.J.5
-
66
-
-
68349130357
-
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
-
10.1038/nm.2000, 19648928
-
Lim E, Vaillant F, Wu D, Forrest NC, Pal B, Hart AH, Asselin-Labat ML, Gyorki DE, Ward T, Partanen A, Feleppa F, Huschtscha LI, Thorne HJ, Fox SB, Yan M, French JD, Brown MA, Smyth GK, Visvader JE, Lindeman GJ. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med 2009, 15:907-913. 10.1038/nm.2000, 19648928.
-
(2009)
Nat Med
, vol.15
, pp. 907-913
-
-
Lim, E.1
Vaillant, F.2
Wu, D.3
Forrest, N.C.4
Pal, B.5
Hart, A.H.6
Asselin-Labat, M.L.7
Gyorki, D.E.8
Ward, T.9
Partanen, A.10
Feleppa, F.11
Huschtscha, L.I.12
Thorne, H.J.13
Fox, S.B.14
Yan, M.15
French, J.D.16
Brown, M.A.17
Smyth, G.K.18
Visvader, J.E.19
Lindeman, G.J.20
more..
-
67
-
-
77956217067
-
Regulation of the HIF-1alpha level is essential for hematopoietic stem cells
-
10.1016/j.stem.2010.06.020, 20804974
-
Takubo K, Goda N, Yamada W, Iriuchishima H, Ikeda E, Kubota Y, Shima H, Johnson RS, Hirao A, Suematsu M, Suda T. Regulation of the HIF-1alpha level is essential for hematopoietic stem cells. Cell Stem Cell 2010, 7:391-402. 10.1016/j.stem.2010.06.020, 20804974.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 391-402
-
-
Takubo, K.1
Goda, N.2
Yamada, W.3
Iriuchishima, H.4
Ikeda, E.5
Kubota, Y.6
Shima, H.7
Johnson, R.S.8
Hirao, A.9
Suematsu, M.10
Suda, T.11
-
68
-
-
77956205122
-
The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche
-
10.1016/j.stem.2010.07.011, 20804973
-
Simsek T, Kocabas F, Zheng J, Deberardinis RJ, Mahmoud AI, Olson EN, Schneider JW, Zhang CC, Sadek HA. The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche. Cell Stem Cell 2010, 7:380-390. 10.1016/j.stem.2010.07.011, 20804973.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 380-390
-
-
Simsek, T.1
Kocabas, F.2
Zheng, J.3
Deberardinis, R.J.4
Mahmoud, A.I.5
Olson, E.N.6
Schneider, J.W.7
Zhang, C.C.8
Sadek, H.A.9
-
69
-
-
0034100836
-
Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3)
-
10.1172/JCI8316, 289179, 10712429
-
Caniggia I, Mostachfi H, Winter J, Gassmann M, Lye SJ, Kuliszewski M, Post M. Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3). J Clin Invest 2000, 105:577-587. 10.1172/JCI8316, 289179, 10712429.
-
(2000)
J Clin Invest
, vol.105
, pp. 577-587
-
-
Caniggia, I.1
Mostachfi, H.2
Winter, J.3
Gassmann, M.4
Lye, S.J.5
Kuliszewski, M.6
Post, M.7
-
70
-
-
16344380951
-
Low O2 tensions and the prevention of differentiation of hES cells
-
10.1073/pnas.0501283102, 554750, 15772165
-
Ezashi T, Das P, Roberts RM. Low O2 tensions and the prevention of differentiation of hES cells. Proc Natl Acad Sci USA 2005, 102:4783-4788. 10.1073/pnas.0501283102, 554750, 15772165.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 4783-4788
-
-
Ezashi, T.1
Das, P.2
Roberts, R.M.3
-
71
-
-
0037380791
-
Hypoxia promotes a dedifferentiated phenotype in ductal breast carcinoma in situ
-
Helczynska K, Kronblad A, Jogi A, Nilsson E, Beckman S, Landberg G, Pahlman S. Hypoxia promotes a dedifferentiated phenotype in ductal breast carcinoma in situ. Cancer Res 2003, 63:1441-1444.
-
(2003)
Cancer Res
, vol.63
, pp. 1441-1444
-
-
Helczynska, K.1
Kronblad, A.2
Jogi, A.3
Nilsson, E.4
Beckman, S.5
Landberg, G.6
Pahlman, S.7
-
72
-
-
5144226211
-
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
-
10.1016/j.ccr.2004.06.022, 15324695
-
Nagata Y, Lan KH, Zhou X, Tan M, Esteva FJ, Sahin AA, Klos KS, Li P, Monia BP, Nguyen NT, Hortobagyi GN, Hung MC, Yu D. PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell 2004, 6:117-127. 10.1016/j.ccr.2004.06.022, 15324695.
-
(2004)
Cancer Cell
, vol.6
, pp. 117-127
-
-
Nagata, Y.1
Lan, K.H.2
Zhou, X.3
Tan, M.4
Esteva, F.J.5
Sahin, A.A.6
Klos, K.S.7
Li, P.8
Monia, B.P.9
Nguyen, N.T.10
Hortobagyi, G.N.11
Hung, M.C.12
Yu, D.13
-
73
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
10.1126/science.1141478, 17463250
-
Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, Lindeman N, Gale CM, Zhao X, Christensen J, Kosaka T, Holmes AJ, Rogers AM, Cappuzzo F, Mok T, Lee C, Johnson BE, Cantley LC, Janne PA. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007, 316:1039-1043. 10.1126/science.1141478, 17463250.
-
(2007)
Science
, vol.316
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
Song, Y.4
Hyland, C.5
Park, J.O.6
Lindeman, N.7
Gale, C.M.8
Zhao, X.9
Christensen, J.10
Kosaka, T.11
Holmes, A.J.12
Rogers, A.M.13
Cappuzzo, F.14
Mok, T.15
Lee, C.16
Johnson, B.E.17
Cantley, L.C.18
Janne, P.A.19
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