메뉴 건너뛰기




Volumn 13, Issue 3, 2011, Pages

Analysis of tumor environmental response and oncogenic pathway activation identifies distinct basal and luminal features in HER2-related breast tumor subtypes

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; GLUCOSE; HER2 PROTEIN, HUMAN; HIF1A PROTEIN, HUMAN; SMALL INTERFERING RNA;

EID: 84860390004     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr2899     Document Type: Article
Times cited : (51)

References (73)
  • 5
    • 72749103664 scopus 로고    scopus 로고
    • Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis
    • 10.1101/gad.1849509, 2779757, 19933147
    • Visvader JE. Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. Genes Dev 2009, 23:2563-2577. 10.1101/gad.1849509, 2779757, 19933147.
    • (2009) Genes Dev , vol.23 , pp. 2563-2577
    • Visvader, J.E.1
  • 6
    • 37049183697 scopus 로고
    • Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • 10.1126/science.3798106, 3798106
    • Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987, 235:177-182. 10.1126/science.3798106, 3798106.
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 10
    • 0037036949 scopus 로고    scopus 로고
    • New drugs for breast cancer
    • 10.1016/S0140-6736(02)09903-8, 12241842
    • Smith IE. New drugs for breast cancer. Lancet 2002, 360:790-792. 10.1016/S0140-6736(02)09903-8, 12241842.
    • (2002) Lancet , vol.360 , pp. 790-792
    • Smith, I.E.1
  • 15
    • 3142587028 scopus 로고    scopus 로고
    • Tumor microenvironmental physiology and its implications for radiation oncology
    • 10.1016/j.semradonc.2004.04.008, 15254862
    • Vaupel P. Tumor microenvironmental physiology and its implications for radiation oncology. Semin Radiat Oncol 2004, 14:198-206. 10.1016/j.semradonc.2004.04.008, 15254862.
    • (2004) Semin Radiat Oncol , vol.14 , pp. 198-206
    • Vaupel, P.1
  • 16
    • 0034321578 scopus 로고    scopus 로고
    • Blood supply, oxygenation status and metabolic micromilieu of breast cancers: characterization and therapeutic relevance
    • Vaupel P, Hockel M. Blood supply, oxygenation status and metabolic micromilieu of breast cancers: characterization and therapeutic relevance. Int J Oncol 2000, 17:869-879.
    • (2000) Int J Oncol , vol.17 , pp. 869-879
    • Vaupel, P.1    Hockel, M.2
  • 17
    • 37549013776 scopus 로고    scopus 로고
    • A microenvironmental model of carcinogenesis
    • 10.1038/nrc2255, 18059462
    • Gatenby RA, Gillies RJ. A microenvironmental model of carcinogenesis. Nat Rev Cancer 2008, 8:56-61. 10.1038/nrc2255, 18059462.
    • (2008) Nat Rev Cancer , vol.8 , pp. 56-61
    • Gatenby, R.A.1    Gillies, R.J.2
  • 18
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia--a key regulatory factor in tumour growth
    • 10.1038/nrc704, 11902584
    • Harris AL. Hypoxia--a key regulatory factor in tumour growth. Nat Rev Cancer 2002, 2:38-47. 10.1038/nrc704, 11902584.
    • (2002) Nat Rev Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 19
    • 0030593729 scopus 로고    scopus 로고
    • Renal-cell carcinoma
    • 10.1056/NEJM199609193351207, 8778606
    • Motzer RJ, Bander NH, Nanus DM. Renal-cell carcinoma. N Engl J Med 1996, 335:865-875. 10.1056/NEJM199609193351207, 8778606.
    • (1996) N Engl J Med , vol.335 , pp. 865-875
    • Motzer, R.J.1    Bander, N.H.2    Nanus, D.M.3
  • 20
    • 0032524285 scopus 로고    scopus 로고
    • P53 inhibits hypoxia-inducible factor-stimulated transcription
    • 10.1074/jbc.273.20.11995, 9575138
    • Blagosklonny MV, An WG, Romanova LY, Trepel J, Fojo T, Neckers L. p53 inhibits hypoxia-inducible factor-stimulated transcription. J Biol Chem 1998, 273:11995-11998. 10.1074/jbc.273.20.11995, 9575138.
    • (1998) J Biol Chem , vol.273 , pp. 11995-11998
    • Blagosklonny, M.V.1    An, W.G.2    Romanova, L.Y.3    Trepel, J.4    Fojo, T.5    Neckers, L.6
  • 22
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics
    • Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu MM, Simons JW, Semenza GL. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 2000, 60:1541-1545.
    • (2000) Cancer Res , vol.60 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3    Laughner, E.4    Hanrahan, C.5    Georgescu, M.M.6    Simons, J.W.7    Semenza, G.L.8
  • 23
    • 0035012605 scopus 로고    scopus 로고
    • HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
    • 10.1128/MCB.21.12.3995-4004.2001, 87062, 11359907
    • Laughner E, Taghavi P, Chiles K, Mahon PC, Semenza GL. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol 2001, 21:3995-4004. 10.1128/MCB.21.12.3995-4004.2001, 87062, 11359907.
    • (2001) Mol Cell Biol , vol.21 , pp. 3995-4004
    • Laughner, E.1    Taghavi, P.2    Chiles, K.3    Mahon, P.C.4    Semenza, G.L.5
  • 26
    • 20444490000 scopus 로고    scopus 로고
    • Spatial heterogeneity and oxygen dependence of glucose consumption in R3230Ac and fibrosarcomas of the Fischer 344 rat
    • 10.1158/0008-5472.CAN-04-3900, 15958560
    • Schroeder T, Yuan H, Viglianti BL, Peltz C, Asopa S, Vujaskovic Z, Dewhirst MW. Spatial heterogeneity and oxygen dependence of glucose consumption in R3230Ac and fibrosarcomas of the Fischer 344 rat. Cancer Res 2005, 65:5163-5171. 10.1158/0008-5472.CAN-04-3900, 15958560.
    • (2005) Cancer Res , vol.65 , pp. 5163-5171
    • Schroeder, T.1    Yuan, H.2    Viglianti, B.L.3    Peltz, C.4    Asopa, S.5    Vujaskovic, Z.6    Dewhirst, M.W.7
  • 28
    • 1542618348 scopus 로고    scopus 로고
    • The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
    • 10.1073/pnas.0308061100, 373461, 14985505
    • Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci USA 2004, 101:3329-3335. 10.1073/pnas.0308061100, 373461, 14985505.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 3329-3335
    • Shaw, R.J.1    Kosmatka, M.2    Bardeesy, N.3    Hurley, R.L.4    Witters, L.A.5    DePinho, R.A.6    Cantley, L.C.7
  • 30
    • 0027162708 scopus 로고
    • Geographical mapping of metabolites in biological tissue with quantitative bioluminescence and single photon imaging
    • 10.1007/BF00157805, 7689547
    • Mueller-Klieser W, Walenta S. Geographical mapping of metabolites in biological tissue with quantitative bioluminescence and single photon imaging. Histochem J 1993, 25:407-420. 10.1007/BF00157805, 7689547.
    • (1993) Histochem J , vol.25 , pp. 407-420
    • Mueller-Klieser, W.1    Walenta, S.2
  • 32
    • 0033764353 scopus 로고    scopus 로고
    • Review of methods used to study oxygen transport at the microcirculatory level
    • 10.1002/1097-0215(20001020)90:5<237::AID-IJC1>3.0.CO;2-T, 11091348
    • Dewhirst MW, Klitzman B, Braun RD, Brizel DM, Haroon ZA, Secomb TW. Review of methods used to study oxygen transport at the microcirculatory level. Int J Cancer 2000, 90:237-255. 10.1002/1097-0215(20001020)90:5<237::AID-IJC1>3.0.CO;2-T, 11091348.
    • (2000) Int J Cancer , vol.90 , pp. 237-255
    • Dewhirst, M.W.1    Klitzman, B.2    Braun, R.D.3    Brizel, D.M.4    Haroon, Z.A.5    Secomb, T.W.6
  • 33
    • 0141429084 scopus 로고    scopus 로고
    • Ultrasound guided pO2 measurement of breast cancer reoxygenation after neoadjuvant chemotherapy and hyperthermia treatment
    • 10.1080/0265673031000121517, 12944165
    • Vujaskovic Z, Rosen EL, Blackwell KL, Jones EL, Brizel DM, Prosnitz LR, Samulski TV, Dewhirst MW. Ultrasound guided pO2 measurement of breast cancer reoxygenation after neoadjuvant chemotherapy and hyperthermia treatment. Int J Hyperthermia 2003, 19:498-506. 10.1080/0265673031000121517, 12944165.
    • (2003) Int J Hyperthermia , vol.19 , pp. 498-506
    • Vujaskovic, Z.1    Rosen, E.L.2    Blackwell, K.L.3    Jones, E.L.4    Brizel, D.M.5    Prosnitz, L.R.6    Samulski, T.V.7    Dewhirst, M.W.8
  • 35
    • 0028784650 scopus 로고
    • Correlation of high lactate levels in human cervical cancer with incidence of metastasis
    • Schwickert G, Walenta S, Sundfor K, Rofstad EK, Mueller-Klieser W. Correlation of high lactate levels in human cervical cancer with incidence of metastasis. Cancer Res 1995, 55:4757-4759.
    • (1995) Cancer Res , vol.55 , pp. 4757-4759
    • Schwickert, G.1    Walenta, S.2    Sundfor, K.3    Rofstad, E.K.4    Mueller-Klieser, W.5
  • 37
    • 0034652620 scopus 로고    scopus 로고
    • High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers
    • Walenta S, Wetterling M, Lehrke M, Schwickert G, Sundfor K, Rofstad EK, Mueller-Klieser W. High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Res 2000, 60:916-921.
    • (2000) Cancer Res , vol.60 , pp. 916-921
    • Walenta, S.1    Wetterling, M.2    Lehrke, M.3    Schwickert, G.4    Sundfor, K.5    Rofstad, E.K.6    Mueller-Klieser, W.7
  • 38
    • 3142588858 scopus 로고    scopus 로고
    • Lactate: mirror and motor of tumor malignancy
    • 10.1016/j.semradonc.2004.04.004, 15254870
    • Walenta S, Mueller-Klieser WF. Lactate: mirror and motor of tumor malignancy. Semin Radiat Oncol 2004, 14:267-274. 10.1016/j.semradonc.2004.04.004, 15254870.
    • (2004) Semin Radiat Oncol , vol.14 , pp. 267-274
    • Walenta, S.1    Mueller-Klieser, W.F.2
  • 39
  • 42
    • 58149157900 scopus 로고    scopus 로고
    • The genomic analysis of lactic acidosis and acidosis response in human cancers
    • 10.1371/journal.pgen.1000293, 2585811, 19057672
    • Chen JL, Lucas JE, Schroeder T, Mori S, Wu J, Nevins J, Dewhirst M, West M, Chi JT. The genomic analysis of lactic acidosis and acidosis response in human cancers. PLoS Genet 2008, 4:e1000293. 10.1371/journal.pgen.1000293, 2585811, 19057672.
    • (2008) PLoS Genet , vol.4
    • Chen, J.L.1    Lucas, J.E.2    Schroeder, T.3    Mori, S.4    Wu, J.5    Nevins, J.6    Dewhirst, M.7    West, M.8    Chi, J.T.9
  • 43
    • 34848815630 scopus 로고    scopus 로고
    • Gene expression programs of human smooth muscle cells: tissue-specific differentiation and prognostic significance in breast cancers
    • 1994710, 17907811
    • Chi JT, Rodriguez EH, Wang Z, Nuyten DS, Mukherjee S, van de Rijn M, van de Vijver MJ, Hastie T, Brown PO. Gene expression programs of human smooth muscle cells: tissue-specific differentiation and prognostic significance in breast cancers. PLoS Genet 2007, 3:1770-1784. 1994710, 17907811.
    • (2007) PLoS Genet , vol.3 , pp. 1770-1784
    • Chi, J.T.1    Rodriguez, E.H.2    Wang, Z.3    Nuyten, D.S.4    Mukherjee, S.5    van de Rijn, M.6    van de Vijver, M.J.7    Hastie, T.8    Brown, P.O.9
  • 44
    • 78049415422 scopus 로고    scopus 로고
    • Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA
    • 10.1371/journal.pgen.1001093, 2937306, 20844768
    • Chen JL, Merl D, Peterson CW, Wu J, Liu PY, Yin H, Muoio DM, Ayer DE, West M, Chi JT. Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA. PLoS Genet 2010, 6:e1001093. 10.1371/journal.pgen.1001093, 2937306, 20844768.
    • (2010) PLoS Genet , vol.6
    • Chen, J.L.1    Merl, D.2    Peterson, C.W.3    Wu, J.4    Liu, P.Y.5    Yin, H.6    Muoio, D.M.7    Ayer, D.E.8    West, M.9    Chi, J.T.10
  • 45
    • 78049422909 scopus 로고    scopus 로고
    • Latent factor analysis to discover pathway-associated putative segmental aneuploidies in human cancers
    • 10.1371/journal.pcbi.1000920, 2932681, 20824128
    • Lucas JE, Kung HN, Chi JT. Latent factor analysis to discover pathway-associated putative segmental aneuploidies in human cancers. PLoS Comput Biol 2010, 6:e1000920. 10.1371/journal.pcbi.1000920, 2932681, 20824128.
    • (2010) PLoS Comput Biol , vol.6
    • Lucas, J.E.1    Kung, H.N.2    Chi, J.T.3
  • 47
    • 34248233109 scopus 로고    scopus 로고
    • Isogenic normal basal and luminal mammary epithelial isolated by a novel method show a differential response to ionizing radiation
    • 10.1158/0008-5472.CAN-06-4065, 17409405
    • Huper G, Marks JR. Isogenic normal basal and luminal mammary epithelial isolated by a novel method show a differential response to ionizing radiation. Cancer Res 2007, 67:2990-3001. 10.1158/0008-5472.CAN-06-4065, 17409405.
    • (2007) Cancer Res , vol.67 , pp. 2990-3001
    • Huper, G.1    Marks, J.R.2
  • 48
    • 66249092010 scopus 로고    scopus 로고
    • Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation
    • 10.1158/0008-5472.CAN-08-2689, 19435925
    • Saito S, Furuno A, Sakurai J, Sakamoto A, Park HR, Shin-Ya K, Tsuruo T, Tomida A. Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation. Cancer Res 2009, 69:4225-4234. 10.1158/0008-5472.CAN-08-2689, 19435925.
    • (2009) Cancer Res , vol.69 , pp. 4225-4234
    • Saito, S.1    Furuno, A.2    Sakurai, J.3    Sakamoto, A.4    Park, H.R.5    Shin-Ya, K.6    Tsuruo, T.7    Tomida, A.8
  • 49
    • 0023631608 scopus 로고
    • Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo
    • 10.1016/0092-8674(87)90449-1, 3032456
    • Sinn E, Muller W, Pattengale P, Tepler I, Wallace R, Leder P. Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo. Cell 1987, 49:465-475. 10.1016/0092-8674(87)90449-1, 3032456.
    • (1987) Cell , vol.49 , pp. 465-475
    • Sinn, E.1    Muller, W.2    Pattengale, P.3    Tepler, I.4    Wallace, R.5    Leder, P.6
  • 52
    • 34548803430 scopus 로고    scopus 로고
    • Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer
    • 10.1073/pnas.0702387104, 1941796, 17670948
    • Franovic A, Gunaratnam L, Smith K, Robert I, Patten D, Lee S. Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer. Proc Natl Acad Sci USA 2007, 104:13092-13097. 10.1073/pnas.0702387104, 1941796, 17670948.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 13092-13097
    • Franovic, A.1    Gunaratnam, L.2    Smith, K.3    Robert, I.4    Patten, D.5    Lee, S.6
  • 53
    • 51649096739 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells
    • 10.1158/1541-7786.MCR-07-2177, 2775817, 18644974
    • Niu G, Briggs J, Deng J, Ma Y, Lee H, Kortylewski M, Kujawski M, Kay H, Cress WD, Jove R, Yu H. Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells. Mol Cancer Res 2008, 6:1099-1105. 10.1158/1541-7786.MCR-07-2177, 2775817, 18644974.
    • (2008) Mol Cancer Res , vol.6 , pp. 1099-1105
    • Niu, G.1    Briggs, J.2    Deng, J.3    Ma, Y.4    Lee, H.5    Kortylewski, M.6    Kujawski, M.7    Kay, H.8    Cress, W.D.9    Jove, R.10    Yu, H.11
  • 54
    • 46949094778 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha is closely linked to an aggressive phenotype in breast cancer
    • 10.1007/s10549-007-9742-1, 17805961
    • Yamamoto Y, Ibusuki M, Okumura Y, Kawasoe T, Kai K, Iyama K, Iwase H. Hypoxia-inducible factor 1alpha is closely linked to an aggressive phenotype in breast cancer. Breast Cancer Res Treat 2008, 110:465-475. 10.1007/s10549-007-9742-1, 17805961.
    • (2008) Breast Cancer Res Treat , vol.110 , pp. 465-475
    • Yamamoto, Y.1    Ibusuki, M.2    Okumura, Y.3    Kawasoe, T.4    Kai, K.5    Iyama, K.6    Iwase, H.7
  • 56
    • 0033618371 scopus 로고    scopus 로고
    • Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines
    • 10.1074/jbc.274.31.21528, 10419456
    • Nakatani K, Thompson DA, Barthel A, Sakaue H, Liu W, Weigel RJ, Roth RA. Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines. J Biol Chem 1999, 274:21528-21532. 10.1074/jbc.274.31.21528, 10419456.
    • (1999) J Biol Chem , vol.274 , pp. 21528-21532
    • Nakatani, K.1    Thompson, D.A.2    Barthel, A.3    Sakaue, H.4    Liu, W.5    Weigel, R.J.6    Roth, R.A.7
  • 58
    • 0023950817 scopus 로고
    • Expression of basal and luminal epithelium-specific keratins in normal, benign, and malignant breast tissue
    • 10.1093/jnci/80.9.691, 2453676
    • Dairkee SH, Puett L, Hackett AJ. Expression of basal and luminal epithelium-specific keratins in normal, benign, and malignant breast tissue. J Natl Cancer Inst 1988, 80:691-695. 10.1093/jnci/80.9.691, 2453676.
    • (1988) J Natl Cancer Inst , vol.80 , pp. 691-695
    • Dairkee, S.H.1    Puett, L.2    Hackett, A.J.3
  • 60
    • 30944450821 scopus 로고    scopus 로고
    • Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma
    • 10.1038/modpathol.3800528, 16341146
    • Livasy CA, Karaca G, Nanda R, Tretiakova MS, Olopade OI, Moore DT, Perou CM. Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma. Mod Pathol 2006, 19:264-271. 10.1038/modpathol.3800528, 16341146.
    • (2006) Mod Pathol , vol.19 , pp. 264-271
    • Livasy, C.A.1    Karaca, G.2    Nanda, R.3    Tretiakova, M.S.4    Olopade, O.I.5    Moore, D.T.6    Perou, C.M.7
  • 62
    • 33751202983 scopus 로고    scopus 로고
    • GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland
    • 10.1016/j.cell.2006.09.048, 2646406, 17129787
    • Kouros-Mehr H, Slorach EM, Sternlicht MD, Werb Z. GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland. Cell 2006, 127:1041-1055. 10.1016/j.cell.2006.09.048, 2646406, 17129787.
    • (2006) Cell , vol.127 , pp. 1041-1055
    • Kouros-Mehr, H.1    Slorach, E.M.2    Sternlicht, M.D.3    Werb, Z.4
  • 65
    • 18644366801 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors
    • 10.1593/neo.04430, 1501147, 15967109
    • Robey IF, Lien AD, Welsh SJ, Baggett BK, Gillies RJ. Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors. Neoplasia 2005, 7:324-330. 10.1593/neo.04430, 1501147, 15967109.
    • (2005) Neoplasia , vol.7 , pp. 324-330
    • Robey, I.F.1    Lien, A.D.2    Welsh, S.J.3    Baggett, B.K.4    Gillies, R.J.5
  • 69
    • 0034100836 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3)
    • 10.1172/JCI8316, 289179, 10712429
    • Caniggia I, Mostachfi H, Winter J, Gassmann M, Lye SJ, Kuliszewski M, Post M. Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3). J Clin Invest 2000, 105:577-587. 10.1172/JCI8316, 289179, 10712429.
    • (2000) J Clin Invest , vol.105 , pp. 577-587
    • Caniggia, I.1    Mostachfi, H.2    Winter, J.3    Gassmann, M.4    Lye, S.J.5    Kuliszewski, M.6    Post, M.7
  • 70
    • 16344380951 scopus 로고    scopus 로고
    • Low O2 tensions and the prevention of differentiation of hES cells
    • 10.1073/pnas.0501283102, 554750, 15772165
    • Ezashi T, Das P, Roberts RM. Low O2 tensions and the prevention of differentiation of hES cells. Proc Natl Acad Sci USA 2005, 102:4783-4788. 10.1073/pnas.0501283102, 554750, 15772165.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 4783-4788
    • Ezashi, T.1    Das, P.2    Roberts, R.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.