Smac-mimetic compound SM-164 induces radiosensitization in breast cancer cells through activation of caspases and induction of apoptosis

Breast Cancer Research and Treatment

Volumn 133, Issue 1, 2012, Pages 189-199

  Yang, Dong ^a,b   Zhao, Yongchao ^a   Li, Amy Y ^a   Wang, Shaomeng ^c   Wang, Gongxian ^b   Sun, Yi ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b NANCHANG UNIVERSITY   (China)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Apoptosis; Caspase activation; cIAP 1 degradation; Radiosensitization; XIAP

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; INHIBITOR OF APOPTOSIS PROTEIN 1; RADIOSENSITIZING AGENT; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SM 164; SM 173; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS; Z VAD FMK;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG PROTEIN BINDING; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SECRETION; PROTEIN SYNTHESIS INHIBITION; RADIOSENSITIZATION;

APOPTOSIS; BICYCLO COMPOUNDS, HETEROCYCLIC; BREAST NEOPLASMS; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; ENZYME ACTIVATION; ENZYME ACTIVATORS; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; OLIGOPEPTIDES; PROTEIN BINDING; RADIATION-SENSITIZING AGENTS; RNA INTERFERENCE; TRIAZOLES;

EID: 84860336246     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-011-1752-3     Document Type: Article

References (38)

1. A Jemal F Bray MM Center J Ferlay E Ward D Forman 2011 Global cancer statistics CA Cancer J Clin 61 69 90 21296855 10.3322/caac.20107
2. P Malmstrom L Holmberg H Anderson J Mattsson PE Jonsson L Tennvall-Nittby G Balldin L Loven JH Svensson C Ingvar T Moller E Holmberg A Wallgren 2003 Breast conservation surgery, with and without radiotherapy, in women with lymph node-negative breast cancer: a randomised clinical trial in a population with access to public mammography screening Eur J Cancer 39 1690 1697 12888363 10.1016/S0959-8049(03)00324-1 1:STN:280:DC%2BD3szlsFCntg%3D%3D (Pubitemid 36897605)
3. JK Jameel VS Rao L Cawkwell PJ Drew 2004 Radioresistance in carcinoma of the breast Breast 13 452 460 15563851 10.1016/j.breast.2004.08.004 1:STN:280:DC%2BD2crptFSitw%3D%3D (Pubitemid 39618816)
4. JM Gee RI Nicholson 2003 Expanding the therapeutic repertoire of epidermal growth factor receptor blockade: radiosensitization Breast Cancer Res 5 126 129 12793892 10.1186/bcr584 1:CAS:528:DC%2BD3sXjt12ju7w%3D (Pubitemid 36519404)
5. TJ Jorgensen 2009 Enhancing radiosensitivity: targeting the DNA repair pathways Cancer Biol Ther 8 665 670 19287209 1:CAS:528:DC%2BD1MXotFSjsbg%3D
6. CI Sartor 2000 Biological modifiers as potential radiosensitizers: targeting the epidermal growth factor receptor family Semin Oncol 27 15 20 11236022 1:CAS:528:DC%2BD3MXhsFGktr0%3D Discussion: 92-100 (Pubitemid 32172251)
7. QL Deveraux JC Reed 1999 IAP family proteins-suppressors of apoptosis Genes Dev 13 239 252 9990849 10.1101/gad.13.3.239 1:CAS:528:DyaK1MXht1KgsL0%3D
8. Y Shi 2004 Caspase activation, inhibition, and reactivation: a mechanistic view Protein Sci 13 1979 1987 15273300 10.1110/ps.04789804 1:CAS:528:DC%2BD2cXmtlCrsr8%3D (Pubitemid 38989605)
9. C Du M Fang Y Li L Li X Wang 2000 Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition Cell 102 33 42 10929711 10.1016/S0092-8674(00)00008-8 1:CAS:528: DC%2BD3cXkvFCrsbc%3D
10. AM Verhagen PG Ekert M Pakusch J Silke LM Connolly GE Reid RL Moritz RJ Simpson DL Vaux 2000 Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins Cell 102 43 53 10929712 10.1016/S0092-8674(00)00009-X 1:CAS:528:DC%2BD3cXkvFCrtr4%3D
11. J Chai C Du JW Wu S Kyin X Wang Y Shi 2000 Structural and biochemical basis of apoptotic activation by Smac/DIABLO Nature 406 855 862 10972280 10.1038/35022514 1:CAS:528:DC%2BD3cXmsVCrsLk%3D (Pubitemid 30664254)
12. S Hu X Yang 2003 Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO J Biol Chem 278 10055 10060 12525502 10.1074/jbc.M207197200 1:CAS:528:DC%2BD3sXitVCksbk%3D (Pubitemid 36800260)
13. G Wu J Chai TL Suber JW Wu C Du X Wang Y Shi 2000 Structural basis of IAP recognition by Smac/DIABLO Nature 408 1008 1012 11140638 10.1038/35050012 1:CAS:528:DC%2BD3MXhslahsQ%3D%3D (Pubitemid 32101651)
14. CR Arnt MV Chiorean MP Heldebrant GJ Gores SH Kaufmann 2002 Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ J Biol Chem 277 44236 44243 12218061 10.1074/jbc. M207578200 1:CAS:528:DC%2BD38Xos1akt78%3D (Pubitemid 36157856)
15. S Giagkousiklidis M Vogler MA Westhoff H Kasperczyk KM Debatin S Fulda 2005 Sensitization for gamma-irradiation-induced apoptosis by second mitochondria-derived activator of caspase Cancer Res 65 10502 10513 16288043 10.1158/0008-5472.CAN-05-0866 1:CAS:528:DC%2BD2MXht1Wgu7%2FF (Pubitemid 41743746)
16. L Li RM Thomas H Suzuki JK De Brabander X Wang PG Harran 2004 A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death Science 305 1471 1474 15353805 10.1126/science.1098231 1:CAS:528:DC%2BD2cXntFartL8%3D (Pubitemid 39167668)
17. H Sun Z Nikolovska-Coleska J Lu JL Meagher CY Yang S Qiu Y Tomita Y Ueda S Jiang K Krajewski PP Roller JA Stuckey S Wang 2007 Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP J Am Chem Soc 129 15279 15294 17999504 10.1021/ja074725f 1:CAS:528:DC%2BD2sXht1yrur%2FI (Pubitemid 350247811)
18. K Zobel L Wang E Varfolomeev MC Franklin LO Elliott HJ Wallweber DC Okawa JA Flygare D Vucic WJ Fairbrother K Deshayes 2006 Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs ACS Chem Biol 1 525 533 17168540 10.1021/cb600276q 1:CAS:528:DC%2BD28Xps12jsbk%3D
19. D Chauhan P Neri M Velankar K Podar T Hideshima M Fulciniti P Tassone N Raje C Mitsiades N Mitsiades P Richardson L Zawel M Tran N Munshi KC Anderson 2007 Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM) Blood 109 1220 1227 17032924 10.1182/blood-2006-04-015149 1:CAS:528:DC%2BD2sXjtFertb4%3D (Pubitemid 46220671)
20. CJ Glover K Hite R DeLosh DA Scudiero MJ Fivash LR Smith RJ Fisher JW Wu Y Shi RA Kipp GL McLendon EA Sausville RH Shoemaker 2003 A high-throughput screen for identification of molecular mimics of Smac/DIABLO utilizing a fluorescence polarization assay Anal Biochem 320 157 169 12927820 10.1016/S0003-2697(03)00389-0 1:CAS:528:DC%2BD3sXmsVGksLo%3D (Pubitemid 36962838)
21. K Mizukawa A Kawamura T Sasayama K Tanaka M Kamei M Sasaki E Kohmura 2006 Synthetic Smac peptide enhances the effect of etoposide-induced apoptosis in human glioblastoma cell lines J Neurooncol 77 3 247 255 16575541 10.1007/s11060-005-9045-5 1:CAS:528:DC%2BD28XmvVCjurc%3D (Pubitemid 44404390)
22. JC Wilkinson AS Wilkinson FL Scott RA Csomos GS Salvesen CS Duckett 2004 Neutralization of Smac/Diablo by inhibitors of apoptosis (IAPs). A caspase-independent mechanism for apoptotic inhibition J Biol Chem 279 51082 51090 15371416 10.1074/jbc.M408655200 1:CAS:528:DC%2BD2cXhtVaqsr3E (Pubitemid 40017850)
23. TY Wu KW Wagner B Bursulaya PG Schultz QL Deveraux 2003 Development and characterization of nonpeptidic small molecule inhibitors of the XIAP/caspase-3 interaction Chem Biol 10 759 767 12954335 10.1016/S1074-5521(03)00157-1 1:CAS:528:DC%2BD3sXmvFSisbc%3D (Pubitemid 37089851)
24. KM Bockbrader M Tan Y Sun 2005 A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells Oncogene 24 7381 7388 16044155 10.1038/sj.onc.1208888 1:CAS:528:DC%2BD2MXhtF2ns7%2FF (Pubitemid 41622242)
25. DJ Chen S Huerta 2009 Smac mimetics as new cancer therapeutics Anticancer Drugs 20 646 658 19550293 10.1097/CAD.0b013e32832ced78 1:CAS:528: DC%2BD1MXovVOhsbg%3D
26. J Lu L Bai H Sun Z Nikolovska-Coleska D McEachern S Qiu RS Miller H Yi S Shangary Y Sun JL Meagher JA Stuckey S Wang 2008 SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP Cancer Res 68 9384 9393 19010913 10.1158/0008-5472.CAN-08-2655 1:CAS:528:DC%2BD1cXhtlOmt7vE
27. J Yang D McEachern W Li MA Davis H Li MA Morgan L Bai JT Sebolt H Sun TS Lawrence S Wang Y Sun 2011 Radiosensitization of head and neck squamous cell carcinoma by a SMAC-mimetic compound, SM-164, requires activation of caspases Mol Cancer Ther 10 658 669 21282353 10.1158/1535-7163.MCT-10-0643 1:CAS:528:DC%2BC3MXkslSrtLg%3D
28. Z Nikolovska-Coleska R Wang X Fang H Pan Y Tomita P Li PP Roller K Krajewski NG Saito JA Stuckey S Wang 2004 Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization Anal Biochem 332 261 273 15325294 10.1016/j.ab.2004.05.055 1:CAS:528: DC%2BD2cXmvFeltL0%3D (Pubitemid 39485734)
29. B Fertil H Dertinger A Courdi EP Malaise 1984 Mean inactivation dose: a useful concept for intercomparison of human cell survival curves Radiat Res 99 73 84 6739728 10.2307/3576448 1:STN:280:DyaL2c3kvVOhtA%3D%3D (Pubitemid 14095136)
30. JE Vince WW Wong N Khan R Feltham D Chau AU Ahmed CA Benetatos SK Chunduru SM Condon M McKinlay R Brink M Leverkus V Tergaonkar P Schneider BA Callus F Koentgen DL Vaux J Silke 2007 IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis Cell 131 682 693 18022363 10.1016/j.cell.2007.10. 037 1:CAS:528:DC%2BD2sXhsVSgur3N (Pubitemid 350103599)
31. M Zheng SE Morgan-Lappe J Yang KM Bockbrader D Pamarthy D Thomas SW Fesik Y Sun 2008 Growth inhibition and radiosensitization of glioblastoma and lung cancer cells by small interfering RNA silencing of tumor necrosis factor receptor-associated factor 2 Cancer Res 68 7570 7578 18794145 10.1158/0008-5472.CAN-08-0632 1:CAS:528:DC%2BD1cXhtFWltb%2FL
32. M Swaroop Y Sun 2003 Mdm2 ligase dead mutants did not act in a dominant negative manner to re-activate p53, but promoted tumor cell growth Anticancer Res 23 3167 3174 12926050 1:CAS:528:DC%2BD3sXntVChtbg%3D (Pubitemid 36975410)
33. SW Fesik 2005 Promoting apoptosis as a strategy for cancer drug discovery Nat Rev Cancer 5 876 885 16239906 10.1038/nrc1736 1:CAS:528:DC%2BD2MXht1Witb7J (Pubitemid 41746032)
34. CM Schlotter U Vogt H Allgayer B Brandt 2008 Molecular targeted therapies for breast cancer treatment Breast Cancer Res 10 211 18671839 10.1186/bcr2112
35. SW Han J Roman 2010 Targeting apoptotic signaling pathways in human lung cancer Curr Cancer Drug Targets 10 566 574 20482489 10.2174/156800910791859461 1:CAS:528:DC%2BC3cXhtFSktLfL
36. CS Straub 2011 Targeting IAPs as an approach to anti-cancer therapy Curr Top Med Chem 11 291 316 21320059 10.2174/156802611794072623 1:CAS:528: DC%2BC3MXkslahsLg%3D
37. MO Hengartner 2000 The biochemistry of apoptosis Nature 407 770 776 11048727 10.1038/35037710 1:CAS:528:DC%2BD3cXnsFWrsLc%3D
38. SW Tait DR Green 2010 Mitochondria and cell death: outer membrane permeabilization and beyond Nat Rev Mol Cell Biol 11 621 632 20683470 10.1038/nrm2952 1:CAS:528:DC%2BC3cXps1egt7w%3D