Human O-sulfated metabolites of (-)-epicatechin and methyl-(-)-epicatechin are poor substrates for commercial aryl-sulfatases: Implications for studies concerned with quantifying epicatechin bioavailability

Pharmacological Research

Volumn 65, Issue 6, 2012, Pages 592-602

  Saha, S ^a   Hollands, W ^a   Needs, P W ^a   Ostertag, L M ^a,b   De Roos, B ^b   Duthie, G G ^b   Kroon, P A ^a  

^a NORWICH RESEARCH PARK   (United Kingdom)

^b ROWETT RESEARCH INSTITUTE   (United Kingdom)

Author keywords

Absorption; Dietary bioactives; Flavonoids; Human metabolism; Phase 2 enzymes; Phenolics; Polyphenols

Indexed keywords

3' METHYLEPICATECHIN; 4' METHYLEPICATECHIN; ARYLSULFATASE; BETA GLUCURONIDASE; DRUG METABOLITE; EPICATECHIN; FLAVONOID; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG URINE LEVEL; FEMALE; HUMAN; HUMAN EXPERIMENT; INCUBATION TIME; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PH; PRIORITY JOURNAL; PROTEIN HYDROLYSIS; QUANTITATIVE STUDY; STANDARD; SULFATION; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ARYLSULFATASES; BIOLOGICAL AVAILABILITY; BIOTRANSFORMATION; CATECHIN; CHROMATOGRAPHY, LIQUID; CROSS-OVER STUDIES; ENGLAND; FEMALE; GLUCURONIDASE; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; MALE; METHYLATION; REPRODUCIBILITY OF RESULTS; SUBSTRATE SPECIFICITY; SULFURIC ACID ESTERS; TANDEM MASS SPECTROMETRY; TIME FACTORS;

EID: 84860300744     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2012.02.005     Document Type: Article

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