Milk does not affect the bioavailability of cocoa powder flavonoid in healthy human

Annals of Nutrition and Metabolism

Volumn 51, Issue 6, 2008, Pages 493-498

  Roura, Elena ^a   Andrés Lacueva, Cristina ^a   Estruch, Ramon ^a   Mata Bilbao, M Lourdes ^a   Izquierdo Pulido, Maria ^a   Waterhouse, Andrew L ^b   Lamuela Raventós, Rosa M ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

( ) Epicatechin; Cocoa flavonoids; Cocoa powder; Human plasma; Milk interaction; Polyphenols, bioavailability

Indexed keywords

EPICATECHIN; FLAVONOID; POLYPHENOL;

ADULT; ARTICLE; BEVERAGE; BIOAVAILABILITY; CACAO; CHEMICAL ANALYSIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; FEMALE; FOOD ANALYSIS; HUMAN; LIQUID CHROMATOGRAPHY; MALE; MILK; OPEN STUDY; POWDER; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY;

ADOLESCENT; ADULT; ANIMALS; BIOLOGICAL AVAILABILITY; CACAO; CHROMATOGRAPHY, LIQUID; CROSS-OVER STUDIES; FEMALE; FLAVONOIDS; HUMANS; MALE; MIDDLE AGED; MILK; PROSPECTIVE STUDIES; TANDEM MASS SPECTROMETRY;

THEOBROMA CACAO;

EID: 39849087275     PISSN: 02506807     EISSN: None     Source Type: Journal    
DOI: 10.1159/000111473     Document Type: Article

References (31)

1. Walle T: Absorption and metabolism of flavonoids. Free Radic Biol Med 2004;36:829-837.
2. Manach C, Scalbert A, Morand C, Rémésy C, Jiménez L: Polyphenols: food sources and bioavailability. Am J Clin Nutr 2004;79:727-747.
3. Lesser S, Cermak R, Wolffram S: Bioavailability of quercetin in pigs is influenced by the dietary fat content. J Nutr 2004;134:1508-1511.
4. Visioli F, Galli C, Grande S, Colonnelli K, Patelli C, Galli G, Caruso D: Hydroxytyrosol excretion differs between rats and human and depends on the vehicle of administration. J Nutr 2003;133:2612-2615.
5. Azuma K, Ippoushi K, Ito H, Higashio H, Terao J: Combination of lipids and emulsifiers enhances the absorption of orally administered quercetin in rats. J Agric Food Chem 2002;50:1706-1712.
6. Donovan JL, Bell JR, Kasim-Karakas S: Catechin is present as metabolites in human plasma after consumption of red wine. J Nutr 1999;129:1662-1668.
7. Donovan JL, Kasim-Karakas S, German JB, Waterhouse AL: Urinary excretion of catechin metabolites by human subjects after red wine consumption. Br J Nutr 2002;87:31-37.
8. Grassi D, Lippi C, Necazione S, Desideri G, Ferri C: Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons. Am J Clin Nutr 2005;81:611-614.
9. Helmunt S, Shewe T, Heiss C, Kelm M: Cocoa polyphenols and inflammatory mediators. Am J Clin Nutr 2005;81:304S-312S.
10. Keen CL, Holt RR, Oteiza PI, Fraga CG, Schmitz HH: Cocoa antioxidants and cardiovascular health. Am J Clin Nutr 2005;81:298S-303S.
11. Lamuela-Raventós RM, Romero-Pérez AI, Andrés-Lacueva C, Tornero A: Health effects of cocoa flavonoids. Food Sci Tech Int 2005;11:159-176.
12. Waterhouse AL, Shirley JR, Donovan JL: Antioxidants in chocolate (letter). Lancet 1996;348:834.
13. Caobisco (Association of the Chocolate, Biscuit and Confectionary Industries of the EU) 2003: Ranking of Consumption of Products of Chocolate. Statistical Bulletin Review, Brussels 2003.
14. Zamora-Ros R, Andrés-Lacueva C, Izquierdo-Pulido M, Lamuela-Raventós RM: Flavonoid consumption in the Spanish children and adult population (pers commun). Vth International Congress of Mediterranean Diet, Barcelona 2004.
15. Serafini M, Bugianesi R, Maiani G, Valtuena S, De Santis S, Crozier A: Plasma antioxidants from chocolate. Nature 2003;424:1013.
16. Schroeter H, Holt RR, Orozco TJ, Schmitz HH, Keen CL: Milk and absorption of dietary flavanols. Nature 2003;426:787-788.
17. Schramm DD, Karim M, Schrader R, Holt RR, Kirkpatrick NJ, Polagruto JA, Ensunsa JL, Schmitz HH, Keen CL: Food effects on the absorption and pharmacokinetics of cocoa flavanols. Life Sci 2003;73:857-869.
18. Van het Hof KH, Kivits GA, Weststrate JA, Tijburg LB: Bioavailability of catechins from tea: the effect of milk. Eur J Clin Nutr 1998;52:356-359.
19. Hollman PC, Van het Hof KH, Tijburg LB, Katan MB: Addition of milk does not affect the absorption of flavonols from tea in man. Free Radic Res 2001;34:297-300.
20. Serafini M, Ghiselli A, Ferro-Luzzi A: In vivo antioxidant effect of green and black tea in man. Eur J Clin Nutr 1996;50:28-32.
21. Langley-Evans SC: Consumption of black tea elicits an increase in plasma antioxidant potential in humans. Int J Food Sci Nutr 2000;51:309-315.
22. Reddy VC, Vidya Sagar GV, Sreeramulu D, Venu L, Raghunath M: Addition of milk does not alter the antioxidant activity of black tea. Ann Nutr Metab 2005;49:189-195.
23. Roura E, Andrés-Lacueva C, Jáuregui O, et al: Rapid LC tandem mass spectrometry assay to quantify plasma (-)-epicatechin metabolites after ingestion a standard portion of cocoa beverage in humans. J Agric Food Chem 2005;53:6190-6194.
24. Wang JF, Keen CL, Fraga CG: A dose-response effect from chocolate consumption on plasma epicatechin and oxidative damage. J Nutr 2000;130:2115S-2119S.
25. Rein D, Fraga CG, Keen CL: Epicatechin in human plasma: in vivo determination and effect of chocolate consumption on plasma oxidation status. J Nutr 2000;130:2109S-2114S.
26. 2 in human plasma after the consumption of a flavanol-rich cocoa. Am J Clin Nutr 2002;4:798-804.
27. Baba S, Osakabe N, Yasuda A, Natsume M, Takizawa T, Nakamura T, Terao J: Bioavailability of (-)-epicatechin upon intake of chocolate and cocoa in human volunteers. Free Radic Res 2000;33:635-641.
28. Richelle M, Tavazzi I: Plasma kinetics in man of epicatechin from black chocolate. Eur J Clin Nutr 1999;53:22-26.
29. Manach C, Williamson G, Morand C, Scalbert A, Rémésy C: Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 2005;81:230S-242S.
30. Starp C, Alteheld B, Stehle P: Characteristics of (+)-catechin and (-)-epicatechin transport across pig intestinal brush border membranes. Ann Nutr Metab 2006;50:59-65.
31. Manach C, Donovan JL: Pharmacokinetics and metabolism of dietary flavonoids in humans. Free Radic Res 2004;38:771-785.