Photochemical Modulation of Ras-Mediated Signal Transduction Using Caged Farnesyltransferase Inhibitors: Activation by One- and Two-Photon Excitation

ChemBioChem

Volumn 13, Issue 7, 2012, Pages 1009-1016

  Abate Pella, Daniel ^a   Zeliadt, Nicholette A ^a   Ochocki, Joshua D ^a   Warmka, Janel K ^a   Dore, Timothy M ^b   Blank, David A ^a   Wattenberg, Elizabeth V ^a   Distefano, Mark D ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

Author keywords

Bromohydroxycoumarin; Caged thiol; Enzyme inhibitor; Farnesylation; Photochemistry; Ras

Indexed keywords

COUMARIN DERIVATIVE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAS PROTEIN;

ALKYLATION; ANIMAL CELL; ARTICLE; CELL STRUCTURE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME LOCALIZATION; FIBROBLAST; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; PHOTOCHEMISTRY; PHOTOLYSIS; PHOTON; PHOTON EXCITATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ULTRAVIOLET RADIATION;

ANIMALS; CELL LINE; COUMARINS; DOGS; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; HUMANS; PHOTOCHEMICAL PROCESSES; PHOTONS; RAS PROTEINS; SIGNAL TRANSDUCTION; SPECTROMETRY, FLUORESCENCE;

EID: 84860239951     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201200063     Document Type: Article

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