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Volumn 125, Issue 3, 2007, Pages 215-223

The role of Ras signaling in lupus T lymphocytes: Biology and pathogenesis

Author keywords

CAPRI; Erk; Farnesylation; PI 3 K; Ras; RasGRP1; Systemic lupus erythematosus; T cell receptor; T lymphocyte

Indexed keywords

RAS PROTEIN; T LYMPHOCYTE RECEPTOR;

EID: 36148952923     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2007.08.008     Document Type: Short Survey
Times cited : (39)

References (74)
  • 1
    • 29744451358 scopus 로고    scopus 로고
    • Regulatory T-cells and autoimmunity
    • NiChoileain N., and Redmond H.P. Regulatory T-cells and autoimmunity. J. Surg. Res. 130 (2006) 124-135
    • (2006) J. Surg. Res. , vol.130 , pp. 124-135
    • NiChoileain, N.1    Redmond, H.P.2
  • 3
    • 33644982044 scopus 로고    scopus 로고
    • Regulation of immune responses by T cells
    • Jiang H., and Chess L. Regulation of immune responses by T cells. N. Engl. J. Med. 354 (2006) 1166-1176
    • (2006) N. Engl. J. Med. , vol.354 , pp. 1166-1176
    • Jiang, H.1    Chess, L.2
  • 4
    • 26244450587 scopus 로고    scopus 로고
    • Manipulation of immune regulation in systemic lupus erythematosus
    • La Cava A., Fang C.J., Singh R.P., Ebling F., and Hahn B.H. Manipulation of immune regulation in systemic lupus erythematosus. Autoimmun. Rev. 4 (2005) 515-519
    • (2005) Autoimmun. Rev. , vol.4 , pp. 515-519
    • La Cava, A.1    Fang, C.J.2    Singh, R.P.3    Ebling, F.4    Hahn, B.H.5
  • 5
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S., Sakaguchi N., Asano M., Itoh M., and Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155 (1995) 1151-1164
    • (1995) J. Immunol. , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 6
    • 0347122087 scopus 로고    scopus 로고
    • Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo
    • Millar D.G., Garza K.M., Odermatt B., Elford A.R., Ono N., Li Z., and Ohashi P.S. Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo. Nat. Med. 9 (2003) 1469-1476
    • (2003) Nat. Med. , vol.9 , pp. 1469-1476
    • Millar, D.G.1    Garza, K.M.2    Odermatt, B.3    Elford, A.R.4    Ono, N.5    Li, Z.6    Ohashi, P.S.7
  • 7
    • 0032036481 scopus 로고    scopus 로고
    • Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain
    • Liossis S.N., Ding X.Z., Dennis G.J., and Tsokos G.C. Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain. J. Clin. Invest. 101 (1998) 1448-1457
    • (1998) J. Clin. Invest. , vol.101 , pp. 1448-1457
    • Liossis, S.N.1    Ding, X.Z.2    Dennis, G.J.3    Tsokos, G.C.4
  • 8
    • 33747080526 scopus 로고    scopus 로고
    • Regulatory T cells and systemic lupus erythematosus
    • Mudd P.A., Teague B.N., and Farris A.D. Regulatory T cells and systemic lupus erythematosus. Scand. J. Immunol. 64 (2006) 211-218
    • (2006) Scand. J. Immunol. , vol.64 , pp. 211-218
    • Mudd, P.A.1    Teague, B.N.2    Farris, A.D.3
  • 9
    • 20444438369 scopus 로고    scopus 로고
    • Paths to understanding the genetic basis of autoimmune disease
    • Rioux J.D., and Abbas A.K. Paths to understanding the genetic basis of autoimmune disease. Nature 435 (2005) 584-589
    • (2005) Nature , vol.435 , pp. 584-589
    • Rioux, J.D.1    Abbas, A.K.2
  • 10
    • 3342890491 scopus 로고    scopus 로고
    • Lupus-like autoimmunity caused by defects in T-cell signal transduction
    • King P.D. Lupus-like autoimmunity caused by defects in T-cell signal transduction. Curr. Opin. Investig. Drugs 5 (2004) 517-523
    • (2004) Curr. Opin. Investig. Drugs , vol.5 , pp. 517-523
    • King, P.D.1
  • 12
    • 33645315549 scopus 로고    scopus 로고
    • Genetics of T cell defects in lupus
    • Chen Y.F., and Morel L. Genetics of T cell defects in lupus. Cell Mol. Immunol. 2 (2005) 403-409
    • (2005) Cell Mol. Immunol. , vol.2 , pp. 403-409
    • Chen, Y.F.1    Morel, L.2
  • 13
    • 0042886906 scopus 로고    scopus 로고
    • Impaired T cell death and lupus-like autoimmunity in T cell-specific adapter protein-deficient mice
    • Drappa J., Kamen L.A., Chan E., Georgiev M., Ashany D., Marti F., and King P.D. Impaired T cell death and lupus-like autoimmunity in T cell-specific adapter protein-deficient mice. J. Exp. Med. 198 (2003) 809-821
    • (2003) J. Exp. Med. , vol.198 , pp. 809-821
    • Drappa, J.1    Kamen, L.A.2    Chan, E.3    Georgiev, M.4    Ashany, D.5    Marti, F.6    King, P.D.7
  • 14
    • 33745839779 scopus 로고    scopus 로고
    • Abnormal Fas/FasL and caspase-3-mediated apoptotic signaling pathways of T lymphocyte subset in patients with systemic lupus erythematosus
    • Xue C., Lan-Lan W., Bei C., Jie C., and Wei-Hua F. Abnormal Fas/FasL and caspase-3-mediated apoptotic signaling pathways of T lymphocyte subset in patients with systemic lupus erythematosus. Cell. Immunol. 239 (2006) 121-128
    • (2006) Cell. Immunol. , vol.239 , pp. 121-128
    • Xue, C.1    Lan-Lan, W.2    Bei, C.3    Jie, C.4    Wei-Hua, F.5
  • 15
    • 33645384693 scopus 로고    scopus 로고
    • Essential role of the T cell-specific adapter protein in the activation of LCK in peripheral T cells
    • Marti F., Garcia G.G., Lapinski P.E., MacGregor J.N., and King P.D. Essential role of the T cell-specific adapter protein in the activation of LCK in peripheral T cells. J. Exp. Med. 203 (2006) 281-287
    • (2006) J. Exp. Med. , vol.203 , pp. 281-287
    • Marti, F.1    Garcia, G.G.2    Lapinski, P.E.3    MacGregor, J.N.4    King, P.D.5
  • 16
    • 1842609782 scopus 로고    scopus 로고
    • Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus
    • Perez de Castro I., Bivona T.G., Philips M.R., and Pellicer A. Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus. Mol. Cell Biol. 24 (2004) 3485-3496
    • (2004) Mol. Cell Biol. , vol.24 , pp. 3485-3496
    • Perez de Castro, I.1    Bivona, T.G.2    Philips, M.R.3    Pellicer, A.4
  • 17
    • 23844500699 scopus 로고    scopus 로고
    • Compartmentalized signalling of Ras
    • Philips M.R. Compartmentalized signalling of Ras. Biochem. Soc. Trans. 33 (2005) 657-661
    • (2005) Biochem. Soc. Trans. , vol.33 , pp. 657-661
    • Philips, M.R.1
  • 18
    • 0036364408 scopus 로고    scopus 로고
    • A growing family of guanine nucleotide exchange factors is responsible for activation of Ras-family GTPases
    • Quilliam L.A., Rebhun J.F., and Castro A.F. A growing family of guanine nucleotide exchange factors is responsible for activation of Ras-family GTPases. Prog. Nucleic Acid Res. Mol. Biol. 71 (2002) 391-444
    • (2002) Prog. Nucleic Acid Res. Mol. Biol. , vol.71 , pp. 391-444
    • Quilliam, L.A.1    Rebhun, J.F.2    Castro, A.F.3
  • 19
    • 0025729180 scopus 로고
    • Differential regulation of rasGAP and neurofibromatosis gene product activities
    • Bollag G., and McCormick F. Differential regulation of rasGAP and neurofibromatosis gene product activities. Nature 351 (1991) 576-579
    • (1991) Nature , vol.351 , pp. 576-579
    • Bollag, G.1    McCormick, F.2
  • 20
    • 33644864788 scopus 로고    scopus 로고
    • Compartmentalized Ras/MAPK Signaling
    • Mor A., and Philips M.R. Compartmentalized Ras/MAPK Signaling. Annu. Rev. Immunol. 24 (2006) 771-800
    • (2006) Annu. Rev. Immunol. , vol.24 , pp. 771-800
    • Mor, A.1    Philips, M.R.2
  • 23
    • 33646777423 scopus 로고    scopus 로고
    • Thematic review series: lipid posttranslational modifications. CAAX modification and membrane targeting of Ras
    • Wright L.P., and Philips M.R. Thematic review series: lipid posttranslational modifications. CAAX modification and membrane targeting of Ras. J. Lipid Res. 47 (2006) 883-891
    • (2006) J. Lipid Res. , vol.47 , pp. 883-891
    • Wright, L.P.1    Philips, M.R.2
  • 25
    • 0038578688 scopus 로고    scopus 로고
    • GTPases and T cell activation
    • Cantrell D.A. GTPases and T cell activation. Immunol. Rev. 192 (2003) 122-130
    • (2003) Immunol. Rev. , vol.192 , pp. 122-130
    • Cantrell, D.A.1
  • 26
    • 33751262186 scopus 로고    scopus 로고
    • Regulation of Ras in lymphocytes: get a GRP
    • Stone J.C. Regulation of Ras in lymphocytes: get a GRP. Biochem. Soc. Trans. 34 (2006) 858-861
    • (2006) Biochem. Soc. Trans. , vol.34 , pp. 858-861
    • Stone, J.C.1
  • 30
    • 0037306522 scopus 로고    scopus 로고
    • The Ras/MAPK cascade and the control of positive selection
    • Alberola-Ila J., and Hernandez-Hoyos G. The Ras/MAPK cascade and the control of positive selection. Immunol. Rev. 191 (2003) 79-96
    • (2003) Immunol. Rev. , vol.191 , pp. 79-96
    • Alberola-Ila, J.1    Hernandez-Hoyos, G.2
  • 31
    • 0033514317 scopus 로고    scopus 로고
    • T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation
    • Yamashita M., Kimura M., Kubo M., Shimizu C., Tada T., Perlmutter R.M., and Nakayama T. T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 1024-1029
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 1024-1029
    • Yamashita, M.1    Kimura, M.2    Kubo, M.3    Shimizu, C.4    Tada, T.5    Perlmutter, R.M.6    Nakayama, T.7
  • 32
    • 0026471013 scopus 로고
    • IL-4 influences IL-2 production and granulomatous inflammation in murine schistosomiasis mansoni
    • Yamashita T., and Boros D.L. IL-4 influences IL-2 production and granulomatous inflammation in murine schistosomiasis mansoni. J. Immunol. 149 (1992) 3659-3664
    • (1992) J. Immunol. , vol.149 , pp. 3659-3664
    • Yamashita, T.1    Boros, D.L.2
  • 33
    • 0029949104 scopus 로고    scopus 로고
    • Non-T cell-derived IL-4 plays an important role in IgE production induced by antigen resensitization and is resistant to FK506
    • Yamashita M., Yamaoka M., Seki N., and Fujii T. Non-T cell-derived IL-4 plays an important role in IgE production induced by antigen resensitization and is resistant to FK506. J. Immunol. 157 (1996) 714-719
    • (1996) J. Immunol. , vol.157 , pp. 714-719
    • Yamashita, M.1    Yamaoka, M.2    Seki, N.3    Fujii, T.4
  • 34
    • 34247866415 scopus 로고    scopus 로고
    • Ras/Erk pathway positively regulates Jak1/STAT6 activity and IL-4 gene expression in Jurkat T cells
    • So E.Y., Oh J., Jang J.Y., Kim J.H., and Lee C.E. Ras/Erk pathway positively regulates Jak1/STAT6 activity and IL-4 gene expression in Jurkat T cells. Mol. Immunol. 44 (2007) 3416-3426
    • (2007) Mol. Immunol. , vol.44 , pp. 3416-3426
    • So, E.Y.1    Oh, J.2    Jang, J.Y.3    Kim, J.H.4    Lee, C.E.5
  • 36
    • 33751268902 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase signalling and FoxO transcription factors in rheumatoid arthritis
    • Reedquist K.A., Ludikhuize J., and Tak P.P. Phosphoinositide 3-kinase signalling and FoxO transcription factors in rheumatoid arthritis. Biochem. Soc. Trans. 34 (2006) 727-730
    • (2006) Biochem. Soc. Trans. , vol.34 , pp. 727-730
    • Reedquist, K.A.1    Ludikhuize, J.2    Tak, P.P.3
  • 37
    • 34147203741 scopus 로고    scopus 로고
    • Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes
    • Roose J.P., Mollenauer M., Ho M., Kurosaki T., and Weiss A. Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes. Mol. Cell. Biol. 27 (2007) 2732-2745
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 2732-2745
    • Roose, J.P.1    Mollenauer, M.2    Ho, M.3    Kurosaki, T.4    Weiss, A.5
  • 38
    • 0036847930 scopus 로고    scopus 로고
    • Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway
    • Hanafusa H., Torii S., Yasunaga T., and Nishida E. Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway. Nat. Cell Biol. 4 (2002) 850-858
    • (2002) Nat. Cell Biol. , vol.4 , pp. 850-858
    • Hanafusa, H.1    Torii, S.2    Yasunaga, T.3    Nishida, E.4
  • 39
    • 33646488029 scopus 로고    scopus 로고
    • Dual effects of Sprouty1 on TCR signaling depending on the differentiation state of the T cell
    • Choi H., Cho S.Y., Schwartz R.H., and Choi K. Dual effects of Sprouty1 on TCR signaling depending on the differentiation state of the T cell. J. Immunol. 176 (2006) 6034-6045
    • (2006) J. Immunol. , vol.176 , pp. 6034-6045
    • Choi, H.1    Cho, S.Y.2    Schwartz, R.H.3    Choi, K.4
  • 41
    • 34447579251 scopus 로고    scopus 로고
    • The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2
    • Mor A., Campi G., Du G., Zheng Y., Foster D.A., Dustin M.L., and Philips M.R. The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2. Nat. Cell Biol. 9 (2007) 713-719
    • (2007) Nat. Cell Biol. , vol.9 , pp. 713-719
    • Mor, A.1    Campi, G.2    Du, G.3    Zheng, Y.4    Foster, D.A.5    Dustin, M.L.6    Philips, M.R.7
  • 43
    • 18944383647 scopus 로고    scopus 로고
    • A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells
    • Roose J.P., Mollenauer M., Gupta V.A., Stone J., and Weiss A. A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. Mol. Cell Biol. 25 (2005) 4426-4441
    • (2005) Mol. Cell Biol. , vol.25 , pp. 4426-4441
    • Roose, J.P.1    Mollenauer, M.2    Gupta, V.A.3    Stone, J.4    Weiss, A.5
  • 44
    • 0035006109 scopus 로고    scopus 로고
    • Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras
    • Cacalano N.A., Sanden D., and Johnston J.A. Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras. Nat. Cell Biol. 3 (2001) 460-465
    • (2001) Nat. Cell Biol. , vol.3 , pp. 460-465
    • Cacalano, N.A.1    Sanden, D.2    Johnston, J.A.3
  • 45
    • 33749011694 scopus 로고    scopus 로고
    • Impact of the immunological synapse on T cell signaling
    • Dustin M.L. Impact of the immunological synapse on T cell signaling. Results Probl. Cell Differ. 43 (2006) 175-198
    • (2006) Results Probl. Cell Differ. , vol.43 , pp. 175-198
    • Dustin, M.L.1
  • 46
    • 0242708766 scopus 로고    scopus 로고
    • Leukocyte functional antigen 1 lowers T cell activation thresholds and signaling through cytohesin-1 and Jun-activating binding protein 1
    • Perez O.D., Mitchell D., Jager G.C., South S., Murriel C., McBride J., Herzenberg L.A., Kinoshita S., and Nolan G.P. Leukocyte functional antigen 1 lowers T cell activation thresholds and signaling through cytohesin-1 and Jun-activating binding protein 1. Nat. Immunol. 4 (2003) 1083-1092
    • (2003) Nat. Immunol. , vol.4 , pp. 1083-1092
    • Perez, O.D.1    Mitchell, D.2    Jager, G.C.3    South, S.4    Murriel, C.5    McBride, J.6    Herzenberg, L.A.7    Kinoshita, S.8    Nolan, G.P.9
  • 48
    • 27644503683 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T-cell lines from human cord blood have functional and molecular properties of T-cell anergy
    • Li L., Godfrey W.R., Porter S.B., Ge Y., June C.H., Blazar B.R., and Boussiotis V.A. CD4+CD25+ regulatory T-cell lines from human cord blood have functional and molecular properties of T-cell anergy. Blood 106 (2005) 3068-3073
    • (2005) Blood , vol.106 , pp. 3068-3073
    • Li, L.1    Godfrey, W.R.2    Porter, S.B.3    Ge, Y.4    June, C.H.5    Blazar, B.R.6    Boussiotis, V.A.7
  • 49
    • 29344448889 scopus 로고    scopus 로고
    • Amelioration of SLE-like manifestations in (NZBxNZW)F1 mice following treatment with a peptide based on the complementarity determining region 1 of an autoantibody is associated with a down-regulation of apoptosis and of the pro-apoptotic factor JNK kinase
    • Rapoport M.J., Sharabi A., Aharoni D., Bloch O., Zinger H., Dayan M., and Mozes E. Amelioration of SLE-like manifestations in (NZBxNZW)F1 mice following treatment with a peptide based on the complementarity determining region 1 of an autoantibody is associated with a down-regulation of apoptosis and of the pro-apoptotic factor JNK kinase. Clin. Immunol. 117 (2005) 262-270
    • (2005) Clin. Immunol. , vol.117 , pp. 262-270
    • Rapoport, M.J.1    Sharabi, A.2    Aharoni, D.3    Bloch, O.4    Zinger, H.5    Dayan, M.6    Mozes, E.7
  • 53
    • 0035096761 scopus 로고    scopus 로고
    • Decreased Ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients
    • Deng C., Kaplan M.J., Yang J., Ray D., Zhang Z., McCune W.J., Hanash S.M., and Richardson B.C. Decreased Ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients. Arthritis Rheum. 44 (2001) 397-407
    • (2001) Arthritis Rheum. , vol.44 , pp. 397-407
    • Deng, C.1    Kaplan, M.J.2    Yang, J.3    Ray, D.4    Zhang, Z.5    McCune, W.J.6    Hanash, S.M.7    Richardson, B.C.8
  • 54
    • 32444443209 scopus 로고    scopus 로고
    • Statins as antiinflammatory and immunomodulatory agents: a future in rheumatologic therapy?
    • Abeles A.M., and Pillinger M.H. Statins as antiinflammatory and immunomodulatory agents: a future in rheumatologic therapy?. Arthritis Rheum. 54 (2006) 393-407
    • (2006) Arthritis Rheum. , vol.54 , pp. 393-407
    • Abeles, A.M.1    Pillinger, M.H.2
  • 57
    • 0033008813 scopus 로고    scopus 로고
    • Decreased expression of the p21ras stimulatory factor hSOS in PBMC from inactive SLE patients
    • Rapoport M.J., Mor A., Amit M., Rosenberg R., Ramot Y., Mizrachi A., and Wysenbeek A.J. Decreased expression of the p21ras stimulatory factor hSOS in PBMC from inactive SLE patients. Lupus 8 (1999) 24-28
    • (1999) Lupus , vol.8 , pp. 24-28
    • Rapoport, M.J.1    Mor, A.2    Amit, M.3    Rosenberg, R.4    Ramot, Y.5    Mizrachi, A.6    Wysenbeek, A.J.7
  • 58
    • 0036700624 scopus 로고    scopus 로고
    • Constitutive up-regulated activity of MAP kinase is associated with down-regulated early p21Ras pathway in lymphocytes of SLE patients
    • Rapoport M.J., Amit M., Aharoni D., Weiss M., Weissgarten J., Bruck N., Buchs A., Bistritzer T., and Molad Y. Constitutive up-regulated activity of MAP kinase is associated with down-regulated early p21Ras pathway in lymphocytes of SLE patients. J. Autoimmun. 19 (2002) 63-70
    • (2002) J. Autoimmun. , vol.19 , pp. 63-70
    • Rapoport, M.J.1    Amit, M.2    Aharoni, D.3    Weiss, M.4    Weissgarten, J.5    Bruck, N.6    Buchs, A.7    Bistritzer, T.8    Molad, Y.9
  • 59
    • 0037289364 scopus 로고    scopus 로고
    • Defective activity of ERK-1 and ERK-2 mitogen-activated protein kinases in peripheral blood T lymphocytes from patients with systemic lupus erythematosus: potential role of altered coupling of Ras guanine nucleotide exchange factor hSos to adapter protein Grb2 in lupus T cells
    • Cedeno S., Cifarelli D.F., Blasini A.M., Paris M., Placeres F., Alonso G., and Rodriguez M.A. Defective activity of ERK-1 and ERK-2 mitogen-activated protein kinases in peripheral blood T lymphocytes from patients with systemic lupus erythematosus: potential role of altered coupling of Ras guanine nucleotide exchange factor hSos to adapter protein Grb2 in lupus T cells. Clin. Immunol. 106 (2003) 41-49
    • (2003) Clin. Immunol. , vol.106 , pp. 41-49
    • Cedeno, S.1    Cifarelli, D.F.2    Blasini, A.M.3    Paris, M.4    Placeres, F.5    Alonso, G.6    Rodriguez, M.A.7
  • 60
    • 0037309152 scopus 로고    scopus 로고
    • Transgenic expression of RasGRP1 induces the maturation of double-negative thymocytes and enhances the production of CD8 single-positive thymocytes
    • Norment A.M., Bogatzki L.Y., Klinger M., Ojala E.W., Bevan M.J., and Kay R.J. Transgenic expression of RasGRP1 induces the maturation of double-negative thymocytes and enhances the production of CD8 single-positive thymocytes. J. Immunol. 170 (2003) 1141-1149
    • (2003) J. Immunol. , vol.170 , pp. 1141-1149
    • Norment, A.M.1    Bogatzki, L.Y.2    Klinger, M.3    Ojala, E.W.4    Bevan, M.J.5    Kay, R.J.6
  • 61
    • 0036848708 scopus 로고    scopus 로고
    • RasGRP1 transduces low-grade TCR signals which are critical for T cell development, homeostasis, and differentiation
    • Priatel J.J., Teh S.J., Dower N.A., Stone J.C., and Teh H.S. RasGRP1 transduces low-grade TCR signals which are critical for T cell development, homeostasis, and differentiation. Immunity 17 (2002) 617-627
    • (2002) Immunity , vol.17 , pp. 617-627
    • Priatel, J.J.1    Teh, S.J.2    Dower, N.A.3    Stone, J.C.4    Teh, H.S.5
  • 62
    • 2442421056 scopus 로고    scopus 로고
    • RasGRP1 sensitizes an immature B cell line to antigen receptor-induced apoptosis
    • Guilbault B., and Kay R.J. RasGRP1 sensitizes an immature B cell line to antigen receptor-induced apoptosis. J. Biol. Chem. 279 (2004) 19523-19530
    • (2004) J. Biol. Chem. , vol.279 , pp. 19523-19530
    • Guilbault, B.1    Kay, R.J.2
  • 63
    • 28244476478 scopus 로고    scopus 로고
    • RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling
    • Coughlin J.J., Stang S.L., Dower N.A., and Stone J.C. RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling. J. Immunol. 175 (2005) 7179-7184
    • (2005) J. Immunol. , vol.175 , pp. 7179-7184
    • Coughlin, J.J.1    Stang, S.L.2    Dower, N.A.3    Stone, J.C.4
  • 65
    • 0037333972 scopus 로고    scopus 로고
    • Hydralazine may induce autoimmunity by inhibiting extracellular signal-regulated kinase pathway signaling
    • Deng C., Lu Q., Zhang Z., Rao T., Attwood J., Yung R., and Richardson B. Hydralazine may induce autoimmunity by inhibiting extracellular signal-regulated kinase pathway signaling. Arthritis Rheum. 48 (2003) 746-756
    • (2003) Arthritis Rheum. , vol.48 , pp. 746-756
    • Deng, C.1    Lu, Q.2    Zhang, Z.3    Rao, T.4    Attwood, J.5    Yung, R.6    Richardson, B.7
  • 66
    • 0033634930 scopus 로고    scopus 로고
    • DNA methylation in the regulation of T cell LFA-1 expression
    • Kaplan M.J., Deng C., Yang J., and Richardson B.C. DNA methylation in the regulation of T cell LFA-1 expression. Immunol. Invest. 29 (2000) 411-425
    • (2000) Immunol. Invest. , vol.29 , pp. 411-425
    • Kaplan, M.J.1    Deng, C.2    Yang, J.3    Richardson, B.C.4
  • 67
    • 0033959282 scopus 로고    scopus 로고
    • The role of DNA hypermethylation in human neoplasia
    • Toyota M., and Issa J.P. The role of DNA hypermethylation in human neoplasia. Electrophoresis 21 (2000) 329-333
    • (2000) Electrophoresis , vol.21 , pp. 329-333
    • Toyota, M.1    Issa, J.P.2
  • 68
    • 33746863731 scopus 로고    scopus 로고
    • Defective activation of protein kinase C and Ras-ERK pathways limits IL-2 production and proliferation by CD4+CD25+ regulatory T cells
    • Hickman S.P., Yang J., Thomas R.M., Wells A.D., and Turka L.A. Defective activation of protein kinase C and Ras-ERK pathways limits IL-2 production and proliferation by CD4+CD25+ regulatory T cells. J. Immunol. 177 (2006) 2186-2194
    • (2006) J. Immunol. , vol.177 , pp. 2186-2194
    • Hickman, S.P.1    Yang, J.2    Thomas, R.M.3    Wells, A.D.4    Turka, L.A.5
  • 69
    • 36148995642 scopus 로고    scopus 로고
    • K. Tenbrock, Y.T. Juang, V.C. Kyttaris, G.C. Tsokos, Altered signal transduction in SLE T cells, Rheumatology (in press) (electronic publication ahead of print).
  • 70
    • 36148976241 scopus 로고    scopus 로고
    • Defective activation of protein kinase C and Ras-ERK pathways limits IL-2 production and +CD25+ regulatory T cells
    • Hickman S.P., Yang J., Thomas R.M., Wells A.D., and Turka L.A. Defective activation of protein kinase C and Ras-ERK pathways limits IL-2 production and +CD25+ regulatory T cells. J. Immunol. 178 (2007) 1938-1947
    • (2007) J. Immunol. , vol.178 , pp. 1938-1947
    • Hickman, S.P.1    Yang, J.2    Thomas, R.M.3    Wells, A.D.4    Turka, L.A.5
  • 73
    • 28444459168 scopus 로고    scopus 로고
    • Ras initiates phosphatidyl-inositol-3-kinase (PI3K)/PKB mediated signalling pathways in untransformed human peripheral blood T lymphocytes
    • Samstag Y., and Nebl G. Ras initiates phosphatidyl-inositol-3-kinase (PI3K)/PKB mediated signalling pathways in untransformed human peripheral blood T lymphocytes. Adv. Enzyme Regul. 45 (2005) 52-62
    • (2005) Adv. Enzyme Regul. , vol.45 , pp. 52-62
    • Samstag, Y.1    Nebl, G.2
  • 74
    • 33846536952 scopus 로고    scopus 로고
    • Phosphorylated ERM is responsible for increased T cell polarization, adhesion, and migration in patients with systemic lupus erythematosus
    • Li Y., Harada T., Juang Y.T., Kyttaris V.C., Wang Y., Zidanic M., Tung K., and Tsokos G.C. Phosphorylated ERM is responsible for increased T cell polarization, adhesion, and migration in patients with systemic lupus erythematosus. J. Immunol. 178 (2007) 1938-1947
    • (2007) J. Immunol. , vol.178 , pp. 1938-1947
    • Li, Y.1    Harada, T.2    Juang, Y.T.3    Kyttaris, V.C.4    Wang, Y.5    Zidanic, M.6    Tung, K.7    Tsokos, G.C.8


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