Cerebral hypoperfusion yields capillary damage in the hippocampal CA1 area that correlates with spatial memory impairment

Neuroscience

Volumn 91, Issue 1, 1999, Pages 203-210

  De Jong, G I ^a   Farkas, E ^a   Stienstra, C M ^a   Plass, J R M ^a   Keijser, J N ^a   De La Torre, J C ^b   Luiten, P G M ^a  

^a Grad Sch Behav Cogn N   (Netherlands)

^b UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

Capillary morphology; Carotid artery ligation; Chronic hypoperfusion; Rat; Spatial learning; Transmission electron microscope

Indexed keywords

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN CAPILLARY; COGNITION; CONTROLLED STUDY; HIPPOCAMPUS; LEARNING; MALE; MAZE TEST; NONHUMAN; PRIORITY JOURNAL; RAT; SPATIAL MEMORY; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; BRAIN ISCHEMIA; CAPILLARIES; CEREBROVASCULAR CIRCULATION; HIPPOCAMPUS; MALE; MAZE LEARNING; MEMORY DISORDERS; MICROSCOPY, ELECTRON; RATS; RATS, WISTAR; SPACE PERCEPTION;

EID: 0032960553     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(98)00659-9     Document Type: Article

References (37)

1. Claudio L. Ultrastructural features of the blood-brain barrier in biopsy tissue from Alzheimer's disease patients. Acta neuropath. 91:1996;6-14.
2. Coyle P. Spatial features of the rat hippocampus vascular system. Expl Neurol. 58:1978;549-561.
3. De Jong G. I., De Weerd H., Schuurman T., Traber J., Luiten P. G. M. Microvascular changes in the aged rat forebrain. Effects of chronic nimodipine treatment. Neurobiol. Aging. 11:1990;381-389.
4. De Jong G. I., Jansen A. S. P., Horváth E., Gispen W. H., Luiten P. G. M. Nimodipine effects on cerebral microvessels and sciatic nerve in aging rats. Neurobiol. Aging. 13:1991;73-81.
5. De Jong G. I., Traber J., Luiten P. G. M. Formation of cerebrovascular anomalies in the aging rat is delayed by chronic nimodipine application. Mech. Agng Devl. 64:1992;255-272.
6. De Jong G. I., De Vos R. A. I., Jansen Steur E. N. H., Luiten P. G. M. Cerebrovascular hypoperfusion: a risk factor for Alzheimer's disease? Ann. N. Y. Acad. Sci. 826:1997;56-74.
7. de la Torre J. C. Impaired brain microcirculation may trigger Alzheimer's disease. Neurosci. Behav. Rev. 18:1994;397-401.
8. de la Torre J. C., Cada A., Nelson N., Davis G., Sutherland R. J., Gonzalez-Lima F. Reduced cytochrome oxidase and memory dysfunction after chronic brain ischemia in aged rats. Neurosci. Lett. 223:1997;165-168.
9. de la Torre J. C., Mussivand T. Can disturbed brain microvasculature cause Alzheimer's disease? Neurol. Res. 15:1993;146-153.
10. Dietrich W. D., Busto R., Ginsberg M. D. Cerebral endothelial microvilli: formation following global forebrain ischemia. J. Neuropath. exp. Neurol. 43:1984;72-83.
11. 123I-beta-CIT single-photon emission tomography in dementia of the Alzheimer-type and diffuse Lewy body disease. Eur. J. nucl. Med. 24:1997;320-325.
12. Eberling J. L., Jagust W. J., Reed B. R., Baker M. G. Reduced temporal lobe blood flow in Alzheimer's disease. Neurobiol. Aging. 13:1992;483-491.
13. Farrell C. R., Stewart P. A., Farrell C. L., Del Mastero R. F. Pericytes in human cerebral microvasculature. Anat. Rec. 218:1987;466-469.
14. Habert M. O., Spampinato U., Mas J. L., Piketty M. L., Bourdel M. C., de Recondo J., Rondot P., Askienazy S. A comparative technetium 99m hexamethylpropylene amine oxime SPET study in different types of dementia. Eur. J. nucl. Med. 18:1991;3-11.
15. Imdahl A., Hossmann K.-A. Morphometric evaluation of post-ischemic capillary perfusion in selective vulnerable areas of gerbils. Acta neuropath. 69:1986;267-271.
16. Kalaria R. N. Cerebral vessels in aging and Alzheimer's disease. Pharmac. Ther. 72:1996;193-214.
17. Kalaria R. N., Bhatti S. U., Lust W. D., Perry G. The amyloid precursor protein in ischemic brain injury and chronic hypoperfusion. Ann. N. Y. Acad. Sci. 695:1993;190-193.
18. Kudo T., Tada K., Takeda M., Nishimura T. Learning impairment and microtubule-associated protein 2 decrease in gerbils under chronic cerebral hypoperfusion. Stroke. 21:1990;1205-1209.
19. Kudo T., Takeda M., Tanimukai S., Nishimura T. Neuropathological changes in the gerbil brain after chronic hypoperfusion. Stroke. 24:1993;259-264.
20. Mironov V., Hritz M. A., LaManna J. C., Hudetz A. G., Harik S. I. Architectural alterations in rats after hypobaric hypoxia. Brain Res. 660:1994;73-80.
21. Mossakwski M. J., Wrzolkowa T., Tukaj C., Gadamski R. Comparative morphometric analysis of terminal vascularization of hippocampal CA1 and CA3 sectors in Mongolian gerbils. Folia neuropath. 31:1994;1-7.
22. Ni J., Ohta H., Matsumoto K., Watanabe H. Progressive cognitive impairment following cerebral hypoperfusion induced by permanent occlusion of bilateral carotid arteries in rats. Brain Res. 653:1994;231-232.
23. Ohnishi T., Hoshi H., Nagamachi S., Jinnouchi S., Flores L. G. II, Futami S., Watanabe K. High-resolution SPECT to assess hippocampal perfusion in neuropsychiatric diseases. J. nucl. Med. 36:1995;1163-1169.
24. Ohta H., Nishikawa H., Kimure H., Anayama H., Miyamoto M. Chronic cerebral hypoperfusion by permanent ligation procedures: learning impairment without brain damage in rats. Neuroscience. 79:1997;1039-1050.
25. Pappas B. A., de la Torre J. C., Davidson C. M., Keyes M. T., Fortin T. Chronic reduction of cerebral blood flow in the adult rat: late emerging CA1 cell loss and memory dysfunction. Brain Res. 708:1996;50-58.
26. Paxinos G. and Watson C. (1986) The Rat Brain in Stereotaxic Coordinates. Academic, London.
27. Perlmutter L. S., Chui H. C. Microangiopathy, the vascular basement membrane and Alzheimer's disease: a review. Brain Res. Bull. 24:1990;677-686.
28. Poucet B., Benhamou S. The neurophysiology of spatial cognition in the rat. Crit. Rev. Neurobiol. 11:1997;101-120.
29. Romanski K., Stamenov B. Ultrastructural study of cerebral cortex and subcortical white matter following ligation of bridging veins in cats. Zentbl. Neurochir. 56:1995;111-116.
30. Sakaki T., Tominaga M., Yabuno T. Microvascular changes associated with postischemic hypoperfusion in rats. Acta neurochir., Vienna. 139:1997;670-677.
31. Scheibel A. B. and Duong T. (1986) Microvascular changes in Alzheimer's disease. In The Biological Substrates of Alzheimer's Disease (ed. Scheibel A. B.), pp. 177-192. Academic, San Diego, CA.
32. Schmidt-Kastner R., Freund T. Selective vulnerability of the hippocampus in brain ischemia. Neuroscience. 40:1991;599-636.
33. Sekhon L. H., Morgan M. K., Spence I. Normal perfusion breakthrough: the role of capillaries. J. Neurosurg. 86:1997;519-524.
34. Sekhon L. H., Morgan M. K., Spence I., Weber N. C. Chronic cerebral hypoperfusion: pathological and behavioral consequences. Neurosurgery. 40:1997;548-556.
35. Sekhon L. H., Morgan M. K., Spence I., Weber N. C. Chronic cerebral hypoperfusion inhibits calcium-induced long-term potentiation in rats. Stroke. 28:1997;1043-1047.
36. Takahashi A., Park H. K., Melgar M. A., Alcocer L., Pinto J., Lenzi T., Diaz F. G., Rafols J. A. Cerebral cortex blood flow and vascular smooth muscle contractility in a rat model of ischemia: a correlative laser Doppler flowmetric and scanning electron microscopic study. Acta neuropath., Berlin. 93:1997;354-368.
37. Zarow C., Barron E., Chang Chui H., Perlmutter L. S. Vascular basement membrane pathology and Alzheimer's disease. Ann. N. Y. Acad. Sci. 826:1997;147-160.