Evidence of remodeling in peripheral airways of patients with mild to moderate asthma: Effect of hydrofluoroalkane-flunisolide

Journal of Allergy and Clinical Immunology

Volumn 116, Issue 5, 2005, Pages 983-989

  Bergeron, Celine ^a   Hauber, Hans Peter ^a   Gotfried, Mark ^b   Newman, Kenneth ^c   Dhanda, Rahul ^c   Servi, Ronald J ^b   Ludwig, Mara S ^a   Hamid, Qutayba ^a  

^a MCGILL UNIVERSITY   (Canada)

^b Pulmonary Associates   (United States)

^c Forest Laboratories   (United States)

Author keywords

Asthma; Flunisolide; Hydrofluoroalkane; Inhaled corticosteroids; Peripheral airways; Remodeling; Small airway

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 3; FLUNISOLIDE; FLUORINATED HYDROCARBON; METHACHOLINE; SALBUTAMOL; TRANSFORMING GROWTH FACTOR BETA;

ADULT; AIRWAY REMODELING; ARTICLE; ASTHMA; BRONCHUS BIOPSY; CELL SUBPOPULATION; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LUNG FUNCTION; MALE; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RESPIRATORY TRACT INJURY; RESPIRATORY TRACT MUCOSA; SAMPLE SIZE; STATISTICAL SIGNIFICANCE; TRANSBRONCHIAL BIOPSY; TREATMENT FAILURE; VITAL CAPACITY;

ACTINS; ADULT; ANTI-ASTHMATIC AGENTS; ASTHMA; BRONCHI; COLLAGEN; DRUG COMBINATIONS; FEMALE; FLUOCINOLONE ACETONIDE; HUMANS; MALE; MUSCLE, SMOOTH; RESPIRATORY FUNCTION TESTS; SEVERITY OF ILLNESS INDEX; TRANSFORMING GROWTH FACTOR BETA; TREATMENT OUTCOME;

EID: 27644560427     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2005.07.029     Document Type: Article

References (46)

1. A. Chetta, A. Foresi, M. Del Donno, G. Bertorelli, A. Pesci, and D. Olivieri Airways remodeling is a distinctive feature of asthma and is related to severity of disease Chest 111 1997 852 857
2. L.P. Boulet, M. Laviolette, H. Turcotte, A. Cartier, M. Dugas, and J.L. Malo Bronchial subepithelial fibrosis correlates with airway responsiveness to methacholine Chest 112 1997 45 52
3. J.A. Elias, Z. Zhu, G. Chupp, and R.J. Homer Airway remodeling in asthma J Clin Invest 104 1999 1001 1006
4. P.K. Jeffery, A.J. Wardlaw, F.C. Nelson, J.V. Collins, and A.B. Kay Bronchial biopsies in asthma: an ultrastructural, quantitative study and correlation with hyperreactivity Am Rev Respir Dis 140 1989 1745 1753
5. J. Huang, R. Olivenstein, R. Taha, Q. Hamid, and M. Ludwig Enhanced proteoglycan deposition in the airway wall of atopic asthmatics Am J Respir Crit Care Med 160 1999 725 729
6. A. Laitinen, A. Altraja, M. Kampe, M. Linden, I. Virtanen, and L.A. Laitinen Tenascin is increased in airway basement membrane of asthmatics and decreased by an inhaled steroid Am J Respir Crit Care Med 156 1997 951 958
7. W.R. Roche, R. Beasley, J.H. Williams, and S.T. Holgate Subepithelial fibrosis in the bronchi of asthmatics Lancet 1 1989 520 524
8. J.W. Wilson, and X. Li The measurement of reticular basement membrane and submucosal collagen in the asthmatic airway Clin Exp Allergy 27 1997 363 371
9. E.M. Karjalainen, A. Lindqvist, L.A. Laitinen, T. Kava, A. Altraja, and M. Halme Airway inflammation and basement membrane tenascin in newly diagnosed atopic and nonatopic asthma Respir Med 97 2003 1045 1051
10. H.W. Chu, J.L. Halliday, R.J. Martin, D.Y. Leung, S.J. Szefler, and S.E. Wenzel Collagen deposition in large airways may not differentiate severe asthma from milder forms of the disease Am J Respir Crit Care Med 158 1998 1936 1944
11. E.M. Minshall, D.Y. Leung, R.J. Martin, Y.L. Song, L. Cameron, and P. Ernst Eosinophil-associated TGF-beta1 mRNA expression and airways fibrosis in bronchial asthma Am J Respir Cell Mol Biol 17 1997 326 333
12. A.L. James, P.S. Maxwell, G. Pearce-Pinto, J.G. Elliot, and N.G. Carroll The relationship of reticular basement membrane thickness to airway wall remodeling in asthma Am J Respir Crit Care Med 166 2002 1590 1595
13. K. Kuwano, C.H. Bosken, P.D. Pare, T.R. Bai, B.R. Wiggs, and J.C. Hogg Small airways dimensions in asthma and in chronic obstructive pulmonary disease Am Rev Respir Dis 148 1993 1220 1225
14. M. Ebina, T. Takahashi, T. Chiba, and M. Motomiya Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma: a 3-D morphometric study Am Rev Respir Dis 148 1993 720 726
15. N. Carroll, J. Elliot, A. Morton, and A. James The structure of large and small airways in nonfatal and fatal asthma Am Rev Respir Dis 147 1993 405 410
16. R.A. Panettieri Jr. Airway smooth muscle: an immunomodulatory cell J Allergy Clin Immunol 110 2002 S269 S274
17. H. Hakonarson, N. Maskeri, C. Carter, and M.M. Grunstein Regulation of TH1- and TH2-type cytokine expression and action in atopic asthmatic sensitized airway smooth muscle J Clin Invest 103 1999 1077 1087
18. M. Synek, R. Beasley, A.J. Frew, D. Goulding, L. Holloway, and F.C. Lampe Cellular infiltration of the airways in asthma of varying severity Am J Respir Crit Care Med 154 1996 224 230
19. E.M. Minshall, J.C. Hogg, and Q.A. Hamid Cytokine mRNA expression in asthma is not restricted to the large airways J Allergy Clin Immunol 101 1998 386 390
20. R.A. Taha, E.M. Minshall, D. Miotto, A. Shimbara, A. Luster, and J.C. Hogg Eotaxin and monocyte chemotactic protein-4 mRNA expression in small airways of asthmatic and nonasthmatic individuals J Allergy Clin Immunol 103 1999 476 483
21. A.M. Bentley, Q. Hamid, D.S. Robinson, E. Schotman, Q. Meng, and B. Assoufi Prednisolone treatment in asthma: reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa Am J Respir Crit Care Med 153 1996 551 556
22. C.J. Trigg, N.D. Manolitsas, J. Wang, M.A. Calderon, A. McAulay, and S.E. Jordan Placebo-controlled immunopathologic study of four months of inhaled corticosteroids in asthma Am J Respir Crit Care Med 150 1994 17 22
23. J. Chakir, J. Shannon, S. Molet, M. Fukakusa, J. Elias, and M. Laviolette Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression J Allergy Clin Immunol 111 2003 1293 1298
24. J. Richards, P. Hirst, G. Pitcairn, S. Mahashabde, W. Abramowitz, and A. Nolting Deposition and pharmacokinetics of flunisolide delivered from pressurized inhalers containing non-CFC and CFC propellants J Aerosol Med 14 2001 197 208
25. H.P. Hauber, M. Gotfried, K. Newman, R. Danda, R.J. Servi, and P. Christodoulopoulos Effect of HFA-flunisolide on peripheral lung inflammation in asthma J Allergy Clin Immunol 112 2003 58 63
26. M. Hoshino, Y. Nakamura, and J.J. Sim Expression of growth factors and remodelling of the airway wall in bronchial asthma Thorax 53 1998 21 27
27. A. James, and N. Carroll Airway smooth muscle in health and disease; methods of measurement and relation to function Eur Respir J 15 2000 782 789
28. L. Benayoun, A. Druilhe, M.C. Dombret, M. Aubier, and M. Pretolani Airway structural alterations selectively associated with severe asthma Am J Respir Crit Care Med 167 2003 1360 1368
29. M.J. Gizycki, E. Adelroth, A.V. Rogers, P.M. O'Byrne, and P.K. Jeffery Myofibroblast involvement in the allergen-induced late response in mild atopic asthma Am J Respir Cell Mol Biol 16 1997 664 673
30. A.M. Vignola, P. Chanez, G. Chiappara, A. Merendino, E. Pace, and A. Rizzo Transforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitis Am J Respir Crit Care Med 156 1997 591 599
31. A. Fine, and R.H. Goldstein The effect of transforming growth factor-beta on cell proliferation and collagen formation by lung fibroblasts J Biol Chem 262 1987 3897 3902
32. R.A. Ignotz, and J. Massague Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix J Biol Chem 261 1986 4337 4345
33. N. Venkatesan, P.J. Roughley, and M.S. Ludwig Proteoglycan expression in bleomycin lung fibroblasts: role of transforming growth factor-beta(1) and interferon-gamma Am J Physiol Lung Cell Mol Physiol 283 2002 L806 L814
34. D.R. Edwards, G. Murphy, J.J. Reynolds, S.E. Whitham, A.J. Docherty, and P. Angel Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor EMBO J 6 1987 1899 1904
35. P.K. Jeffery Pathology of asthma Br Med Bull 48 1992 23 39
36. R. Lundgren, M. Soderberg, P. Horstedt, and R. Stenling Morphological studies of bronchial mucosal biopsies from asthmatics before and after ten years of treatment with inhaled steroids Eur Respir J 1 1988 883 889
37. L.P. Boulet, H. Turcotte, M. Laviolette, F. Naud, M.C. Bernier, and S. Martel Airway hyperresponsiveness, inflammation, and subepithelial collagen deposition in recently diagnosed versus long-standing mild asthma: influence of inhaled corticosteroids Am J Respir Crit Care Med 162 2000 1308 1313
38. D. Olivieri, A. Chetta, M. Del Donno, G. Bertorelli, A. Casalini, and A. Pesci Effect of short-term treatment with low-dose inhaled fluticasone propionate on airway inflammation and remodeling in mild asthma: a placebo-controlled study Am J Respir Crit Care Med 155 1997 1864 1871
39. M. Hoshino, M. Takahashi, Y. Takai, and J. Sim Inhaled corticosteroids decrease subepithelial collagen deposition by modulation of the balance between matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in asthma J Allergy Clin Immunol 104 1999 356 363
40. C. Ward, M. Pais, R. Bish, D. Reid, B. Feltis, and D. Johns Airway inflammation, basement membrane thickening and bronchial hyperresponsiveness in asthma Thorax 57 2002 309 316
41. J.K. Sont, L.N. Willems, E.H. Bel, J.H. van Krieken, J.P. Vandenbroucke, and P.J. Sterk Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment. The AMPUL Study Group Am J Respir Crit Care Med 159 1999 1043 1051
42. P.G. Young, S.J. Skinner, and P.N. Black Effects of glucocorticoids and beta-adrenoceptor agonists on the proliferation of airway smooth muscle Eur J Pharmacol 273 1995 137 143
43. A.G. Stewart, D. Fernandes, and P.R. Tomlinson The effect of glucocorticoids on proliferation of human cultured airway smooth muscle Br J Pharmacol 116 1995 3219 3226
44. M. Roth, P.R. Johnson, J.J. Rudiger, G.G. King, Q. Ge, and J.K. Burgess Interaction between glucocorticoids and beta2 agonists on bronchial airway smooth muscle cells through synchronised cellular signalling Lancet 360 2002 1293 1299
45. M. Roth, P.R. Johnson, P. Borger, M.P. Bihl, J.J. Rudiger, and G.G. King Dysfunctional interaction of C/EBPalpha and the glucocorticoid receptor in asthmatic bronchial smooth-muscle cells N Engl J Med 351 2004 560 574
46. S.A. Quadrelli, A.J. Roncoroni, and G. Porcel Analysis of variability in interpretation of spirometric tests Respiration 63 1996 131 136