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Volumn 349, Issue , 2011, Pages 245-263

Inhibition of NF-κB signaling as a strategy in disease therapy

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; APILIMOD; BARDOXOLONE METHYL; BORTEZOMIB; CURCUMIN; DOXORUBICIN; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OLIGONUCLEOTIDE; PROTEIN INHIBITOR; TACROLIMUS; TRANSCRIPTION FACTOR REL; DNA;

EID: 84859946812     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/82-2010-105     Document Type: Article
Times cited : (104)

References (95)
  • 1
    • 2342667387 scopus 로고    scopus 로고
    • The development of proteasome inhibitors as anticancer drugs
    • DOI 10.1016/S1535-6108(04)00120-5, PII S1535610804001205
    • Adams J (2004) The development of proteasome inhibitors as anticancer drugs. Cancer Cell 5:417-421 (Pubitemid 38610244)
    • (2004) Cancer Cell , vol.5 , Issue.5 , pp. 417-421
    • Adams, J.1
  • 4
    • 0032084331 scopus 로고    scopus 로고
    • The NF-κB/Rel family of proteins mediates A β-induced neurotoxicity and glial activation
    • DOI 10.1016/S0169-328X(98)00066-7, PII S0169328X98000667
    • Bales KR, Du Y, Dodel RC, Yan GM, Hamilton-Byrd E, Paul SM (1998) The NF-κB/Rel family of proteins mediates Aβ-induced neurotoxicity and glial activation. Brain Res Mol Brain Res 57:63-72 (Pubitemid 28279561)
    • (1998) Molecular Brain Research , vol.57 , Issue.1 , pp. 63-72
    • Bales, K.R.1    Du, Y.2    Dodel, R.C.3    Yan, G.-M.4    Hamilton-Byrd, E.5    Paul, S.M.6
  • 6
    • 33750432183 scopus 로고    scopus 로고
    • Nuclear factor-κB and inhibitor of κB kinase pathways in oncogenic initiation and progression
    • DOI 10.1038/sj.onc.1209942, PII 1209942
    • Bassères D, Baldwin AS (2006) Nuclear factor-κB and inhibitor of κB kinase pathways in oncogenic initiation and progression. Oncogene 25:6817-6830 (Pubitemid 44657854)
    • (2006) Oncogene , vol.25 , Issue.51 , pp. 6817-6830
    • Basseres, D.S.1    Baldwin, A.S.2
  • 7
    • 85047699031 scopus 로고    scopus 로고
    • Identification of signal transduction pathways involved in constitutive NF-κB activation in breast cancer cells
    • DOI 10.1038/sj/onc/1205243
    • Bhat-Nakshatri P, Sweeney CJ, Nakshatri H (2002) Identification of signal transduction pathways involved in constitutive activation in breast cancer cells. Oncogene 21:2066-2078 (Pubitemid 34270895)
    • (2002) Oncogene , vol.21 , Issue.13 , pp. 2066-2078
    • Bhat-Nakshatri, P.1    Sweeney, C.J.2    Nakshatri, H.3
  • 11
    • 0033917674 scopus 로고    scopus 로고
    • Distinct roles for the NF-κB1 (p50) and c-Rel transcription factors in inflammatory arthritis
    • Campbell IK, Gerondakis S, O'Donnell K, Wicks IP (2000) Distinct roles for the NF-κB1 (p50) and c-Rel transcription factors in inflammatory arthritis. J Clin Invest 105:1799-1806 (Pubitemid 30421761)
    • (2000) Journal of Clinical Investigation , vol.105 , Issue.12 , pp. 1799-1806
    • Campbell, I.K.1    Gerondakis, S.2    O'Donnell, K.3    Wicks, I.P.4
  • 12
    • 67649823926 scopus 로고    scopus 로고
    • Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IκB kinase ε: A distinct kinase mediates Ser-172 phosphorylation and activation
    • Clark K, Plater L, Peggie M, Cohen P (2009) Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IκB kinase ε: a distinct kinase mediates Ser-172 phosphorylation and activation. J Biol Chem 284:14136-14146
    • (2009) J Biol Chem , vol.284 , pp. 14136-14146
    • Clark, K.1    Plater, L.2    Peggie, M.3    Cohen, P.4
  • 13
    • 51249095133 scopus 로고    scopus 로고
    • The IKK-related kinase: From innate immunity to oncogenesis
    • Clément JF, Meloche S, Servant MJ (2008) The IKK-related kinase: from innate immunity to oncogenesis. Cell Res 18:889-899
    • (2008) Cell Res , vol.18 , pp. 889-899
    • Clément, J.F.1    Meloche, S.2    Servant, M.J.3
  • 15
    • 33750454819 scopus 로고    scopus 로고
    • Mutations in the NF-κB signaling pathway: Implications for human disease
    • DOI 10.1038/sj.onc.1209939, PII 1209939
    • Courtois G, Gilmore TD (2006) Mutations in the NF-κB signaling pathway: implications for human disease. Oncogene 25:6831-6843 (Pubitemid 44657855)
    • (2006) Oncogene , vol.25 , Issue.51 , pp. 6831-6843
    • Courtois, G.1    Gilmore, T.D.2
  • 16
    • 0035328584 scopus 로고    scopus 로고
    • Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: Implications for systemic nuclear factor-κB inhibition
    • Cusack JC Jr, Liu R, Houston M, Abendroth K, Elliott PJ, Adams J, Baldwin AS Jr (2001) Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-κB inhibition. Cancer Res 61:3535-3540 (Pubitemid 32694955)
    • (2001) Cancer Research , vol.61 , Issue.9 , pp. 3535-3540
    • Cusack Jr., J.C.1    Liu, R.2    Houston, M.3    Abendroth, K.4    Elliott, P.J.5    Adams, J.6    Baldwin Jr., A.S.7
  • 17
    • 0035905313 scopus 로고    scopus 로고
    • Constitutive nuclear factor κB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells
    • DOI 10.1084/jem.194.12.1861
    • Davis RE, Brown KD, Siebenlist U, Staudt LM (2001) Constitutive nuclear factor κB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells. J Exp Med 194:1861-1874 (Pubitemid 34028664)
    • (2001) Journal of Experimental Medicine , vol.194 , Issue.12 , pp. 1861-1874
    • Eric Davis, R.1    Brown, K.D.2    Siebenlist, U.3    Staudt, L.M.4
  • 20
    • 33750475959 scopus 로고    scopus 로고
    • Cross-talk between nuclear receptors and nuclear factor κB
    • De Bosscher K, Vanden Berge W, Haegeman G (2006) Cross-talk between nuclear receptors and nuclear factor κB. Oncogene 25:6868-6886
    • (2006) Oncogene , vol.25 , pp. 6868-6886
    • De Bosscher, K.1    Vanden Berge, W.2    Haegeman, G.3
  • 22
    • 29244439558 scopus 로고    scopus 로고
    • Inducible IκB kinase/IκB kinase ε expression is induced by CK2 and promotes aberrant nuclear factor-κB activation in breast cancer cells
    • DOI 10.1158/0008-5472.CAN-05-1602
    • Eddy SF, Guo S, Demicco EG, Romieu-Mourez R, Landesman-Bollag E, Seldin DC, Sonenshein GE (2005) Inducible IκB kinase/IκB kinase ε expression is induced by CK2 and promotes aberrant nuclear factor-κB activation in breast cancer cells. Cancer Res 65:11375-11383 (Pubitemid 41823949)
    • (2005) Cancer Research , vol.65 , Issue.24 , pp. 11375-11383
    • Eddy, S.F.1    Guo, S.2    Demicco, E.G.3    Romieu-Mourez, R.4    Landesman-Bollag, E.5    Seldin, D.C.6    Sonenshein, G.E.7
  • 24
    • 0032102139 scopus 로고    scopus 로고
    • IL-10 down-regulates human microglial IL-8 by inhibition of NF-κB activation
    • Ehrlich LC, Hu S, Peterson PK, Chao CC (1998) IL-10 down-regulates human microglial IL-8 by inhibition of NF-κB activation. Neuroreport 9:1723-1726 (Pubitemid 28289174)
    • (1998) NeuroReport , vol.9 , Issue.8 , pp. 1723-1726
    • Ehrlich, L.C.1    Hu, S.2    Peterson, P.K.3    Chao, C.C.4
  • 26
    • 45449112571 scopus 로고    scopus 로고
    • NF-kB p52, RelB and c-Rel are transported into the nucleus via a subset of importin alpha molecules
    • Fagerlund R, Melén K, Cao X, Julkunen I (2008) NF-kB p52, RelB and c-Rel are transported into the nucleus via a subset of importin alpha molecules. Cell Signal 20:1442-1451
    • (2008) Cell Signal , vol.20 , pp. 1442-1451
    • Fagerlund, R.1    Melén, K.2    Cao, X.3    Julkunen, I.4
  • 27
    • 43249106841 scopus 로고    scopus 로고
    • Regulation of programmed cell death by NF-κB and its role in tumorigenesis and therapy
    • Fan Y, Dutta J, Gupta N, Fan G, Gélinas C (2008) Regulation of programmed cell death by NF-κB and its role in tumorigenesis and therapy. Adv Exp Med Biol 615:223-250
    • (2008) Adv Exp Med Biol , vol.615 , pp. 223-250
    • Fan, Y.1    Dutta, J.2    Gupta, N.3    Fan, G.4    Gélinas, C.5
  • 28
    • 0032502719 scopus 로고    scopus 로고
    • Lactacystin, proteasome function, and cell fate
    • DOI 10.1074/jbc.273.15.8545
    • Fenteany G, Schreiber SL (1998) Lactacystin, proteasome function, and cell fate. J Biol Chem 273:8545-8548 (Pubitemid 28176125)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.15 , pp. 8545-8548
    • Fenteany, G.1    Schreiber, S.L.2
  • 29
    • 37849022679 scopus 로고    scopus 로고
    • Marine natural products as targeted modulators of the transcription factor NF-κB
    • Folmer F, Jaspars DM, Diederich M (2008) Marine natural products as targeted modulators of the transcription factor NF-κB. Biochem Pharmacol 75:603-617
    • (2008) Biochem Pharmacol , vol.75 , pp. 603-617
    • Folmer, F.1    Jaspars, D.M.2    Diederich, M.3
  • 30
    • 67149084553 scopus 로고    scopus 로고
    • Ariad's NFκB patent claims shot down on appeal
    • Garber K (2009) Ariad's NFκB patent claims shot down on appeal. Nat Biotechnol 27:494-495
    • (2009) Nat Biotechnol , vol.27 , pp. 494-495
    • Garber, K.1
  • 31
    • 2942618506 scopus 로고    scopus 로고
    • Role of cysteine residues of p65/NF-κB on the inhibition by the sesquiterpene lactone parthenolide and N-ethyl maleimide, and on its transactivating potential
    • DOI 10.1016/j.lfs.2004.01.024, PII S0024320504003443
    • García-Piñeres AJ, Lindenmeyer MT, Merfort I (2004) Role of cysteine residues of p65/NF-κB on the inhibition by the sesquiterpene lactone parthenolide and N-ethyl maleimide, and on its transactivating potential. Life Sci 75:841-856 (Pubitemid 38737421)
    • (2004) Life Sciences , vol.75 , Issue.7 , pp. 841-856
    • Garcia-Pineres, A.J.1    Lindenmeyer, M.T.2    Merfort, I.3
  • 32
    • 34547598337 scopus 로고    scopus 로고
    • Multiple myeloma: Lusting for NF-κB
    • Gilmore TD (2007) Multiple myeloma: lusting for NF-κB. Cancer Cell 12:95-97
    • (2007) Cancer Cell , vol.12 , pp. 95-97
    • Gilmore, T.D.1
  • 33
    • 33750446341 scopus 로고    scopus 로고
    • Inhibitors of NF-κB signaling:785 and counting
    • Gilmore TD, Herscovitch M (2006) Inhibitors of NF-κB signaling:785 and counting. Oncogene 25:6887-6899
    • (2006) Oncogene , vol.25 , pp. 6887-6899
    • Gilmore, T.D.1    Herscovitch, M.2
  • 34
    • 1842432464 scopus 로고    scopus 로고
    • The c-Rel transcription factor and B-cell proliferation: A deal with the devil
    • DOI 10.1038/sj.onc.1207410
    • Gilmore TD, Kalaitzidis D, Liang M-C, Starczynowski DT (2004) The c-Rel transcription factor and B-cell proliferation: a deal with the devel. Oncogene 23:2275-2286 (Pubitemid 38496782)
    • (2004) Oncogene , vol.23 , Issue.13 , pp. 2275-2286
    • Gilmore, T.D.1    Kalaitzidis, D.2    Liang, M.-C.3    Starczynowski, D.T.4
  • 39
    • 38849199203 scopus 로고    scopus 로고
    • Shared principles in NF-κB signaling
    • Hayden MS, Ghosh S (2008) Shared principles in NF-κB signaling. Cell 132:344-362
    • (2008) Cell , vol.132 , pp. 344-362
    • Hayden, M.S.1    Ghosh, S.2
  • 40
    • 33645693662 scopus 로고    scopus 로고
    • Enantioselective total syntheses of (-)-clastolactacystin β-lactone and 7-epi-(-)-clasto-lactacystin β-lactone
    • Hayes CJ, Sherlock AE, Selby MD (2006) Enantioselective total syntheses of (-)-clastolactacystin β-lactone and 7-epi-(-)-clasto-lactacystin β-lactone. Org Biomol Chem 4:193-195
    • (2006) Org Biomol Chem , vol.4 , pp. 193-195
    • Hayes, C.J.1    Sherlock, A.E.2    Selby, M.D.3
  • 42
    • 33750433585 scopus 로고    scopus 로고
    • Manipulation of the nuclear factor-κB pathway and the innate immune response by viruses
    • DOI 10.1038/sj.onc.1209941, PII 1209941
    • Hiscott J, Nguyen T-LA, Arguello M, Nakhaei P, Paz S (2006) Manipulation of the nuclear factor-κB pathway and the innate immune response by viruses. Oncogene 25:6844-6867 (Pubitemid 44657856)
    • (2006) Oncogene , vol.25 , Issue.51 , pp. 6844-6867
    • Hiscott, J.1    Nguyen, T.-L.A.2    Arguello, M.3    Nakhaei, P.4    Paz, S.5
  • 44
    • 0031808369 scopus 로고    scopus 로고
    • Mediation by NF-κB of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors
    • Jobin C, Hellerbrand C, Licato LL, Brenner DA, Sartor RB (1998) Mediation by NF-κB of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors. Gut 42:779-787 (Pubitemid 28277216)
    • (1998) Gut , vol.42 , Issue.6 , pp. 779-787
    • Jobin, C.1    Hellerbrand, C.2    Licato, L.L.3    Brenner, D.A.4    Sartor, R.B.5
  • 45
    • 13944252475 scopus 로고    scopus 로고
    • Transcription factor cross-talk: The estrogen receptor and NF-κB
    • DOI 10.1016/j.tem.2005.01.004
    • Kalaitzidis D, Gilmore TD (2005) Transcription factor cross-talk: the estrogen receptor and NF-κB. Trends Endocrinol Metab 16:46-52 (Pubitemid 40270849)
    • (2005) Trends in Endocrinology and Metabolism , vol.16 , Issue.2 , pp. 46-52
    • Kalaitzidis, D.1    Gilmore, T.D.2
  • 46
    • 0034680928 scopus 로고    scopus 로고
    • Inhibition of NF-κB activation by arsenite through reaction with a critical cysteine in the activation loop of IκB kinase
    • Kapahi P, Takahashi T, Natoli G, Adams SR, Chen Y, Tsien RY, Karin M (2000) Inhibition of NF-κB activation by arsenite through reaction with a critical cysteine in the activation loop of IκB kinase. J Biol Chem 275:36062-36066
    • (2000) J Biol Chem , vol.275 , pp. 36062-36066
    • Kapahi, P.1    Takahashi, T.2    Natoli, G.3    Adams, S.R.4    Chen, Y.5    Tsien, R.Y.6    Karin, M.7
  • 47
    • 0346505340 scopus 로고    scopus 로고
    • The IKK NF-κB system: A treasure trove for drug development
    • Karin M, Yamamoto Y, Wang QM (2004) The IKK NF-κB system: a treasure trove for drug development. Nat Rev Drug Discov 3:17-26 (Pubitemid 38088695)
    • (2004) Nature Reviews Drug Discovery , vol.3 , Issue.1 , pp. 17-26
    • Karin, M.1    Yamamoto, Y.2    Wang, Q.M.3
  • 48
    • 54949116587 scopus 로고    scopus 로고
    • Therapeutic effect of the potent IL-12/IL-23 inhibitor STA-5326 on experimental autoimmune uveoretinitis
    • Keino H, Watanabe T, Sato Y, Niikura M, Wada Y, Okada A (2008) Therapeutic effect of the potent IL-12/IL-23 inhibitor STA-5326 on experimental autoimmune uveoretinitis. Arthritis Res Ther 10:R122
    • (2008) Arthritis Res Ther , vol.10
    • Keino, H.1    Watanabe, T.2    Sato, Y.3    Niikura, M.4    Wada, Y.5    Okada, A.6
  • 50
    • 0034879173 scopus 로고    scopus 로고
    • The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IκB kinase
    • DOI 10.1016/S1074-5521(01)00049-7, PII S1074552101000497
    • Kwok BH, Koh B, Ndubuisi MI, Elofsson M, Crews CM (2001) The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IκB kinase. Chem Biol 8:759-766 (Pubitemid 32752455)
    • (2001) Chemistry and Biology , vol.8 , Issue.8 , pp. 759-766
    • Kwok, B.H.B.1    Koh, B.2    Ndubuisi, M.I.3    Elofsson, M.4    Crews, C.M.5
  • 51
    • 33746160313 scopus 로고    scopus 로고
    • Development of luciferase reporter-based cell assays
    • DOI 10.1089/adt.2006.4.307
    • Lai C, Jiang X, Li X (2006) Development of luciferase reporter-based cell assays. Assay Drug Dev Technol 4:307-315 (Pubitemid 44083585)
    • (2006) Assay and Drug Development Technologies , vol.4 , Issue.3 , pp. 307-315
    • Lai, C.1    Jiang, X.2    Li, X.3
  • 53
    • 58549104540 scopus 로고    scopus 로고
    • Compensatory IKKα activation of classical NF-κB signaling during IKKβ inhibition identified by an RNA interference sensitization screen
    • Lam LT, Davis RE, Ngo VN, Lenz G, Wright G, Xu W, Zhao H, Yu X, Dang L, Staudt LM (2008) Compensatory IKKα activation of classical NF-κB signaling during IKKβ inhibition identified by an RNA interference sensitization screen. Proc Natl Acad Sci USA 105:20798-20803
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 20798-20803
    • Lam, L.T.1    Davis, R.E.2    Ngo, V.N.3    Lenz, G.4    Wright, G.5    Xu, W.6    Zhao, H.7    Yu, X.8    Dang, L.9    Staudt, L.M.10
  • 55
    • 53249129484 scopus 로고    scopus 로고
    • Advances in targeting IKK and IKK-related kinases for cancer therapy
    • Lee DF, Hung MC (2008) Advances in targeting IKK and IKK-related kinases for cancer therapy. Clin Cancer Res 14:5656-5662
    • (2008) Clin Cancer Res , vol.14 , pp. 5656-5662
    • Lee, D.F.1    Hung, M.C.2
  • 56
    • 0030781140 scopus 로고    scopus 로고
    • In vivo suppression of NF-κB and preservation of IκBα by interleukin- 10 and interleukin-13
    • Lentsch AB, Shanley TP, Sarma V, Ward PA (1997) In vivo suppression of NF-κB and preservation of IκBα by interleukin-10 and interleukin-13. J Clin Invest 100:2443-2448 (Pubitemid 27514883)
    • (1997) Journal of Clinical Investigation , vol.100 , Issue.10 , pp. 2443-2448
    • Lentsch, A.B.1    Shanley, T.P.2    Sarma, V.3    Ward, P.A.4
  • 59
    • 0038237037 scopus 로고    scopus 로고
    • Jesterone dimer, a synthetic derivative of the fungal metabolite jesterone, blocks activation of transcription factor nuclear factor κB by inhibiting the inhibitor of κB kinase
    • DOI 10.1124/mol.64.1.123
    • Liang M-C, Bardhan S, Li C, Pace EA, Porco JA Jr, Gilmore TD (2003) Jesterone dimer, a synthetic derivative of the fungal metabolite jesterone, blocks activation of transcription factor nuclear factor κB by inhibiting the inhibitor of κB kinase. Mol Pharmacol 64:123-131 (Pubitemid 36759824)
    • (2003) Molecular Pharmacology , vol.64 , Issue.1 , pp. 123-131
    • Liang, M.-C.1    Bardhan, S.2    Li, C.3    Pace, E.A.4    Porco Jr., J.A.5    Gilmore, T.D.6
  • 60
    • 31044445246 scopus 로고    scopus 로고
    • Inhibition of transcription factor NF-κB signaling proteins IKKβ and p65 through specific cysteine residues by epoxyquinone a monomer: Correlation with its anti-cancer cell growth activity
    • DOI 10.1016/j.bcp.2005.11.013, PII S000629520500777X
    • Liang M-C, Bardhan S, Pace EA, Rosman D, Beutler JA, Porco JA Jr, Gilmore TD (2006) Inhibition of transcription factor NF-κB signaling proteins IKKβ and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity. Biochem Pharmacol 71:634-645 (Pubitemid 43121997)
    • (2006) Biochemical Pharmacology , vol.71 , Issue.5 , pp. 634-645
    • Liang, M.-C.1    Bardhan, S.2    Pace, E.A.3    Rosman, D.4    Beutler, J.A.5    Porco Jr., J.A.6    Gilmore, T.D.7
  • 61
    • 0029006149 scopus 로고
    • Inhibition of nuclear translocation of transcription factor NF-κB by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence
    • Lin YZ, Yao SY, Veach RA, Torgerson TR, Hawiger J (1995) Inhibition of nuclear translocation of transcription factor NF-κB by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. J Biol Chem 270:14255-14258
    • (1995) J Biol Chem , vol.270 , pp. 14255-14258
    • Lin, Y.Z.1    Yao, S.Y.2    Veach, R.A.3    Torgerson, T.R.4    Hawiger, J.5
  • 62
    • 33846839443 scopus 로고    scopus 로고
    • Deletion of NEMO/IKKγ in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma
    • DOI 10.1016/j.ccr.2006.12.016, PII S1535610807000207
    • Luedde T, Bereza N, Kotsikoris V, van Loo G, Nenci A, De Vos R, Roskams T, Trautwein C, Pasparakis M (2007) Deletion of NEMO/IKKγ in liver parenchymal cells causes steatoheptatis and hepatocellular carincoma. Cancer Cell 11:119-132 (Pubitemid 46209851)
    • (2007) Cancer Cell , vol.11 , Issue.2 , pp. 119-132
    • Luedde, T.1    Beraza, N.2    Kotsikoris, V.3    Van Loo, G.4    Nenci, A.5    De Vos, R.6    Roskams, T.7    Trautwein, C.8    Pasparakis, M.9
  • 63
    • 0027980321 scopus 로고
    • The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB
    • DOI 10.1016/S0092-8674(94)90482-0
    • Palombella VJ, Rando OJ, Goldberg AL, Maniatis T (1994) The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Cell 78:773-785 (Pubitemid 24294453)
    • (1994) Cell , vol.78 , Issue.5 , pp. 773-785
    • Palombella, V.J.1    Rando, O.J.2    Goldberg, A.L.3    Maniatis, T.4
  • 64
    • 70450198853 scopus 로고    scopus 로고
    • Direct covalent modification as a strategy to inhibit nuclear factor-κB
    • Pande V, Sousa SF, Ramos MJ (2009) Direct covalent modification as a strategy to inhibit nuclear factor-κB. Curr Med Chem 16:4261-4273
    • (2009) Curr Med Chem , vol.16 , pp. 4261-4273
    • Pande, V.1    Sousa, S.F.2    Ramos, M.J.3
  • 65
    • 68649096651 scopus 로고    scopus 로고
    • TBK1-targeted suppression of TRIF-dependent signaling pathway of Toll-like receptors by 6-shogaol, an active component of ginger
    • Park SJ, Lee MY, Bon BS, Youn HS (2009) TBK1-targeted suppression of TRIF-dependent signaling pathway of Toll-like receptors by 6-shogaol, an active component of ginger. Biosci Biotechnol Biochem 73:1474-1478
    • (2009) Biosci Biotechnol Biochem , vol.73 , pp. 1474-1478
    • Park, S.J.1    Lee, M.Y.2    Bon, B.S.3    Youn, H.S.4
  • 66
    • 70350513270 scopus 로고    scopus 로고
    • Regulation of tissue homeostasis by NF-κB signaling: Implications for inflammatory diseases
    • Pasparakis M (2009) Regulation of tissue homeostasis by NF-κB signaling: implications for inflammatory diseases. Nat Rev Immunol 9:778-788
    • (2009) Nat Rev Immunol , vol.9 , pp. 778-788
    • Pasparakis, M.1
  • 67
    • 33750457370 scopus 로고    scopus 로고
    • Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway
    • DOI 10.1038/sj.onc.1209937, PII 1209937
    • Perkins ND (2006) Post-translational modifications regulating the activity and function of the nuclear factor κB pathway. Oncogene 25:6717-6730 (Pubitemid 44657848)
    • (2006) Oncogene , vol.25 , Issue.51 , pp. 6717-6730
    • Perkins, N.D.1
  • 68
    • 0035868342 scopus 로고    scopus 로고
    • Her-2/neu overexpression induces NF-κB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IκB-α that can be inhibited by the tumor suppressor PTEN
    • DOI 10.1038/sj.onc.1204257
    • Pianetti S, Arsura M, Romieu-Mourez R, Coffey RJ, Sonenshein GE (2001) Her-1/Neu overexpression induces NF-κB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IκB-α that can be inhibited by the tumor suppressor PTEN. Oncogene 20:1287-1299 (Pubitemid 32269934)
    • (2001) Oncogene , vol.20 , Issue.11 , pp. 1287-1299
    • Pianetti, S.1    Arsura, M.2    Romieu-Mourez, R.3    Coffey, R.J.4    Sonenshein, G.E.5
  • 69
    • 65649109750 scopus 로고    scopus 로고
    • Inhibition of transcription factors by plantderived compounds and their implications in inflammation and cancer
    • Ríos JL, Recio MC, Escandell JM, Andújar I (2009) Inhibition of transcription factors by plantderived compounds and their implications in inflammation and cancer. Curr Pharm Des 15:1212-1237
    • (2009) Curr Pharm Des , vol.15 , pp. 1212-1237
    • Ríos, J.L.1    Recio, M.C.2    Escandell, J.M.3    Andújar, I.4
  • 71
    • 33750443289 scopus 로고    scopus 로고
    • IκB kinase complexes: Gateways to NF-κB activation and transcription
    • DOI 10.1038/sj.onc.1209934, PII 1209934
    • Scheidereit C (2006) IκB kinase complexes: gateways to NF-κB activation and transcription. Oncogene 25:6685-6705 (Pubitemid 44657846)
    • (2006) Oncogene , vol.25 , Issue.51 , pp. 6685-6705
    • Scheidereit, C.1
  • 73
    • 33645693409 scopus 로고    scopus 로고
    • A synthetic triterpenoid, CDDO-Me, inhibits IκBα kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor κB-regulated gene products in human leukemic cells
    • Shishodia S, Sethi G, Konopleva M, Andreeff M, Aggarwal BB (2006) A synthetic triterpenoid, CDDO-Me, inhibits IκBα kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor κB-regulated gene products in human leukemic cells. Clin Cancer Res 12:1828-1838
    • (2006) Clin Cancer Res , vol.12 , pp. 1828-1838
    • Shishodia, S.1    Sethi, G.2    Konopleva, M.3    Andreeff, M.4    Aggarwal, B.B.5
  • 74
    • 67650744586 scopus 로고    scopus 로고
    • The role of ubiquitin in NF-κB regulatory pathways
    • Skaug B, Jiang X, Chen ZJ (2009) The role of ubiquitin in NF-κB regulatory pathways. Annu Rev Biochem 78:769-796
    • (2009) Annu Rev Biochem , vol.78 , pp. 769-796
    • Skaug, B.1    Jiang, X.2    Chen, Z.J.3
  • 76
    • 33750358664 scopus 로고    scopus 로고
    • Use of cell permeable NBD peptides for suppression of inflammation
    • DOI 10.1136/ard.2006.058438
    • Strickland I, Ghosh S (2006) Use of cell permeable NBD peptides for suppression of inflammation. Ann Rheum Dis 65(Suppl 3):iii75-iii82 (Pubitemid 44629109)
    • (2006) Annals of the Rheumatic Diseases , vol.65 , Issue.SUPPL. 3
    • Strickland, I.1    Ghosh, S.2
  • 77
    • 74949096197 scopus 로고    scopus 로고
    • A phase I trial of bortezomib with temozolomide in patients with advanced melanoma: Toxicities, antitumor effects, and modulation of therapeutic targets
    • Su Y, Amiri KI, Horton LW, Yu Y, Ayers GD, Koehler E, Kelley MC, Puzanov I, Richmond A, Sosman JA (2010) A phase I trial of bortezomib with temozolomide in patients with advanced melanoma: toxicities, antitumor effects, and modulation of therapeutic targets. Clin Cancer Res 16:348-357
    • (2010) Clin Cancer Res , vol.16 , pp. 348-357
    • Su, Y.1    Amiri, K.I.2    Horton, L.W.3    Yu, Y.4    Ayers, G.D.5    Koehler, E.6    Kelley, M.C.7    Puzanov, I.8    Richmond, A.9    Sosman, J.A.10
  • 81
    • 16444372422 scopus 로고    scopus 로고
    • Targeting β-transducin repeat-containing protein E3 ubiquitin ligase augments the effects of antitumor drugs on breast cancer cells
    • DOI 10.1158/0008-5472.CAN-04-2597
    • Tang W, Li Y, Yu D, Thomas-Tikhonenko A, Spiegelman VS, Fuchs SY (2005) Targeting β-transducin repeat-containing protein E3 ubiquitin ligase augments the effects of antitumor drugs on breast cancer cells. Cancer Res 65:1904-1908 (Pubitemid 40478619)
    • (2005) Cancer Research , vol.65 , Issue.5 , pp. 1904-1908
    • Tang, W.1    Li, Y.2    Yu, D.3    Thomas-Tikhonenko, A.4    Spiegelman, V.S.5    Fuchs, S.Y.6
  • 82
    • 70349967965 scopus 로고    scopus 로고
    • Anti-TNF biologic agents still the therapy of choice for rheumatoid arthritis
    • Taylor PC, Feldmann (2009) Anti-TNF biologic agents still the therapy of choice for rheumatoid arthritis. Nat Rev Rheumatol 5:578-582
    • (2009) Nat Rev Rheumatol , vol.5 , pp. 578-582
    • Taylor, P.C.1    Feldmann2
  • 83
    • 64549141966 scopus 로고    scopus 로고
    • RNAi-mediated c-Rel silencing leads to apoptosis of B cell tumor cells and suppresses antigenic immune response in vivo
    • Tian W, Liou H-C (2009) RNAi-mediated c-Rel silencing leads to apoptosis of B cell tumor cells and suppresses antigenic immune response in vivo. PLoS ONE 4:e5028
    • (2009) PLoS ONE , vol.4
    • Tian, W.1    Liou, H.-C.2
  • 84
    • 0032400997 scopus 로고    scopus 로고
    • 1
    • Torgerson TR, Colosia AD, Donahue JP, Lin Y-Z, Hawiger J (1998) Regulation of NF-κB, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization sequence of NF-κB p50. J Immunol 161:6084-6092 (Pubitemid 28535979)
    • (1998) Journal of Immunology , vol.161 , Issue.11 , pp. 6084-6092
    • Torgerson, T.R.1    Colosia, A.D.2    Donahue, J.P.3    Lin, Y.-Z.4    Hawiger, J.5
  • 85
    • 44449155518 scopus 로고    scopus 로고
    • The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection
    • Tran TA, McCoy MK, Sporn MB, Tansey MG (2008) The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection. J Neuroinflammation 5:14
    • (2008) J Neuroinflammation , vol.5 , pp. 14
    • Tran, T.A.1    McCoy, M.K.2    Sporn, M.B.3    Tansey, M.G.4
  • 86
    • 0031655752 scopus 로고    scopus 로고
    • The therapeutic utility of interleukin-II in the treatment of inflammatory disease
    • DOI 10.1517/13543784.7.9.1501
    • Trepicchio WL, Dorner AJ (1998) The therapeutic utility of Interleukin-11 in the treatment of inflammatory disease. Expert Opin Investig Drugs 7:1501-1504 (Pubitemid 28408811)
    • (1998) Expert Opinion on Investigational Drugs , vol.7 , Issue.9 , pp. 1501-1504
    • Trepicchio, W.L.1    Dorner, A.J.2
  • 88
    • 0037206564 scopus 로고    scopus 로고
    • Molecular design and biological activities of NF-κB inhibitors
    • Umezawa K, Chaicharoenpong C (2002) Molecular design and biological activities of NF-κB inhibitors. Mol Cells 14:163-167 (Pubitemid 41594968)
    • (2002) Molecules and Cells , vol.14 , Issue.2 , pp. 163-167
    • Umezawa, K.1    Chaicharoenpong, C.2
  • 89
    • 0028907128 scopus 로고
    • FK506 inhibits antigen receptor-mediated induction of c-rel in B and T lymphoid cells
    • Venkataraman L, Burakoff SJ, Sen R (1995) FK506 inhibits antigen receptor-mediated induction of c-rel in B and T lymphoid cells. J Exp Med 181:1091-1099
    • (1995) J Exp Med , vol.181 , pp. 1091-1099
    • Venkataraman, L.1    Burakoff, S.J.2    Sen, R.3
  • 91
    • 0142126182 scopus 로고    scopus 로고
    • Towards molecular diagnosis and targeted therapy of lymphoid malignancies
    • DOI 10.1016/S0037-1963(03)00194-X
    • Wiestner A, Staudt LM (2003) Towards molecular diagnosis and targeted therapy of lymphoid malignancies. Semin Hematol 40:296-307 (Pubitemid 37296779)
    • (2003) Seminars in Hematology , vol.40 , Issue.4 , pp. 296-307
    • Wiestner, A.1    Staudt, L.M.2
  • 94
    • 2442549643 scopus 로고    scopus 로고
    • Induction of cell cycle arrest and apoptosis by the proteasome inhibitor PS-341 in hodgkin disease cell lines is independent of inhibitor of nuclear factor-κB mutations or activation of the CD30, CD40, and RANK receptors
    • DOI 10.1158/1078-0432.CCR-03-0494
    • Zheng B, Georgakis GV, Li Y, Bharti A, McConkey D, Aggarwal BB, Younes A (2004) Induction of cell cycle arrest and apoptosis by the proteasome inhibitor PS-341 in Hodgkin disease cell lines is independent of inhibitor of nuclear factor-κB mutations or activation of the CD30, CD40, and RANK receptors. Clin Cancer Res 10:3207-3215 (Pubitemid 38619702)
    • (2004) Clinical Cancer Research , vol.10 , Issue.9 , pp. 3207-3215
    • Zheng, B.1    Georgakis, G.V.2    Li, Y.3    Bharti, A.4    McConkey, D.5    Aggarwal, B.B.6    Younes, A.7


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