Therapeutic effect of the potent IL-12/IL-23 inhibitor STA-5326 on experimental autoimmune uveoretinitis

Arthritis Research and Therapy

Volumn 10, Issue 5, 2008, Pages

  Keino, Hiroshi ^a   Watanabe, Takayo ^a   Sato, Yasuhiko ^a   Niikura, Mamoru ^a   Wada, Yumiko ^b   Okada, Annabelle A ^a  

^a KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Synta Pharmaceuticals Corp   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 17; INTERLEUKIN 23; INTERPHOTORECEPTOR RETINOID BINDING PROTEIN; STA 5326; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG; EYE PROTEIN; INTERSTITIAL RETINOL-BINDING PROTEIN; MORPHOLINE DERIVATIVE; RETINOL BINDING PROTEIN;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; DRUG DOSE COMPARISON; DRUG EFFICACY; ENUCLEATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EYE EXAMINATION; EYE FUNDUS; FEMALE; FLOW CYTOMETRY; HISTOPATHOLOGY; IMMUNIZATION; IN VITRO STUDY; LYMPH NODE CELL; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; SUPERNATANT; UVEORETINITIS; ANIMAL; BIOSYNTHESIS; BLOOD; C57BL MOUSE; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; IMMUNOLOGY; METABOLISM; PATHOLOGY; UVEITIS;

ANIMALS; AUTOIMMUNE DISEASES; CD4-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EYE PROTEINS; FEMALE; FLOW CYTOMETRY; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-12 SUBUNIT P40; INTERLEUKIN-17; INTERLEUKIN-23; MICE; MICE, INBRED C57BL; MORPHOLINES; RETINOL-BINDING PROTEINS; TRIAZINES; UVEITIS;

EID: 54949116587     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar2530     Document Type: Article

References (34)

1. Oppmann B Lesley R Blom B Timans JC Xu Y Hunte B Vega F Yu N Wang J Singh K Zonin F Vaisberg E Churakova T Liu M Gorman D Wagner J Zurawski S Liu Y Abrams JS Moore KW Rennick D de Waal-Malefyt R Hannum C Bazan JF Kastelein RA Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 Immunity 2000, 13:715-725. 10.1016/S1074-7613(00)00070-4 11114383
2. Parham C Chirica M Timans J Vaisberg E Travis M Cheung J Pflanz S Zhang R Singh KP Vega F To W Wagner J O'Farrell AM McClanahan T Zurawski S Hannum C Gorman D Rennick DM Kastelein RA de Waal Malefyt R Moore KW A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R J Immunol 2002, 168:5699-5708. 12023369
3. Aggarwal S Ghilardi N Xie MH de Sauvage FJ Gurney AL Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17 J Biol Chem 2003, 278:1910-1914. 10.1074/ jbc.M207577200 12417590
4. Langrish CL Chen Y Blumenschein WM Mattson J Basham B Sedgwick JD McClanahan T Kastelein RA Cua DJ IL-23 drives a pathogenic T cell population that induces autoimmune inflammation J Exp Med 2005, 201:233-240. 2212798 15657292 10.1084/jem.20041257
5. Leonard JP Waldburger KE Goldman SJ Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12 J Exp Med 1995, 181:381-386. 2191822 7528773 10.1084/jem.181.1.381
6. Malfait AM Butler DM Presky DH Maini RN Brennan FM Feldmann M Blockade of IL-12 during the induction of collagen-induced arthritis (CIA) markedly attenuates the severity of the arthritis Clin Exp Immunol 1998, 111:377-383. 1904910 9486407 10.1046/j.1365-2249.1998.00485.x
7. Cua DJ Sherlock J Chen Y Murphy CA Joyce B Seymour B Lucian L To W Kwan S Churakova T Zurawski S Wiekowski M Lira SA Gorman D Kastelein RA Sedgwick JD Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain Nature 2003, 421:744-748. 10.1038/nature01355 12610626
8. Murphy CA Langrish CL Chen Y Blumenschein W McClanahan T Kastelein RA Sedgwick JD Cua DJ Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation J Exp Med 2003, 198:1951-1957. 2194162 14662908 10.1084/jem.20030896
9. Yen D Cheung J Scheerens H Poulet F McClanahan T McKenzie B Kleinschek MA Owyang A Mattson J Blumenschein W Murphy E Sathe M Cua DJ Kastelein RA Rennick D IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6 J Clin Invest 2006, 116:1310-1316. 1451201 16670770 10.1172/JCI21404
10. Mannon PJ: Fuss IJ Mayer L Elson CO Sandborn WJ Present D Dolin B Goodman N Groden C Hornung RL Quezado M Yang Z Neurath MF Salfeld J Veldman GM Schwertschlag U Strober W Anti-interleukin-12 antibody for active Crohn's disease N Engl J Med 2004, 351:2069-2079. 10.1056/ NEJMoa033402 15537905
11. Toichi E Torres G McCormick TS Chang T Mascelli MA Kauffman CL Aria N Gottlieb AB Everitt DE Frederick B Pendley CE Cooper KD An anti-IL-12p40 antibody down-regulates type 1 cytokines, chemokines, and IL-12/IL-23 in psoriasis J Immunol 2006, 177:4917-4926. 16982934
12. Krueger GG Langley RG Leonardi C Yeilding N Guzzo C Wang Y Dooley LT Lebwohl M A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis N Engl J Med 2007, 356:580-592. 10.1056/ NEJMoa062382 17287478
13. Wacker WB Lipton MM Experimental allergic uveitis: Homologous retina as uveitogenic antigen Nature 1965, 206:253-254. 10.1038/206253a0 5836315
14. Caspi RR Roberge FG Chan CC Wiggert B Chader GJ Rozenszajn LA Lando Z Nussenblatt RB A new model of autoimmune disease. Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens J Immunol 1988, 140:1490-1495. 3346541
15. Chan CC Caspi RR Ni M Leake WC Wiggert B Chader GJ Nussenblatt RB Pathology of experimental autoimmune uveoretinitis in mice J Autoimmun 1990, 3:247-255. 10.1016/0896-8411(90)90144-H 2397018
16. Caspi RR Roberge FG McAllister CG el-Saied M Kuwabara T Gery I Hanna E Nussenblatt RB T cell lines mediating experimental autoimmune uveoretinitis (EAU) in the rat J Immunol 1986, 136:928-933. 2416842
17. Gregerson DS Obritsch WF Fling SP Cameron JD S-antigen-specific rat T cell lines recognize peptide fragments of S-antigen and mediate experimental autoimmune uveoretinitis and pinealitis J Immunol 1986, 136:2875-2882. 2420873
18. Mochizuki M Kuwabara T McAllister C Nussenblatt RB Gery I Adoptive transfer of experimental autoimmune uveoretinitis in rats. Immunopathogenic mechanisms and histologic features Invest Ophthalmol Vis Sci 1985, 26:1-9. 3967952
19. Caspi RR Th1 and Th2 responses in pathogenesis and regulation of experimental autoimmune uveoretinitis Int Rev Immunol 2002, 21:197-208. 10.1080/08830180212063 12424843
20. Tang J Zhu W Silver PB Su SB Chan CC Caspi RR Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signature and is driven by unique effector mechanisms: Initial encounter with autoantigen defines disease phenotype J Immunol 2007, 178:5578-5587. 17442940
21. Amadi-Obi A Yu CR Liu X Mahdi RM Clarke GL Nussenblatt RB Gery I Lee YS Egwuagu CE TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1 Nat Med 2007, 13:711-718. 10.1038/nm1585 17496900
22. Peng Y Han G Shao H Wang Y Kaplan HJ Sun D Characterization of IL-17+ interphotoreceptor retinoid-binding protein-specific T cells in experimental autoimmune uveitis Invest Ophthalmol Vis Sci 2007, 48:4153-4161. 2567912 17724201 10.1167/iovs.06-1189
23. Yoshimura T Sonoda KH Miyazaki Y Iwakura Y Ishibashi T Yoshimura A Yoshida H Differential roles for IFN-gamma and IL-17 in experimental autoimmune uveoretinitis Int Immunol 2008, 20:209-214. 10.1093/intimm/ dxm135 18156624
24. Luger D Silver PB Tang J Cua D Chen Z Iwakura Y Bowman EP Sgambellone NM Chan CC Caspi RR Either a Th17 or a Th1 effector response can drive autoimmunity: Conditions of disease induction affect dominant effector category J Exp Med 2008, 205:799-810. 2292220 18391061 10.1084/ jem.20071258
25. Tarrant TK Silver PB Chan CC Wiggert B Caspi RR Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis J Immunol 1998, 161:122-127. 9647215
26. Yokoi H Kato K Kezuka T Sakai J Usui M Yagita H Okumura K Prevention of experimental autoimmune uveoretinitis by monoclonal antibody to interleukin-12 Eur J Immunol 1997, 27:641-646. 10.1002/eji.1830270310 9079803
27. Sanjabi S Hoffmann A Liou HC Baltimore D Smale ST Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages Proc Natl Acad Sci USA 2000, 97:12705-12710. 18828 11058167 10.1073/pnas.230436397
28. Carmody RJ Ruan Q Liou HC Chen YH Essential roles of c-Rel in TLR-induced IL-23 p19 gene expression in dendritic cells J Immunol 2007, 178:186-191. 17182554
29. Wada Y Lu R Zhou D Chu J Przewloka T Zhang S Li L Wu Y Qin J Balasubramanyam V Barsoum J Ono M Selective abrogation of Th1 response by STA- a potent IL-12/IL-23 inhibitor Blood 2007, 109:1156-1164. 17053051 10.1182/blood-2006-04-019398
30. Avichezer D Chan CC Silver PB Wiggert B Caspi RR Residues 1-20 of IRBP and whole IRBP elicit different uveitogenic and immunological responses in interferon gamma deficient mice Exp Eye Res 2000, 71:111-118. 10.1006/ exer.2000.0860 10930316
31. Thurau SR Chan CC Nussenblatt RB Caspi RR Oral tolerance in a murine model of relapsing experimental autoimmune uveoretinitis (EAU): induction of protective tolerance in primed animals Clin Exp Immunol 1997, 109:370-376. 1904752 9276535 10.1046/j.1365-2249.1997.4571356.x
32. Happel KI Zheng M Young E Quinton LJ Lockhart E Ramsay AJ Shellito JE Schurr JR Bagby GJ Nelson S Kolls JK Cutting edge: Roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection J Immunol 2003, 170:4432-4436. 12707317
33. Happel KI Dubin PJ Zheng M Ghilardi N Lockhart C Quinton LJ Odden AR Shellito JE Bagby GJ Nelson S Kolls JK Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae J Exp Med 2005, 202:761-769. 2212952 16157683 10.1084/jem.20050193
34. Wada Y IL-12/IL-23 inhibitors: A promising approach to the treatment of inflammatory disorders Drugs of the Future 2008, 33:49-63.