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Volumn 117, Issue 2, 2012, Pages 166-177

Targeting the IGF-1R signaling and mechanisms for epigenetic gene silencing in human multiple myeloma

Author keywords

Epigenetics; IGF 1; Multiple myeloma

Indexed keywords

SOMATOMEDIN C RECEPTOR;

EID: 84859903474     PISSN: 03009734     EISSN: None     Source Type: Journal    
DOI: 10.3109/03009734.2012.659293     Document Type: Review
Times cited : (5)

References (95)
  • 2
    • 34547106018 scopus 로고    scopus 로고
    • Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
    • DOI 10.1038/nrc2189, PII NRC2189
    • Hideshima T, Mitsiades C, Tonon G, Richardson PG, Anderson KC. Understanding multiple myeloma pathogene-sis in the bone marrow to identify new therapeutic targets. Nat Rev Cancer. 2007;7:585-98. (Pubitemid 47106630)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.8 , pp. 585-598
    • Hideshima, T.1    Mitsiades, C.2    Tonon, G.3    Richardson, P.G.4    Anderson, K.C.5
  • 3
    • 27244445489 scopus 로고    scopus 로고
    • Molecular pathogenesis and a consequent classification of multiple myeloma
    • DOI 10.1200/JCO.2005.05.021
    • Bergsagel PL, Kuehl WM. Molecular pathogenesis and a consequent classification of multiple myeloma. J Clin Oncol. 2005;23:6333-8. (Pubitemid 46218843)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.26 , pp. 6333-6338
    • Bergsagel, P.L.1    Kuehl, W.M.2
  • 5
    • 0003018482 scopus 로고    scopus 로고
    • Multiple myeloma cell lines
    • Waters J, Palsson B, editors Dordrecht, The Netherlands: Kluwer Academic Publishers
    • Jernberg-Wiklund H, Nilsson K. Multiple myeloma cell lines. In: Waters J, Palsson B, editors. Cancer cell lines part 3: leukemias and lymphomas. Dordrecht, The Netherlands: Kluwer Academic Publishers; 2000. p 81-155.
    • (2000) Cancer Cell Lines Part 3: Leukemias and Lymphomas , pp. 81-155
    • Jernberg-Wiklund, H.1    Nilsson, K.2
  • 8
    • 77951628921 scopus 로고    scopus 로고
    • SUMOylation mediates the nuclear translocation and signaling of the IGF-1 receptor
    • Sehat B, Tofigh A, Lin Y, Trocme E, Liljedahl U, Lagergren J, et al. SUMOylation mediates the nuclear translocation and signaling of the IGF-1 receptor. Sci Signal. 2010;3:ra10.
    • (2010) Sci Signal. , vol.3
    • Sehat, B.1    Tofigh, A.2    Lin, Y.3    Trocme, E.4    Liljedahl, U.5    Lagergren, J.6
  • 9
    • 77950556094 scopus 로고    scopus 로고
    • IGF-1 suppresses Bim expression in multiple myeloma via epigenetic and posttranslational mechanisms
    • De Bruyne E, Bos TJ, Schuit F, Van Valckenborgh E, Menu E, Thorrez L, et al. IGF-1 suppresses Bim expression in multiple myeloma via epigenetic and posttranslational mechanisms. Blood. 2010;115:2430-40.
    • (2010) Blood. , vol.115 , pp. 2430-2440
    • De Bruyne, E.1    Bos, T.J.2    Schuit, F.3    Van Valckenborgh, E.4    Menu, E.5    Thorrez, L.6
  • 11
    • 36749027626 scopus 로고    scopus 로고
    • Genetic events in the pathogenesis of multiple myeloma
    • DOI 10.1016/j.beha.2007.08.004, PII S1521692607000643, New Insights into the Biology and Advances in the Management of Multiple Myeloma
    • Chng WJ, Glebov O, Bergsagel PL, Kuehl WM. Genetic events in the pathogenesis of multiple myeloma. Best Pract Res Clin Haematol. 2007;20:571-96. (Pubitemid 350215376)
    • (2007) Best Practice and Research in Clinical Haematology , vol.20 , Issue.4 , pp. 571-596
    • Chng, W.J.1    Glebov, O.2    Bergsagel, P.L.3    Kuehl, W.M.4
  • 13
    • 33747480248 scopus 로고    scopus 로고
    • Monoclonal gammopathy of undetermined significance
    • DOI 10.1111/j.1365-2141.2006.06235.x
    • Kyle RA, Rajkumar SV. Monoclonal gammopathy of undetermined significance. Br J Haematol. 2006;134:573-89. (Pubitemid 44255500)
    • (2006) British Journal of Haematology , vol.134 , Issue.6 , pp. 573-589
    • Kyle, R.A.1    Vincent Rajkumar, S.2
  • 15
    • 77957733923 scopus 로고    scopus 로고
    • Gene expression profiling for molecular classification of multiple myeloma in newly diagnosed patients
    • Broyl A, Hose D, Lokhorst H, de Knegt Y, Peeters J, Jauch A, et al. Gene expression profiling for molecular classification of multiple myeloma in newly diagnosed patients. Blood. 2010;116:2543-53.
    • (2010) Blood. , vol.116 , pp. 2543-2553
    • Broyl, A.1    Hose, D.2    Lokhorst, H.3    De Knegt, Y.4    Peeters, J.5    Jauch, A.6
  • 16
    • 3242777803 scopus 로고    scopus 로고
    • Advances in biology of multiple myeloma: Clinical applications
    • DOI 10.1182/blood-2004-01-0037
    • Hideshima T, Bergsagel PL, Kuehl WM, Anderson KC. Advances in biology of multiple myeloma: clinical applications. Blood. 2004;104:607-18. (Pubitemid 38970551)
    • (2004) Blood , vol.104 , Issue.3 , pp. 607-618
    • Hideshima, T.1    Bergsagel, P.L.2    Kuehl, W.M.3    Anderson, K.C.4
  • 17
    • 79951504474 scopus 로고    scopus 로고
    • Translocation t(14;16) and multiple myeloma: Is it really an independent prognostic factor?
    • Avet-Loiseau H, Malard F, Campion L, Magrangeas F, Sebban C, Lioure B, et al. Translocation t(14;16) and multiple myeloma: is it really an independent prognostic factor? Blood. 2011;117:2009-11.
    • (2011) Blood. , vol.117 , pp. 2009-2011
    • Avet-Loiseau, H.1    Malard, F.2    Campion, L.3    Magrangeas, F.4    Sebban, C.5    Lioure, B.6
  • 20
    • 85009921564 scopus 로고    scopus 로고
    • Frequent inactivation of the cyclin-dependent kinase inhibitor p18 by homozygous deletion in multiple myeloma cell lines: Ectopic p18 expression inhibits growth and induces apoptosis
    • DOI 10.1038/sj/leu/2402328
    • Kulkarni MS, Daggett JL, Bender TP, Kuehl WM, Bergsagel PL, Williams ME. Frequent inactivation of the cyclin-dependent kinase inhibitor p18 by homozygous deletion in multiple myeloma cell lines: ectopic p18 expression inhibits growth and induces apoptosis. Leukemia. 2002;16: 127-34. (Pubitemid 34105608)
    • (2002) Leukemia , vol.16 , Issue.1 , pp. 127-134
    • Kulkarni, M.S.1    Daggett, J.L.2    Bender, T.P.3    Kuehl, W.M.4    Bergsagel, P.L.5    Williams, M.E.6
  • 21
    • 0034667606 scopus 로고    scopus 로고
    • Insulin-like growth factor i is a dual effector of multiple myeloma cell growth
    • Ge NL, Rudikoff S. Insulin-like growth factor I is a dual effector of multiple myeloma cell growth. Blood. 2000;96: 2856-61.
    • (2000) Blood. , vol.96 , pp. 2856-2861
    • Ge, N.L.1    Rudikoff, S.2
  • 24
    • 79958095463 scopus 로고    scopus 로고
    • Clinical and biological implications of MYC activation: A common difference between MGUS and newly diagnosed multiple myeloma
    • Chng WJ, Huang GF, Chung TH, Ng SB, Gonzalez-Paz N, Troska-Price T, et al. Clinical and biological implications of MYC activation: a common difference between MGUS and newly diagnosed multiple myeloma. Leukemia. 2011;25: 1026-35.
    • (2011) Leukemia. , vol.25 , pp. 1026-1035
    • Chng, W.J.1    Huang, G.F.2    Chung, T.H.3    Ng, S.B.4    Gonzalez-Paz, N.5    Troska-Price, T.6
  • 26
    • 0026582025 scopus 로고
    • Perspectives on the origins of multiple myeloma and plasmacytomas in mice
    • Potter M. Perspectives on the origins of multiple myeloma and plasmacytomas in mice. Hematol Oncol Clin North Am. 1992;6:211-23.
    • (1992) Hematol Oncol Clin North Am. , vol.6 , pp. 211-223
    • Potter, M.1
  • 27
    • 54249092519 scopus 로고    scopus 로고
    • Prediction of survival in multiple myeloma based on gene expression profiles reveals cell cycle and chromosomal instability signatures in high-risk patients and hyperdiploid signatures in low-risk patients: A study of the Intergroupe Francophone du Myelome
    • Decaux O, Lode L, Magrangeas F, Charbonnel C, Gouraud W, Jezequel P, et al. Prediction of survival in multiple myeloma based on gene expression profiles reveals cell cycle and chromosomal instability signatures in high-risk patients and hyperdiploid signatures in low-risk patients: a study of the Intergroupe Francophone du Myelome. J Clin Oncol. 2008;26:4798-805.
    • (2008) J Clin Oncol. , vol.26 , pp. 4798-4805
    • Decaux, O.1    Lode, L.2    Magrangeas, F.3    Charbonnel, C.4    Gouraud, W.5    Jezequel, P.6
  • 32
    • 0025818653 scopus 로고
    • Heterogeneity in response to interleukin 6 (IL-6), expression of IL-6 and IL-6 receptor mRNA ina panel ofestablished human multiple myeloma cell lines
    • Jernberg H, Pettersson M, Kishimoto T, Nilsson K. Heterogeneity in response to interleukin 6 (IL-6), expression of IL-6 and IL-6 receptor mRNA ina panel ofestablished human multiple myeloma cell lines. Leukemia. 1991;5:255-65.
    • (1991) Leukemia. , vol.5 , pp. 255-265
    • Jernberg, H.1    Pettersson, M.2    Kishimoto, T.3    Nilsson, K.4
  • 33
    • 0030742741 scopus 로고    scopus 로고
    • The effects on growth and survival of IL-6 can be dissociated in the U- 266-1970/U-266-1984 and HL407E/HL407L human multiple myeloma cell lines
    • Spets H, Jernberg-Wiklund H, Sambade C, Soderberg O, Nilsson K. The effects on growth and survival of IL-6 can be dissociated in the U-266-1970/U-266-1984 and HL407E/HL407L human multiple myeloma cell lines. Br J Haematol. 1997;98:126-33. (Pubitemid 27348806)
    • (1997) British Journal of Haematology , vol.98 , Issue.1 , pp. 126-133
    • Spets, H.1    Jernberg-Wiklund, H.2    Sambade, C.3    Soderberg, O.4    Nilsson, K.5
  • 34
    • 9544221630 scopus 로고    scopus 로고
    • Insulin-like growth factor I is a growth and survival factor in human multiple myeloma cell lines
    • Georgii-Hemming P, Wiklund HJ, Ljunggren O, Nilsson K. Insulin-like growth factor I is a growth and survival factor in human multiple myeloma cell lines. Blood. 1996;88:2250-8. (Pubitemid 26307929)
    • (1996) Blood , vol.88 , Issue.6 , pp. 2250-2258
    • Georgii-Hemming, P.1    Jernberg Wiklund, H.2    Ljunggren, O.3    Nilsson, K.4
  • 35
    • 0025243571 scopus 로고
    • IL-6 as a growth factor for human multiple myeloma cells\-A short overview
    • Nilsson K, Jernberg H, Pettersson M. IL-6 as a growth factor for human multiple myeloma cells\-a short overview. Curr Top Microbiol Immunol. 1990;166:3-12.
    • (1990) Curr Top Microbiol Immunol , vol.166 , pp. 3-12
    • Nilsson, K.1    Jernberg, H.2    Pettersson, M.3
  • 36
    • 0023849455 scopus 로고
    • Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas
    • Kawano M, Hirano T, Matsuda T, Taga T, Horii Y, Iwato K, et al. Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature. 1988; 332:83-5.
    • (1988) Nature. , vol.332 , pp. 83-85
    • Kawano, M.1    Hirano, T.2    Matsuda, T.3    Taga, T.4    Horii, Y.5    Iwato, K.6
  • 37
    • 0031181228 scopus 로고    scopus 로고
    • A role for insulin-like growth factor in the regulation of IL-6-responsive human myeloma cell line growth
    • Jelinek DF, Witzig TE, Arendt BK. A role for insulin-like growth factor in the regulation of IL-6- responsive human myeloma cell line growth. J Immunol. 1997;159:487-96. (Pubitemid 127493736)
    • (1997) Journal of Immunology , vol.159 , Issue.1 , pp. 487-496
    • Jelinek, D.F.1    Witzig, T.E.2    Arendt, B.K.3
  • 38
    • 34047227257 scopus 로고    scopus 로고
    • Control of Apoptosis in Human Multiple Myeloma by Insulin-like Growth Factor I (IGF-I)
    • DOI 10.1016/S0065-230X(06)97006-7, PII S0065230X06970067
    • Jernberg-Wiklund H, Nilsson K. Control of apoptosis in human multiple myeloma by insulin-like growth factor I (IGF-I). Adv Cancer Res. 2007;97:139-65. (Pubitemid 46541692)
    • (2007) Advances in Cancer Research , vol.97 , pp. 139-165
    • Jernberg-Wiklund, H.1    Nilsson, K.2
  • 39
    • 28544437352 scopus 로고    scopus 로고
    • Growth factors and antiapoptotic signaling pathways in multiple myeloma
    • DOI 10.1038/sj.leu.2403970, PII 2403970
    • van de Donk NW, Lokhorst HM, Bloem AC. Growth factors and antiapoptotic signaling pathways in multiple myeloma. Leukemia. 2005;19:2177-85. (Pubitemid 41741612)
    • (2005) Leukemia , vol.19 , Issue.12 , pp. 2177-2185
    • Van De Donk, N.W.1    Lokhorst, H.M.2    Bloem, A.C.3
  • 41
    • 0034655957 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and interleukin-6 in paracrine tumor- stromal cell interactions in multiple myeloma
    • Dankbar B, Padro T, Leo R, Feldmann B, Kropff M, Mesters RM, et al. Vascular endothelial growth factor and interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma. Blood. 2000;95:2630-6. (Pubitemid 30210543)
    • (2000) Blood , vol.95 , Issue.8 , pp. 2630-2636
    • Dankbar, B.1    Padro, T.2    Leo, R.3    Feldmann, B.4    Kropff, M.5    Mesters, R.M.6    Serve, H.7    Berdel, W.E.8    Kienast, J.9
  • 42
    • 0032939906 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 acts as a chemoattractant factor for 5T2 multiple myeloma cells
    • Vanderkerken K, Asosingh K, Braet F, Van Riet I, Van Camp B. Insulin-like growth factor-1 acts as a chemoat-tractant factor for 5T2 multiple myeloma cells. Blood. 1999; 93:235-41. (Pubitemid 29019408)
    • (1999) Blood , vol.93 , Issue.1 , pp. 235-241
    • Vanderkerken, K.1    Asosingh, K.2    Braet, F.3    Van Riet, I.4    Van Camp, B.5
  • 43
    • 0038398622 scopus 로고    scopus 로고
    • The insulin-like growth factor system and cancer
    • DOI 10.1016/S0304-3835(03)00159-9
    • LeRoith D, Roberts CT Jr. The insulin-like growth factor system and cancer. Cancer Lett. 2003;195:127-37. (Pubitemid 36588961)
    • (2003) Cancer Letters , vol.195 , Issue.2 , pp. 127-137
    • LeRoith, D.1    Roberts Jr., C.T.2
  • 44
    • 0032800850 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: Evidence for a second mechanism of IGF-I signaling
    • Pandini G, Vigneri R, Costantino A, Frasca F, Ippolito A, Fujita-Yamaguchi Y, et al. Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling. Clin Cancer Res. 1999;5:1935-44. (Pubitemid 29334478)
    • (1999) Clinical Cancer Research , vol.5 , Issue.7 , pp. 1935-1944
    • Pandini, G.1    Vigneri, R.2    Costantino, A.3    Frasca, F.4    Ippolito, A.5    Fujita-Yamaguchi, Y.6    Siddle, K.7    Goldfine, I.D.8    Belfiore, A.9
  • 45
    • 0037131385 scopus 로고    scopus 로고
    • Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved
    • DOI 10.1074/jbc.M202766200
    • Pandini G, Frasca F, Mineo R, Sciacca L, Vigneri R, Belfiore A. Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved. J Biol Chem. 2002;277: 39684-95. (Pubitemid 35190951)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.42 , pp. 39684-39695
    • Pandini, G.1    Frasca, F.2    Mineo, R.3    Sciacca, L.4    Vigneri, R.5    Belfiore, A.6
  • 47
    • 0036892647 scopus 로고    scopus 로고
    • Serum insulinlike growth factor is not elevated in patients with multiple myeloma but is still a prognostic factor
    • DOI 10.1182/blood-2002-05-1406
    • Standal T, Borset M, Lenhoff S, Wisloff F, Stordal B, Sundan A, et al. Serum insulinlike growth factor is not elevated in patients with multiple myeloma but is still a prognostic factor. Blood. 2002;100:3925-9. (Pubitemid 35396856)
    • (2002) Blood , vol.100 , Issue.12 , pp. 3925-3929
    • Standal, T.1    Borset, M.2    Lenhoff, S.3    Wisloff, F.4    Stordal, B.5    Sundan, A.6    Waage, A.7    Seidel, C.8
  • 50
    • 0036559535 scopus 로고    scopus 로고
    • Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis
    • DOI 10.1016/S1535-6108(02)00055-7
    • Lopez T, Hanahan D. Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis. Cancer Cell. 2002;1:339-53. (Pubitemid 41039136)
    • (2002) Cancer Cell , vol.1 , Issue.4 , pp. 339-353
    • Lopez, T.1    Hanahan, D.2
  • 51
    • 21244493635 scopus 로고    scopus 로고
    • Treatment of hematologic malignancies and solid tumors by inhibiting IGF receptor signaling
    • DOI 10.1586/14737140.5.3.487
    • Mitsiades CS, Mitsiades N. Treatment of hematologic malignancies and solid tumors by inhibiting IGF receptor signaling. Expert Rev Anticancer Ther. 2005;5:487-99. (Pubitemid 40894980)
    • (2005) Expert Review of Anticancer Therapy , vol.5 , Issue.3 , pp. 487-499
    • Mitsiades, C.S.1    Mitsiades, N.2
  • 52
    • 0032931282 scopus 로고    scopus 로고
    • The control of proliferation, survival and apo-ptosis in human multiple myeloma cells in vitro
    • discussion 33
    • Nilsson K, Georgii-Hemming P, Spets H, Jernberg-Wiklund H. The control of proliferation, survival and apo-ptosis in human multiple myeloma cells in vitro. Curr Top Microbiol Immunol. 1999;246:325-32; discussion 33.
    • (1999) Curr Top Microbiol Immunol. , vol.246 , pp. 325-332
    • Nilsson, K.1    Georgii-Hemming, P.2    Spets, H.3    Jernberg-Wiklund, H.4
  • 53
    • 0344492724 scopus 로고    scopus 로고
    • The somatostatin analog octreotide inhibits growth of interleukin-6 (IL- 6)-dependent and IL-6-independent human multiple myeloma cell lines
    • Georgii-Hemming P, Stromberg T, Janson ET, Stridsberg M, Wiklund HJ, Nilsson K. The somatostatin analog octreotide inhibits growth of interleukin-6 (IL-6)-dependent and IL-6-independent human multiple myeloma cell lines. Blood. 1999; 93:1724-31. (Pubitemid 29102501)
    • (1999) Blood , vol.93 , Issue.5 , pp. 1724-1731
    • Georgii-Hemming, P.1    Stromberg, T.2    Janson, E.T.3    Stridsberg, M.4    Wiklund, H.J.5    Nilsson, K.6
  • 55
    • 77955736995 scopus 로고    scopus 로고
    • Type 1 insulin-like growth factor receptor translocates to the nucleus of human tumor cells
    • Aleksic T, Chitnis MM, Perestenko OV, Gao S, Thomas PH, Turner GD, et al. Type 1 insulin-like growth factor receptor translocates to the nucleus of human tumor cells. Cancer Res. 2010;70:6412-19.
    • (2010) Cancer Res. , vol.70 , pp. 6412-6419
    • Aleksic, T.1    Chitnis, M.M.2    Perestenko, O.V.3    Gao, S.4    Thomas, P.H.5    Turner, G.D.6
  • 56
    • 33645217263 scopus 로고    scopus 로고
    • EGFR signaling pathway in breast cancers: From traditional signal transduction to direct nuclear translocalization
    • Lo HW, Hsu SC, Hung MC. EGFR signaling pathway in breast cancers: from traditional signal transduction to direct nuclear translocalization. Breast Cancer Res Treat. 2006;95: 211-18.
    • (2006) Breast Cancer Res Treat. , vol.95 , pp. 211-218
    • Lo, H.W.1    Hsu, S.C.2    Hung, M.C.3
  • 57
    • 78651364746 scopus 로고    scopus 로고
    • Over-accumulation of nuclear IGF-1 receptor in tumor cells requires elevated expression of the receptor and the SUMO-conjugating enzyme Ubc9
    • Deng H, Lin Y, Badin M, Vasilcanu D, Stromberg T, Jernberg-Wiklund H, et al. Over-accumulation of nuclear IGF-1 receptor in tumor cells requires elevated expression of the receptor and the SUMO-conjugating enzyme Ubc9. Biochem Biophys Res Commun. 2011;404:667-71.
    • (2011) Biochem Biophys Res Commun. , vol.404 , pp. 667-671
    • Deng, H.1    Lin, Y.2    Badin, M.3    Vasilcanu, D.4    Stromberg, T.5    Jernberg-Wiklund, H.6
  • 60
    • 0041814539 scopus 로고    scopus 로고
    • Multiple myeloma biology: Lessons from the 5TMM models
    • DOI 10.1034/j.1600-065X.2003.00035.x
    • Vanderkerken K, Asosingh K, Croucher P, Van Camp B. Multiple myeloma biology: lessons from the 5TMM models. Immunol Rev. 2003;194:196-206. (Pubitemid 36896125)
    • (2003) Immunological Reviews , vol.194 , pp. 196-206
    • Vanderkerken, K.1    Asosingh, K.2    Croucher, P.3    Van Camp, B.4
  • 62
    • 34548018304 scopus 로고    scopus 로고
    • The insulin-like growth factor 1 receptor in cancer: Old focus, new future
    • DOI 10.1016/j.ejca.2007.05.021, PII S0959804907004340
    • Hartog H, Wesseling J, Boezen HM, van der Graaf WT. The insulin-like growth factor 1 receptor in cancer: old focus, new future. Eur J Cancer. 2007;43:1895-904. (Pubitemid 47284866)
    • (2007) European Journal of Cancer , vol.43 , Issue.13 , pp. 1895-1904
    • Hartog, H.1    Wesseling, J.2    Boezen, H.M.3    Van Der Graaf, W.T.4
  • 63
    • 79953647468 scopus 로고    scopus 로고
    • Small molecule inhibitors of the IGF-1R/IR axis for the treatment of cancer
    • Buck E, Mulvihill M. Small molecule inhibitors of the IGF-1R/IR axis for the treatment of cancer. Expert Opin Investig Drugs. 2011;20:605-21.
    • (2011) Expert Opin Investig Drugs. , vol.20 , pp. 605-621
    • Buck, E.1    Mulvihill, M.2
  • 66
    • 1642494838 scopus 로고    scopus 로고
    • Cyclolignans as Inhibitors of the Insulin-Like Growth Factor-1 Receptor and Malignant Cell Growth
    • DOI 10.1158/0008-5472.CAN-03-2522
    • Girnita A, Girnita L, del Prete F, Bartolazzi A, Larsson O, Axelson M. Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth. Cancer Res. 2004;64:236-42. (Pubitemid 38114104)
    • (2004) Cancer Research , vol.64 , Issue.1 , pp. 236-242
    • Girnita, A.1    Girnita, L.2    Del Prete, F.3    Bartolazzi, A.4    Larsson, O.5    Axelson, M.6
  • 67
    • 49249125421 scopus 로고    scopus 로고
    • Phase I, pharmacokinetic and pharmacodynamic study of the anti-insulinlike growth factor type 1 Receptor monoclonal antibody CP-751, 871 in patients with multiple myeloma
    • Lacy MQ, Alsina M, Fonseca R, Paccagnella ML, Melvin CL, Yin D, et al. Phase I, pharmacokinetic and pharmacodynamic study of the anti-insulinlike growth factor type 1 Receptor monoclonal antibody CP-751, 871 in patients with multiple myeloma. J Clin Oncol. 2008;26:3196-203.
    • (2008) J Clin Oncol. , vol.26 , pp. 3196-3203
    • Lacy, M.Q.1    Alsina, M.2    Fonseca, R.3    Paccagnella, M.L.4    Melvin, C.L.5    Yin, D.6
  • 68
    • 33845959800 scopus 로고    scopus 로고
    • Antibody targeting of the insulin-like growth factor I receptor enhances the anti-tumor response of multiple myeloma to chemotherapy through inhibition of tumor proliferation and angiogenesis
    • DOI 10.1007/s00262-006-0196-9
    • Wu KD, Zhou L, Burtrum D, Ludwig DL, Moore MA. Antibody targeting of the insulin-like growth factor I receptor enhances the anti-tumor response of multiple myeloma to chemotherapy through inhibition of tumor proliferation and angiogenesis. Cancer Immunol Immunother. 2007;56:343-57. (Pubitemid 46035904)
    • (2007) Cancer Immunology, Immunotherapy , vol.56 , Issue.3 , pp. 343-357
    • Wu, K.-D.1    Zhou, L.2    Burtrum, D.3    Ludwig, D.L.4    Moore, M.A.S.5
  • 69
    • 57149127369 scopus 로고    scopus 로고
    • IGF-1 receptor inhibitors in clinical trials\-early lessons
    • Weroha SJ, Haluska P. IGF-1 receptor inhibitors in clinical trials\-early lessons. J Mammary Gland Biol Neoplasia. 2008; 13:471-83.
    • (2008) J Mammary Gland Biol Neoplasia. , vol.13 , pp. 471-483
    • Weroha, S.J.1    Haluska, P.2
  • 70
    • 79952685382 scopus 로고    scopus 로고
    • Molecular characterization of acquired tolerance of tumor cells to picropodophyllin (PPP)
    • Hashemi J, Worrall C, Vasilcanu D, Fryknas M, Sulaiman L, Karimi M, et al. Molecular characterization of acquired tolerance of tumor cells to picropodophyllin (PPP). PLoS One. 2011;6:e14757.
    • (2011) PLoS One. , vol.6
    • Hashemi, J.1    Worrall, C.2    Vasilcanu, D.3    Fryknas, M.4    Sulaiman, L.5    Karimi, M.6
  • 71
    • 33745100153 scopus 로고    scopus 로고
    • The insulin-like growth factor-1 receptor inhibitor PPP produces only very limited resistance in tumor cells exposed to long-term selection
    • DOI 10.1038/sj.onc.1209339, PII 1209339
    • Vasilcanu D, Weng WH, Girnita A, Lui WO, Vasilcanu R, Axelson M, et al. The insulin-like growth factor-1 receptor inhibitor PPP produces only very limited resistance in tumor cells exposed to long-term selection. Oncogene. 2006;25: 3186-95. (Pubitemid 43881559)
    • (2006) Oncogene , vol.25 , Issue.22 , pp. 3186-3195
    • Vasilcanu, D.1    Weng, W.-H.2    Girnita, A.3    Lui, W.-O.4    Vasilcanu, R.5    Axelson, M.6    Larsson, O.7    Larsson, C.8    Girnita, L.9
  • 72
    • 77953973648 scopus 로고    scopus 로고
    • Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy
    • Ulanet DB, Ludwig DL, Kahn CR, Hanahan D. Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy. Proc Natl Acad Sci USA. 2010;107:10791-8.
    • (2010) Proc Natl Acad Sci USA. , vol.107 , pp. 10791-10798
    • Ulanet, D.B.1    Ludwig, D.L.2    Kahn, C.R.3    Hanahan, D.4
  • 73
    • 79952672340 scopus 로고    scopus 로고
    • Clinical phase i study with an insulin-like growth factor-1 receptor inhibitor: Experiences in patients with squamous non-small cell lung carcinoma
    • Ekman S, Frodin JE, Harmenberg J, Bergman A, Hedlund A, Dahg P, et al. Clinical phase I study with an insulin-like growth factor-1 receptor inhibitor: experiences in patients with squamous non-small cell lung carcinoma. Acta Oncol. 2011;5:441-7.
    • (2011) Acta Oncol. , vol.5 , pp. 441-447
    • Ekman, S.1    Frodin, J.E.2    Harmenberg, J.3    Bergman, A.4    Hedlund, A.5    Dahg, P.6
  • 75
    • 10244229652 scopus 로고    scopus 로고
    • In vivo antitumor effects of the mTOR inhibitor CCI-779 against human multiple myeloma cells in a xenograft model
    • DOI 10.1182/blood-2004-03-1153
    • Frost P, Moatamed F, Hoang B, Shi Y, Gera J, Yan H, et al. In vivo antitumor effects of the mTOR inhibitor CCI-779 against human multiple myeloma cells in a xenograft model. Blood. 2004;104:4181-7. (Pubitemid 39620172)
    • (2004) Blood , vol.104 , Issue.13 , pp. 4181-4187
    • Frost, P.1    Moatamed, F.2    Hoang, B.3    Shi, Y.4    Gera, J.5    Yan, H.6    Frost, P.7    Gibbons, J.8    Lichtenstein, A.9
  • 76
    • 33745220580 scopus 로고    scopus 로고
    • Synergy between an IGF-1R antibody and Raf/MEK/ERK and PI3K/Akt/mTOR pathway inhibitors in suppressing IGF-1R-mediated growth in hematopoietic cells
    • DOI 10.1038/sj.leu.2404217, PII 2404217
    • Bertrand FE, Steelman LS, Chappell WH, Abrams SL, Shelton JG, White ER, et al. Synergy between an IGF-1R antibody and Raf/MEK/ERK and PI3K/Akt/mTOR pathway inhibitors in suppressing IGF-1R-mediated growth in hemato-poietic cells. Leukemia. 2006;20:1254-60. (Pubitemid 43905829)
    • (2006) Leukemia , vol.20 , Issue.7 , pp. 1254-1260
    • Bertrand, F.E.1    Steelman, L.S.2    Chappell, W.H.3    Abrams, S.L.4    Shelton, J.G.5    White, E.R.6    Ludwig, D.L.7    McCubrey, J.A.8
  • 81
    • 33646870495 scopus 로고    scopus 로고
    • Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
    • Bracken AP, Dietrich N, Pasini D, Hansen KH, Helin K. Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev. 2006;20:1123-36.
    • (2006) Genes Dev. , vol.20 , pp. 1123-1136
    • Bracken, A.P.1    Dietrich, N.2    Pasini, D.3    Hansen, K.H.4    Helin, K.5
  • 82
    • 4644319204 scopus 로고    scopus 로고
    • Stem cells and cancer: The polycomb connection
    • DOI 10.1016/j.cell.2004.08.005, PII S0092867404007457
    • Valk-Lingbeek ME, Bruggeman SW, van Lohuizen M. Stem cells and cancer; the polycomb connection. Cell. 2004;118: 409-18. (Pubitemid 39485661)
    • (2004) Cell , vol.118 , Issue.4 , pp. 409-418
    • Valk-Lingbeek, M.E.1    Bruggeman, S.W.M.2    Van Lohuizen, M.3
  • 83
    • 42649112047 scopus 로고    scopus 로고
    • An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
    • DOI 10.1038/ng.127, PII NG127
    • Ben-Porath I, Thomson MW, Carey VJ, Ge R, Bell GW, Regev A, et al. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet. 2008;40:499-507. (Pubitemid 351601215)
    • (2008) Nature Genetics , vol.40 , Issue.5 , pp. 499-507
    • Ben-Porath, I.1    Thomson, M.W.2    Carey, V.J.3    Ge, R.4    Bell, G.W.5    Regev, A.6    Weinberg, R.A.7
  • 84
    • 78751662908 scopus 로고    scopus 로고
    • The Polycomb complex PRC2 and its mark in life
    • Margueron R, Reinberg D. The Polycomb complex PRC2 and its mark in life. Nature. 2011;469:343-9.
    • (2011) Nature. , vol.469 , pp. 343-349
    • Margueron, R.1    Reinberg, D.2
  • 85
    • 33750379420 scopus 로고    scopus 로고
    • Polycomb silencers control cell fate, development and cancer
    • DOI 10.1038/nrc1991, PII NRC1991
    • Sparmann A, van Lohuizen M. Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer. 2006;6:846-56. (Pubitemid 44629896)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.11 , pp. 846-856
    • Sparmann, A.1    Van Lohuizen, M.2
  • 86
    • 80053427396 scopus 로고    scopus 로고
    • Roles of the Polycomb group proteins in stem cells and cancer
    • Richly H, Aloia L, Di Croce L. Roles of the Polycomb group proteins in stem cells and cancer. Cell Death Dis. 2011;2:e204.
    • (2011) Cell Death Dis. , vol.2
    • Richly, H.1    Aloia, L.2    Di Croce, L.3
  • 87
    • 79953163994 scopus 로고    scopus 로고
    • Chromatin states in pluripotent, differentiated, and reprogrammed cells
    • Fisher CL, Fisher AG. Chromatin states in pluripotent, differentiated, and reprogrammed cells. Curr Opin Genet Dev. 2011;21:140-6.
    • (2011) Curr Opin Genet Dev. , vol.21 , pp. 140-146
    • Fisher, C.L.1    Fisher, A.G.2
  • 90
    • 77954376911 scopus 로고    scopus 로고
    • The Polycomb group protein Bmi-1 is essential for the growth of multiple myeloma cells
    • Jagani Z, Wiederschain D, Loo A, He D, Mosher R, Fordjour P, et al. The Polycomb group protein Bmi-1 is essential for the growth of multiple myeloma cells. Cancer Res. 2010;70:5528-38.
    • (2010) Cancer Res. , vol.70 , pp. 5528-5538
    • Jagani, Z.1    Wiederschain, D.2    Loo, A.3    He, D.4    Mosher, R.5    Fordjour, P.6
  • 91
    • 0021961434 scopus 로고
    • The in vitro effect of leucocyte α-interferon on human myeloma cells in a semisolid agar culture system
    • Brenning G. The in vitro effect of leucocyte alpha-interferon on human myeloma cells in a semisolid agar culture system. Scand J Haematol. 1985;35:178-85. (Pubitemid 15241007)
    • (1985) Scandinavian Journal of Haematology , vol.35 , Issue.2 , pp. 178-185
    • Brenning, G.1


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