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Volumn 70, Issue 13, 2010, Pages 5528-5538

The polycomb group protein Bmi-1 is essential for the growth of multiple myeloma cells

Author keywords

[No Author keywords available]

Indexed keywords

BMI1 PROTEIN; SHORT HAIRPIN RNA;

EID: 77954376911     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-4229     Document Type: Article
Times cited : (55)

References (51)
  • 1
    • 0025863346 scopus 로고
    • Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging
    • van Lohuizen M, Verbeek S, Scheijen B, Wientjens E, van der Gulden H, Berns A. Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging. Cell 1991;65:737-52. (Pubitemid 121001306)
    • (1991) Cell , vol.65 , Issue.5 , pp. 737-752
    • Van Lohuizen, M.1    Verbeek, S.2    Scheijen, B.3    Wientjens, E.4    Van Der Gulden, H.5    Berns, A.6
  • 2
    • 0025727771 scopus 로고
    • Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice
    • Haupt Y, Alexander WS, Barri G, Klinken SP, Adams JM. Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice. Cell 1991;65:753-63. (Pubitemid 121001307)
    • (1991) Cell , vol.65 , Issue.5 , pp. 753-763
    • Haupt, Y.1    Alexander, W.S.2    Barri, G.3    Klinken, S.P.4    Adams, J.M.5
  • 3
    • 0025773264 scopus 로고
    • Sequence similarity between the mammalian bmi-1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z)2
    • van Lohuizen M, Frasch M, Wientjens E, Berns A. Sequence similarity between the mammalian bmi-1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z)2. Nature 1991;353:353-5.
    • (1991) Nature , vol.353 , pp. 353-355
    • Van Lohuizen, M.1    Frasch, M.2    Wientjens, E.3    Berns, A.4
  • 4
    • 33845799903 scopus 로고    scopus 로고
    • Polycomb silencing mechanisms and the management of genomic programmes
    • DOI 10.1038/nrg1981, PII NRG1981
    • Schwartz YB, Pirrotta V. Polycomb silencing mechanisms and the management of genomic programmes. Nat Rev Genet 2007;8:9-22. (Pubitemid 46006046)
    • (2007) Nature Reviews Genetics , vol.8 , Issue.1 , pp. 9-22
    • Schwartz, Y.B.1    Pirrotta, V.2
  • 5
    • 0033569429 scopus 로고    scopus 로고
    • Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc- Induced apoptosis via INK4a/ARF
    • DOI 10.1101/gad.13.20.2678
    • Jacobs JJ, Scheijen B, Voncken JW, Kieboom K, Berns A, van Lohuizen M. Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF. Genes Dev 1999;13:2678-90. (Pubitemid 29508555)
    • (1999) Genes and Development , vol.13 , Issue.20 , pp. 2678-2690
    • Jacobs, J.J.L.1    Scheijen, B.2    Voncken, J.-W.3    Kieboom, K.4    Berns, A.5    Van Lohuizen, M.6
  • 6
    • 0033552813 scopus 로고    scopus 로고
    • The oncogene and Polycombgroup gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
    • DOI 10.1038/16476
    • Jacobs JJ, Kieboom K, Marino S, DePinho RA, van Lohuizen M. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 1999;397:164-8. (Pubitemid 29050921)
    • (1999) Nature , vol.397 , Issue.6715 , pp. 164-168
    • Jacobs, J.L.1    Kieboom, K.2    Marino, S.3    Depinho, R.A.4    Van Lohuizen, M.5
  • 10
    • 9244248707 scopus 로고    scopus 로고
    • Overexpression of Bmi-1 oncoprotein correlates with axillary lymph node metastases in invasive ductal breast cancer
    • Kim JH, Yoon SY, Jeong SH, et al. Overexpression of Bmi-1 oncoprotein correlates with axillary lymph node metastases in invasive ductal breast cancer. Breast 2004;13:383-8.
    • (2004) Breast , vol.13 , pp. 383-388
    • Kim, J.H.1    Yoon, S.Y.2    Jeong, S.H.3
  • 11
    • 33748951908 scopus 로고    scopus 로고
    • Essential role for activation of the polycomb group (PcG) protein chromatin silencing pathway in metastatic prostate cancer
    • Berezovska OP, Glinskii AB, Yang Z, Li XM, Hoffman RM, Glinsky GV. Essential role for activation of the Polycomb group (PcG) protein chromatin silencing pathway in metastatic prostate cancer. Cell Cycle 2006;5:1886-901. (Pubitemid 44435335)
    • (2006) Cell Cycle , vol.5 , Issue.16 , pp. 1886-1901
    • Berezovska, O.P.1    Glinskii, A.B.2    Yang, Z.3    Li, X.-M.4    Hoffman, R.M.5    Glinsky, G.V.6
  • 15
    • 20444457518 scopus 로고    scopus 로고
    • Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer
    • DOI 10.1172/JCI23412
    • Glinsky GV, Berezovska O, Glinskii AB. Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer. J Clin Invest 2005;115:1503-21. (Pubitemid 40814659)
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.6 , pp. 1503-1521
    • Glinsky, G.V.1    Berezovska, O.2    Glinskii, A.B.3
  • 16
    • 25444532087 scopus 로고    scopus 로고
    • Death-from-cancer signatures and stem cell contribution to metastatic cancer
    • Glinsky GV. Death-from-cancer signatures and stem cell contribution to metastatic cancer. Cell Cycle 2005;4:1171-5.
    • (2005) Cell Cycle , vol.4 , pp. 1171-1175
    • Glinsky, G.V.1
  • 17
    • 50149092414 scopus 로고    scopus 로고
    • Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion
    • Dovey JS, Zacharek SJ, Kim CF, Lees JA. Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion. Proc Natl Acad Sci U S A 2008;105:11857-62.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 11857-11862
    • Dovey, J.S.1    Zacharek, S.J.2    Kim, C.F.3    Lees, J.A.4
  • 18
    • 57349121020 scopus 로고    scopus 로고
    • Bmi1 is required for Hedgehog pathway-driven medulloblastoma expansion
    • 1345p following 1349
    • Michael LE, Westerman BA, Ermilov AN, et al. Bmi1 is required for Hedgehog pathway-driven medulloblastoma expansion. Neoplasia 2008;10:1343-9, 1345p following 1349.
    • (2008) Neoplasia , vol.10 , pp. 1343-1349
    • Michael, L.E.1    Westerman, B.A.2    Ermilov, A.N.3
  • 21
    • 53049085085 scopus 로고    scopus 로고
    • BMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repression
    • Douglas D, Hsu JH, Hung L, et al. BMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repression. Cancer Res 2008;68:6507-15.
    • (2008) Cancer Res , vol.68 , pp. 6507-6515
    • Douglas, D.1    Hsu, J.H.2    Hung, L.3
  • 22
    • 0037673984 scopus 로고    scopus 로고
    • Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells
    • DOI 10.1038/nature01572
    • Lessard J, Sauvageau G. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 2003;423:255-60. (Pubitemid 40852690)
    • (2003) Nature , vol.423 , Issue.6937 , pp. 255-260
    • Lessard, J.1    Sauvageau, G.2
  • 24
    • 0242667922 scopus 로고    scopus 로고
    • Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation
    • DOI 10.1038/nature02060
    • Molofsky AV, Pardal R, Iwashita T, Park IK, Clarke MF, Morrison SJ. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature 2003;425:962-7. (Pubitemid 37376927)
    • (2003) Nature , vol.425 , Issue.6961 , pp. 962-967
    • Molofsky, A.V.1    Pardal, R.2    Iwashita, T.3    Park, I.-K.4    Clarke, M.F.5    Morrison, S.J.6
  • 25
    • 33745728170 scopus 로고    scopus 로고
    • Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells
    • Liu S, Dontu G, Mantle ID, et al. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res 2006;66:6063-71.
    • (2006) Cancer Res , vol.66 , pp. 6063-6071
    • Liu, S.1    Dontu, G.2    Mantle, I.D.3
  • 26
    • 0141765902 scopus 로고    scopus 로고
    • New insights into the pathophysiology of multiple myeloma
    • DOI 10.1016/S1470-2045(03)01195-1, PII S1470204503011951
    • Seidl S, Kaufmann H, Drach J. New insights into the pathophysiology of multiple myeloma. Lancet Oncol 2003;4:557-64. (Pubitemid 38351713)
    • (2003) Lancet Oncology , vol.4 , Issue.9 , pp. 557-564
    • Seidl, S.1    Kaufmann, H.2    Drach, J.3
  • 28
    • 59449092185 scopus 로고    scopus 로고
    • Single-vector inducible lentiviral RNAi system for oncology target validation
    • Wiederschain D, Wee S, Chen L, et al. Single-vector inducible lentiviral RNAi system for oncology target validation. Cell Cycle 2009;8:498-504.
    • (2009) Cell Cycle , vol.8 , pp. 498-504
    • Wiederschain, D.1    Wee, S.2    Chen, L.3
  • 29
    • 42349098051 scopus 로고    scopus 로고
    • BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells
    • DOI 10.1158/0008-5472.CAN-07-2508
    • Huang S, Sinicrope FA. BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells. Cancer Res 2008;68:2944-51. (Pubitemid 351556295)
    • (2008) Cancer Research , vol.68 , Issue.8 , pp. 2944-2951
    • Huang, S.1    Sinicrope, F.A.2
  • 30
    • 66249116702 scopus 로고    scopus 로고
    • PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers
    • Wee S, Jagani Z, Xiang KX, et al. PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers. Cancer Res 2009;69:4286-93.
    • (2009) Cancer Res , vol.69 , pp. 4286-4293
    • Wee, S.1    Jagani, Z.2    Xiang, K.X.3
  • 31
    • 0036947892 scopus 로고    scopus 로고
    • Robust estimators for expression analysis
    • Hubbell E, Liu WM, Mei R. Robust estimators for expression analysis. Bioinformatics 2002;18:1585-92.
    • (2002) Bioinformatics , vol.18 , pp. 1585-1592
    • Hubbell, E.1    Liu, W.M.2    Mei, R.3
  • 32
    • 0025066941 scopus 로고
    • More powerful procedures for multiple significance testing
    • Hochberg Y, Benjamini Y. More powerful procedures for multiple significance testing. Stat Med 1990;9:811-8. (Pubitemid 20343989)
    • (1990) Statistics in Medicine , vol.9 , Issue.7 , pp. 811-818
    • Hochberg, Y.1    Benjamini, Y.2
  • 34
    • 0037175389 scopus 로고    scopus 로고
    • A caspase cleavage fragment of p115 induces fragmentation of the Golgi apparatus and apoptosis
    • Chiu R, Novikov L, Mukherjee S, Shields D. A caspase cleavage fragment of p115 induces fragmentation of the Golgi apparatus and apoptosis. J Cell Biol 2002;159:637-48.
    • (2002) J Cell Biol , vol.159 , pp. 637-648
    • Chiu, R.1    Novikov, L.2    Mukherjee, S.3    Shields, D.4
  • 35
    • 0028788309 scopus 로고
    • Microfilament reorganization during apoptosis: The role of Gas2, a possible substrate for ICE-like proteases
    • Brancolini C, Benedetti M, Schneider C. Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE-like proteases. EMBO J 1995;14:5179-90.
    • (1995) EMBO J , vol.14 , pp. 5179-5190
    • Brancolini, C.1    Benedetti, M.2    Schneider, C.3
  • 38
    • 0030832165 scopus 로고    scopus 로고
    • AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal
    • Tewari M, Yu M, Ross B, Dean C, Giordano A, Rubin R. AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal. Cancer Res 1997;57:4063-9. (Pubitemid 27427698)
    • (1997) Cancer Research , vol.57 , Issue.18 , pp. 4063-4069
    • Tewari, M.1    Yu, M.2    Ross, B.3    Dean, C.4    Giordano, A.5    Rubin, R.6
  • 39
    • 69949114353 scopus 로고    scopus 로고
    • Transforming Growth Factor-{β}1 (TGF-{β}1) induces human osteoclast apoptosis by upregulating Bim
    • Houde N, Chamoux E, Bisson M, Roux S. Transforming Growth Factor-{β}1 (TGF-{β}1) induces human osteoclast apoptosis by upregulating Bim. J Biol Chem 2009;284:23397-404.
    • (2009) J Biol Chem , vol.284 , pp. 23397-23404
    • Houde, N.1    Chamoux, E.2    Bisson, M.3    Roux, S.4
  • 40
    • 35648953299 scopus 로고    scopus 로고
    • Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics
    • DOI 10.1371/journal.pmed.0040316
    • Cragg MS, Kuroda J, Puthalakath H, Huang DC, Strasser A. Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics. PLoS Med 2007;4: 1681-9; discussion 1690. (Pubitemid 350035457)
    • (2007) PLoS Medicine , vol.4 , Issue.10 , pp. 1681-1690
    • Cragg, M.S.1    Kuroda, J.2    Puthalakath, H.3    Huang, D.C.S.4    Strasser, A.5
  • 41
    • 56849117387 scopus 로고    scopus 로고
    • Transient potent BCR-ABL inhibition is sufficient to commit chronic myeloid leukemia cells irreversibly to apoptosis
    • Shah NP, Kasap C, Weier C, et al. Transient potent BCR-ABL inhibition is sufficient to commit chronic myeloid leukemia cells irreversibly to apoptosis. Cancer Cell 2008;14:485-93.
    • (2008) Cancer Cell , vol.14 , pp. 485-493
    • Shah, N.P.1    Kasap, C.2    Weier, C.3
  • 42
    • 73149111929 scopus 로고    scopus 로고
    • A region of the human HOXD cluster that confers polycomb-group responsiveness
    • Woo CJ, Kharchenko PV, Daheron L, Park PJ, Kingston RE. A region of the human HOXD cluster that confers polycomb-group responsiveness. Cell 140:99-110.
    • Cell , vol.140 , pp. 99-110
    • Woo, C.J.1    Kharchenko, P.V.2    Daheron, L.3    Park, P.J.4    Kingston, R.E.5
  • 43
    • 33746378638 scopus 로고    scopus 로고
    • Signalling and survival pathways in multiple myeloma
    • DOI 10.1016/j.ejca.2005.12.026, PII S0959804906003182
    • Bommert K, Bargou RC, Stuhmer T. Signalling and survival pathways in multiple myeloma. Eur J Cancer 2006;42:1574-80. (Pubitemid 44118772)
    • (2006) European Journal of Cancer , vol.42 , Issue.11 , pp. 1574-1580
    • Bommert, K.1    Bargou, R.C.2    Stuhmer, T.3
  • 44
    • 58249101211 scopus 로고    scopus 로고
    • Bone marrow microenvironment and the identification of new targets for myeloma therapy
    • Podar K, Chauhan D, Anderson KC. Bone marrow microenvironment and the identification of new targets for myeloma therapy. Leukemia 2009;23:10-24.
    • (2009) Leukemia , vol.23 , pp. 10-24
    • Podar, K.1    Chauhan, D.2    Anderson, K.C.3
  • 45
    • 33750379420 scopus 로고    scopus 로고
    • Polycomb silencers control cell fate, development and cancer
    • DOI 10.1038/nrc1991, PII NRC1991
    • Sparmann A, van Lohuizen M. Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer 2006;6:846-56. (Pubitemid 44629896)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.11 , pp. 846-856
    • Sparmann, A.1    Van Lohuizen, M.2
  • 46
    • 0030611381 scopus 로고    scopus 로고
    • Perturbation of B and T cell development and predisposition to lymphomagenesis in Emu Bmi1 transgenic mice require the Bmi1 RING finger
    • Alkema MJ, Jacobs H, van Lohuizen M, Berns A. Pertubation of B and T cell development and predisposition to lymphomagenesis in Emu Bmi1 transgenic mice require the Bmi1 RING finger. Oncogene 1997;15:899-910. (Pubitemid 27399551)
    • (1997) Oncogene , vol.15 , Issue.8 , pp. 899-910
    • Alkema, M.J.1    Jacobs, H.2    Van Lohuizen, M.3    Berns, A.4
  • 47
    • 35948990017 scopus 로고    scopus 로고
    • Bmi-1 cooperates with HRas to transform human mammary epithelial cells via dysregulation of multiple growth-regulatory pathways
    • Datta S, Hoenerhoff MJ, Bommi P, et al. Bmi-1 cooperates with HRas to transform human mammary epithelial cells via dysregulation of multiple growth-regulatory pathways. Cancer Res 2007;67:10286-95.
    • (2007) Cancer Res , vol.67 , pp. 10286-10295
    • Datta, S.1    Hoenerhoff, M.J.2    Bommi, P.3
  • 48
    • 69449096782 scopus 로고    scopus 로고
    • BMI1 cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases
    • Hoenerhoff MJ, Chu I, Barkan D, et al. BMI1 cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases. Oncogene 2009;28:3022-32.
    • (2009) Oncogene , vol.28 , pp. 3022-3032
    • Hoenerhoff, M.J.1    Chu, I.2    Barkan, D.3
  • 49
    • 33846850149 scopus 로고    scopus 로고
    • Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins
    • Guo WJ, Datta S, Band V, Dimri GP. Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins. Mol Biol Cell 2007;18:536-46.
    • (2007) Mol Biol Cell , vol.18 , pp. 536-546
    • Guo, W.J.1    Datta, S.2    Band, V.3    Dimri, G.P.4
  • 50
    • 33846884216 scopus 로고    scopus 로고
    • The Bcl-2 family protein inhibitor, ABT-737, has substantial antimyeloma activity and shows synergistic effect with dexamethasone and melphalan
    • Trudel S, Stewart AK, Li Z, et al. The Bcl-2 family protein inhibitor, ABT-737, has substantial antimyeloma activity and shows synergistic effect with dexamethasone and melphalan. Clin Cancer Res 2007;13:621-9.
    • (2007) Clin Cancer Res , vol.13 , pp. 621-629
    • Trudel, S.1    Stewart, A.K.2    Li, Z.3
  • 51
    • 33646870495 scopus 로고    scopus 로고
    • Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
    • Bracken AP, Dietrich N, Pasini D, Hansen KH, Helin K. Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev 2006;20:1123-36.
    • (2006) Genes Dev , vol.20 , pp. 1123-1136
    • Bracken, A.P.1    Dietrich, N.2    Pasini, D.3    Hansen, K.H.4    Helin, K.5


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