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Volumn 194, Issue , 2003, Pages 196-206

Multiple myeloma biology: Lessons from the 5TMM models

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; BISPHOSPHONIC ACID DERIVATIVE; CD45 ANTIGEN; HYBRID PROTEIN; LAMININ 1; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PAMIDRONIC ACID; ZOLEDRONIC ACID;

EID: 0041814539     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-065X.2003.00035.x     Document Type: Review
Times cited : (96)

References (64)
  • 1
  • 2
    • 0032532608 scopus 로고    scopus 로고
    • Primary myeloma cells growing in SCID-hu mice: A model for studying the biology and treatment of myeloma and its manifestations
    • Yaccoby S, Barlogie B, Epstein J. Primary myeloma cells growing in SCID-hu mice: a model for studying the biology and treatment of myeloma and its manifestations. Blood 1998;92:2908-2913.
    • (1998) Blood , vol.92 , pp. 2908-2913
    • Yaccoby, S.1    Barlogie, B.2    Epstein, J.3
  • 3
    • 0037085787 scopus 로고    scopus 로고
    • Oncogenesis of multiple myeloma: 14q32 and 13q chromosomal abnormalities are not randomly distributed, but correlate with natural history, immunological features, and clinical presentation
    • Avet-Loiseau H, et al. Oncogenesis of multiple myeloma: 14q32 and 13q chromosomal abnormalities are not randomly distributed, but correlate with natural history, immunological features, and clinical presentation. Blood 2002;99:2185-2191.
    • (2002) Blood , vol.99 , pp. 2185-2191
    • Avet-Loiseau, H.1
  • 4
    • 0025336906 scopus 로고
    • Age-related monoclonal gammapathies: Clinical lessons from the aging C57BL mouse
    • Radl J. Age-related monoclonal gammapathies: clinical lessons from the aging C57BL mouse. Immunol Today 1990;11:234-236.
    • (1990) Immunol Today , vol.11 , pp. 234-236
    • Radl, J.1
  • 5
    • 0018351394 scopus 로고
    • Idiopathic paraproteinemia. II. Transplantation of the paraprotein-producing clone from old to young C57BL/KaLwRij mice
    • Radl J, De Glopper ED, Schuit HR, Zurcher C. Idiopathic paraproteinemia. II. Transplantation of the paraprotein-producing clone from old to young C57BL/KaLwRij mice. J Immunol 1979;122:609-613.
    • (1979) J Immunol , vol.122 , pp. 609-613
    • Radl, J.1    De Glopper, E.D.2    Schuit, H.R.3    Zurcher, C.4
  • 6
    • 0030056093 scopus 로고    scopus 로고
    • Follow-up of bone lesions in an experimental multiple myeloma mouse model: Description using X-ray dedicated for mammography
    • Vanderkerken K, Goes E, De Raeve H, Radl J, Van Camp B. Follow-up of bone lesions in an experimental multiple myeloma mouse model: description using X-ray dedicated for mammography. Br J Cancer 1996;73:1463-1465.
    • (1996) Br J Cancer , vol.73 , pp. 1463-1465
    • Vanderkerken, K.1    Goes, E.2    De Raeve, H.3    Radl, J.4    Van Camp, B.5
  • 7
    • 0030749836 scopus 로고    scopus 로고
    • Organ involvement and phenotypic adhesion profile of 5T2 and 5T33 myeloma cells in the C57BL/KaLwRij mouse
    • Vanderkerken K, et al. Organ involvement and phenotypic adhesion profile of 5T2 and 5T33 myeloma cells in the C57BL/KaLwRij mouse. Br J Cancer 1997;76:451-460.
    • (1997) Br J Cancer , vol.76 , pp. 451-460
    • Vanderkerken, K.1
  • 8
    • 0035895055 scopus 로고    scopus 로고
    • Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma
    • Croucher PI, et al. Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma. Blood 2001;98:3534-3540.
    • (2001) Blood , vol.98 , pp. 3534-3540
    • Croucher, P.I.1
  • 9
    • 18344376170 scopus 로고    scopus 로고
    • Murine 5T multiple myeloma cells induce angiogenesis in vitro and in vivo
    • Van Valckenborgh E, et al. Murine 5T multiple myeloma cells induce angiogenesis in vitro and in vivo. Br J Cancer 2002;86:796-802.
    • (2002) Br J Cancer , vol.86 , pp. 796-802
    • Van Valckenborgh, E.1
  • 10
    • 0024330897 scopus 로고
    • Detection of monoclonal B lymphocytes in bone marrow and peripheral blood of multiple myeloma patients by immunoglobulin gene rearrangement studies
    • Van Riet I, Heirman C, Lacor P, De Waele M, Thielemans K, Van Camp B. Detection of monoclonal B lymphocytes in bone marrow and peripheral blood of multiple myeloma patients by immunoglobulin gene rearrangement studies. Br J Haematol 1989;73:289-295.
    • (1989) Br J Haematol , vol.73 , pp. 289-295
    • Van Riet, I.1    Heirman, C.2    Lacor, P.3    De Waele, M.4    Thielemans, K.5    Van Camp, B.6
  • 11
    • 0023607981 scopus 로고
    • Evidence for peripheral blood B lymphocyte but not T lymphocyte involvement in multiple myeloma
    • Berenson J, Wong R, Kim K, Brown N, Lichtenstein A. Evidence for peripheral blood B lymphocyte but not T lymphocyte involvement in multiple myeloma. Blood 1987;70:1550-1553.
    • (1987) Blood , vol.70 , pp. 1550-1553
    • Berenson, J.1    Wong, R.2    Kim, K.3    Brown, N.4    Lichtenstein, A.5
  • 12
    • 0026786675 scopus 로고
    • Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutations but show no intraclonal variation
    • Bakkus MH, Heirman C, Van Riet I, Van Camp B, Thielemans K. Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutations but show no intraclonal variation. Blood 1992;80:2326-2335.
    • (1992) Blood , vol.80 , pp. 2326-2335
    • Bakkus, M.H.1    Heirman, C.2    Van Riet, I.3    Van Camp, B.4    Thielemans, K.5
  • 13
    • 0031985198 scopus 로고    scopus 로고
    • Multiple myeloma: Increasing evidence for a multistep transformation process
    • Hallek M, Bergsagel PL, Anderson KC. Multiple myeloma: increasing evidence for a multistep transformation process. Blood 1998;91:3-21.
    • (1998) Blood , vol.91 , pp. 3-21
    • Hallek, M.1    Bergsagel, P.L.2    Anderson, K.C.3
  • 14
    • 0030001675 scopus 로고    scopus 로고
    • Lymphocyte homing and homeostasis
    • Butcher EC, Picker LJ. Lymphocyte homing and homeostasis. Science 1996;272:60-66.
    • (1996) Science , vol.272 , pp. 60-66
    • Butcher, E.C.1    Picker, L.J.2
  • 15
    • 50549121134 scopus 로고
    • Distribution of secondary growths in cancer of the breast
    • Paget S. Distribution of secondary growths in cancer of the breast. Lancet 1889;1:571-573.
    • (1889) Lancet , vol.1 , pp. 571-573
    • Paget, S.1
  • 16
    • 0036172639 scopus 로고    scopus 로고
    • Chemokines-linking receptors to response
    • Watson ML. Chemokines-linking receptors to response. Immunology 2002;105:121-124.
    • (2002) Immunology , vol.105 , pp. 121-124
    • Watson, M.L.1
  • 17
    • 17144473106 scopus 로고    scopus 로고
    • Chemokine receptor homo- or heterodimerization activates distinct signaling pathways
    • Mellado M et al. Chemokine receptor homo- or heterodimerization activates distinct signaling pathways. EMBO J 2001;10:2497-2507.
    • (2001) EMBO J , vol.10 , pp. 2497-2507
    • Mellado, M.1
  • 18
    • 0036172306 scopus 로고    scopus 로고
    • Chemokine signalling: Pivoting around multiple phosphoinositide 3-kinases
    • Curnock AP, Logan MK, Ward SG. Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases. Immunology 2002;105:125-136.
    • (2002) Immunology , vol.105 , pp. 125-136
    • Curnock, A.P.1    Logan, M.K.2    Ward, S.G.3
  • 19
    • 0033973841 scopus 로고    scopus 로고
    • Selective initial in vivo homing pattern of 5T2 multiple myeloma cells in the C57BlKaLwRij mouse
    • Vanderkerken K, et al. Selective initial in vivo homing pattern of 5T2 multiple myeloma cells in the C57BlKaLwRij mouse. Br J Cancer 2000;82:953-959.
    • (2000) Br J Cancer , vol.82 , pp. 953-959
    • Vanderkerken, K.1
  • 20
    • 0036186907 scopus 로고    scopus 로고
    • Monocyte chemoattractant-1 (MCP-1), secreted by bone marrow endothelial cells, induces chemoattraction of 5T multiple myeloma cells
    • Vanderkerken K, et al. Monocyte chemoattractant-1 (MCP-1), secreted by bone marrow endothelial cells, induces chemoattraction of 5T multiple myeloma cells. Clin Exp Metastasis 2002;19:87-90.
    • (2002) Clin Exp Metastasis , vol.19 , pp. 87-90
    • Vanderkerken, K.1
  • 21
    • 0029907810 scopus 로고    scopus 로고
    • Different CD44 splicing patterns define prognostic subgroups in multiple myeloma
    • Stauder R, et al. Different CD44 splicing patterns define prognostic subgroups in multiple myeloma. Blood 1996;88:3101-3108.
    • (1996) Blood , vol.88 , pp. 3101-3108
    • Stauder, R.1
  • 22
    • 0031787644 scopus 로고    scopus 로고
    • CD44 isoforms distinguish between bone marrow plasma cells from normal individuals and patients with multiple myeloma at different stages of disease
    • Van Driel M, Gunthert U, Stauder R, Joling P, Lokhorst HM, Bloem AC. CD44 isoforms distinguish between bone marrow plasma cells from normal individuals and patients with multiple myeloma at different stages of disease. Leukemia 1998;12:1821-1828.
    • (1998) Leukemia , vol.12 , pp. 1821-1828
    • Van Driel, M.1    Gunthert, U.2    Stauder, R.3    Joling, P.4    Lokhorst, H.M.5    Bloem, A.C.6
  • 23
    • 18144451249 scopus 로고    scopus 로고
    • In vivo induction of insulin-like growth factor-I receptor and CD44v6 confers homing and adhesion to murine multiple myeloma cells
    • Asosingh K, et al. In vivo induction of insulin-like growth factor-I receptor and CD44v6 confers homing and adhesion to murine multiple myeloma cells. Cancer Res 2000;60:3096-3104.
    • (2000) Cancer Res , vol.60 , pp. 3096-3104
    • Asosingh, K.1
  • 24
    • 0035300537 scopus 로고    scopus 로고
    • A unique pathway in the homing of murine multiple myeloma cells: CD44v10 mediates binding to bone marrow endothelium
    • Asosingh K, Günthert U, De Raeve H, Van Riet I, Van Camp B, Vanderkerken K. A unique pathway in the homing of murine multiple myeloma cells: CD44v10 mediates binding to bone marrow endothelium. Cancer Res 2001;61:2862-2865.
    • (2001) Cancer Res , vol.61 , pp. 2862-2865
    • Asosingh, K.1    Günthert, U.2    De Raeve, H.3    Van Riet, I.4    Van Camp, B.5    Vanderkerken, K.6
  • 25
    • 0035798442 scopus 로고    scopus 로고
    • The high affinity 67 kD laminin receptor is expressed by multiple myeloma cells and mediates cell migration
    • Vande Broek I, Vanderkerken K, De Greef C, Asosingh K, Van Camp B, Van Riet I. The high affinity 67 kD laminin receptor is expressed by multiple myeloma cells and mediates cell migration. Br J Cancer 2001;85:1387-1395.
    • (2001) Br J Cancer , vol.85 , pp. 1387-1395
    • Vande Broek, I.1    Vanderkerken, K.2    De Greef, C.3    Asosingh, K.4    Van Camp, B.5    Van Riet, I.6
  • 26
    • 85014285855 scopus 로고    scopus 로고
    • Distinct IL-6 signal transduction leads to growth arrest and death in B cells or growth promotion and cell survival in myeloma cells
    • Cheung WC, Van Ness B. Distinct IL-6 signal transduction leads to growth arrest and death in B cells or growth promotion and cell survival in myeloma cells. Leukemia 2002;16:1182-1188.
    • (2002) Leukemia , vol.16 , pp. 1182-1188
    • Cheung, W.C.1    Van Ness, B.2
  • 27
    • 0034332169 scopus 로고    scopus 로고
    • Heterogeneity in therapeutic response of genetically altered myeloma cell lines to interleukin 6, dexamethasone, doxorubicin, and melphalan
    • Rowley M, Liu P, Van Ness B. Heterogeneity in therapeutic response of genetically altered myeloma cell lines to interleukin 6, dexamethasone, doxorubicin, and melphalan. Blood 2000;96:3175-3180.
    • (2000) Blood , vol.96 , pp. 3175-3180
    • Rowley, M.1    Liu, P.2    Van Ness, B.3
  • 28
    • 0027960892 scopus 로고
    • Interleukin-6 prevents dexame-thasone-induced myeloma cell death
    • Hardin J, et al. Interleukin-6 prevents dexame-thasone-induced myeloma cell death. Blood 1994;84:3063-3070.
    • (1994) Blood , vol.84 , pp. 3063-3070
    • Hardin, J.1
  • 29
    • 9544221630 scopus 로고    scopus 로고
    • Insulin-like growth factor I is a growth and survival factor in human multiple myeloma cell lines
    • Georgii-Hemming P, Wiklund HJ, Ljunggren O, Nilsson K. Insulin-like growth factor I is a growth and survival factor in human multiple myeloma cell lines. Blood 1996;88:2250-2258.
    • (1996) Blood , vol.88 , pp. 2250-2258
    • Georgii-Hemming, P.1    Wiklund, H.J.2    Ljunggren, O.3    Nilsson, K.4
  • 30
    • 0026896029 scopus 로고
    • The matrix-degrading metalloproteinases
    • Matrisian LM. The matrix-degrading metalloproteinases. BioEssays 1992;14:455-463.
    • (1992) BioEssays , vol.14 , pp. 455-463
    • Matrisian, L.M.1
  • 31
    • 0032520784 scopus 로고    scopus 로고
    • Bi-directional induction of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 during T lymphoma/endothelial cell contact: Implication of ICAM-1
    • Aoudjit F, Potworowski EF, St-Pierre Y. Bi-directional induction of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 during T lymphoma/endothelial cell contact: implication of ICAM-1. J Immunol 1998;160:2967-2973.
    • (1998) J Immunol , vol.160 , pp. 2967-2973
    • Aoudjit, F.1    Potworowski, E.F.2    St-Pierre, Y.3
  • 32
    • 0029443042 scopus 로고
    • Neutrophil proteinases and matrix degradation. The cell biology of pericellular proteolysis
    • Owen CA, Campbell EJ. Neutrophil proteinases and matrix degradation. The cell biology of pericellular proteolysis. Semin Cell Biol 1995;6:367-376.
    • (1995) Semin Cell Biol , vol.6 , pp. 367-376
    • Owen, C.A.1    Campbell, E.J.2
  • 33
    • 0026467070 scopus 로고
    • Membrane proteases: Roles in tissue remodeling and tumour invasion
    • Chen WT. Membrane proteases: roles in tissue remodeling and tumour invasion. Curr Opin Cell Biol 1992;4:802-809.
    • (1992) Curr Opin Cell Biol , vol.4 , pp. 802-809
    • Chen, W.T.1
  • 34
    • 0037145325 scopus 로고    scopus 로고
    • Upregulation of matrix metalloproteinase-9 in murine 5T33 multiple myeloma cells by interaction with bone marrow endothelial cells
    • Van Valckenborgh E, et al. Upregulation of matrix metalloproteinase-9 in murine 5T33 multiple myeloma cells by interaction with bone marrow endothelial cells. Int J Cancer 2002;101:512-518.
    • (2002) Int J Cancer , vol.101 , pp. 512-518
    • Van Valckenborgh, E.1
  • 35
    • 0033134764 scopus 로고    scopus 로고
    • Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma
    • Vacca A, et al. Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma. Blood 1999;93:3064-3073.
    • (1999) Blood , vol.93 , pp. 3064-3073
    • Vacca, A.1
  • 36
    • 0027140406 scopus 로고
    • Extracellular matrix 6: Role of matrix metalloproteinases in tumor invasion and metastasis
    • Stetler-Stevenson WG, Liotta LA, Kleiner DE Jr. Extracellular matrix 6: role of matrix metalloproteinases in tumor invasion and metastasis. FASEB J 1993;7:1434-1441.
    • (1993) FASEB J , vol.7 , pp. 1434-1441
    • Stetler-Stevenson, W.G.1    Liotta, L.A.2    Kleiner D.E., Jr.3
  • 37
    • 0037655672 scopus 로고    scopus 로고
    • Emerging roles for proteinases in cancer
    • Noël A, et al. Emerging roles for proteinases in cancer. Invasion Metastasis 1997;17:221-239.
    • (1997) Invasion Metastasis , vol.17 , pp. 221-239
    • Noël, A.1
  • 38
    • 0030926412 scopus 로고    scopus 로고
    • Recycling of the urokinase receptor upon internalization of the uPA: Serpin complexes
    • Nykjaer A, et al. Recycling of the urokinase receptor upon internalization of the uPA: serpin complexes. EMBO J 1997;16:2610-2620.
    • (1997) EMBO J , vol.16 , pp. 2610-2620
    • Nykjaer, A.1
  • 39
    • 0036459199 scopus 로고    scopus 로고
    • Mechanisms involved in the differential bone marrow homing of CD45 subsets in 5T murine model of myeloma
    • Asosingh K, et al. Mechanisms involved in the differential bone marrow homing of CD45 subsets in 5T murine model of myeloma. Clin Exp Metastasis 2002;19:583-591.
    • (2002) Clin Exp Metastasis , vol.19 , pp. 583-591
    • Asosingh, K.1
  • 41
    • 0032939906 scopus 로고    scopus 로고
    • Insulin-like growth factor-I acts as a chemoattractant factor for 5T2 multiple myeloma cells
    • Vanderkerken K, Asosingh K, Braet F, Van Riet I, Van Camp B. Insulin-like growth factor-I acts as a chemoattractant factor for 5T2 multiple myeloma cells. Blood 1999;93:235-241.
    • (1999) Blood , vol.93 , pp. 235-241
    • Vanderkerken, K.1    Asosingh, K.2    Braet, F.3    Van Riet, I.4    Van Camp, B.5
  • 43
    • 0025083071 scopus 로고
    • Critical factors in the biology of human cancer metastasis: Twenty-eighth G.H.A. Clowes memorial award lecture
    • Fidler IJ. Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. Cancer Res 1990;50:6130-6138.
    • (1990) Cancer Res , vol.50 , pp. 6130-6138
    • Fidler, I.J.1
  • 44
    • 0035902141 scopus 로고    scopus 로고
    • The microenvironment of the tumour-host interface
    • Liotta LA, Kohn EC. The microenvironment of the tumour-host interface. Nature, 2001;411:375-379.
    • (2001) Nature , vol.411 , pp. 375-379
    • Liotta, L.A.1    Kohn, E.C.2
  • 45
    • 0027302498 scopus 로고
    • Interleukin-6 gene expression in multiple myeloma: A characteristic of immature tumor cells
    • Hata H, Xiao H, Petrucci MT, Woodliff J, Chang R, Epstein J. Interleukin-6 gene expression in multiple myeloma: a characteristic of immature tumor cells. Blood 1993;81:3357-3364.
    • (1993) Blood , vol.81 , pp. 3357-3364
    • Hata, H.1    Xiao, H.2    Petrucci, M.T.3    Woodliff, J.4    Chang, R.5    Epstein, J.6
  • 46
    • 0030015735 scopus 로고    scopus 로고
    • The labelling index of primitive plasma cells determines the clinical behaviour of patients with myelomatosis
    • Joshua D, Petersen A, Brown R, Pope B, Snowdon L, Gibson J. The labelling index of primitive plasma cells determines the clinical behaviour of patients with myelomatosis. Br J Haematol 1996;94:76-81.
    • (1996) Br J Haematol , vol.94 , pp. 76-81
    • Joshua, D.1    Petersen, A.2    Brown, R.3    Pope, B.4    Snowdon, L.5    Gibson, J.6
  • 47
    • 0035164061 scopus 로고    scopus 로고
    • +) 5T multiple myeloma cells
    • +) 5T multiple myeloma cells. Exp Hematol 2001;29:77-84.
    • (2001) Exp Hematol , vol.29 , pp. 77-84
    • Asosingh, K.1
  • 48
    • 0037606041 scopus 로고    scopus 로고
    • Multiple myeloma tumor progression in the 5T2 murine model is a multi-stage and dynamic process of differentiation, proliferation, invasion and apoptosis
    • in press
    • Asosingh K, De Raeve H, Van Riet I, Van Camp B, Vanderkerken K. Multiple myeloma tumor progression in the 5T2 murine model is a multi-stage and dynamic process of differentiation, proliferation, invasion and apoptosis. Blood 2003 (in press).
    • (2003) Blood
    • Asosingh, K.1    De Raeve, H.2    Van Riet, I.3    Van Camp, B.4    Vanderkerken, K.5
  • 49
    • 0032533909 scopus 로고    scopus 로고
    • Induction of CD45 expression and proliferation in U-266 myeloma cell line by interleukin-6
    • Mahmoud MS, Ishikawa H, Fujii R, Kawano MM. Induction of CD45 expression and proliferation in U-266 myeloma cell line by interleukin-6. Blood 1998;92:3887-3897.
    • (1998) Blood , vol.92 , pp. 3887-3897
    • Mahmoud, M.S.1    Ishikawa, H.2    Fujii, R.3    Kawano, M.M.4
  • 50
    • 0032951029 scopus 로고    scopus 로고
    • MPC-1-CD49e- immature myeloma cells include CD45+ subpopulations that can proliferate in response to IL-6 in human myelomas
    • Fujii R, Ishikawa H, Mahmoud MS, Asaoku H, Kawano MM. MPC-1-CD49e- immature myeloma cells include CD45+ subpopulations that can proliferate in response to IL-6 in human myelomas. Br J Haematol 1999;105:131-140.
    • (1999) Br J Haematol , vol.105 , pp. 131-140
    • Fujii, R.1    Ishikawa, H.2    Mahmoud, M.S.3    Asaoku, H.4    Kawano, M.M.5
  • 51
    • 0033611467 scopus 로고    scopus 로고
    • OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
    • Kong YY, et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 1999;397:315-323.
    • (1999) Nature , vol.397 , pp. 315-323
    • Kong, Y.Y.1
  • 52
    • 0032540319 scopus 로고    scopus 로고
    • Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    • Lacey DL, et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 1998;93:165-176.
    • (1998) Cell , vol.93 , pp. 165-176
    • Lacey, D.L.1
  • 53
    • 0033519221 scopus 로고    scopus 로고
    • The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts
    • Burgess TL, et al. The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts. J Cell Biol 1999;145:527-538.
    • (1999) J Cell Biol , vol.145 , pp. 527-538
    • Burgess, T.L.1
  • 54
    • 0030989969 scopus 로고    scopus 로고
    • Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis
    • Tsuda E, et al. Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis. Biochem Biophys Res Commun 1997;234:137-142.
    • (1997) Biochem Biophys Res Commun , vol.234 , pp. 137-142
    • Tsuda, E.1
  • 55
    • 0031005576 scopus 로고    scopus 로고
    • Osteoprotegerin: A novel secreted protein involved in the regulation of bone density
    • Simonet WS, et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 1997;89:309-319.
    • (1997) Cell , vol.89 , pp. 309-319
    • Simonet, W.S.1
  • 56
    • 79960970987 scopus 로고    scopus 로고
    • Anti-tumor effect of recombinant OPG in the murine 5T33MM model
    • Vanderkerken K, Asosingh K, Van Camp B, Croucher P. Anti-tumor effect of recombinant OPG in the murine 5T33MM model. Blood 2001;98:637a.
    • (2001) Blood , vol.98
    • Vanderkerken, K.1    Asosingh, K.2    Van Camp, B.3    Croucher, P.4
  • 57
    • 0037439916 scopus 로고    scopus 로고
    • Recombinant osteoprotegerin decreases tumor burden and increases survival in a murine model of multiple myeloma
    • Vanderkerken K, et al. Recombinant osteoprotegerin decreases tumor burden and increases survival in a murine model of multiple myeloma. Cancer Res 2003;63:287-289.
    • (2003) Cancer Res , vol.63 , pp. 287-289
    • Vanderkerken, K.1
  • 58
    • 0021907418 scopus 로고
    • Influence of treatment with APD-bisphosphonate on the bone lesions in the mouse 5T2 multiple myeloma
    • Radl J, et al. Influence of treatment with APD-bisphosphonate on the bone lesions in the mouse 5T2 multiple myeloma. Cancer 1985;55:1030-1040.
    • (1985) Cancer , vol.55 , pp. 1030-1040
    • Radl, J.1
  • 59
    • 0242308942 scopus 로고    scopus 로고
    • Zoledroinc acid treatment of 5T2MM-bearing mice inhibits the development of myeloma bone disease: Evidence for decreased osteolysis, tumor burden and angiogenesis, and increased survival
    • in press
    • Croucher PI, et al. Zoledroinc acid treatment of 5T2MM-bearing mice inhibits the development of myeloma bone disease: evidence for decreased osteolysis, tumor burden and angiogenesis, and increased survival. J Bone Mineral Res 2003 (in press).
    • (2003) J Bone Mineral Res
    • Croucher, P.I.1
  • 60
    • 0001099271 scopus 로고
    • Effect of long-term treatment with the bisphosphonate APD on 5T2 mouse multiple myeloma
    • Radl J, Van Camp B, eds. Monoclonal Gammapathies III - Clinical Significance and Basic Mechanisms. Leiden: EURAGE
    • Croese JW, Zurcher C, van den Enden-Vieveen MHM, Radl J. Effect of long-term treatment with the bisphosphonate APD on 5T2 mouse multiple myeloma. In: Radl J, Van Camp B, eds. Monoclonal Gammapathies III - Clinical Significance and Basic Mechanisms. Topics in Aging Research in Europe, vol. 14. Leiden: EURAGE, 1991;239:199-203.
    • (1991) Topics in Aging Research in Europe , vol.14 , pp. 199-203
    • Croese, J.W.1    Zurcher, C.2    Van Den Enden-Vieveen, M.H.M.3    Radl, J.4
  • 61
    • 0028246112 scopus 로고
    • Evidence that the clonogenic cell in multiple myeloma originates from a pre-switched but somatically mutated B cell
    • Bakkus MH, Van Riet I, Van Camp B, Thielemans K. Evidence that the clonogenic cell in multiple myeloma originates from a pre-switched but somatically mutated B cell. Br J Haematol 1994;87:68-74.
    • (1994) Br J Haematol , vol.87 , pp. 68-74
    • Bakkus, M.H.1    Van Riet, I.2    Van Camp, B.3    Thielemans, K.4
  • 62
    • 0027257608 scopus 로고
    • The bone marrow of multiple myeloma patients contains B cell populations at different stages of differentiation that are clonally related to the malignant plasma cell
    • Billadeau D, Ahmann G, Greipp P, Van Ness B. The bone marrow of multiple myeloma patients contains B cell populations at different stages of differentiation that are clonally related to the malignant plasma cell. J Exp Med 1993;178:1023-1031.
    • (1993) J Exp Med , vol.178 , pp. 1023-1031
    • Billadeau, D.1    Ahmann, G.2    Greipp, P.3    Van Ness, B.4
  • 63
    • 0034895198 scopus 로고    scopus 로고
    • Myeloma isotype-switch variants in the murine 5T myeloma model: Evidence that myeloma IgM and IgA expressing subclones can originate from the IgG expressing tumor
    • Bakkus MH, et al. Myeloma isotype-switch variants in the murine 5T myeloma model: evidence that myeloma IgM and IgA expressing subclones can originate from the IgG expressing tumor. Leukemia 2001;15:1127-1132.
    • (2001) Leukemia , vol.15 , pp. 1127-1132
    • Bakkus, M.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.