-
1
-
-
33750470057
-
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination
-
Vedadi M, et al.: Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination. Proc Natl Acad Sci USA 2006;103:15835-15840
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 15835-15840
-
-
Vedadi, M.1
-
2
-
-
18244380348
-
High-density miniaturized thermal shift assays as a general strategy for drug discovery
-
Pantoliano MW, et al.: High-density miniaturized thermal shift assays as a general strategy for drug discovery. J Biomol Screen 2001;6:429-440
-
(2001)
J. Biomol. Screen.
, vol.6
, pp. 429-440
-
-
Pantoliano, M.W.1
-
3
-
-
37249005205
-
The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability
-
Niesen FH, et al.: The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability. Nat Protoc 2007;2:2212-2221
-
(2007)
Nat. Protoc.
, vol.2
, pp. 2212-2221
-
-
Niesen, F.H.1
-
4
-
-
4143121255
-
Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery
-
Lo M-C, et al.: Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery. Anal Biochem 2004;332:153-159
-
(2004)
Anal. Biochem.
, vol.332
, pp. 153-159
-
-
Lo, M.-C.1
-
5
-
-
33751559579
-
Screening for ligands using a generic and high-throughput light-scattering-based assay
-
Senisterra GA, et al.: Screening for ligands using a generic and high-throughput light-scattering-based assay. J Biomol Screen 2006;11:940-948
-
(2006)
J. Biomol. Screen.
, vol.11
, pp. 940-948
-
-
Senisterra, G.A.1
-
6
-
-
0035338647
-
The ligand affinity of proteins measured by isothermal denaturation kinetics
-
Epps DE, et al.: The ligand affinity of proteins measured by isothermal denaturation kinetics. Anal Biochem 2001;292:40-50
-
(2001)
Anal. Biochem.
, vol.292
, pp. 40-50
-
-
Epps, D.E.1
-
7
-
-
0020085035
-
Anilinonaphthalene sulfonate fluorescence and amino acid transport in yeast
-
Slavik J, et al.: Anilinonaphthalene sulfonate fluorescence and amino acid transport in yeast. J Membr Biol 1982;64:175-179
-
(1982)
J. Membr. Biol.
, vol.64
, pp. 175-179
-
-
Slavik, J.1
-
8
-
-
40049099087
-
Microscale fluorescent thermal stability assay for membrane proteins
-
Alexandrov AI, et al.: Microscale fluorescent thermal stability assay for membrane proteins. Structure 2008;16:351-359
-
(2008)
Structure
, vol.16
, pp. 351-359
-
-
Alexandrov, A.I.1
-
9
-
-
0025281866
-
Study of strong to ultratight protein interactions using differential scanning calorimetry
-
Brandts JF, Lin LN. Study of strong to ultratight protein interactions using differential scanning calorimetry. Biochemistry 1990;29:6927-6940
-
(1990)
Biochemistry
, vol.29
, pp. 6927-6940
-
-
Brandts, J.F.1
Lin, L.N.2
-
10
-
-
20144384268
-
Decrypting the biochemical function of an essential gene from Streptococcus pneumoniae using ThermoFluor technology
-
Carver TE, et al.: Decrypting the biochemical function of an essential gene from Streptococcus pneumoniae using ThermoFluor technology. J Biol Chem 2005; 280:11704-11712
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 11704-11712
-
-
Carver, T.E.1
-
11
-
-
16344382388
-
Thermodynamic stability of carbonic anhydrase: Measurements of binding affinity and stoichiometry using ThermoFluor
-
Matulis D, et al.: Thermodynamic stability of carbonic anhydrase: measurements of binding affinity and stoichiometry using ThermoFluor. Biochemistry 2005;44: 5258-5266
-
(2005)
Biochemistry
, vol.44
, pp. 5258-5266
-
-
Matulis, D.1
-
12
-
-
78650485354
-
Thermodynamic analysis of ligand-induced changes in protein thermal unfolding applied to high-throughput determination of ligand affinities with extrinsic fluorescent dyes
-
Layton CJ, Hellinga HW: Thermodynamic analysis of ligand-induced changes in protein thermal unfolding applied to high-throughput determination of ligand affinities with extrinsic fluorescent dyes. Biochemistry 2010;49:10831-10841
-
(2010)
Biochemistry
, vol.49
, pp. 10831-10841
-
-
Layton, C.J.1
Hellinga, H.W.2
-
13
-
-
56049092342
-
A quantitative model of thermal stabilization and destabilization of proteins by ligands
-
Cimmperman P, et al.: A quantitative model of thermal stabilization and destabilization of proteins by ligands. Biophys J 2008;95:3222-3231
-
(2008)
Biophys. J.
, vol.95
, pp. 3222-3231
-
-
Cimmperman, P.1
-
14
-
-
77956191215
-
Biophysical characterization of recombinant proteins: A key to higher structural genomics success
-
Vedadi M, et al.: Biophysical characterization of recombinant proteins: a key to higher structural genomics success. J Struct Biol 2010;172:107-119
-
(2010)
J. Struct. Biol.
, vol.172
, pp. 107-119
-
-
Vedadi, M.1
-
15
-
-
77949407880
-
Assessing the stability of membrane proteins to detect ligand binding using differential static light scattering
-
Senisterra GA, et al.: Assessing the stability of membrane proteins to detect ligand binding using differential static light scattering. J Biomol Screen 2010; 15:314-320
-
(2010)
J. Biomol. Screen.
, vol.15
, pp. 314-320
-
-
Senisterra, G.A.1
-
16
-
-
40749162764
-
Atlas-A high-throughput affinity-based screening technology for soluble proteins: Technology application using p38 MAP kinase
-
Patel R, et al.: ATLAS-a high-throughput affinity-based screening technology for soluble proteins: technology application using p38 MAP kinase. Assay Drug Dev Technol 2008;6:55-68
-
(2008)
Assay. Drug. Dev. Technol.
, vol.6
, pp. 55-68
-
-
Patel, R.1
-
17
-
-
40749086044
-
Identification of ligand binding by protein stabilization: Comparison of ATLAS with biophysical and enzymatic methods
-
Thompson PA, et al.: Identification of ligand binding by protein stabilization: comparison of ATLAS with biophysical and enzymatic methods. Assay Drug Dev Technol 2008;6:69-81
-
(2008)
Assay. Drug. Dev. Technol.
, vol.6
, pp. 69-81
-
-
Thompson, P.A.1
-
18
-
-
0031214756
-
A new ultrasensitive scanning calorimeter
-
Plotnikov VV, et al.: A new ultrasensitive scanning calorimeter. Anal Biochem 1997;250:237-244
-
(1997)
Anal. Biochem.
, vol.250
, pp. 237-244
-
-
Plotnikov, V.V.1
-
19
-
-
0038612496
-
An autosampling differential scanning calorimeter instrument for studying molecular interactions
-
Plotnikov V, et al.: An autosampling differential scanning calorimeter instrument for studying molecular interactions. Assay Drug Dev Technol 2002; 1:83-90
-
(2002)
Assay. Drug. Dev. Technol.
, vol.1
, pp. 83-90
-
-
Plotnikov, V.1
-
20
-
-
51649126604
-
Demonstration of MEMS-based differential scanning calorimetry for detemining thermodynamic properties of biomolecules
-
Wang L, Wang B, Lin Q: Demonstration of MEMS-based differential scanning calorimetry for detemining thermodynamic properties of biomolecules. Sensor Actuat B Chem 2008;134:953-958
-
(2008)
Sensor. Actuat. B. Chem.
, vol.134
, pp. 953-958
-
-
Wang, L.1
Wang, B.2
Lin, Q.3
-
21
-
-
0000826487
-
Biochemical applications of differential scanning calorimetry
-
Sturtevant JM: Biochemical applications of differential scanning calorimetry. Ann Rev Phys Chem 1987;38:463-488
-
(1987)
Ann. Rev. Phys. Chem.
, vol.38
, pp. 463-488
-
-
Sturtevant, J.M.1
-
22
-
-
33644499478
-
Monitoring protein aggregation during thermal unfolding in circular dichroism experiments
-
Benjwal S, et al.: Monitoring protein aggregation during thermal unfolding in circular dichroism experiments. Protein Sci 2006;15:635-639
-
(2006)
Protein. Sci.
, vol.15
, pp. 635-639
-
-
Benjwal, S.1
-
23
-
-
0032821769
-
Thermal conformational changes of bovine fibrinogen by differential scanning calorimetry and circular dichroism
-
Chen Y, et al.: Thermal conformational changes of bovine fibrinogen by differential scanning calorimetry and circular dichroism. Int J Biol Macromol 1999;26:129-134
-
(1999)
Int. J. Biol. Macromol.
, vol.26
, pp. 129-134
-
-
Chen, Y.1
-
24
-
-
33846814867
-
How does dextran sulfate prevent heat induced aggregation of protein? The mechanism and its limitation as aggregation inhibitor
-
Chung K, et al.: How does dextran sulfate prevent heat induced aggregation of protein? The mechanism and its limitation as aggregation inhibitor. Biochim Biophys Acta 2007;1774:249-257
-
(2007)
Biochim Biophys. Acta.
, vol.1774
, pp. 249-257
-
-
Chung, K.1
-
25
-
-
0038752634
-
Irreversible unfolding of the neutral pH form of influenza hemagglutinin demonstrates that it is not in a metastable state
-
Epand RF, Epand RM: Irreversible unfolding of the neutral pH form of influenza hemagglutinin demonstrates that it is not in a metastable state. Biochemistry 2003;42:5052-5057
-
(2003)
Biochemistry
, vol.42
, pp. 5052-5057
-
-
Epand, R.F.1
Epand, R.M.2
-
26
-
-
0032982258
-
Reversibility of heat-induced denaturation of the recombinant human megakaryocyte growth and development factor
-
Narhi LO, et al.: Reversibility of heat-induced denaturation of the recombinant human megakaryocyte growth and development factor. Pharm Res 1999; 16:799-807
-
(1999)
Pharm Res.
, vol.16
, pp. 799-807
-
-
Narhi, L.O.1
-
27
-
-
0027300586
-
Thermal transitions in the purple membrane from Halobacterium halobium
-
Shnyrov VL, Mateo PL: Thermal transitions in the purple membrane from Halobacterium halobium. FEBS Lett 1993;324:237-240
-
(1993)
FEBS Lett.
, vol.324
, pp. 237-240
-
-
Shnyrov, V.L.1
Mateo, P.L.2
-
28
-
-
0027489832
-
Thermodynamics of unfolding for turkey ovomucoid third domain: Thermal and chemical denaturation
-
Swint L, Robertson AD: Thermodynamics of unfolding for turkey ovomucoid third domain: thermal and chemical denaturation. Protein Sci 1993;2: 2037-2049
-
(1993)
Protein. Sci.
, vol.2
, pp. 2037-2049
-
-
Swint, L.1
Robertson, A.D.2
-
29
-
-
0017836908
-
Statistical mechanical deconvolutiion of thermal transitions in macromolecules I. Theory and application to homogeneous systems
-
Freire E, Biltonen RL: Statistical mechanical deconvolutiion of thermal transitions in macromolecules. I. Theory and application to homogeneous systems. Biopolymers 1978;17:463-479
-
(1978)
Biopolymers
, Issue.17
, pp. 463-479
-
-
Freire, E.1
Biltonen, R.L.2
-
30
-
-
0030976566
-
Thermodynamic features of the thermal unfolding of human serumalbumin
-
Pico GA: Thermodynamic features of the thermal unfolding of human serumalbumin. Int J Biol Macromol 1997;20:63-73
-
(1997)
Int. J. Biol. Macromol.
, vol.20
, pp. 63-73
-
-
Pico, G.A.1
-
31
-
-
0027080868
-
Domains in lambda Cro repressor A calorimetric study
-
Griko YV, et al.: Domains in lambda Cro repressor. A calorimetric study. Biochemistry 1992;31:12701-12705
-
(1992)
Biochemistry
, vol.31
, pp. 12701-12705
-
-
Griko, Y.V.1
-
32
-
-
0021692301
-
Domains in human plasminogen
-
Novokhatny V V, et al.: Domains in human plasminogen. J Mol Biol 1984; 179:215-232
-
(1984)
J. Mol. Biol.
, Issue.179
, pp. 215-232
-
-
Novokhatny, V.V.1
-
33
-
-
0024291325
-
Differential scanning calorimetric study of the thermal denaturation of aspartate transcarbamoylase of Escherichia coli
-
Edge V, et al.: Differential scanning calorimetric study of the thermal denaturation of aspartate transcarbamoylase of Escherichia coli. Biochemistry 1988;27:8081-8087
-
(1988)
Biochemistry
, vol.27
, pp. 8081-8087
-
-
Edge, V.1
-
34
-
-
0033961193
-
A calorimetric study of the influence of calcium on the stability of bovine alpha-lactalbumin
-
Hendrix T, et al.: A calorimetric study of the influence of calcium on the stability of bovine alpha-lactalbumin. Biophys Chem 2000;84:27-34
-
(2000)
Biophys. Chem.
, vol.84
, pp. 27-34
-
-
Hendrix, T.1
-
35
-
-
0029157132
-
The unfolding thermodynamics of c-type lysozymes: A calorimetric study of the heat denaturation of equine lysozyme
-
Griko Y V, et al.: The unfolding thermodynamics of c-type lysozymes: a calorimetric study of the heat denaturation of equine lysozyme. J Mol Biol 1995;252:447-459
-
(1995)
J. Mol. Biol.
, vol.252
, pp. 447-459
-
-
Griko Y, V.1
-
36
-
-
77949789023
-
High throughput thermostability screening of monoclonal antibody formulations
-
He F, et al.: High throughput thermostability screening of monoclonal antibody formulations. J Pharm Sci 2010;99:1707-1720
-
(2010)
J. Pharm. Sci.
, vol.99
, pp. 1707-1720
-
-
He, F.1
-
37
-
-
0027080869
-
Influence of transition rates and scan rate on kinetic simulations of differential scanning calorimetry profiles of reversible and irreversible protein denaturation
-
Lepock JR, et al.: Influence of transition rates and scan rate on kinetic simulations of differential scanning calorimetry profiles of reversible and irreversible protein denaturation. Biochemistry 1992;31:12706-12712
-
(1992)
Biochemistry
, vol.31
, pp. 12706-12712
-
-
Lepock, J.R.1
-
38
-
-
77952323466
-
Differential scanning calorimetry and fluorescence study of lactoperoxidase as a function of guanidinium-HCl, urea, and pH
-
Zelent B, et al.: Differential scanning calorimetry and fluorescence study of lactoperoxidase as a function of guanidinium-HCl, urea, and pH. Biochim Biophys Acta 2010;1804:1508-1515
-
(2010)
Biochim Biophys Acta.
, vol.1804
, pp. 1508-1515
-
-
Zelent, B.1
-
39
-
-
55549107475
-
Thermodynamic characterization of the palm tree Roystonea regia peroxidase stability
-
Zamorano LS, et al.: Thermodynamic characterization of the palm tree Roystonea regia peroxidase stability. Biochimie 2008;90:1737-1749
-
(2008)
Biochimie
, vol.90
, pp. 1737-1749
-
-
Zamorano, L.S.1
-
40
-
-
43149094397
-
Thermal inactivation, denaturation and aggregation of mitochondrial aspartate aminotransferase
-
Golub NV, et al.: Thermal inactivation, denaturation and aggregation of mitochondrial aspartate aminotransferase. Biophys Chem 2008;135:125-131
-
(2008)
Biophys. Chem.
, vol.135
, pp. 125-131
-
-
Golub, N.V.1
-
41
-
-
24044521927
-
Kinetically controlled thermal response of beta2- microglobulin amyloid fibrils
-
Sasahara K, et al.: Kinetically controlled thermal response of beta2- microglobulin amyloid fibrils. J Mol Biol 2005;352:700-711
-
(2005)
J. Mol. Biol.
, vol.352
, pp. 700-711
-
-
Sasahara, K.1
-
42
-
-
79951895571
-
Formulation development of therapeutic monoclonal antibodies using high-throughput fluorescence and static light scattering techniques: Role of conformational and colloidal stability
-
Goldberg DS, et al.: Formulation development of therapeutic monoclonal antibodies using high-throughput fluorescence and static light scattering techniques: role of conformational and colloidal stability. J Pharm Sci 2010; 100:1306-1315
-
(2010)
J. Pharm. Sci.
, vol.100
, pp. 1306-1315
-
-
Goldberg, D.S.1
-
43
-
-
0034717059
-
Interpretation of DSC data on protein denaturation complicated by kinetic and irreversible effects
-
Grinberg V Y, et al.: Interpretation of DSC data on protein denaturation complicated by kinetic and irreversible effects. J Biotechnol 2000;79:269-280
-
(2000)
J. Biotechnol.
, vol.79
, pp. 269-280
-
-
Grinberg V, Y.1
-
44
-
-
0033616740
-
Transition state of the rate-limiting step of heat denaturation of Cry3A delta-endotoxin
-
Potekhin SA, et al.: Transition state of the rate-limiting step of heat denaturation of Cry3A delta-endotoxin. Biochemistry 1999;38:4121-4127
-
(1999)
Biochemistry
, vol.38
, pp. 4121-4127
-
-
Potekhin, S.A.1
-
45
-
-
29544441514
-
Combined spectroscopic and calorimetric characterization of rubredoxin reversible thermal transition
-
Henriques BJ, et al.: Combined spectroscopic and calorimetric characterization of rubredoxin reversible thermal transition. J Biol Inorg Chem 2006;11:73-81
-
(2006)
J. Biol. Inorg. Chem.
, vol.11
, pp. 73-81
-
-
Henriques, B.J.1
-
46
-
-
0035835043
-
Thermal denaturation of porcine pepsin: A study by circular dichroism
-
Tello-Solis SR, Romero-Garcia B: Thermal denaturation of porcine pepsin: a study by circular dichroism. Int J Biol Macromol 2001;28:129-133
-
(2001)
Int. J. Biol. Macromol
, vol.28
, pp. 129-133
-
-
Tello-Solis, S.R.1
Romero-Garcia, B.2
-
47
-
-
0031873691
-
Scan-rate dependence in protein calorimetry: The reversible transitions of Bacillus circulans xylanase and a disulfide-bridge mutant
-
Davoodi J, et al.: Scan-rate dependence in protein calorimetry: the reversible transitions of Bacillus circulans xylanase and a disulfide-bridge mutant. Protein Sci 1998;7:1538-1544
-
(1998)
Protein. Sci.
, vol.7
, pp. 1538-1544
-
-
Davoodi, J.1
-
48
-
-
34249073088
-
Structural and chemical profiling of the human cytosolic sulfotransferases
-
Allali-Hassani A, et al.: Structural and chemical profiling of the human cytosolic sulfotransferases. PLoS Biol 2007;5:e97
-
(2007)
PLoS Biol.
, vol.5
-
-
Allali-Hassani, A.1
-
49
-
-
38049155899
-
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases
-
Fedorov O, et al.: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci USA 2007;104:20523-20528
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 20523-20528
-
-
Fedorov, O.1
-
50
-
-
58849105958
-
Functional assignment of solute-binding proteins of ABC transporters using a fluorescence-based thermal shift assay
-
Giuliani SE, et al.: Functional assignment of solute-binding proteins of ABC transporters using a fluorescence-based thermal shift assay. Biochemistry 2008;47:13974-13984
-
(2008)
Biochemistry
, vol.47
, pp. 13974-13984
-
-
Giuliani, S.E.1
-
51
-
-
33749603042
-
Thermal stability landscape for Klenow DNA polymerase as a function of pH and salt concentration
-
Richard AJ, et al.: Thermal stability landscape for Klenow DNA polymerase as a function of pH and salt concentration. Biochim Biophys Acta 2006;1764:1546-1552
-
(2006)
Biochim. Biophys. Acta.
, vol.1764
, pp. 1546-1552
-
-
Richard, A.J.1
-
52
-
-
50849088311
-
Crystal and solution structure, stability and post-translational modifications of collapsin response mediator protein 2
-
Majava V, et al.: Crystal and solution structure, stability and post-translational modifications of collapsin response mediator protein 2. FEBS J 2008;275: 4583-4596
-
(2008)
FEBS J.
, vol.275
, pp. 4583-4596
-
-
Majava, V.1
-
53
-
-
43049095602
-
Methods for protein characterization by mass spectrometry, thermal shift (ThermoFluor) assay, and multiangle or static light scattering
-
Nettleship JE, et al.: Methods for protein characterization by mass spectrometry, thermal shift (ThermoFluor) assay, and multiangle or static light scattering. Methods Mol Biol 2008;426:299-318
-
(2008)
Methods Mol. Biol.
, vol.426
, pp. 299-318
-
-
Nettleship, J.E.1
-
54
-
-
33748929006
-
Thermofluor-based high-throughput stability optimization of proteins for structural studies
-
Ericsson UB, et al.: Thermofluor-based high-throughput stability optimization of proteins for structural studies. Anal Biochem 2006;357:289-298
-
(2006)
Anal. Biochem.
, vol.357
, pp. 289-298
-
-
Ericsson, U.B.1
-
55
-
-
67651042924
-
Buffer optimization of thermal melt assays of Plasmodium proteins for detection of small-molecule ligands
-
Crowther GJ, et al.: Buffer optimization of thermal melt assays of Plasmodium proteins for detection of small-molecule ligands. J Biomol Screen 2009;14: 700-707
-
(2009)
J. Biomol. Screen.
, vol.14
, pp. 700-707
-
-
Crowther, G.J.1
-
56
-
-
70350668615
-
A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity
-
Allali-Hassani A, et al.: A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity. Biochem J 2009;424:15-26
-
(2009)
Biochem J.
, vol.424
, pp. 15-26
-
-
Allali-Hassani, A.1
-
57
-
-
62449120440
-
Stability of two beta-tropomyosin isoforms: Effects of mutation Arg91Gly
-
Nevzorov I, et al.: Stability of two beta-tropomyosin isoforms: effects of mutation Arg91Gly. J Muscle Res Cell Motil 2008;29:173-176
-
(2008)
J.. Muscle. Res. Cell Motil.
, vol.29
, pp. 173-176
-
-
Nevzorov, I.1
-
58
-
-
34948897631
-
Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder
-
Hong BS, et al.: Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder. J Biol Chem 2007;282:27984-27993
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 27984-27993
-
-
Hong, B.S.1
-
59
-
-
67849129183
-
High-throughput thermal scanning: A general, rapid dyebinding thermal shift screen for protein engineering
-
Lavinder JJ, et al.: High-throughput thermal scanning: a general, rapid dyebinding thermal shift screen for protein engineering. J Am Chem Soc 2009; 131:3794-3795
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 3794-3795
-
-
Lavinder, J.J.1
-
60
-
-
33749850046
-
Universal screening methods and applications of ThermoFluor
-
Cummings MD, et al.: Universal screening methods and applications of ThermoFluor. J Biomol Screen 2006;11:854-863
-
(2006)
J. Biomol. Screen.
, vol.11
, pp. 854-863
-
-
Cummings, M.D.1
-
61
-
-
36749070911
-
A MurF inhibitor that disrupts cell wall biosynthesis in Escherichia coli
-
Baum EZ, et al.: A MurF inhibitor that disrupts cell wall biosynthesis in Escherichia coli. Antimicrob Agents Chemother 2007;51:4420-4426
-
(2007)
Antimicrob Agents Chemother
, vol.51
, pp. 4420-4426
-
-
Baum, E.Z.1
-
62
-
-
13944274061
-
Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells
-
Grasberger BL, et al.: Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells. J Med Chem 2005;48:909-912
-
(2005)
J. Med. Chem.
, vol.48
, pp. 909-912
-
-
Grasberger, B.L.1
-
63
-
-
77955363182
-
Protein lysine methyltransferase G9a inhibitors: Design, syn thesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines
-
Liu F, et al.: Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy- quinazolines. J Med Chem 2010;53:5844-5857
-
(2010)
J. Med. Chem.
, vol.53
, pp. 5844-5857
-
-
Liu, F.1
-
64
-
-
73249124141
-
Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a
-
Liu F, et al.: Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a. J Med Chem 2009;52:7950-7953
-
(2009)
J. Med. Chem.
, vol.52
, pp. 7950-7953
-
-
Liu, F.1
-
65
-
-
79960493567
-
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
-
Vedadi M, et al: A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol 2011;7:566-574
-
(2011)
Nat. Chem. Biol.
, vol.7
, pp. 566-574
-
-
Vedadi, M.1
-
66
-
-
68649121168
-
Effect of metal ion on the structural stability of tumour suppressor protein p53 DNA-binding domain
-
Xue Y, et al.: Effect of metal ion on the structural stability of tumour suppressor protein p53 DNA-binding domain. J Biochem 2009;146:193-200
-
(2009)
J. Biochem.
, vol.146
, pp. 193-200
-
-
Xue, Y.1
-
67
-
-
48349137105
-
The threat of instability: Neurodegeneration predicted by protein destabilization and aggregation propensity
-
Meiering EM: The threat of instability: neurodegeneration predicted by protein destabilization and aggregation propensity. PLoS Biol 2008;6:e193
-
(2008)
PLoS Biol.
, vol.6
-
-
Meiering, E.M.1
-
68
-
-
44849085505
-
Application of high-throughput isothermal denaturation to assess protein stability and screen for ligands
-
Senisterra GA, et al.: Application of high-throughput isothermal denaturation to assess protein stability and screen for ligands. J Biomol Screen 2008;13: 337-342
-
(2008)
J. Biomol. Screen.
, vol.13
, pp. 337-342
-
-
Senisterra, G.A.1
-
69
-
-
40749163248
-
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
-
Christofk HR, et al.: The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 2008;452:230-233
-
(2008)
Nature.
, vol.452
, pp. 230-233
-
-
Christofk, H.R.1
-
70
-
-
40749099894
-
Pyruvate kinase M2 is a phosphotyrosine-binding protein
-
Christofk HR, et al.: Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature 2008;452:181-186
-
(2008)
Nature.
, vol.452
, pp. 181-186
-
-
Christofk, H.R.1
-
71
-
-
0037369803
-
Mutations in genes encoding fast-twitch contractile proteins cause distal arthrogryposis syndromes
-
Sung SS, et al.: Mutations in genes encoding fast-twitch contractile proteins cause distal arthrogryposis syndromes. Am J Hum Genet 2003;72:681-690
-
(2003)
Am. J. Hum. Genet.
, vol.72
, pp. 681-690
-
-
Sung, S.S.1
-
72
-
-
0034841005
-
Vertebrate tropomyosin: Distribution, properties and function
-
Perry SV: Vertebrate tropomyosin: distribution, properties and function. J Muscle Res Cell Motil 2001;22:5-49
-
(2001)
J. Muscle. Res. Cell Motil.
, vol.22
, pp. 5-49
-
-
Perry, S.V.1
-
73
-
-
77950518604
-
Thermolability of mutant MMACHC protein in the vitamin B12-responsive cblC disorder
-
Froese DS, et al.: Thermolability of mutant MMACHC protein in the vitamin B12-responsive cblC disorder. Mol Genet Metab 2010;100:29-36
-
(2010)
Mol. Genet. Metab.
, vol.100
, pp. 29-36
-
-
Froese, D.S.1
-
74
-
-
51149112727
-
Crystallization and preliminary X-ray analysis of CrgA, a LysR-type transcriptional regulator from pathogenic Neisseria meningitides MC58
-
Sainsbury S, et al.: Crystallization and preliminary X-ray analysis of CrgA, a LysR-type transcriptional regulator from pathogenic Neisseria meningitides MC58. Acta Crystallogr Sect F Struct Biol Cryst Commun 2008;64:797-801
-
(2008)
Acta. Crystallogr Sect. F. Struct Biol. Cryst. Commun.
, vol.64
, pp. 797-801
-
-
Sainsbury, S.1
-
75
-
-
34047155031
-
Enhancing recombinant protein quality and yield by protein stability profiling
-
Mezzasalma TM, et al.: Enhancing recombinant protein quality and yield by protein stability profiling. J Biomol Screen 2007;12:418-428
-
(2007)
J. Biomol. Screen.
, vol.12
, pp. 418-428
-
-
Mezzasalma, T.M.1
-
76
-
-
79960001045
-
Comparison of fluorescence and light scattering based methods to assess formation and stability of protein-protein complexes
-
Kopec J, Schneider G: Comparison of fluorescence and light scattering based methods to assess formation and stability of protein-protein complexes. J Struct Biol 2011;175:216-223
-
(2011)
J. Struct. Biol.
, vol.175
, pp. 216-223
-
-
Kopec, J.1
Schneider, G.2
-
77
-
-
79951892441
-
Screening of monoclonal antibody formulations based on highthroughput thermostability and viscositymeasurements: Design of experiment and statistical analysis
-
He F, et al.: Screening of monoclonal antibody formulations based on highthroughput thermostability and viscositymeasurements: design of experiment and statistical analysis. J Pharm Sci 2011;100:1330-1340
-
(2011)
J. Pharm. Sci.
, vol.100
, pp. 1330-1340
-
-
He, F.1
|