Crystal structures of human pantothenate kinases: Insights into allosteric regulation and mutations linked to a neurodegeneration disorder

Journal of Biological Chemistry

Volumn 282, Issue 38, 2007, Pages 27984-27993

  Bum, Soo Hong ^a   Senisterra, Guillermo ^a   Rabeh, Wael M ^a   Vedadi, Masoud ^a   Leonardi, Roberta ^c   Zhang, Yong Mei ^c   Rock, Charles O ^c   Jackowski, Suzanne ^c   Park, Hee Won ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC REGULATION; FEEDBACK INHIBITOR; NEURODEGENERATION DISORDER; THIOESTERS;

CATALYST ACTIVITY; CRYSTAL STRUCTURE; DISEASES; ENZYME INHIBITION; ESTERS; GENES; NEUROLOGY;

ENZYME ACTIVITY;

ACETYL COENZYME A; MUTANT PROTEIN; PANTOTHENATE KINASE; PANTOTHENATE KINASE1; PANTOTHENATE KINASE3; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; CRYSTAL STRUCTURE; DEGENERATIVE DISEASE; ENZYME BINDING; ENZYME STRUCTURE; GENE MUTATION; MISSENSE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION;

ALLOSTERIC SITE; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR CONFORMATION; MUTAGENESIS, SITE-DIRECTED; MUTATION; NEURODEGENERATIVE DISEASES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN BINDING; THERMODYNAMICS;

EID: 34948897631     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M701915200     Document Type: Article

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