Multiple endonucleases function to repair covalent topoisomerase I complexes in Saccharomyces cerevisiae

Genetics

Volumn 170, Issue 2, 2005, Pages 591-600

  Deng, Changchun ^a   Brown, James A ^a   You, Dongqing ^a,b   Brown, J Martin ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN; DNA TOPOISOMERASE; DOUBLE STRANDED DNA; ENDONUCLEASE; MRE11 PROTEIN; PROTEIN MUS81; PROTEIN RAD1; PROTEIN RAD27; PROTEIN SAE2; PROTEIN SLX1; PROTEIN SLX4; PROTEIN TDP1; UNCLASSIFIED DRUG;

ARTICLE; CELL PROTECTION; DELETION MUTANT; DNA ADDUCT; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; DNA SUPERCOILING; DRUG SENSITIVITY; EPISTASIS; FUNGUS GROWTH; GENOTYPE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

CAMPTOTHECIN; DNA ADDUCTS; DNA DAMAGE; DNA REPAIR; DNA TOPOISOMERASES, TYPE I; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDODEOXYRIBONUCLEASES; ENDONUCLEASES; EPISTASIS, GENETIC; EXODEOXYRIBONUCLEASES; GENE DELETION; MEIOSIS; MITOSIS; MODELS, BIOLOGICAL; MODELS, GENETIC; PHOSPHORIC DIESTER HYDROLASES; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES CEREVISIAE;

EID: 22144434446     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: 10.1534/genetics.104.028795     Document Type: Article

References (29)

1. BASTIN-SHANOWER, S. A., W. M. FRICKE, J. R. MULLEN and S. J. BRILL, 2003 The mechanism of Mus81-Mms4 cleavage site selection distinguishes it from the homologous endonuclease Rad1-Rad10. Mol. Cell. Biol. 23: 3487-3496.
2. BEGLEY, T. J., A. S. ROSENBACH, T. IDEKER and L. D. SAMSON, 2002 Damage recovery pathways in Saccharomyces cerevisiae revealed by genomic phenotyping and interactome mapping. Mol. Cancer Res. 1: 103-112.
3. BENNETT, C. B., L. K. LEWIS, G. KARTHIKEYAN, K. S. LOBACHEV, Y. H. JIN et al., 2001 Genes required for ionizing radiation resistance in yeast. Nat. Genet. 29: 426-434.
4. BIRRELL, G. W., G. GIAEVER, A. M. CHU, R. W. DAVIS and J. M. BROWN, 2001 A genome-wide screen in Saccharomyces cerevisiae for genes affecting UV radiation sensitivity. Proc. Natl. Acad. Sci. USA 98: 12608-12613.
5. BIRRELL, G. W., J. A. BROWN, H. I. WU, G. GIAEVER, A. M. CHU et al., 2002 Transcriptional response of Saccharomyces cerevisiae to DNA-damaging agents does not identify the genes that protect against these agents. Proc. Natl. Acad. Sci. USA 99: 8778-8783.
6. CHANG, M., M. BELLAOUI, C. BOONE and G. W. BROWN, 2002 A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage. Proc. Natl. Acad. Sci. USA 99:16934-16939.
7. DE LAAT, W. L., E. APPELDOORN, N. G. JASPERS and J. H. HOEIJMAKERS, 1998 DNA structural elements required for ERCC1-XPF endonuclease activity. J. Biol. Chem. 273: 7835-7842.
8. FRICKE, W. M., and S. J. BRILL, 2003 Slx1-Slx4 is a second structure-specific endonuclease functionally redundant with Sgs1-Top3. Genes Dev. 17: 1768-1778.
9. GAME, J. C., G. W. BIRRELL, J. A. BROWN, T. SHIBATA, C. BACCARI et al., 2003 Use of a genome-wide approach to identify new genes that control resistance of Saccharomyces cerevisiae to ionizing radiation. Radiat. Res. 160: 14-24.
10. GIAEVER, G., A. M. CHU, L. NI, C. CONNELLY, L. RILES et al., 2002 Functional profiling of the Saccharomyces cerevisiae genome. Nature 418: 387-391.
11. HSIANG, Y. H., M. G. LIHOU and L. F. LIU, 1989 Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. Cancer Res. 49: 5077-5082.
12. KALIRAMAN, V., J. R. MULLEN, W. M. FRICKE, S. A. BASTIN-SHANOWER and S. J. BRILL, 2001 Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonuclease. Genes Dev. 15: 2730-2740.
13. KEENEY, S., and N. KLECKNER, 1995 Covalent protein-DNA complexes at the o' strand termini of meiosis-specific double-strand breaks in yeast. Proc. Natl. Acad. Sci. USA 92: 11274-11278.
14. KEENEY, S., C. N. GIROUX and N. KLECKNER, 1997 Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family. Cell 88: 375-384.
15. LIU, C., J. J. POULIOT and H. A. NASH, 2002 Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1. Proc. Natl. Acad. Sci. USA 99: 14970-14975.
16. MCKEE, A. H., and N. KLECKNER, 1997 A general method for identifying recessive diploid-specific mutations in Saccharomyces cerevisiae, its application to the isolation of mutants blocked at intermediate stages of meiotic prophase and characterization of a new gene SAE2. Genetics 146: 797-816.
17. MOREAU, S.J. R. FERGUSON and L. S. SYMINGTON, 1999 The nuclease activity of Mrell is required for meiosis but not for mating type switching, endjoining, or telomere maintenance. Mol. Cell. Biol. 19: 556-566.
18. MULLEN, J. R., V. KALIRAMAN, S. S. IBRAHIM and S. J. BRILL, 2001 Requirement for three novel protein complexes in the absence of the Sgsl DNA helicase in Saccharomyces cerevisiae. Genetics 157: 103-118.
19. POULIOT, J. J., K. C. YAO, C. A. ROBERTSON and H. A. NASH, 1999 Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes. Science 286: 552-555.
20. POURQUIER, P., L. M. UENG, J. FERTALA, D. WANG, H. J. PARK et al., 1999 Induction of reversible complexes between eukaryotic DNA topoisomerase I and DNA-containing oxidative base damages. 7, 8-dihydro-8-oxoguanine and 5-hydroxycytosine. J. Biol. Chem. 274: 8516-8523.
21. PRINZ, S., A. AMON and F. KLEIN, 1997 Isolation of COM1, a new gene required to complete meiotic double-strand break-induced recombination in Saccharomyces cerevisiae. Genetics 146: 781-795.
22. RATTRAY, A. J., C. B. MCGILL, B. K. SHAFER and J. N. STRATHERN, 2001 Fidelity of mitotic double-strand-break repair in Saccharomyces cerevisiae: a role for SAE2/COM1. Genetics 158: 109-122.
23. SVEJSTRUP, J. Q., K. CHRISTIANSEN, I. I. GROMOVA, A. H. AXDERSEN and O. WESTERGAARD, 1991 New technique for uncoupling the cleavage and religation reactions of eukaryotic topoisomerase I. The mode of action of camptothecin at a specific recognition site. J. Mol. Biol. 222: 669-678.
24. USUI, T., T. OHTA, H. OSHIUMI, J. TOMIZAWA, H. OGAWA et al., 1998 Complex formation and functional versatility of Mre11 of budding yeast in recombination. Cell 95: 705-716.
25. VANCE, J. R., and T. E. WILSON, 2001 Repair of DNA strand breaks by the overlapping functions of lesion-specific and non-lesion-specific DNA 3′ phosphatases. Mol. Cell. Biol. 21: 7191-7198.
26. VANCE, J. R., and T. E. WILSON, 2002 Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Topi replicative damage. Proc. Natl. Acad. Sci. USA 99: 13669-13674.
27. WU, H. I., J. A. BROWN, M. J. DORIE, L. LAZZERONI and J. M. BROWN, 2004 Genome-wide identification of genes conferring resistance to the anticancer agents cisplatin, oxaliplatin, and mitomycin C. Cancer Res. 64: 3940-3948.
28. XIE, Y., Y. LIU, J. L. ARGUESO, L. A. HENRICKSEN, H. I. KAO et. al., 2001 Identification of rad27 mutations that confer differential defects in mutation avoidance, repeat tract instability, and flap cleavage. Mol. Cell. Biol. 21: 4889-4899.
29. YANG, S. W., A. B. BURGIN, JR., B. N. HUIZENGA, C. A. ROBERTSON, K. C. YAO et al., 1996 A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases. Proc. Natl. Acad. Sci. USA 93: 11534-11539.