Mechanistic insight into the role of transition-state stabilization in cyclophilin A

Journal of the American Chemical Society

Volumn 131, Issue 1, 2009, Pages 147-152

  Hamelberg, Donald ^a   Mecammon, J Andrew ^b  

^a GEORGIA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACCELERATED MOLECULAR DYNAMICS; ARGININE RESIDUE; CARBONYL OXYGEN; CATALYTIC MECHANISMS; CELL SIGNALING; CIS ISOMERS; CIS-TRANS; CIS-TRANS ISOMERIZATION; CYCLOPHILIN; CYCLOPHILIN A; ENZYME-SUBSTRATE COMPLEXES; EXPERIMENTAL TECHNIQUES; EXPLICIT SOLVENTS; HYDROGEN BOND INTERACTION; ISOMERASES; ISOMERIC STATE; N-TERMINAL; NH GROUPS; PEPTIDE BONDS; PREFERENTIAL BINDING; SWITCHING MECHANISM; TRANS ISOMERS; TRANSITION STATE;

AMINES; AMINO ACIDS; BIOLOGY; CELL MEMBRANES; ELECTRON TRANSITIONS; HYDROGEN; HYDROGEN BONDS; ISOMERIZATION; ISOMERS; MOLECULAR DYNAMICS; OXYGEN; QUANTUM CHEMISTRY; STABILIZATION; SUBSTRATES;

ENZYMES;

ARGININE; CYCLOPHILIN A; OXYGEN; PEPTIDE; SOLVENT; OLIGOPEPTIDE; PEPTIDYLPROLYL ISOMERASE;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING KINETICS; CATALYSIS; CIS ISOMER; CIS TRANS ISOMERISM; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; MOLECULAR DYNAMICS; PROTEIN INTERACTION; PROTEIN STABILITY; SIMULATION; TRANS ISOMER; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; ISOMERISM; METABOLISM; THERMODYNAMICS;

ARGININE; BINDING SITES; CATALYSIS; CYCLOPHILIN A; HYDROGEN BONDING; ISOMERISM; MODELS, MOLECULAR; OLIGOPEPTIDES; PEPTIDYLPROLYL ISOMERASE; THERMODYNAMICS;

EID: 62649138297     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja806146g     Document Type: Article

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