Wolfram syndrome 1 gene (WFS1) product localizes to secretory granules and determines granule acidification in pancreatic β-cells

Human Molecular Genetics

Volumn 20, Issue 7, 2011, Pages 1274-1284

  Hatanaka, Masayuki ^a   Tanabe, Katsuya ^a   Yanai, Akie ^a   Ohta, Yasuharu ^a   Kondo, Manabu ^a   Akiyama, Masaru ^a   Shinoda, Koh ^a   Oka, Yoshitomo ^b   Tanizawa, Yukio ^a  

^a YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; INSULIN; PROINSULIN; UNCLASSIFIED DRUG; WOLFRAM SYNDROME 1 PROTEIN;

ACIDIFICATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CELL PH; CONTROLLED STUDY; MALE; MOUSE; NONHUMAN; NULL ALLELE; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROCESSING; SECRETORY GRANULE; WILD TYPE; WOLFRAM SYNDROME;

ANIMALS; CALCIUM; ENDOPLASMIC RETICULUM; EXOCYTOSIS; GLUCOSE; HOMEOSTASIS; HUMANS; INSULIN-SECRETING CELLS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; PROINSULIN; SECRETORY VESICLES; SWEETENING AGENTS; WOLFRAM SYNDROME;

MUS;

EID: 79952586301     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddq568     Document Type: Article

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