Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats

Neuroscience Letters

Volumn 453, Issue 1, 2009, Pages 58-61

  Xu, Jingjing ^a   Wang, Shuzhen ^a   Lin, Youting ^a   Cao, Lili ^a   Wang, Rong ^b   Chi, Zhaofu ^a  

^a SHANDONG UNIVERSITY   (China)

^b Qilu Hospital of Shandong University   (China)

Author keywords

Ghrelin; Hippocampus; Neuronal death; Neuroprotective effect; Pilocarpine; Seizure

Indexed keywords

CASPASE 3; GHRELIN; PHOSPHATIDYLINOSITOL 3 KINASE; PILOCARPINE; PROTEIN BAX; PROTEIN BNIP3; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELL DEATH; CELL LOSS; CONTROLLED STUDY; HIPPOCAMPUS; MALE; NEUROPROTECTION; NISSL STAINING; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL DEATH; GHRELIN; HIPPOCAMPUS; MALE; NEUROPROTECTIVE AGENTS; PILOCARPINE; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRAMIDAL CELLS; RANDOM ALLOCATION; RATS; RATS, WISTAR; SEIZURES; SIGNAL TRANSDUCTION;

EID: 61349154154     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2009.01.067     Document Type: Article

References (24)

1. Asnaghi L., Calastretti A., Bevilacqua A., D'Agnano I., Gatti G., Canti G., Delia D., Capaccioli S., and Nicolin A. Bcl-2 phosphorylation and apoptosis activated by damaged microtubules require mTOR and are regulated by Akt. Oncogene 23 (2004) 5781-5791
2. Berilgen M.S., Mungen B., Ustundag B., and Demir C. Serum ghrelin levels are enhanced in patients with epilepsy. Seizure 15 (2006) 106-111
3. Chung H., Kim E., Lee D.H., Seo S., Ju S., Lee D., Kim H., and Park S. Ghrelin inhibits apoptosis in hypothalamic neuronal cells during oxygen-glucose deprivation. Endocrinology 148 (2007) 148-159
4. Delhanty P.J., van Koetsveld P.M., Gauna C., van de Zande B., Vitale G., Holfland L.J., and van der Lely A.J. Ghrelin and its unacylated isoform stimulated the growth of adrenocortical tumor cells via an anti-apoptotic pathway. Am. J. Endocrinol. Metab. 293 (2007) 302-309
5. Franke T.F., Kaplan D.R., and Cantley L.C. PI3K: downstream AKTion blocks apoptosis. Cell 88 (1997) 435-437
6. Granata R., Settanni F., Biancone L., Trovato L., Nano R., Bertuzii F., Destefanis S., Annunziata M., Martinetti M., Catapano F., Ghè C., Isgaard J., Papotti M., Ghigo E., and Muccioli G. Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic β-cells and human islets: involvement of 3′,5′-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2 and phosphatidyl inositol 3-kinase/Akt signaling. Endocrinology 148 (2007) 512-529
7. Guan X.M., Yu H., Palyha O.C., Mckee K.K., Feighner S.D., Sirinathsinghji D.J., Smith R.G., Van der Ploeg L.H., and Howard A.D. Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Mol. Brain Res. 48 (1997) 23-29
8. Guevas B.D., Lu Y., Mao M., Zhang J., LaPushin R., Siminovitch K., and Mills G.B. Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase. J. Biol. Chem. 276 (2001) 27455-27461
9. Henshall D.C., Araki T., Schindler C.K., Lan J.Q., Tiekoter K.L., Taki W., and Simon R.P. Activation of Bcl-2-associated death protein and counter-response of Akt within cell populations during seizure-induced neuronal death. J. Neurosci. 22 (2002) 8458-8465
10. Hou Z.C., Miao Y.Y., Gao L., Pan H., and Zhu S.G. Ghrelin-containing neuron in cerebral cortex and hypothalamus linked with the DVC of brainstem in rat. Regul. Pept. 134 (2006) 126-131
11. Hui L., Pei D.S., Zhang Q.G., Guan Q.H., and Zhang G.Y. The neuroprotection of insulin on ischemic brain injury in rat hippocampus through negative regulation of JNK signaling pathway by PI3K/Akt activation. Brain Res. 1052 (2005) 1-9
12. Kluck R.M., Bossy-Wetzel E., Green D.R., and Newmeyer D.D. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275 (1997) 1132-1136
13. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., and Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 (1999) 656-660
14. Liu Y., Wang P.S., Xie D., Liu K., and Chen L. Ghrelin reduces injury of hippocampal neurons in a rat model of cerebral ischemia/reperfusion. Chin. J. Physiol. 49 (2006) 244-250
15. Miao Y.Y., Xia Q., Hou Z.C., Zheng Y., Pan H., and Zhu S.G. Ghrelin protects cortical neuron against focal ischemia/reperfusion in rats. Biochem. Biophys. Res. Commun. 359 (2007) 780-795
16. Nakazato M., Murakami N., Date Y., Kojima M., Matsuo H., Kangawa K., and Matsukura S. A role for ghrelin in the central regulation of feeding. Nature 409 (2001) 194-198
17. Nogueiras R., Tovar S., Mitchell S.E., Rayner D.V., Archer Z.A., Dieguez C., and Williams L.M. Regulation of growth hormone secretagogue receptor gene expression in the arcuate nuclei of the rat by leptin and ghrelin. Diabetes 53 (2004) 2552-2558
18. Obay B.D., Tasdemir E., Tümer C., Bilgin H.M., and Atmaca M. Dose dependent effects of ghrelin on pentylenetetrazole-induced oxidative stress in a rat seizure model. Peptides 29 (2008) 448-455
19. Obay B.D., Tasdemir E., Tümer C., Bilgin H.M., and Sermet A. Antiepileptic effects of ghrelin on pentylenetetrazole-induced seizures in rats. Peptides 28 (2007) 1214-1219
20. Peino R., Baldelli R., Rodriguez-Garcia J., Rodriguez-Segade S., Kojima M., Kangawa K., Arvat E., Ghigo E., Dieguez C., and Casanueva F.F. Ghrelin-induced growth hormone secretion in humans. Eur. J. Endocrinol. 143 (2000) R11-14
21. Racine R.J. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr. Clin. Neurophysiol. 32 (1972) 281-294
22. Rak A., Szczepankiewicz D., and Gregoraszczuk E.Ł. Expression of ghrelin receptor, GHSR-1α, and its functional role in the porcine ovarian follicles. Growth Horm. IGF Res. 19 (2009) 68-76
23. Tschöp M., Smiley D.L., and Heiman M.L. Ghrelin induces adiposity in rodents. Nature 407 (2000) 908-913
24. Zhang Y.W., Ying B.W., Shi L.X., Fan H., Yang D.M., Xu D., Wei Y.G., Hu X.B., Zhang Y.G., Zhang X.H., Wang T., Liu D.S., Dou L.Y., Chen G., Jiang F., and Wen F.Q. Ghrelin inhibit cell apoptosis in pancreatic beta cell line HIT-T15 via mitogen-activated protein kinase/phosphoinositide3-kinase pathways. Toxicology 237 (2007) 194-202