Beneficial effects of desacyl-ghrelin, hexarelin and EP-80317 in models of status epilepticus

European Journal of Pharmacology

Volumn 670, Issue 1, 2011, Pages 130-136

  Biagini, Giuseppe ^a   Torsello, Antonio ^b   Marinelli, Carla ^a   Gualtieri, Fabio ^a   Vezzali, Riccardo ^a   Coco, Silvia ^b   Bresciani, Elena ^b   Locatelli, Vittorio ^b  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

Desacyl ghrelin; Epilepsy; Ghrelin; Growth hormone secretagogue; Kainate; Pilocarpine

Indexed keywords

DESACYL GHRELIN; EP 80317; GHRELIN; GROWTH HORMONE RELEASING FACTOR DERIVATIVE; HEXARELIN; JMV 2959; KAINIC ACID; MACIMORELIN; PILOCARPINE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; EPILEPTIC STATE; GRAND MAL SEIZURE; MALE; MORTALITY; NONHUMAN; PRIORITY JOURNAL; RAT; SURVIVAL RATE; TONIC CLONIC SEIZURE; TREATMENT OUTCOME;

ANIMALS; DISEASE MODELS, ANIMAL; GHRELIN; KAINIC ACID; MALE; OLIGOPEPTIDES; PEPTIDES; PILOCARPINE; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES; STATUS EPILEPTICUS;

EID: 80054743461     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.08.020     Document Type: Article

References (42)

1. A. Asakawa, A. Inui, M. Fujimiya, R. Sakamaki, N. Shinfuku, Y. Ueta, M.M. Meguid, and M. Kasuga Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin Gut 54 2005 18 24 (Pubitemid 40007213)
2. A. Aslan, M. Yildirim, M. Ayyildiz, A. Güven, and E. Agar The role of nitric oxide in the inhibitory effect of ghrelin against penicillin-induced epileptiform activity in rat Neuropeptides 43 2009 295 302
3. M. Avoli, M. D'Antuono, J. Louvel, R. Köhling, G. Biagini, R. Pumain, G. D'Arcangelo, and V. Tancredi Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro Prog. Neurobiol. 68 2002 167 207
4. S. Aydin, E. Dag, Y. Ozkan, O. Arslan, G. Koc, S. Bek, S. Kirbas, T. Kasikci, D. Abasli, Z. Gokcil, Z. Odabasi, and Z. Catak Time-dependent changes in the serum levels of prolactin, nesfatin-1 and ghrelin as a marker of epileptic attacks young male patients Peptides 32 2011 1276 1280
5. G. Baldanzi, N. Filigheddu, S. Cutrupi, F. Catapano, S. Bonissoni, A. Fubini, D. Malan, G. Baj, R. Granata, F. Broglio, M. Papotti, N. Surico, F. Bussolino, J. Isgaard, R. Deghenghi, F. Sinigaglia, M. Prat, G. Muccioli, E. Ghigo, and A. Graziani Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT J. Cell Biol. 159 2002 1029 1037 (Pubitemid 36055757)
6. S. Balosso, M. Maroso, M. Sanchez-Alavez, T. Ravizza, A. Frasca, T. Bartfai, and A. Vezzani A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1β Brain 131 2008 3256 3265
7. Y. Ben-Ari, and R. Cossart Kainate, a double agent that generates seizures: two decades of progress Trends Neurosci. 23 2000 580 587
8. G. Biagini, E. Baldelli, D. Longo, M.B. Contri, U. Guerrini, L. Sironi, P. Gelosa, I. Zini, D.S. Ragsdale, and M. Avoli Proepileptic influence of a focal vascular lesion affecting entorhinal cortex-CA3 connections after status epilepticus J. Neuropathol. Exp. Neurol. 67 2008 687 701
9. A. Bortel, M. Lévesque, G. Biagini, J. Gotman, and M. Avoli Convulsive status epilepticus duration as determinant for epileptogenesis and interictal discharge generation in the rat limbic system Neurobiol. Dis. 40 2010 478 489
10. K. Bujold, D. Rhainds, C. Jossart, M. Febbraio, S. Marleau, and H. Ong CD36-mediated cholesterol efflux is associated with PPARγ activation via a MAPK-dependent COX-2 pathway in macrophages Cardiovasc. Res. 83 2009 457 464
11. I. Bulgarelli, L. Tamiazzo, E. Bresciani, D. Rapetti, S. Caporali, D. Lattuada, V. Locatelli, and A. Torsello Desacyl-ghrelin and synthetic GH-secretagogues modulate the production of inflammatory cytokines in mouse microglia cells stimulated by beta-amyloid fibrils J. Neurosci. Res. 87 2009 2718 2727
12. C.Y. Chen, A. Asakawa, M. Fujimiya, S.D. Lee, and A. Inui Ghrelin gene products and the regulation of food intake and gut motility Pharmacol. Rev. 61 2009 430 481
13. G. Curia, D. Longo, G. Biagini, R.S. Jones, and M. Avoli The pilocarpine model of temporal lobe epilepsy J. Neurosci. Methods 172 2008 143 157
14. A.P. Davenport, T.I. Bonner, S.M. Foord, A.J. Harmar, R.R. Neubig, J.P. Pin, M. Spedding, M. Kojima, and K. Kangawa International Union of Pharmacology. LVI. Ghrelin receptor nomenclature, distribution, and function Pharmacol. Rev. 57 2005 541 546 (Pubitemid 43036440)
15. L. Demange, D. Boeglin, A. Moulin, D. Mousseaux, J. Ryan, G. Bergé, D. Gagne, A. Heitz, D. Perrissoud, V. Locatelli, A. Torsello, J.C. Galleyrand, J.A. Fehrentz, and J. Martinez Synthesis and pharmacological in vitro and in vivo evaluations of novel triazole derivatives as ligands of the ghrelin receptor. 1 J. Med. Chem. 50 2007 1939 1957 (Pubitemid 46626603)
16. A. Demers, N. McNicoll, M. Febbraio, M. Servant, S. Marleau, R. Silverstein, and H. Ong Identification of the growth hormone-releasing peptide binding site in CD36: a photoaffinity cross-linking study Biochem. J. 382 2004 417 424 (Pubitemid 39243907)
17. P.F. Fabene, G. Navarro Mora, M. Martinello, B. Rossi, F. Merigo, L. Ottoboni, S. Bach, S. Angiari, D. Benati, A. Chakir, L. Zanetti, F. Schio, A. Osculati, P. Marzola, E. Nicolato, J.W. Homeister, L. Xia, J.B. Lowe, R.P. McEver, F. Osculati, A. Sbarbati, E.C. Butcher, and G. Constantin A role for leukocyte-endothelial adhesion mechanisms in epilepsy Nat. Med. 14 2008 1377 1383
18. V. Guerlavais, D. Boeglin, D. Mousseaux, C. Oiry, A. Heitz, R. Deghenghi, V. Locatelli, A. Torsello, C. Ghé, F. Catapano, G. Muccioli, J.C. Galleyrand, J.A. Fehrentz, and J. Martinez New active series of growth hormone secretagogues J. Med. Chem. 46 2003 1191 1203 (Pubitemid 36428224)
19. S. Hwang, M. Moon, S. Kim, L. Hwang, K.J. Ahn, and S. Park Neuroprotective effect of ghrelin is associated with decreased expression of prostate apoptosis response-4 Endocr. J. 56 2009 609 617
20. I. Johansson, S. Destefanis, N.D. Aberg, M.A. Aberg, K. Blomgren, C. Zhu, C. Ghè, R. Granata, E. Ghigo, G. Muccioli, P.S. Eriksson, and J. Isgaard Proliferative and protective effects of growth hormone secretagogues on adult rat hippocampal progenitor cells Endocrinology 149 2008 2191 2199 (Pubitemid 351574514)
21. M.J. Kleinz, J.J. Maguire, J.N. Skepper, and A.P. Davenport Functional and immunocytochemical evidence for a role of ghrelin and des-octanoyl ghrelin in the regulation of vascular tone in man Cardiovasc. Res. 69 2006 227 235 (Pubitemid 41814824)
22. M. Kojima, and K. Kangawa Ghrelin: structure and function Physiol. Rev. 85 2005 495 522 (Pubitemid 40404635)
23. K.I. Koyama, D. Yasuhara, T. Nakahara, T. Harada, M. Uehara, M. Ushikai, A. Asakawa, and A. Inui Changes in acyl ghrelin, des-acyl ghrelin, and ratio of acyl ghrelin to total ghrelin with short-term refeeding in female inpatients with restricting-type anorexia nervosa Horm. Metab. Res. 42 2010 595 598
24. P.V. Lear, M.J. Iglesias, S. Feijóo-Bandín, D. Rodríguez-Penas, A. Mosquera-Leal, V. García-Rúa, O. Gualillo, C. Ghè, E. Arnoletti, G. Muccioli, C. Diéguez, J.R. González-Juanatey, and F. Lago Des-acyl ghrelin has specific binding sites and different metabolic effects from ghrelin in cardiomyocytes Endocrinology 151 2010 3286 3298
25. J. Lee, E. Lim, Y. Kim, E. Li, and S. Park Ghrelin attenuates kainic acid-induced neuronal cell death in the mouse hippocampus J. Endocrinol. 205 2010 263 270
26. N. Marchi, Q. Fan, C. Ghosh, V. Fazio, F. Bertolini, G. Betto, A. Batra, E. Carlton, I. Najm, T. Granata, and D. Janigro Antagonism of peripheral inflammation reduces the severity of status epilepticus Neurobiol. Dis. 33 2009 171 181
27. M. Maroso, S. Balosso, T. Ravizza, J. Liu, E. Aronica, A.M. Iyer, C. Rossetti, M. Molteni, M. Casalgrandi, A.A. Manfredi, M.E. Bianchi, and A. Vezzani Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures Nat. Med. 16 2010 413 419
28. Y. Miao, Q. Xia, Z. Hou, Y. Zheng, H. Pan, and S. Zhu Ghrelin protects cortical neuron against focal ischemia/reperfusion in rats Biochem. Biophys. Res. Commun. 359 2007 795 800 (Pubitemid 46899020)
29. A. Moulin, L. Demange, G. Bergé, D. Gagne, J. Ryan, D. Mousseaux, A. Heitz, D. Perrissoud, V. Locatelli, A. Torsello, J.C. Galleyrand, J.A. Fehrentz, and J. Martinez Toward potent ghrelin receptor ligands based on trisubstituted 1,2,4-triazole structure. 2. Synthesis and pharmacological in vitro and in vivo evaluations J. Med. Chem. 50 2007 5790 5806 (Pubitemid 350106034)
30. A. Moulin, L. Demange, J. Ryan, D. Mousseaux, P. Sanchez, G. Bergé, D. Gagne, D. Perrissoud, V. Locatelli, A. Torsello, J.C. Galleyrand, J.A. Fehrentz, and J. Martinez New trisubstituted 1,2,4-triazole derivatives as potent ghrelin receptor antagonists. 3. Synthesis and pharmacological in vitro and in vivo evaluations J. Med. Chem. 51 2008 689 693 (Pubitemid 351252298)
31. 125I-labeled ghrelin to membranes from human hypothalamus and pituitary gland J. Endocrinol. Invest. 24 2001 RC7 RC9
32. G. Muccioli, F. Broglio, E. Tarabra, and E. Ghigo Known and unknown growth hormone secretagogue receptors and their ligands E. Ghigo, A. Benso, F. Broglio, Endocrine Updates vol. 23 2004 Springer Berlin 27 45
33. E.G. Neal, and J.H. Cross Efficacy of dietary treatments for epilepsy J. Hum. Nutr. Diet. 23 2010 113 119
34. B.D. Obay, E. Tasdemir, C. Tümer, H.M. Bilgin, and A. Sermet Antiepileptic effects of ghrelin on pentylenetetrazole-induced seizures in rats Peptides 28 2007 1214 1219 (Pubitemid 46843389)
35. C. Pemberton, P. Wimalasena, T. Yandle, S. Soule, and M. Richards C-terminal pro-ghrelin peptides are present in the human circulation Biochem. Biophys. Res. Commun. 310 2003 567 573 (Pubitemid 37163702)
36. F. Prodam, S. Bellone, G. Casara, F. De Rienzo, E.C. Grassino, I. Bonsignori, I. Demarchi, A. Rapa, G. Radetti, and G. Bona Ghrelin levels are reduced in prepubertal epileptic children under treatment with carbamazepine or valproic acid Epilepsia 51 2010 312 315
37. R.J. Racine Modification of seizure activity by electrical stimulation. II. Motor seizure Electroencephalogr. Clin. Neurophysiol. 32 1972 281 294
38. S.S. Spencer When should temporal-lobe epilepsy be treated surgically? Lancet Neurol. 1 2002 375 382 (Pubitemid 37159163)
39. L. Uva, L. Librizzi, N. Marchi, F. Noe, R. Bongiovanni, A. Vezzani, D. Janigro, and M. de Curtis Acute induction of epileptiform discharges by pilocarpine in the in vitro isolated guinea-pig brain requires enhancement of blood-brain barrier permeability Neuroscience 151 2008 303 312
40. J.D. Veldhuis, and C.Y. Bowers Integrating GHS into the ghrelin system Int. J. Pept. 2010 pii 879503, PMID 20798846
41. J.W. Wheless History of the ketogenic diet Epilepsia 49 Suppl. 8 2008 3 5
42. J. Xu, S. Wang, Y. Lin, L. Cao, R. Wang, and Z. Chi Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats Neurosci. Lett. 453 2009 58 61