메뉴 건너뛰기




Volumn 27, Issue 5, 2012, Pages 537-548

Intranasal administration: A potential solution for cross-BBB delivering neurotrophic factors

Author keywords

Intranasal; Neurodegenerative diseases; Neuroprotection; Neurotrophic factors; Stroke

Indexed keywords

NERVE GROWTH FACTOR;

EID: 84859339989     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (33)

References (115)
  • 1
    • 0028788303 scopus 로고
    • A phase I study of recombinant human ciliary neurotrophic factor (rHCNTF) in patients with amyotrophic lateral sclerosis. The ALS CNTF Treatment Study (ACTS) Phase I-II Study Group
    • ACTS-Phase-I/II-Study-Group
    • ACTS-Phase-I/II-Study-Group. (1995). A phase I study of recombinant human ciliary neurotrophic factor (rHCNTF) in patients with amyotrophic lateral sclerosis. The ALS CNTF Treatment Study (ACTS) Phase I-II Study Group. Clin. Neuropharmacol. 18, 515-532.
    • (1995) Clin. Neuropharmacol , vol.18 , pp. 515-532
  • 2
    • 0024962725 scopus 로고
    • Potential use of nerve growth factor to treat Alzheimer's disease
    • Ad-Hoc-Working-Group
    • Ad-Hoc-Working-Group. (1989). Potential use of nerve growth factor to treat Alzheimer's disease. Science 243, 11.
    • (1989) Science , vol.243 , pp. 11
  • 4
    • 2442646665 scopus 로고    scopus 로고
    • A double-blind placebocontrolled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis
    • ALS-CNTF-Treatment-Study-Group, ALS CNTF Treatment Study Group
    • ALS-CNTF-Treatment-Study-Group. (1996). A double-blind placebocontrolled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis. ALS CNTF Treatment Study Group. Neurology 46, 1244-1249.
    • (1996) Neurology , vol.46 , pp. 1244-1249
  • 6
    • 0034328085 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant human nerve growth factor in patients with diabetic polyneuropathy: A randomized controlled trial
    • rhNGF Clinical Investigator Group
    • Apfel S.C., Schwartz S., Adornato B.T., Freeman R., Biton V., Rendell M., Vinik A., Giuliani M., Stevens J.C., Barbano R. and Dyck P.J. (2000). Efficacy and safety of recombinant human nerve growth factor in patients with diabetic polyneuropathy: A randomized controlled trial. rhNGF Clinical Investigator Group. JAMA 284, 2215-2221.
    • (2000) JAMA , vol.284 , pp. 2215-2221
    • Apfel, S.C.1    Schwartz, S.2    Adornato, B.T.3    Freeman, R.4    Biton, V.5    Rendell, M.6    Vinik, A.7    Giuliani, M.8    Stevens, J.C.9    Barbano, R.10    Dyck, P.J.11
  • 7
    • 0032892598 scopus 로고    scopus 로고
    • Potential usefulness of basic fibroblast growth factor as a treatment for stroke
    • Ay H., Ay I., Koroshetz W.J. and Finklestein S.P. (1999). Potential usefulness of basic fibroblast growth factor as a treatment for stroke. Cerebrovasc. Dis. 9, 131-135.
    • (1999) Cerebrovasc. Dis , vol.9 , pp. 131-135
    • Ay, H.1    Ay, I.2    Koroshetz, W.J.3    Finklestein, S.P.4
  • 8
    • 58149192688 scopus 로고    scopus 로고
    • Delivery of peptides to the brain: Emphasis on therapeutic development
    • Banks W.A. (2008). Delivery of peptides to the brain: emphasis on therapeutic development. Biopolymers 90, 589-594.
    • (2008) Biopolymers , vol.90 , pp. 589-594
    • Banks, W.A.1
  • 9
    • 67650033008 scopus 로고    scopus 로고
    • Characteristics of compounds that cross the bloodbrain barrier
    • Banks W.A. (2009). Characteristics of compounds that cross the bloodbrain barrier. BMC Neurol. 9 (Suppl 1), S3.
    • (2009) BMC Neurol , vol.9 , Issue.SUPPL. 1
    • Banks, W.A.1
  • 10
    • 64449086483 scopus 로고    scopus 로고
    • Angiogenesis after cerebral ischemia
    • Beck H. and Plate K.H. (2009). Angiogenesis after cerebral ischemia. Acta. Neuropathol. 117, 481-496.
    • (2009) Acta. Neuropathol , vol.117 , pp. 481-496
    • Beck, H.1    Plate, K.H.2
  • 13
    • 0034455569 scopus 로고    scopus 로고
    • Randomized controlled trial of brain-derived neurotrophic factor in Guillain-Barre syndrome: A pilot study
    • Bensa S., Hadden R.D., Hahn A., Hughes R.A. and Willison H.J. (2000). Randomized controlled trial of brain-derived neurotrophic factor in Guillain-Barre syndrome: a pilot study. Eur. J. Neurol. 7, 423-426.
    • (2000) Eur. J. Neurol , vol.7 , pp. 423-426
    • Bensa, S.1    Hadden, R.D.2    Hahn, A.3    Hughes, R.A.4    Willison, H.J.5
  • 14
    • 0000787909 scopus 로고
    • An experimental study of the role of neurons in the dissemination of polymyelitis virus in the nervous system
    • Bodian D. and Howe H.A. (1940). An experimental study of the role of neurons in the dissemination of polymyelitis virus in the nervous system. Brain 63, 135-162.
    • (1940) Brain , vol.63 , pp. 135-162
    • Bodian, D.1    Howe, H.A.2
  • 16
    • 54949093631 scopus 로고    scopus 로고
    • Harmful effects of cadmium on olfactory system in mice
    • Bondier J.R., Michel G., Propper A. and Badot P.M. (2008). Harmful effects of cadmium on olfactory system in mice. Inhal. Toxicol. 20, 1169-1177.
    • (2008) Inhal. Toxicol , vol.20 , pp. 1169-1177
    • Bondier, J.R.1    Michel, G.2    Propper, A.3    Badot, P.M.4
  • 19
    • 8644289303 scopus 로고    scopus 로고
    • Spread and replication of and immune response to gamma134.5-negative herpes simplex virus type 1 vectors in BALB/c mice
    • Broberg E.K., Peltoniemi J., Nygardas M., Vahlberg T., Roytta M. and Hukkanen V. (2004). Spread and replication of and immune response to gamma134.5-negative herpes simplex virus type 1 vectors in BALB/c mice. J. Virol. 78, 13139-13152.
    • (2004) J. Virol , vol.78 , pp. 13139-13152
    • Broberg, E.K.1    Peltoniemi, J.2    Nygardas, M.3    Vahlberg, T.4    Roytta, M.5    Hukkanen, V.6
  • 21
    • 0037125974 scopus 로고    scopus 로고
    • Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice
    • Capsoni S., Giannotta S. and Cattaneo A. (2002). Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice. Proc. Natl. Acad. Sci. USA 99, 12432-12437.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 12432-12437
    • Capsoni, S.1    Giannotta, S.2    Cattaneo, A.3
  • 23
  • 24
    • 24644474375 scopus 로고    scopus 로고
    • Drug delivery across the blood-brain barrier
    • Chen Y., Dalwadi G. and Benson H.A. (2004). Drug delivery across the blood-brain barrier. Curr. Drug Deliv. 1, 361-376.
    • (2004) Curr. Drug Deliv , vol.1 , pp. 361-376
    • Chen, Y.1    Dalwadi, G.2    Benson, H.A.3
  • 25
    • 0026521942 scopus 로고
    • IGF-I and IGF-II protect cultured hippocampal and septal neurons against calcium-mediated hypoglycemic damage
    • Cheng B. and Mattson M.P. (1992). IGF-I and IGF-II protect cultured hippocampal and septal neurons against calcium-mediated hypoglycemic damage. J. Neurosci. 12, 1558-1566.
    • (1992) J. Neurosci , vol.12 , pp. 1558-1566
    • Cheng, B.1    Mattson, M.P.2
  • 26
    • 0003048736 scopus 로고    scopus 로고
    • Trafermin in acute ischemic stroke. Results of a phase II/III randomized efficacy study (abstract)
    • Clark W.M., Schim J.D., Kasner S.E. and Victor S. (2000). Trafermin in acute ischemic stroke. Results of a phase II/III randomized efficacy study (abstract). Neurology 54.
    • (2000) Neurology , pp. 54
    • Clark, W.M.1    Schim, J.D.2    Kasner, S.E.3    Victor, S.4
  • 30
    • 48549098794 scopus 로고    scopus 로고
    • Preliminary results from a phase I/II study of perillyl alcohol intranasal administration in adults with recurrent malignant gliomas
    • discussion
    • da Fonseca C.O., Schwartsmann G., Fischer J., Nagel J., Futuro D., Quirico-Santos T. and Gattass C.R. (2008b). Preliminary results from a phase I/II study of perillyl alcohol intranasal administration in adults with recurrent malignant gliomas. Surg. Neurol. 70, 259-266; discussion 266-257.
    • (2008) Surg. Neurol , vol.70 , pp. 259-266
    • da Fonseca, C.O.1    Schwartsmann, G.2    Fischer, J.3    Nagel, J.4    Futuro, D.5    Quirico-Santos, T.6    Gattass, C.R.7
  • 31
    • 34347387938 scopus 로고    scopus 로고
    • Strategies to improve drug delivery across the blood-brain barrier
    • de Boer A.G. and Gaillard P.J. (2007). Strategies to improve drug delivery across the blood-brain barrier. Clin. Pharmacokinet. 46, 553-576.
    • (2007) Clin. Pharmacokinet , vol.46 , pp. 553-576
    • de Boer, A.G.1    Gaillard, P.J.2
  • 32
    • 14944384581 scopus 로고    scopus 로고
    • Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice
    • De Rosa R., Garcia A.A., Braschi C., Capsoni S., Maffei L., Berardi N. and Cattaneo A. (2005). Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice. Proc. Natl. Acad. Sci. USA 102, 3811-3816.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 3811-3816
    • de Rosa, R.1    Garcia, A.A.2    Braschi, C.3    Capsoni, S.4    Maffei, L.5    Berardi, N.6    Cattaneo, A.7
  • 33
  • 34
    • 77949833508 scopus 로고    scopus 로고
    • Intranasal delivery to the central nervous system: Mechanisms and experimental considerations
    • Dhuria S.V., Hanson L.R. and Frey W.H. 2nd. (2010). Intranasal delivery to the central nervous system: mechanisms and experimental considerations. J. Pharm. Sci. 99, 1654-1673.
    • (2010) J. Pharm. Sci , vol.99 , pp. 1654-1673
    • Dhuria, S.V.1    Hanson, L.R.2    Frey II, W.H.3
  • 35
    • 0028137577 scopus 로고
    • Ciliary neurotrophic factor: Pharmacokinetics and acute-phase response in rat
    • Dittrich F., Thoenen H. and Sendtner M. (1994). Ciliary neurotrophic factor: pharmacokinetics and acute-phase response in rat. Ann. Neurol. 35, 151-163.
    • (1994) Ann. Neurol , vol.35 , pp. 151-163
    • Dittrich, F.1    Thoenen, H.2    Sendtner, M.3
  • 36
    • 63449098569 scopus 로고    scopus 로고
    • Intranasal oxytocin increases positive communication and reduces cortisol levels during couple conflict
    • Ditzen B., Schaer M., Gabriel B., Bodenmann G., Ehlert U. and Heinrichs M. (2009). Intranasal oxytocin increases positive communication and reduces cortisol levels during couple conflict. Biol. Psychiatry 65, 728-731.
    • (2009) Biol. Psychiatry , vol.65 , pp. 728-731
    • Ditzen, B.1    Schaer, M.2    Gabriel, B.3    Bodenmann, G.4    Ehlert, U.5    Heinrichs, M.6
  • 40
    • 67650848390 scopus 로고    scopus 로고
    • Intranasal delivery of erythropoietin plus insulin-like growth factor-I for acute neuroprotection in stroke. Laboratory Investigation
    • Fletcher L., Kohli S., Sprague S.M., Scranton R.A., Lipton S.A., Parra A., Jimenez D.F. and Digicaylioglu M. (2009). Intranasal delivery of erythropoietin plus insulin-like growth factor-I for acute neuroprotection in stroke. Laboratory investigation. J. Neurosurg. 111, 164-170.
    • (2009) J. Neurosurg , vol.111 , pp. 164-170
    • Fletcher, L.1    Kohli, S.2    Sprague, S.M.3    Scranton, R.A.4    Lipton, S.A.5    Parra, A.6    Jimenez, D.F.7    Digicaylioglu, M.8
  • 42
    • 0037117459 scopus 로고    scopus 로고
    • Filamentous phage as vectormediated antibody delivery to the brain
    • Frenkel D. and Solomon B. (2002). Filamentous phage as vectormediated antibody delivery to the brain. Proc. Natl. Acad. Sci. USA 99, 5675-5679.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 5675-5679
    • Frenkel, D.1    Solomon, B.2
  • 44
    • 0028807947 scopus 로고
    • Effect of hyperthyroidism on circulating levels of free and total IGF-I and IGFBPs in rats
    • Frystyk J., Gronbaek H., Skjaerbaek C. and Flyvbjerg A. (1995). Effect of hyperthyroidism on circulating levels of free and total IGF-I and IGFBPs in rats. Am. J. Physiol. 269, E840-845.
    • (1995) Am. J. Physiol , vol.269
    • Frystyk, J.1    Gronbaek, H.2    Skjaerbaek, C.3    Flyvbjerg, A.4
  • 48
    • 0021972843 scopus 로고
    • Ischemic brain edema following occlusion of the middle cerebral artery in the rat. I: The time courses of the brain water, sodium and potassium contents and blood-brain barrier permeability to 125I-albumin
    • Gotoh O., Asano T., Koide T. and Takakura K. (1985). Ischemic brain edema following occlusion of the middle cerebral artery in the rat. I: The time courses of the brain water, sodium and potassium contents and blood-brain barrier permeability to 125I-albumin. Stroke 16, 101-109.
    • (1985) Stroke , vol.16 , pp. 101-109
    • Gotoh, O.1    Asano, T.2    Koide, T.3    Takakura, K.4
  • 49
    • 0042626540 scopus 로고    scopus 로고
    • P-Glycoprotein attenuates brain uptake of substrates after nasal instillation
    • Graff C.L. and Pollack G.M. (2003). P-Glycoprotein attenuates brain uptake of substrates after nasal instillation. Pharm. Res. 20, 1225-1230.
    • (2003) Pharm. Res , vol.20 , pp. 1225-1230
    • Graff, C.L.1    Pollack, G.M.2
  • 51
    • 67349263081 scopus 로고    scopus 로고
    • A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder
    • Guastella A.J., Howard A.L., Dadds M.R., Mitchell P. and Carson D.S. (2009). A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder. Psychoneuroendocrinology 34, 917-923.
    • (2009) Psychoneuroendocrinology , vol.34 , pp. 917-923
    • Guastella, A.J.1    Howard, A.L.2    Dadds, M.R.3    Mitchell, P.4    Carson, D.S.5
  • 53
    • 33846848061 scopus 로고    scopus 로고
    • Strategies for intranasal delivery of therapeutics for the prevention and treatment of neuroAIDS
    • Hanson L.R. and Frey W.H. 2nd. (2007). Strategies for intranasal delivery of therapeutics for the prevention and treatment of neuroAIDS. J. Neuroimmune Pharmacol. 2, 81-86.
    • (2007) J. Neuroimmune Pharmacol , vol.2 , pp. 81-86
    • Hanson, L.R.1    Frey II, W.H.2
  • 55
    • 0030928225 scopus 로고    scopus 로고
    • Pharmacology of neurotrophic factors
    • Hefti F. (1997). Pharmacology of neurotrophic factors. Annu. Rev. Pharmacol. Toxicol. 37, 239-267.
    • (1997) Annu. Rev. Pharmacol. Toxicol , vol.37 , pp. 239-267
    • Hefti, F.1
  • 56
    • 32944479751 scopus 로고    scopus 로고
    • Multiple sclerosis -- a coordinated immune attack across the blood brain barrier
    • Hemmer B., Cepok S., Zhou D. and Sommer N. (2004). Multiple sclerosis -- a coordinated immune attack across the blood brain barrier. Curr. Neurovasc. Res. 1, 141-150.
    • (2004) Curr. Neurovasc. Res , vol.1 , pp. 141-150
    • Hemmer, B.1    Cepok, S.2    Zhou, D.3    Sommer, N.4
  • 57
    • 77952741221 scopus 로고    scopus 로고
    • Intranasal insulin: From nose to brain
    • Henkin R.I. (2010). Intranasal insulin: from nose to brain. Nutrition 26, 624-633.
    • (2010) Nutrition , vol.26 , pp. 624-633
    • Henkin, R.I.1
  • 58
    • 0034718896 scopus 로고    scopus 로고
    • Regenerating the damaged central nervous system
    • Horner P.J. and Gage F.H. (2000). Regenerating the damaged central nervous system. Nature 407, 963-970.
    • (2000) Nature , vol.407 , pp. 963-970
    • Horner, P.J.1    Gage, F.H.2
  • 60
    • 77956231757 scopus 로고    scopus 로고
    • The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia
    • Iadecola C. (2010). The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia. Acta. Neuropathol. 120, 287-296.
    • (2010) Acta. Neuropathol , vol.120 , pp. 287-296
    • Iadecola, C.1
  • 61
    • 0034095651 scopus 로고    scopus 로고
    • Transport of drugs from the nasal cavity to the central nervous system
    • Illum L. (2000). Transport of drugs from the nasal cavity to the central nervous system. Eur. J. Pharm. Sci. 11, 1-18.
    • (2000) Eur. J. Pharm. Sci , vol.11 , pp. 1-18
    • Illum, L.1
  • 62
    • 1042269557 scopus 로고    scopus 로고
    • Is nose-to-brain transport of drugs in man a reality
    • Illum L. (2004). Is nose-to-brain transport of drugs in man a reality? J. Pharm. Pharmacol. 56, 3-17.
    • (2004) J. Pharm. Pharmacol , vol.56 , pp. 3-17
    • Illum, L.1
  • 63
    • 78650748359 scopus 로고    scopus 로고
    • Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats
    • Jiang Y., Wei N., Lu T., Zhu J., Xu G. and Liu X. (2011a). Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats. Neuroscience 172, 398-405.
    • (2011) Neuroscience , vol.172 , pp. 398-405
    • Jiang, Y.1    Wei, N.2    Lu, T.3    Zhu, J.4    Xu, G.5    Liu, X.6
  • 64
    • 79955122693 scopus 로고    scopus 로고
    • Intranasal delivery of stem cells to the brain
    • Jiang Y., Zhu J., Xu G. and Liu X. (2011b). Intranasal delivery of stem cells to the brain. Expert Opin. Drug Deliv. 8, 623-632.
    • (2011) Expert Opin. Drug Deliv , vol.8 , pp. 623-632
    • Jiang, Y.1    Zhu, J.2    Xu, G.3    Liu, X.4
  • 65
    • 0033432875 scopus 로고    scopus 로고
    • Peptides crossing the blood-brain barrier: Some unusual observations
    • Kastin A.J., Pan W., Maness L.M. and Banks W.A. (1999). Peptides crossing the blood-brain barrier: some unusual observations. Brain Res. 848, 96-100.
    • (1999) Brain Res , vol.848 , pp. 96-100
    • Kastin, A.J.1    Pan, W.2    Maness, L.M.3    Banks, W.A.4
  • 66
    • 0025265681 scopus 로고
    • Selective and nonselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II
    • Knusel B., Michel P.P., Schwaber J.S. and Hefti F. (1990). Selective and nonselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II. J. Neurosci. 10, 558-570.
    • (1990) J. Neurosci , vol.10 , pp. 558-570
    • Knusel, B.1    Michel, P.P.2    Schwaber, J.S.3    Hefti, F.4
  • 67
    • 65249096594 scopus 로고    scopus 로고
    • Insulin-like growth factor I: A potential neuroprotective compound for the treatment of acute ischemic stroke?
    • Kooijman R., Sarre S., Michotte Y. and De Keyser J. (2009). Insulin-like growth factor I: a potential neuroprotective compound for the treatment of acute ischemic stroke? Stroke 40, e83-88.
    • (2009) Stroke , vol.40
    • Kooijman, R.1    Sarre, S.2    Michotte, Y.3    de Keyser, J.4
  • 70
    • 6844266272 scopus 로고    scopus 로고
    • Effect of recombinant human insulin-like growth factor-I on progression of ALS. A placebo-controlled study
    • The North America ALS/IGF-I Study Group
    • Lai E.C., Felice K.J., Festoff B.W., Gawel M.J., Gelinas D.F., Kratz R., Murphy M.F., Natter H.M., Norris F.H. and Rudnicki S.A. (1997). Effect of recombinant human insulin-like growth factor-I on progression of ALS. A placebo-controlled study. The North America ALS/IGF-I Study Group. Neurology 49, 1621-1630.
    • (1997) Neurology , vol.49 , pp. 1621-1630
    • Lai, E.C.1    Felice, K.J.2    Festoff, B.W.3    Gawel, M.J.4    Gelinas, D.F.5    Kratz, R.6    Murphy, M.F.7    Natter, H.M.8    Norris, F.H.9    Rudnicki, S.A.10
  • 72
    • 0027285510 scopus 로고
    • GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
    • Lin L.F., Doherty D.H., Lile J.D., Bektesh S. and Collins F. (1993). GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260, 1130-1132.
    • (1993) Science , vol.260 , pp. 1130-1132
    • Lin, L.F.1    Doherty, D.H.2    Lile, J.D.3    Bektesh, S.4    Collins, F.5
  • 73
    • 67349099863 scopus 로고    scopus 로고
    • Intranasal administration of IGF-1 attenuates hypoxic-ischemic brain injury in neonatal rats
    • Lin S., Fan L.W., Rhodes P.G. and Cai Z. (2009). Intranasal administration of IGF-1 attenuates hypoxic-ischemic brain injury in neonatal rats. Exp. Neurol. 217, 361-370.
    • (2009) Exp. Neurol , vol.217 , pp. 361-370
    • Lin, S.1    Fan, L.W.2    Rhodes, P.G.3    Cai, Z.4
  • 74
    • 0035875455 scopus 로고    scopus 로고
    • Intranasal administration of insulin-like growth factor-I bypasses the blood-brain barrier and protects against focal cerebral ischemic damage
    • Liu X.F., Fawcett J.R., Thorne R.G., DeFor T.A. and Frey W.H. 2nd. (2001). Intranasal administration of insulin-like growth factor-I bypasses the blood-brain barrier and protects against focal cerebral ischemic damage. J. Neurol. Sci. 187, 91-97.
    • (2001) J. Neurol. Sci , vol.187 , pp. 91-97
    • Liu, X.F.1    Fawcett, J.R.2    Thorne, R.G.3    Defor, T.A.4    Frey II, W.H.5
  • 75
    • 34548036512 scopus 로고    scopus 로고
    • Intranasally delivered TGF-beta1 enters brain and regulates gene expressions of its receptors in rats
    • Ma Y.P., Ma M.M., Ge S., Guo R.B., Zhang H.J., Frey W.H. 2nd, Xu G.L. and Liu X.F. (2007). Intranasally delivered TGF-beta1 enters brain and regulates gene expressions of its receptors in rats. Brain Res. Bull. 74, 271-277.
    • (2007) Brain Res. Bull , vol.74 , pp. 271-277
    • Ma, Y.P.1    Ma, M.M.2    Ge, S.3    Guo, R.B.4    Zhang, H.J.5    Frey II, W.H.6    Xu, G.L.7    Liu, X.F.8
  • 76
    • 60649091914 scopus 로고    scopus 로고
    • Intranasal delivery of transforming growth factorbeta1 in mice after stroke reduces infarct volume and increases neurogenesis in the subventricular zone
    • Ma M., Ma Y., Yi X., Guo R., Zhu W., Fan X., Xu G., Frey W.H. 2nd and Liu X. (2008a). Intranasal delivery of transforming growth factorbeta1 in mice after stroke reduces infarct volume and increases neurogenesis in the subventricular zone. BMC Neurosci. 9, 117.
    • (2008) BMC Neurosci , vol.9 , pp. 117
    • Ma, M.1    Ma, Y.2    Yi, X.3    Guo, R.4    Zhu, W.5    Fan, X.6    Xu, G.7    Frey II, W.H.8    Liu, X.9
  • 77
    • 42749087764 scopus 로고    scopus 로고
    • Intranasal bFGF-induced progenitor cell proliferation and neuroprotection after transient focal cerebral ischemia
    • Ma Y.P., Ma M.M., Cheng S.M., Ma H.H., Yi X.M., Xu G.L. and Liu X.F. (2008b). Intranasal bFGF-induced progenitor cell proliferation and neuroprotection after transient focal cerebral ischemia. Neurosci. Lett. 437, 93-97.
    • (2008) Neurosci. Lett , vol.437 , pp. 93-97
    • Ma, Y.P.1    Ma, M.M.2    Cheng, S.M.3    Ma, H.H.4    Yi, X.M.5    Xu, G.L.6    Liu, X.F.7
  • 79
    • 0027463404 scopus 로고
    • Contributions of ions and albumin to the formation and resolution of ischemic brain edema
    • Menzies S.A., Betz A.L. and Hoff J.T. (1993). Contributions of ions and albumin to the formation and resolution of ischemic brain edema. J. Neurosurg. 78, 257-266.
    • (1993) J. Neurosurg , vol.78 , pp. 257-266
    • Menzies, S.A.1    Betz, A.L.2    Hoff, J.T.3
  • 80
    • 34248218097 scopus 로고    scopus 로고
    • Can nasal drug delivery bypass the blood-brain barrier?: Questioning the direct transport theory
    • Merkus F.W. and van den Berg M.P. (2007). Can nasal drug delivery bypass the blood-brain barrier?: questioning the direct transport theory. Drugs R. D. 8, 133-144.
    • (2007) Drugs R. D , vol.8 , pp. 133-144
    • Merkus, F.W.1    van den Berg, M.P.2
  • 81
    • 0037799484 scopus 로고    scopus 로고
    • Direct access of drugs to the human brain after intranasal drug administration?
    • Merkus P., Guchelaar H.J., Bosch D.A. and Merkus F.W. (2003). Direct access of drugs to the human brain after intranasal drug administration? Neurology 60, 1669-1671.
    • (2003) Neurology , vol.60 , pp. 1669-1671
    • Merkus, P.1    Guchelaar, H.J.2    Bosch, D.A.3    Merkus, F.W.4
  • 83
    • 0035845757 scopus 로고    scopus 로고
    • Effect of poly-L-arginine on the nasal absorption of FITC-dextran of different molecular weights and recombinant human granulocyte colonystimulating factor (rhG-CSF) in rats
    • Miyamoto M., Natsume H., Satoh I., Ohtake K., Yamaguchi M., Kobayashi D., Sugibayashi K. and Morimoto Y. (2001). Effect of poly-L-arginine on the nasal absorption of FITC-dextran of different molecular weights and recombinant human granulocyte colonystimulating factor (rhG-CSF) in rats. Int. J. Pharm. 226, 127-138.
    • (2001) Int. J. Pharm , vol.226 , pp. 127-138
    • Miyamoto, M.1    Natsume, H.2    Satoh, I.3    Ohtake, K.4    Yamaguchi, M.5    Kobayashi, D.6    Sugibayashi, K.7    Morimoto, Y.8
  • 88
    • 0032404127 scopus 로고    scopus 로고
    • Transport of brain-derived neurotrophic factor across the blood-brain barrier
    • Pan W., Banks W.A., Fasold M.B., Bluth J. and Kastin A.J. (1998). Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 37, 1553-1561.
    • (1998) Neuropharmacology , vol.37 , pp. 1553-1561
    • Pan, W.1    Banks, W.A.2    Fasold, M.B.3    Bluth, J.4    Kastin, A.J.5
  • 89
    • 12344273726 scopus 로고    scopus 로고
    • The blood-brain barrier: Bottleneck in brain drug development
    • Pardridge W.M. (2005). The blood-brain barrier: bottleneck in brain drug development. NeuroRx 2, 3-14.
    • (2005) NeuroRx , vol.2 , pp. 3-14
    • Pardridge, W.M.1
  • 90
    • 13144282676 scopus 로고    scopus 로고
    • Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: A two-year outcome study
    • Patel N.K., Bunnage M., Plaha P., Svendsen C.N., Heywood P. and Gill S.S. (2005). Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: a two-year outcome study. Ann. Neurol. 57, 298-302.
    • (2005) Ann. Neurol , vol.57 , pp. 298-302
    • Patel, N.K.1    Bunnage, M.2    Plaha, P.3    Svendsen, C.N.4    Heywood, P.5    Gill, S.S.6
  • 91
    • 0031028248 scopus 로고    scopus 로고
    • Intrathecal ciliary neurotrophic factor delivery for treatment of amyotrophic lateral sclerosis (phase I trial)
    • discussion 99-100
    • Penn R.D., Kroin J.S., York M.M. and Cedarbaum J.M. (1997). Intrathecal ciliary neurotrophic factor delivery for treatment of amyotrophic lateral sclerosis (phase I trial). Neurosurgery 40, 94-99; discussion 99-100.
    • (1997) Neurosurgery Discussion , vol.40 , pp. 94-99
    • Penn, R.D.1    Kroin, J.S.2    York, M.M.3    Cedarbaum, J.M.4
  • 92
    • 33747368249 scopus 로고    scopus 로고
    • Blood-brain barrier: Structural components and function under physiologic and pathologic conditions
    • Persidsky Y., Ramirez S.H., Haorah J. and Kanmogne G.D. (2006). Blood-brain barrier: structural components and function under physiologic and pathologic conditions. J. Neuroimmune Pharmacol. 1, 223-236.
    • (2006) J. Neuroimmune Pharmacol , vol.1 , pp. 223-236
    • Persidsky, Y.1    Ramirez, S.H.2    Haorah, J.3    Kanmogne, G.D.4
  • 97
    • 0032873417 scopus 로고    scopus 로고
    • Neuroprotection mediated via neurotrophic factors and induction of neurotrophic factors
    • Semkova I. and Krieglstein J. (1999). Neuroprotection mediated via neurotrophic factors and induction of neurotrophic factors. Brain Res. Brain Res. Rev. 30, 176-188.
    • (1999) Brain Res. Brain Res. Rev , vol.30 , pp. 176-188
    • Semkova, I.1    Krieglstein, J.2
  • 98
    • 0026749255 scopus 로고
    • Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy
    • Sendtner M., Schmalbruch H., Stockli K.A., Carroll P., Kreutzberg G.W. and Thoenen H. (1992). Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy. Nature 358, 502-504.
    • (1992) Nature , vol.358 , pp. 502-504
    • Sendtner, M.1    Schmalbruch, H.2    Stockli, K.A.3    Carroll, P.4    Kreutzberg, G.W.5    Thoenen, H.6
  • 99
    • 14844311296 scopus 로고    scopus 로고
    • Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor
    • Slevin J.T., Gerhardt G.A., Smith C.D., Gash D.M., Kryscio R. and Young B. (2005). Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor. J. Neurosurg. 102, 216-222.
    • (2005) J. Neurosurg , vol.102 , pp. 216-222
    • Slevin, J.T.1    Gerhardt, G.A.2    Smith, C.D.3    Gash, D.M.4    Kryscio, R.5    Young, B.6
  • 100
    • 34047220707 scopus 로고    scopus 로고
    • Unilateral intraputamenal glial cell line-derived neurotrophic factor in patients with Parkinson disease: Response to 1 year of treatment and 1 year of withdrawal
    • Slevin J.T., Gash D.M., Smith C.D., Gerhardt G.A., Kryscio R., Chebrolu H., Walton A., Wagner R. and Young A.B. (2007). Unilateral intraputamenal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year of treatment and 1 year of withdrawal. J. Neurosurg. 106, 614-620.
    • (2007) J. Neurosurg , vol.106 , pp. 614-620
    • Slevin, J.T.1    Gash, D.M.2    Smith, C.D.3    Gerhardt, G.A.4    Kryscio, R.5    Chebrolu, H.6    Walton, A.7    Wagner, R.8    Young, A.B.9
  • 102
    • 0344076149 scopus 로고    scopus 로고
    • A controlled trial of recombinant methionyl human BDNF in ALS: The BDNF Study Group (Phase III)
    • The-BDNF-Study-Group
    • The-BDNF-Study-Group. (1999). A controlled trial of recombinant methionyl human BDNF in ALS: The BDNF Study Group (Phase III). Neurology 52, 1427-1433.
    • (1999) Neurology , vol.52 , pp. 1427-1433
  • 103
    • 0000543835 scopus 로고    scopus 로고
    • Clinical safety trial of intravenous basic fibroblast growth factor (bFGF, FIBLAST) in acute stroke (abstract)
    • The-Fibroblast-Safety-Study-Group
    • The-Fibroblast-Safety-Study-Group. (1998). Clinical safety trial of intravenous basic fibroblast growth factor (bFGF, FIBLAST) in acute stroke (abstract). Stroke 29, 287.
    • (1998) Stroke , vol.29 , pp. 287
  • 104
    • 0035693963 scopus 로고    scopus 로고
    • Delivery of neurotrophic factors to the central nervous system: Pharmacokinetic considerations
    • Thorne R.G. and Frey W.H. 2nd. (2001). Delivery of neurotrophic factors to the central nervous system: pharmacokinetic considerations. Clin. Pharmacokinet. 40, 907-946.
    • (2001) Clin. Pharmacokinet , vol.40 , pp. 907-946
    • Thorne, R.G.1    Frey II, W.H.2
  • 105
    • 3242740239 scopus 로고    scopus 로고
    • Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration
    • Thorne R.G., Pronk G.J., Padmanabhan V. and Frey W.H. 2nd. (2004). Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience 127, 481-496.
    • (2004) Neuroscience , vol.127 , pp. 481-496
    • Thorne, R.G.1    Pronk, G.J.2    Padmanabhan, V.3    Frey II, W.H.4
  • 106
    • 40949134628 scopus 로고    scopus 로고
    • Delivery of interferon-beta to the monkey nervous system following intranasal administration
    • Thorne R.G., Hanson L.R., Ross T.M., Tung D. and Frey W.H. 2nd. (2008). Delivery of interferon-beta to the monkey nervous system following intranasal administration. Neuroscience 152, 785-797.
    • (2008) Neuroscience , vol.152 , pp. 785-797
    • Thorne, R.G.1    Hanson, L.R.2    Ross, T.M.3    Tung, D.4    Frey II, W.H.5
  • 107
    • 34248382560 scopus 로고    scopus 로고
    • Psychophysiological analysis of the influence of vasopressin on speech in patients with post-stroke aphasias
    • Tsikunov S.G. and Belokoskova S.G. (2007). Psychophysiological analysis of the influence of vasopressin on speech in patients with post-stroke aphasias. Span J. Psychol. 10, 178-188.
    • (2007) Span J. Psychol , vol.10 , pp. 178-188
    • Tsikunov, S.G.1    Belokoskova, S.G.2
  • 109
    • 55049099223 scopus 로고    scopus 로고
    • Intranasally delivered bFGF enhances neurogenesis in adult rats following cerebral ischemia
    • Wang Z.L., Cheng S.M., Ma M.M., Ma Y.P., Yang J.P., Xu G.L. and Liu X.F. (2008). Intranasally delivered bFGF enhances neurogenesis in adult rats following cerebral ischemia. Neurosci. Lett. 446, 30-35.
    • (2008) Neurosci. Lett , vol.446 , pp. 30-35
    • Wang, Z.L.1    Cheng, S.M.2    Ma, M.M.3    Ma, Y.P.4    Yang, J.P.5    Xu, G.L.6    Liu, X.F.7
  • 110
    • 0035692887 scopus 로고    scopus 로고
    • A double-blind placebo-controlled clinical trial of recombinant human brain-derived neurotrophic factor (rhBDNF) in diabetic polyneuropathy
    • Wellmer A., Misra V.P., Sharief M.K., Kopelman P.G. and Anand P. (2001). A double-blind placebo-controlled clinical trial of recombinant human brain-derived neurotrophic factor (rhBDNF) in diabetic polyneuropathy. J. Peripher. Nerv. Syst. 6, 204-210.
    • (2001) J. Peripher. Nerv. Syst , vol.6 , pp. 204-210
    • Wellmer, A.1    Misra, V.P.2    Sharief, M.K.3    Kopelman, P.G.4    Anand, P.5
  • 111
    • 0022245786 scopus 로고
    • Behavioural and neurochemical effects of chronic intraventricular injections of nerve growth factor in adult rats with fimbria lesions
    • Will B. and Hefti F. (1985). Behavioural and neurochemical effects of chronic intraventricular injections of nerve growth factor in adult rats with fimbria lesions. Behav. Brain Res. 17, 17-24.
    • (1985) Behav. Brain Res , vol.17 , pp. 17-24
    • Will, B.1    Hefti, F.2
  • 112
    • 55149091591 scopus 로고    scopus 로고
    • From nose to brain: Understanding transport capacity and transport rate of drugs
    • Wu H., Hu K. and Jiang X. (2008). From nose to brain: understanding transport capacity and transport rate of drugs. Expert Opin. Drug Deliv. 5, 1159-1168.
    • (2008) Expert Opin. Drug Deliv , vol.5 , pp. 1159-1168
    • Wu, H.1    Hu, K.2    Jiang, X.3
  • 114
    • 77954233247 scopus 로고    scopus 로고
    • VEGF promotes angiogenesis and functional recovery in stroke rats
    • Yang J.P., Liu H.J. and Liu X.F. (2010). VEGF promotes angiogenesis and functional recovery in stroke rats. J. Invest. Surg. 23, 149-155.
    • (2010) J. Invest. Surg , vol.23 , pp. 149-155
    • Yang, J.P.1    Liu, H.J.2    Liu, X.F.3
  • 115
    • 0034988984 scopus 로고    scopus 로고
    • Neuroprotection in transient focal brain ischemia after delayed intravenous administration of brainderived neurotrophic factor conjugated to a blood-brain barrier drug targeting system (editorial comment)
    • Zhang Y. and Pardridge W.M. (2001). Neuroprotection in transient focal brain ischemia after delayed intravenous administration of brainderived neurotrophic factor conjugated to a blood-brain barrier drug targeting system (editorial comment). Stroke 32, 1378-1384.
    • (2001) Stroke , vol.32 , pp. 1378-1384
    • Zhang, Y.1    Pardridge, W.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.