New therapeutic approach for brain tumors: Intranasal delivery of telomerase inhibitor GRN163

Neuro-Oncology

Volumn 10, Issue 2, 2008, Pages 112-120

  Hashizume, Rintaro ^a   Ozawa, Tomoko ^a   Gryaznov, Sergei M ^b   Bollen, Andrew W ^a   Lamborn, Kathleen R ^a   Frey II, William H ^c   Deen, Dennis F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GERON CORPORATION   (United States)

^c HEALTHPARTNERS RESEARCH FOUNDATION   (United States)

Author keywords

Brain tumors; GRN163; Intranasal delivery; Telomerase inhibitor; Xenografts

Indexed keywords

FLUORESCEIN ISOTHIOCYANATE; GRN 163; ISOTHIOCYANIC ACID; OLIGONUCLEOTIDE; TELOMERASE INHIBITOR; UNCLASSIFIED DRUG; ENZYME INHIBITOR; GRN163; TELOMERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN TISSUE; BRAIN TUMOR; CANCER INHIBITION; CANCER THERAPY; CELL KILLING; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG UPTAKE; HUMAN; HUMAN CELL; LIFESPAN; MALE; NON INVASIVE PROCEDURE; NONHUMAN; NOSE CAVITY; ONCOLOGY; RAT; SURVIVAL; THERMODYNAMICS; TUMOR CELL; TUMOR GROWTH; TUMOR XENOGRAFT; ANIMAL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG SCREENING; GLIOMA; INTRANASAL DRUG ADMINISTRATION; NUDE RAT; TUMOR CELL LINE;

ADMINISTRATION, INTRANASAL; ANIMALS; BRAIN NEOPLASMS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GLIOMA; HUMANS; MALE; OLIGONUCLEOTIDES; RATS; RATS, NUDE; TELOMERASE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 44849116327     PISSN: 15228517     EISSN: 15235866     Source Type: Journal    
DOI: 10.1215/15228517-2007-052     Document Type: Article

References (28)

1. CBTRUS, Central Brain Tumor Registry of the United States. Primary Brain Tumors in the United States: Statistical Report Tables, 1998-2002. 2005. Available at http://www.cbtrus.org/2005-2006/tables/2006.table18-19.pdf.
2. Dhanda DS, Frey WH 2nd, Leopold D, Kompella UB. Approaches for drug deposition in the human olfactory epithelium. Drug Deliv Tech-nol. 2005;5:64-72.
3. Thorne RG, Pronk GJ, Padmanabhan V, Frey WH 2nd. Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience. 2004;127:481-496.
4. Thorne RG, Emory CR, Ala TA, Frey WH 2nd. Quantitative analysis of the olfactory pathway for drug delivery to the brain. Brain Res. 1995;692:278-282.
5. Thorne RG, Frey WH 2nd. Delivery of neurotrophic factors to the central nervous system: pharmacokinetic considerations. Clin Phar-macokinet. 2001;40:907-946.
6. Wang F, Jiang X, Lu W. Profiles of methotrexate in blood and CSF following intranasal and intravenous administration to rats. Int J Pharm. 2003;263:1-7.
7. Shingaki T, Sakane T, Yamashita S, Sezaki H, Yoshiharu T, Shoubu S. Transnasal delivery of aniticancer drugs to the brain tumor: a new strategy for brain tumor chemotherapy. Drug Deliv System. 1999;14:365-371.
8. Sakane T, Yamashita S, Yata N, Sezaki H. Transnasal delivery of 5-flu-orouracil to the brain in the rat. J Drug Target. 1999;7:233-240.
9. Wang D, Gao Y, Yun L. Study on brain targeting of raltitrexed following intranasal administration in rats. Cancer Chemother Pharmacol. 2006;57:97-104.
10. Le S, Zhu JJ, Anthony DC, Greider CW, Black PM. Telomerase activity in human gliomas. Neurosurgery. 1998;42:1120-1125.
11. Ozawa T, Gryaznov SM, Hu LJ, et al. Antitumor effects of specific telomerase inhibitor GRN163 in human glioblastoma xenografts. Neuro-Oncology. 2004;6:218-226.
12. Bobo RH, Laske DW, Akbasak A, Morrison PF, Dedrick RL, Oldfield EH. Convection-enhanced delivery of macromolecules in the brain. Proc Natl Acad Sci USA. 1994;91:2076-2080.
13. Huynh GH, Deen DF, Szoka FC Jr. Barriers to carrier mediated drug and gene delivery to brain tumors. J Control Release. 2006;110: 236-259.
14. Gryaznov SM, Pongracz K, Matray T, et al. Telomerase inhibitors-oli- gonucleotide phosphoramidates as potential therapeutic agents. Nucleosides Nucleotides Nucleic Acids. 2001 ;20:401-410.
15. Pongracz K, Gryaznov SM. Alpha-oligodeoxyribonucleotide N3'→P5' phosphoramidates: synthesis and duplex formation. Nucleic Acids Res. 1998;26:1099-1106.
16. Gryaznov SM, Letsinger RL. Synthesis and properties of oligonucle-otides containing aminodeoxythymidine units. Nucleic Acids Res. 1992;20:3403-3409.
17. Ozawa T, Wang J, Hu LJ, Bollen AW, Lamborn KR, Deen DF. Growth of human glioblastomas as xenografts in the brains of athymic rats. In Vivo. 2002;16:55-60.
18. Balin BJ, Broadwell RD, Salcman M, el-Kalliny M. Avenues for entry of peripherally administered protein to the central nervous system in mouse, rat, and squirrel monkey. J Comp Neurol. 1986;251: 260-280.
19. H erbert BS, Pongracz K, Shay JW, Gryaznov SM. Oligonucleotide N3'→P5' phosphoramidates as efficient telomerase inhibitors. Oncogene. 2002;21:638-642.
20. Mamot C, Nguyen JB, Pourdehnad M, et al. Extensive distribution of liposomes in rodent brains and brain tumors following convection- enhanced delivery. J Neurooncol. 2004;68:1-9.
21. Kawakami K, Kawakami M, Kioi M, Husain SR, Puri RK. Distribution kinetics of targeted cytotoxin in glioma by bolus or convection-enhanced delivery in a murine model. J Neurosurg. 2004;101:1004-1011.
22. Groothuis DR. The blood-brain and blood-tumor barriers: a review of strategies for increasing drug delivery. Neuro-Oncology 2000;2:45-59.
23. Asai A, Oshima Y, Yamamoto Y, et al. A novel telomerase template antagonist (GRN163) as a potential anticancer agent. Cancer Res. 2003;63:3931-3939.
24. Herbert B, Pitts AE, Baker SI, et al. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc Natl Acad Sci USA. 1999;96:14276-14281.
25. Benedict C, Hallschmid M, Hatke A, et al. Intranasal insulin improves memory in humans. Psychoneuroendocrinology. 2004;29:1326-1334.
26. Reger MA, Watson GS, Frey WH 2nd, et al. Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype. Neurobiol Aging. 2006;27:451-458.
27. Born J, Lange T, Kern W, McGregor GP, Bickel U, Fehm HL. Sniffing neuropeptides: a transnasal approach to the human brain. Nat Neuro-sci. 2002;5:514-516.
28. da Fonseca CO, Landeiro JA, Clark SS, Quirico-Santos T, da Costa Carvalho Mda G, Gattass CR. Recent advances in the molecular genetics of malignant gliomas disclose targets for antitumor agent perillyl alcohol. Surg Neurol. 2006;65(suppl.):S1:2-1:8; discussion S1:8-1:9.