Effect of poly-L-arginine on the nasal absorption of FITC-dextran of different molecular weights and recombinant human granulocyte colony-stimulating factor (rhG-CSF) in rats

International Journal of Pharmaceutics

Volumn 226, Issue 1-2, 2001, Pages 127-138

  Miyamoto, Misao ^a   Natsume, Hideshi ^b   Satoh, Izumi ^b   Ohtake, Kazuo ^b   Yamaguchi, Masatoshi ^c   Kobayashi, Daisuke ^b   Sugibayashi, Kenji ^b   Morimoto, Yasunori ^b  

^a NISSAN CHEMICAL INDUSTRIES LTD   (Japan)

^b JOSAI UNIVERSITY   (Japan)

^c Prefectural Kakizaki Hospital   (Japan)

Author keywords

Absorption enhancer; FITC dextran; Intranasal drug delivery system; Nasal absorption; Poly L arginine; Recombinant human granulocyte colony stimulating factor (rhG CSF)

Indexed keywords

DEXTRAN; DEXTRAN DERIVATIVE; POLYARGININE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ANIMAL EXPERIMENT; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; IN VIVO STUDY; MACROMOLECULE; MALE; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; RAT;

ABSORPTION; ANALYSIS OF VARIANCE; ANIMALS; AREA UNDER CURVE; ARGININE; DEXTRANS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; FLUORESCEIN-5-ISOTHIOCYANATE; GRANULOCYTE COLONY STIMULATING FACTOR, RECOMBINANT; HALF-LIFE; MOLECULAR WEIGHT; NASAL CAVITY; RATS; RATS, WISTAR;

EID: 0035845757     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00797-9     Document Type: Article

References (38)

1. Chitosan as a nasal delivery system: Evaluation of insulin absorption enhancement and effect on nasal membrane integrity using rat models
2. Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2)
3. Cationic proteins alter smooth muscle function by an epithelium-dependent mechanism
4. Cationic proteins induce airway hyperresponsiveness dependent on charge interactions
5. Effect of polycations on permeability of glomerular epithelial cell monolayers to albumin
6. Effect of surfactants on the nasal absorption of insulin in rats
7. The structural barrier of absorptive mucosae: Site difference of the permeability of fluorescein isothiocyanate-labelled dextran in rabbits
8. Evaluation of enhancers to increase nasal absorption using Ussing chamber technique
9. Effect of sodium taurodihydrofusidate on nasal drug delivery: Differences in its concentration and penetrant molecular weight
10. Chitosan as a novel delivery system for peptide drugs
11. Cyclodextrins as protection agents against enhancer damage in nasal delivery system I. Assessment of effect by measurement of erythrocyte haemolysis
12. Cyclodextrins as protection agents against enhancer damage in nasal delivery system II. Effect on in vivo absorption of insulin and histopathology of nasal membrane
13. Adsorption of recombinant human granulocyte colony-stimulating factor (rhG-CSF) to polyvinyl chloride, polypropylene, and glass: Effect of solvent additives
14. N-trimethyl chitosan chloride as a potential absorption enhancer across mucosal surfaces: In vitro evaluation in intestinal epithelial cells (Caco-2)
15. In vitro permeation of several model drugs across rabbit nasal mucosa
16. Disposition of Marograstim (KW-2228) (3): Pharmacokinetic studies of KW-2228 in rats
17. Absorption of recombinant human granulocyte colony-stimulating factor (rhG-CSF) from rat nasal mucosa
18. Effects of surfactants and protease inhibitors on nasal absorption of recombinant human granulocyte colony-stimulating factor (rhG-CSF) in rats
19. Effects of absorption enhancers on rat nasal epithelium in vivo: Release of marker compounds in the nasal cavity
20. Polycation-induced enhancement of epithelial paracellular permeability in independent of tight junctional characteristics
21. Analysis of structural requirements for the absorption of drug and macromolecules from the nasal cavity
22. Absorption enhancers in nasal drug delivery: Efficacy and safety
23. Improved nasal absorption of drugs using poly-L-arginine: Effect of concentration and molecular weight of poly-L-arginine on the nasal absorption of FITC-dextran in rats
24. Screening of cationic compounds as an absorption enhancer for nasal drug delivery
25. Improvement of pharmacological response after intranasal administration of peptide drugs by poly-L-arginine as a novel absorption enhancer in rats
26. Pulmonary absorption of recombinant methionyl human granulocyte colony-stimulating factor (r-huG-CSF) after intratracheal instillation to the hamster
27. Pulmonary delivery of powders and solutions containing recombinant human granulocyte colony-stimulating factor (rhG-CSF) to the rabbit
28. Effects of dosing solution on the nasal absorption of non-glycosylated recombinant human granulocyte colony-stimulating factor in rats
29. Effectiveness and toxicity screening of various absorption enhancers using Caco-2 cell monolayers
30. Chitosans as absorption enhancers for poorly absorbable drugs 2: Mechanism of absorption enhancement
31. Evaluation of the clearance characteristics of bioadhesive systems in humans
32. Phase I study of KW-2228 in normal healthy volunteers
33. Pharmacological activity of tablets containing recombinant human granulocyte colony-stimulating factor (rhG-CSF) in rats
34. Cationic proteins increase the permeability of cultured rabbit tracheal epithelial cells: Modification by heparin and extracellular calcium
35. Effectiveness and toxicity screening of various absorption enhancers in the large intestine: Intestinal absorption of phenol red and protein and phospholipid release from the intestinal membrane
36. Effectiveness and toxicity screening of various absorption enhancers in the rat small intestine: Effects of absorption enhancers on the intestinal absorption of phenol red and the release of protein and phospholipids from the intestinal membrane
37. A pharmacokinetic analysis program (MULTI) for microcomputer