Activation of PKR/eIF2α signaling cascade is associated with dihydrotestosterone-induced cell cycle arrest and apoptosis in human liver cells

Journal of Cellular Biochemistry

Volumn 113, Issue 5, 2012, Pages 1800-1808

  Dai, Rongyang ^a   Yan, Dongmei ^a   Li, Juan ^a   Chen, Shaokun ^a   Liu, Youping ^a   Chen, Run ^a   Duan, Chunyan ^a   Wei, Mei ^a   Li, Hong ^a   He, Tao ^a  

^a SOUTHWEST MEDICAL UNIVERSITY   (China)

Author keywords

APOPTOSIS; CELL CYCLE ARREST; DIHYDROTESTOSTERONE; LIVER CELLS; PKR eIF2

Indexed keywords

ANDROGEN RECEPTOR; ANDROSTANOLONE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HEAT SHOCK PROTEIN 27; PROTEIN KINASE R;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INDUCTION; HUMAN; HUMAN CELL; LIVER CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANDROGEN ANTAGONISTS; APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL LINE; DIHYDROTESTOSTERONE; EIF-2 KINASE; EUKARYOTIC INITIATION FACTOR-2; FLUTAMIDE; HEP G2 CELLS; HEPATOCYTES; HSP27 HEAT-SHOCK PROTEINS; HUMANS; RECEPTORS, ANDROGEN; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR CHOP;

EUKARYOTA;

EID: 84859043702     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24051     Document Type: Article

References (44)

1. Anderson KM, Liao S,. 1968. Selective retention of dihydrotestosterone by prostatic nuclei. Nature 219: 277-279.
2. Baron S, Manin M, Beaudoin C, Leotoing L, Communal Y, Veyssiere G, Morel L,. 2004. Androgen receptor mediates non-genomic activation of phosphatidylinositol 3-OH kinase in androgen-sensitive epithelial cells. J Biol Chem 279: 14579-14586. (Pubitemid 38618845)
3. Bartsch G, Rittmaster RS, Klocker H,. 2002. [Dihydrotestosterone and the role of 5 alpha-reductase inhibitors in benign prostatic hyperplasia]. Urologe A 41: 412-424. (Pubitemid 36070145)
4. Benali-Furet NL, Chami M, Houel L, De Giorgi F, Vernejoul F, Lagorce D, Buscail L, Bartenschlager R, Ichas F, Rizzuto R, Paterlini-Brechot P,. 2005. Hepatitis C virus core triggers apoptosis in liver cells by inducing ER stress and ER calcium depletion. Oncogene 24: 4921-4933. (Pubitemid 41129096)
5. Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D, Yuan J,. 2005. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science 307: 935-939. (Pubitemid 40229232)
6. Bruchovsky N, Wilson JD,. 1968. The conversion of testosterone to 5-alpha-androstan-17-beta-ol-3-one by rat prostate in vivo and in vitro. J Biol Chem 243: 2012-2021.
7. Canbay A, Kip SN, Kahraman A, Gieseler RK, Nayci A, Gerken G,. 2005. Apoptosis and fibrosis in non-alcoholic fatty liver disease. Turk J Gastroenterol 16: 1-6. (Pubitemid 40570604)
8. Chen JJ, London IM,. 1995. Regulation of protein synthesis by heme-regulated eIF-2 alpha kinase. Trends Biochem Sci 20: 105-108.
9. Cherasse Y, Maurin AC, Chaveroux C, Jousse C, Carraro V, Parry L, Deval C, Chambon C, Fafournoux P, Bruhat A,. 2007. The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP. Nucleic Acids Res 35: 5954-5965. (Pubitemid 47514487)
10. Dai RY, Chen Y, Fu J, Dong LW, Ren YB, Yang GZ, Qian YW, Cao J, Tang SH, Yang SL, Wang HY,. 2009. p28GANK inhibits endoplasmic reticulum stress-induced cell death via enhancement of the endoplasmic reticulum adaptive capacity. Cell Res 19: 1243-1257.
11. Dever TE,. 2002. Gene-specific regulation by general translation factors. Cell 108: 545-556. (Pubitemid 34260879)
12. Dey M, Cao C, Sicheri F, Dever TE,. 2007. Conserved intermolecular salt bridge required for activation of protein kinases PKR, GCN2, and PERK. J Biol Chem 282: 6653-6660. (Pubitemid 47100827)
13. Georget V, Lobaccaro JM, Terouanne B, Mangeat P, Nicolas JC, Sultan C,. 1997. Trafficking of the androgen receptor in living cells with fused green fluorescent protein-androgen receptor. Mol Cell Endocrinol 129: 17-26. (Pubitemid 27229213)
14. Guicciardi ME, Gores GJ,. 2010. Apoptosis as a mechanism for liver disease progression. Semin Liver Dis 30: 402-410.
15. Harding HP, Novoa I, Zhang Y, Zeng H, Wek R, Schapira M, Ron D,. 2000. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell 6: 1099-1108.
16. Hershey JW,. 1991. Translational control in mammalian cells. Annu Rev Biochem 60: 717-755.
17. Holcik M, Sonenberg N,. 2005. Translational control in stress and apoptosis. Nat Rev Mol Cell Biol 6: 318-327. (Pubitemid 40516898)
18. Hu P, Han Z, Couvillon AD, Exton JH,. 2004. Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death. J Biol Chem 279: 49420-49429. (Pubitemid 39625828)
19. Ito H, Iwamoto I, Inaguma Y, Takizawa T, Nagata K, Asano T, Kato K,. 2005. Endoplasmic reticulum stress induces the phosphorylation of small heat shock protein, Hsp27. J Cell Biochem 95: 932-941. (Pubitemid 41420141)
20. Jaeschke H, Gujral JS, Bajt ML,. 2004. Apoptosis and necrosis in liver disease. Liver Int 24: 85-89. (Pubitemid 38584992)
21. Jagus R, Joshi B, Barber GN,. 1999. PKR, apoptosis and cancer. Int J Biochem Cell Biol 31: 123-138. (Pubitemid 29094794)
22. Jie X, Lang C, Jian Q, Chaoqun L, Dehua Y, Yi S, Yanping J, Luokun X, Qiuping Z, Hui W, Feili G, Boquan J, Youxin J, Jinquan T,. 2007. Androgen activates PEG10 to promote carcinogenesis in hepatic cancer cells. Oncogene 26: 5741-5751. (Pubitemid 47312814)
23. Kandel ES, Skeen J, Majewski N, Di Cristofano A, Pandolfi PP, Feliciano CS, Gartel A, Hay N,. 2002. Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage. Mol Cell Biol 22: 7831-7841. (Pubitemid 35217294)
24. Kokontis JM, Hay N, Liao S,. 1998. Progression of LNCaP prostate tumor cells during androgen deprivation: Hormone-independent growth, repression of proliferation by androgen, and role for p27Kip1 in androgen-induced cell cycle arrest. Mol Endocrinol 12: 941-953. (Pubitemid 30660662)
25. Kokontis JM, Liao S,. 1999. Molecular action of androgen in the normal and neoplastic prostate. Vitam Horm 55: 219-307.
26. Liao S,. 1994. Androgen action: Molecular mechanism and medical application. J Formos Med Assoc 93: 741-751.
27. Lin HY, Yu IC, Wang RS, Chen YT, Liu NC, Altuwaijri S, Hsu CL, Ma WL, Jokinen J, Sparks JD, Yeh S, Chang C,. 2008. Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor. Hepatology 47: 1924-1935. (Pubitemid 351945560)
28. Ma WL, Hsu CL, Wu MH, Wu CT, Wu CC, Lai JJ, Jou YS, Chen CW, Yeh S, Chang C,. 2008. Androgen receptor is a new potential therapeutic target for the treatment of hepatocellular carcinoma. Gastroenterology 135: 947-955, 955 e1-5.
29. Malhi H, Kaufman RJ,. 2011. Endoplasmic reticulum stress in liver disease. J Hepatol 54: 795-809.
30. Nanji AA,. 1998. Apoptosis and alcoholic liver disease. Semin Liver Dis 18: 187-190. (Pubitemid 28224009)
31. Pyrko P, Schonthal AH, Hofman FM, Chen TC, Lee AS,. 2007. The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas. Cancer Res 67: 9809-9816. (Pubitemid 47621228)
32. Raven JF, Koromilas AE,. 2008. PERK and PKR: Old kinases learn new tricks. Cell Cycle 7: 1146-1150. (Pubitemid 351749264)
33. Roberts MS, Anderson RA, Swarbrick J, Moore DE,. 1978. The percutaneous absorption of phenolic compounds: The mechanism of diffusion across the stratum corneum. J Pharm Pharmacol 30: 486-490. (Pubitemid 8379905)
34. Schuchmann M, Galle PR,. 2001. Apoptosis in liver disease. Eur J Gastroenterol Hepatol 13: 785-790. (Pubitemid 32656591)
35. Shtivelman E, Sussman J, Stokoe D,. 2002. A role for PI 3-kinase and PKB activity in the G2/M phase of the cell cycle. Curr Biol 12: 919-924. (Pubitemid 34689227)
36. Sun M, Yang L, Feldman RI, Sun XM, Bhalla KN, Jove R, Nicosia SV, Cheng JQ,. 2003. Activation of phosphatidylinositol 3-kinase/Akt pathway by androgen through interaction of p85alpha, androgen receptor, and Src. J Biol Chem 278: 42992-43000. (Pubitemid 37345912)
37. Szegezdi E, Logue SE, Gorman AM, Samali A,. 2006. Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep 7: 880-885. (Pubitemid 44523966)
38. Taylor SS, Haste NM, Ghosh G,. 2005. PKR and eIF2alpha: Integration of kinase dimerization, activation, and substrate docking. Cell 122: 823-825. (Pubitemid 41345196)
39. Tsihlias J, Zhang W, Bhattacharya N, Flanagan M, Klotz L, Slingerland J,. 2000. Involvement of p27Kip1 in G1 arrest by high dose 5 alpha- dihydrotestosterone in LNCaP human prostate cancer cells. Oncogene 19: 670-679. (Pubitemid 30102918)
40. Vassilatou E, Lafoyianni S, Vryonidou A, Ioannidis D, Kosma L, Katsoulis K, Papavassiliou E, Tzavara I,. 2010. Increased androgen bioavailability is associated with non-alcoholic fatty liver disease in women with polycystic ovary syndrome. Hum Reprod 25: 212-220.
41. Vattem KM, Wek RC,. 2004. Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. Proc Natl Acad Sci USA 101: 11269-11274. (Pubitemid 39038336)
42. Wu MH, Ma WL, Hsu CL, Chen YL, Ou JH, Ryan CK, Hung YC, Yeh S, Chang C,. 2010. Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription. Sci Transl Med 2: 32ra35.
43. Xu C, Bailly-Maitre B, Reed JC,. 2005. Endoplasmic reticulum stress: Cell life and death decisions. J Clin Invest 115: 2656-2664. (Pubitemid 41434389)
44. Zhao M, Zimmermann A,. 1997. Apoptosis in human hepatocellular carcinoma and in liver cell dysplasia is correlated with p53 protein immunoreactivity. J Clin Pathol 50: 394-400. (Pubitemid 27278443)