Apoptosis in human hepatocellular carcinoma and in liver cell dysplasia is correlated with p53 protein immunoreactivity

Journal of Clinical Pathology

Volumn 50, Issue 5, 1997, Pages 394-400

  Zhao, M ^a   Zimmermann, A ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Apoptosis; Hepatocellular carcinoma; Liver cell dysplasia; p53 protein

Indexed keywords

PROTEIN P53;

APOPTOSIS; ARTICLE; DYSPLASIA; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; LIVER BIOPSY; LIVER CELL; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN DETERMINATION;

EID: 0031011087     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.50.5.394     Document Type: Article

References (45)

1. Searle J, Harmon BV, Bishop CJ, Kerr JFR. The significance of cell death by apoptosis in hepatobiliary disease. J Gastroenterol Hepatol 1987;2:77-96.
2. Wyllie AH, Kerr JFR, Currie AR. Cell death: the significance of apoptosis. Int Rev Cytol 1980;68:251-300.
3. Bursch W, Lauer B, Timmermann-Trosiener I, Barthel G, Schuppler J, Schulte-Hermann R. Controlled cell death (apoptosis) of normal and putative pre-neoplastic cells in rat liver following withdrawal of tumor promoters. Carcinogenesis 1984;5:453-8.
4. Bursch W, Paffe S, Putz B, Barthel G, Schulte-Hermann R. Determination of the length of the histological stages of apoptosis in rat liver and altered hepatic foci. Carcinogenesis 1990;11:847-53.
5. Schulte-Hermann R, Timmermann-Trosiener I, Barthel G, Bursch W. DNA synthesis, apoptosis, and phenotypic expression as determinants of growth of altered foci in rat liver during phenobarbital promotion. Cancer Res 1990; 50:5127-35.
6. Schulte-Hermann R, Bursch W, Kraupp-Grasl B, Oberhammer F, Wagner A, Jirtle R. Cell proliferation and apoptosis in normal liver and preneoplastic foci. Environ Health Perspect 1993;101(suppl 5):87-90.
7. Bursch W, Graslkraupp B, Ellinger A, Torok L, Kienzl H, Mullauer L, et al. Active cell death: role in hepatocarcinogenesis and subtypes. Biochem Cell Biol 1995;72:11-12.
8. Allen PD, Bustin SA, Macey MG, Johnston DH, Williams NS, Newland AC Programmed cell death (apoptosis) in immunity and haematological neoplasia. Br J Biomed Sci 1993;50:135-49.
9. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992;119:493-501.
10. Ansari B, Coates PJ, Greenstein BD, Hall PA. In situ end-labelling detects DNA strand breaks in apoptosis and other physiological and pathological states. J Pathol 1993;170:1-8.
11. Afford SC, Hübscher S, Strain AJ, Adams DH, Neuberger JM, Apoptosis in the human liver during allograft rejection and end-stage liver disease. J Pathol 1995;176:373-80.
12. Hino N, Higashi T, Nouso K, Nakatsukasa H, Tsuji T. Apoptosis and proliferation of human hepatocellular carcinoma. Liver 1996;16:123-9.
13. Nakanuma Y, Terada T, Ueda K, Terasaki S, Nonomura A, Matsui O. Adenomatous hyperplasia of the liver as a precancerous lesions. Liver 1993;13:1-9.
14. Gibson JB, Sobin LH. Histological typing of tumors of the liver, biliary tract and pancreas. International histological classification of tumours. 20. Geneva: World Health Organisation, 1978.
15. Nakashima T, Kojiro M. Hepatocellular carcinoma. An atlas of its pathology. Tokyo: Springer, 1987.
16. Edmondson HA, Steiner PE. Primary carcinoma of the liver. A study of 100 cases among 48,900 necropsies. Cancer 1954;7:462-503.
17. Zhao M, Zhang NX, Du ZY, Laissue JA, Zimmermann A. Three types of liver cell dysplasia (LCD) in small cirrhotic nodules are distinguishable by karyometry and PCNA labelling, and their features resemble distinct grades of hepatocellular carcinoma. Histol Histopathol 1994;9:73-83.
18. Zhao M, Zhang NX, Laissue JA, Zimmermann A. Immunohistochemical analysis of p53 protein overexpression in liver cell dysplasia and in hepatocellular carcinoma. Virchows Arch 1994;424:613-21.
19. Galand P, Degraef C. Cyclin/PCNA immunostaining as an alternative to tritiated thymidine pulse labelling for marking S phase cells in paraffin sections from animal and human tissues. Cell Tissue Kinet 1989;22:383-92.
20. Bravo R, MacDonald-Bravo H. Existence of two populations of cyclin proliferating cell nuclear antigen during the cell cycle: association with DNA replication sites. J Cell Biol 1987;105:1549-54.
21. Garcia RL, Coltrera MD, Gown AM. Analysis of proliferative grade using anti- PCNA cyclin monoclonal antibodies m fixed, embedded tissues. Am J Pathol 1989;135:733-9.
22. Gelb AB, Kamel OW, LeBrun DP, Warnke RA. Estimation of tumor growth fractions in archival formalin-fixed, paraffin-embedded tissues using two anti-PCNA/cyclin monoclonal antibodies. Factors affecting reactivity. Am J Pathol 1992;141:1453-8.
23. Majno G, Joris I. Apoptosis, oncosis and necrosis. An overview of cell death. Am J Pathol 1995;146:3-15.
24. Alison MR, Sarraf CE. Liver cell death: patterns and mechanisms. Gut 1994;35:577-81.
25. Patel T, Gores GJ. Apoptosis and hepatobiliary disease. Hepatology 1995;21:1725-41.
26. Bursch W, Lauer B, Timmermann-Trosiener I, Barthel G, Schuppler J, Schulte-Hermann R. Controlled death (apoptosis) of normal and putative pre-neoplastic cells in rat liver following withdrawal of tumor promoters. Carcinogenesis 1984;5:453-8.
27. Columbano A, Ledda-Columbano GM, Coni PP, Faa G, Liguori C, Santa Cruz G, et al. Occurrence of cell death (apoptosis) during the involution of liver hyperplasia. Lab Invest 1985;52:670-5.
28. Klion FM, Schaffner F. The ultrastructure of acidophilic "councilman-like" bodies in the liver. Am J Pathol 1966;48: 755-67.
29. Columbano A, Ledda-Columbana GM, Lee G, Rajalakshmi S, Sarma DSR. Occurrence of cell death (apoptosis) in preneoplastic and neoplastic liver cells. Am J Pathol 1984;116:441-6.
30. Zerban H, Radig S, Kopp-Schneider A, Bannasch P. Cell proliferation and cell death (apoptosis) in hepatic preneoplasia and neoplasia are closely related to phenotypic cellular diversity and instability. Carcinogenesis 1994;15:2467-73.
31. Tessitore L, Costelli P, Sacchi C, Piacentini M, Baccino FM. The role of apop- tosis in growing and stationary rat ascites hepatoma, Yoshida AH-130. J Pathol 1993;171: 301-9.
32. Kong J, Ringer DP. Immunohistochemical assessment of cell proliferation and death levels in well and poorly differentiated rat liver tumors [abstract]. Proc Am Assoc Cancer Res 1995;36:230.
33. Kong J, Ringer DP. Quantitative in situ image analysis of apoptosis in well and poorly differentiated tumors from rat liver. Am J Pathol 1995;147:1626-32.
34. Gourdeau H, Walker PR. Evidence for trans regulation of apoptosis in intertypic somatic cell hybrids. Mol Cell Biol 1994;14:6125-34.
35. Oberhammer F, Fritsch G, Pavelka M, Froschl G, Tiefenbacher R, Purchio T, et al. Induction of apoptosis in cultured hepatocytes and in the regressing liver by transforming growth factor-beta-1 occurs without activation of an endonuclease. Toxicol Lett 1992;64/65:701-4.
36. Oberhammer FA, Pavelka M, Sharma S, Tiefenbacher R, Purchio AF, Busch W, et al. Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor-beta 1. Proc Natl Acad Sci USA 1992;89: 5408-12,
37. Schwall RH, Robbins K, Jardieu P, Chang L, Lai C, Terrel TG. Activin induces cell death in hepatocytes in vivo and vitro. Hepatology 1993;18:347-56.
38. Bour ES, Ward LK, Cornman GA, Isom HC. Tumor necrosis factor-alpha induced apoptosis in hepatocytes in long-term culture. Am J Pathol 1996;148:485-95.
39. Tsukidate K, Yamamoto K, Snyder JW, Farber JL. Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes. Am J Pathol 1993;143:918-25.
40. Hofmann WJ, Volkmann M, Haag D, Otto G, Galle PR. p53 overexpression in HCC is correlated with the proliferative activity but not with EGF-R expression in the tumors [abstract]. Hepatology 1993;18:185.
41. Gottlieb TM, Oren M. p53 in growth control and neoplasia. Biochim Biophys Acta 1996;1287:77-102.
42. Oren M. Relationship of p53 to the control of apoptotic dell death. Semin Cancer Biol 1994;5:221-7.
43. Symonds H, Krall L, Remington L, Saenz-Robles M, Lowe S, Jacks T, Van Dyke T P53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell 1994;78:703-71.
44. Morgenbesser SD, Williams BO, Jacks T, DePino RA. P53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature 1994; 371:72-4.
45. Kaneko Y, Tsukamoto A. Apoptosis and nuclear levels of p53 protein and proliferating cell nuclear antigen in human hepatoma cells cultured with tumor promoters. Cancer Lett 1995;91:11-17.