Involvement of p27(Kip1) in G1 arrest by high dose 5α-dihydrotestosterone in LNCaP human prostate cancer cells

Oncogene

Volumn 19, Issue 5, 2000, Pages 670-679

  Tsihlias, J ^a   Zhang, W ^a   Bhattacharya, N ^a   Flanagan, M ^b,d   Klotz, L ^a   Slingerland, J ^a,c  

^a SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^b GILEAD SCIENCES   (United States)

^c DEPARTMENT OF RADIATION ONCOLOGY   (Canada)

^d Sunesis Pharmaceuticals Inc   (United States)

Author keywords

Androgen; Cell cycle; Cyclin E cdk2; p27; Prostate cancer

Indexed keywords

ANDROSTANOLONE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN E; PROTEIN P16; PROTEIN P21; PROTEIN P27; RETINOBLASTOMA PROTEIN; ANTISENSE OLIGONUCLEOTIDE; CDK2 PROTEIN, HUMAN; CDK4 PROTEIN, HUMAN; CELL CYCLE PROTEIN; CYCLIN D; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLINE; GROWTH INHIBITOR; MICROTUBULE ASSOCIATED PROTEIN; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; CANCER INHIBITION; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN PHOSPHORYLATION; CELL CULTURE; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROSTATE TUMOR; PROTEIN BINDING;

CDC2-CDC28 KINASES; CELL CYCLE PROTEINS; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; CYCLINS; DIHYDROTESTOSTERONE; DOSE-RESPONSE RELATIONSHIP, DRUG; G1 PHASE; GROWTH INHIBITORS; HUMANS; MALE; MICROTUBULE-ASSOCIATED PROTEINS; OLIGONUCLEOTIDES, ANTISENSE; PROSTATIC NEOPLASMS; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0034598559     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1203369     Document Type: Article

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