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Volumn 16, Issue 1, 2005, Pages 1-6

Apoptosis and fibrosis in non-alcoholic fatty liver disease

Author keywords

Apoptosis; Apoptotic bodies; Fibrosis; Inflammation; Non alcoholic steatohepatitis; Nonalcoholic fatty liver disease

Indexed keywords

3 [2 [(2 TERT BUTYLPHENYLAMINOOXALYL)AMINO]PROPIONYLAMINO] 4 OXO 5 (2,3,5,6 TETRAFLUOROPHENOXY)PENTANOIC ACID; ALANINE AMINOTRANSFERASE; ALPHA CHEMOKINE; CASPASE 3; CASPASE 7; CASPASE 8; DEATH RECEPTOR; DEATH RECEPTOR 4; DEATH RECEPTOR 5; FAS ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL 2; PROTEIN BCL XL; SOMATOMEDIN C; TUMOR NECROSIS FACTOR RECEPTOR 1;

EID: 17644428049     PISSN: 13004948     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (14)

References (48)
  • 2
    • 0033200054 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: A proposal for grading and staging the histological lesions
    • Brunt EM, Janney CG, Di Bisceglie AM, et al. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol 1999; 94: 2467-74.
    • (1999) Am J Gastroenterol , vol.94 , pp. 2467-2474
    • Brunt, E.M.1    Janney, C.G.2    Di Bisceglie, A.M.3
  • 3
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002; 346: 1221-31.
    • (2002) N Engl J Med , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 4
    • 9644265298 scopus 로고    scopus 로고
    • Leptin, insulin resistance, and liver fibrosis in human nonalcoholic fatty liver disease
    • Angulo P, Alba LM, Petrovic LM, et al. Leptin, insulin resistance, and liver fibrosis in human nonalcoholic fatty liver disease. J Hepatol 2004; 41: 943-9.
    • (2004) J Hepatol , vol.41 , pp. 943-949
    • Angulo, P.1    Alba, L.M.2    Petrovic, L.M.3
  • 5
    • 0033797838 scopus 로고    scopus 로고
    • Prevalence of obesity and diabetes in patients with cryptogenic cirrhosis: A case-control study
    • Poonawala A, Nair SP, Thuluvath PJ. Prevalence of obesity and diabetes in patients with cryptogenic cirrhosis: a case-control study. Hepatology 2000; 32: 689-92.
    • (2000) Hepatology , vol.32 , pp. 689-692
    • Poonawala, A.1    Nair, S.P.2    Thuluvath, P.J.3
  • 6
    • 0033019013 scopus 로고    scopus 로고
    • Cryptogenic cirrhosis: Clinical characterization and risk factors for underlying disease
    • Caldwell SH, Oelsner DH, Iezzoni JC, et al. Cryptogenic cirrhosis: clinical characterization and risk factors for underlying disease. Hepatology 1999; 29: 664-9.
    • (1999) Hepatology , vol.29 , pp. 664-669
    • Caldwell, S.H.1    Oelsner, D.H.2    Iezzoni, J.C.3
  • 7
    • 0036247430 scopus 로고    scopus 로고
    • Drugs and steatohepatitis
    • Farrell GC. Drugs and steatohepatitis. Semin Liver Dis 2002; 22: 185-94.
    • (2002) Semin Liver Dis , vol.22 , pp. 185-194
    • Farrell, G.C.1
  • 8
    • 0019152816 scopus 로고
    • Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease
    • Ludwig J, Viggiano TR, McGill DB, et al. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc 1980; 55: 434-8.
    • (1980) Mayo Clin Proc , vol.55 , pp. 434-438
    • Ludwig, J.1    Viggiano, T.R.2    McGill, D.B.3
  • 9
    • 0036788277 scopus 로고    scopus 로고
    • Fas enhances fibrogenesis in the bile duct ligated mouse: A link between apoptosis and fibrosis
    • Canbay A, Higuchi H, Bronk SF, et al. Fas enhances fibrogenesis in the bile duct ligated mouse: a link between apoptosis and fibrosis. Gastroenterology 2002; 123: 1323-30.
    • (2002) Gastroenterology , vol.123 , pp. 1323-1330
    • Canbay, A.1    Higuchi, H.2    Bronk, S.F.3
  • 10
    • 0036548118 scopus 로고    scopus 로고
    • Inflammation in response to hepatocellular apoptosis
    • Jaeschke H. Inflammation in response to hepatocellular apoptosis. Hepatology 2002; 35: 964-6.
    • (2002) Hepatology , vol.35 , pp. 964-966
    • Jaeschke, H.1
  • 11
    • 0042744006 scopus 로고    scopus 로고
    • Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis
    • Canbay A, Guicciardi ME, Higuchi H, et al. Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis. J Clin Invest 2003; 112: 152-9.
    • (2003) J Clin Invest , vol.112 , pp. 152-159
    • Canbay, A.1    Guicciardi, M.E.2    Higuchi, H.3
  • 12
    • 5144232785 scopus 로고    scopus 로고
    • Hepatocyte-specific disruption of Bcl-xL leads to continuous hepatocyte apoptosis and liver fibrotic responses
    • Takehara T, Tatsumi T, Suzuki T, et al. Hepatocyte-specific disruption of Bcl-xL leads to continuous hepatocyte apoptosis and liver fibrotic responses. Gastroenterology 2004; 127: 1189-97.
    • (2004) Gastroenterology , vol.127 , pp. 1189-1197
    • Takehara, T.1    Tatsumi, T.2    Suzuki, T.3
  • 13
    • 0042165989 scopus 로고    scopus 로고
    • Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
    • Feldstein AE, Canbay A, Angulo P, et al. Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 2003; 125: 437-43.
    • (2003) Gastroenterology , vol.125 , pp. 437-443
    • Feldstein, A.E.1    Canbay, A.2    Angulo, P.3
  • 14
    • 0034573149 scopus 로고    scopus 로고
    • Apoptosis in resolution of inflammation
    • Savill J. Apoptosis in resolution of inflammation. Kidney Blood Press Res 2000; 23: 173-4.
    • (2000) Kidney Blood Press Res , vol.23 , pp. 173-174
    • Savill, J.1
  • 15
    • 0035434662 scopus 로고    scopus 로고
    • The phosphatidylserine receptor: A crucial molecular switch?
    • Henson PM, Bratton DL, Fadok VA. The phosphatidylserine receptor: a crucial molecular switch? Nat Rev Mol Cell Biol 2001; 2: 627-33.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 627-633
    • Henson, P.M.1    Bratton, D.L.2    Fadok, V.A.3
  • 16
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green DR, Reed JC. Mitochondria and apoptosis. Science 1998; 281: 1309-12.
    • (1998) Science , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 17
    • 0032899887 scopus 로고    scopus 로고
    • Death receptors in liver biology and pathobiology
    • Faubion WA, Gores GJ. Death receptors in liver biology and pathobiology. Hepatology 1999; 29: 1-4.
    • (1999) Hepatology , vol.29 , pp. 1-4
    • Faubion, W.A.1    Gores, G.J.2
  • 18
    • 0035936797 scopus 로고    scopus 로고
    • The TNF and TNF receptor superfamilies: Integrating mammalian biology
    • Locksley RM, Killeen N, Lenardo MJ. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 2001; 104: 487-501.
    • (2001) Cell , vol.104 , pp. 487-501
    • Locksley, R.M.1    Killeen, N.2    Lenardo, M.J.3
  • 19
    • 0032078217 scopus 로고    scopus 로고
    • Caspases: Key mediators of apoptosis
    • Thornberry NA. Caspases: key mediators of apoptosis. Chem Biol 1998; 5: R97-103.
    • (1998) Chem Biol , vol.5
    • Thornberry, N.A.1
  • 20
    • 0028783367 scopus 로고
    • Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage
    • Galle PR, Hofmann WJ, Walczak H, et al. Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage. J Exp Med 1995; 182: 1223-30.
    • (1995) J Exp Med , vol.182 , pp. 1223-1230
    • Galle, P.R.1    Hofmann, W.J.2    Walczak, H.3
  • 21
    • 0031950395 scopus 로고    scopus 로고
    • CD95-induced apoptosis in human liver disease
    • Galle PR, Krammer PH. CD95-induced apoptosis in human liver disease. Semin Liver Dis 1998; 18: 141-51.
    • (1998) Semin Liver Dis , vol.18 , pp. 141-151
    • Galle, P.R.1    Krammer, P.H.2
  • 22
    • 0036708291 scopus 로고    scopus 로고
    • Death receptor-mediated apoptosis and the liver
    • Yoon JH, Gores GJ. Death receptor-mediated apoptosis and the liver. J Hepatol 2002; 37: 400-10.
    • (2002) J Hepatol , vol.37 , pp. 400-410
    • Yoon, J.H.1    Gores, G.J.2
  • 23
    • 1342329725 scopus 로고    scopus 로고
    • The caspase inhibitor IDN-6556 attenuates hepatic injury and fibrosis in the bile duct ligated mouse
    • Canbay A, Feldstein A, Baskin-Bey E, et al. The caspase inhibitor IDN-6556 attenuates hepatic injury and fibrosis in the bile duct ligated mouse. J Pharmacol Exp Ther 2004; 308: 1191-6.
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 1191-1196
    • Canbay, A.1    Feldstein, A.2    Baskin-Bey, E.3
  • 24
    • 0032573581 scopus 로고    scopus 로고
    • Regulation of the proinflammatory effects of Fas ligand (CD95L)
    • Chen JJ, Sun Y, Nabel GJ. Regulation of the proinflammatory effects of Fas ligand (CD95L). Science 1998; 282: 1714-7.
    • (1998) Science , vol.282 , pp. 1714-1717
    • Chen, J.J.1    Sun, Y.2    Nabel, G.J.3
  • 25
    • 0031050205 scopus 로고    scopus 로고
    • Adenovirus-mediated expression of cytokine-induced neutrophil chemoattractant in rat liver induces a neutrophilic hepatitis
    • Maher JJ, Scott MK, Saito JM, et al. Adenovirus-mediated expression of cytokine-induced neutrophil chemoattractant in rat liver induces a neutrophilic hepatitis. Hepatology 1997; 25: 624-30.
    • (1997) Hepatology , vol.25 , pp. 624-630
    • Maher, J.J.1    Scott, M.K.2    Saito, J.M.3
  • 26
    • 0031721754 scopus 로고    scopus 로고
    • Parenchymal cell apoptosis as a signal for sinusoidal sequestration and transendothelial migration of neutrophils in murine models of endotoxin and Fas-antibody-induced liver injury
    • Lawson JA, Fisher MA, Simmons CA, et al. Parenchymal cell apoptosis as a signal for sinusoidal sequestration and transendothelial migration of neutrophils in murine models of endotoxin and Fas-antibody-induced liver injury. Hepatology 1998; 28: 761-7.
    • (1998) Hepatology , vol.28 , pp. 761-767
    • Lawson, J.A.1    Fisher, M.A.2    Simmons, C.A.3
  • 27
    • 0035966059 scopus 로고    scopus 로고
    • Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-kappa B-independent, caspase-3-dependent pathway
    • Faouzi S, Burckhardt BE, Hanson JC, et al. Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-kappa B-independent, caspase-3-dependent pathway. J Biol Chem 2001; 276: 49077-82.
    • (2001) J Biol Chem , vol.276 , pp. 49077-49082
    • Faouzi, S.1    Burckhardt, B.E.2    Hanson, J.C.3
  • 28
    • 0038820117 scopus 로고    scopus 로고
    • Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal
    • Lauber K, Bohn E, Krober SM, et al. Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal. Cell 2003; 113: 717-30.
    • (2003) Cell , vol.113 , pp. 717-730
    • Lauber, K.1    Bohn, E.2    Krober, S.M.3
  • 29
    • 0027291205 scopus 로고
    • Lethal effect of the anti-Fas antibody in mice
    • Ogasawara J, Watanabe-Fukunaga R, Adachi M, et al. Lethal effect of the anti-Fas antibody in mice. Nature 1993; 364: 806-9.
    • (1993) Nature , vol.364 , pp. 806-809
    • Ogasawara, J.1    Watanabe-Fukunaga, R.2    Adachi, M.3
  • 30
    • 0031902464 scopus 로고    scopus 로고
    • Dysregulation of apoptosis as a mechanism of liver disease: An overview
    • Patel T, Roberts LR, Jones BA, et al. Dysregulation of apoptosis as a mechanism of liver disease: an overview. Semin Liver Dis 1998; 18: 105-14.
    • (1998) Semin Liver Dis , vol.18 , pp. 105-114
    • Patel, T.1    Roberts, L.R.2    Jones, B.A.3
  • 31
    • 0030896618 scopus 로고    scopus 로고
    • Differential induction of apoptosis by Fas-Fas ligand interactions in human monocytes and macrophages
    • Kiener PA, Davis PM, Starling GC, et al. Differential induction of apoptosis by Fas-Fas ligand interactions in human monocytes and macrophages. J Exp Med 1997; 185: 1511-6.
    • (1997) J Exp Med , vol.185 , pp. 1511-1516
    • Kiener, P.A.1    Davis, P.M.2    Starling, G.C.3
  • 32
    • 0036636745 scopus 로고    scopus 로고
    • The role of the macrophage in apoptosis: Hunter, gatherer, and regulator
    • Geske FJ, Monks J, Lehman L, Fadok VA. The role of the macrophage in apoptosis: hunter, gatherer, and regulator. Int J Hematol 2002; 76: 16-26.
    • (2002) Int J Hematol , vol.76 , pp. 16-26
    • Geske, F.J.1    Monks, J.2    Lehman, L.3    Fadok, V.A.4
  • 33
    • 0142151769 scopus 로고    scopus 로고
    • Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression
    • Canbay A, Feldstein AE, Higuchi H, et al. Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression. Hepatology 2003; 38: 1188-98.
    • (2003) Hepatology , vol.38 , pp. 1188-1198
    • Canbay, A.1    Feldstein, A.E.2    Higuchi, H.3
  • 34
    • 0032055225 scopus 로고    scopus 로고
    • Activation of caspase 3 (CPP32)-like proteases is essential for TNF-alpha-induced hepatic parenchymal cell apoptosis and neutrophil-mediated necrosis in a murine endotoxin shock model
    • Jaeschke H, Fisher MA, Lawson JA, et al. Activation of caspase 3 (CPP32)-like proteases is essential for TNF-alpha-induced hepatic parenchymal cell apoptosis and neutrophil-mediated necrosis in a murine endotoxin shock model. J Immunol 1998; 160: 3480-6.
    • (1998) J Immunol , vol.160 , pp. 3480-3486
    • Jaeschke, H.1    Fisher, M.A.2    Lawson, J.A.3
  • 35
    • 0035113898 scopus 로고    scopus 로고
    • Clinical and biological relevance of hepatocyte apoptosis in alcoholic hepatitis
    • Ziol M, Tepper M, Lohez M, et al. Clinical and biological relevance of hepatocyte apoptosis in alcoholic hepatitis. J Hepatol 2001; 34: 254-60.
    • (2001) J Hepatol , vol.34 , pp. 254-260
    • Ziol, M.1    Tepper, M.2    Lohez, M.3
  • 36
    • 0036017174 scopus 로고    scopus 로고
    • Neutrophil-mediated tissue injury in alcoholic hepatitis
    • Jaeschke H. Neutrophil-mediated tissue injury in alcoholic hepatitis. Alcohol 2002; 27: 23-7.
    • (2002) Alcohol , vol.27 , pp. 23-27
    • Jaeschke, H.1
  • 37
    • 0034723290 scopus 로고    scopus 로고
    • Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
    • Friedman SL. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 2000; 275: 2247-50.
    • (2000) J Biol Chem , vol.275 , pp. 2247-2250
    • Friedman, S.L.1
  • 38
    • 0034809664 scopus 로고    scopus 로고
    • Interactions between hepatic stellate cells and the immune system
    • Maher JJ. Interactions between hepatic stellate cells and the immune system. Semin Liver Dis 2001; 21: 417-26.
    • (2001) Semin Liver Dis , vol.21 , pp. 417-426
    • Maher, J.J.1
  • 39
    • 0038185316 scopus 로고    scopus 로고
    • Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells
    • Paik YH, Schwabe RF, Bataller R, et al. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology 2003; 37: 1043-55.
    • (2003) Hepatology , vol.37 , pp. 1043-1055
    • Paik, Y.H.1    Schwabe, R.F.2    Bataller, R.3
  • 40
    • 0029864142 scopus 로고    scopus 로고
    • Mediators of hepatic fibrogenesis
    • Gressner AM. Mediators of hepatic fibrogenesis. Hepatogastroenterology 1996; 43: 92-103.
    • (1996) Hepatogastroenterology , vol.43 , pp. 92-103
    • Gressner, A.M.1
  • 41
    • 4544335155 scopus 로고    scopus 로고
    • Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients
    • Ribeiro PS, Cortez-Pinto H, Sola S, et al. Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients. Am J Gastroenterol 2004; 99: 1708-17.
    • (2004) Am J Gastroenterol , vol.99 , pp. 1708-1717
    • Ribeiro, P.S.1    Cortez-Pinto, H.2    Sola, S.3
  • 42
    • 0348134733 scopus 로고    scopus 로고
    • Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice
    • Feldstein A, Canbay A, Guicciardi ME, et al. Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice. J Hepatol 2003; 39: 978-83.
    • (2003) J Hepatol , vol.39 , pp. 978-983
    • Feldstein, A.1    Canbay, A.2    Guicciardi, M.E.3
  • 44
    • 1542515165 scopus 로고    scopus 로고
    • Subliminal Fas stimulation increases the hepatotoxicity of acetaminophen and bromobenzene in mice
    • Tinel M, Berson A, Vadrot N, et al. Subliminal Fas stimulation increases the hepatotoxicity of acetaminophen and bromobenzene in mice. Hepatology 2004; 39: 655-66.
    • (2004) Hepatology , vol.39 , pp. 655-666
    • Tinel, M.1    Berson, A.2    Vadrot, N.3
  • 45
    • 25844520517 scopus 로고    scopus 로고
    • Overweight patients are more susceptible for acute liver failure
    • in press
    • Canbay A, Chen S-Y, Gieseler RK, et al. Overweight patients are more susceptible for acute liver failure. Hepatogastroenterology 2005; in press.
    • (2005) Hepatogastroenterology
    • Canbay, A.1    Chen, S.-Y.2    Gieseler, R.K.3
  • 46
    • 0141996262 scopus 로고    scopus 로고
    • First clinical trial of a novel caspase inhibitor: Anti-apoptotic caspase inhibitor, IDN-6556, improves liver enzymes
    • Valentino KL, Gutierrez M, Sanchez R, et al. First clinical trial of a novel caspase inhibitor: anti-apoptotic caspase inhibitor, IDN-6556, improves liver enzymes. Int J Clin Pharmacol Ther 2003; 41: 441-9.
    • (2003) Int J Clin Pharmacol Ther , vol.41 , pp. 441-449
    • Valentino, K.L.1    Gutierrez, M.2    Sanchez, R.3
  • 47
    • 2942729545 scopus 로고    scopus 로고
    • Suramin inhibits death receptor-induced apoptosis in vitro and fulminant apoptotic liver damage in mice
    • Eichhorst ST, Krueger A, Muerkoster S, et al. Suramin inhibits death receptor-induced apoptosis in vitro and fulminant apoptotic liver damage in mice. Nat Med 2004; 10: 602-9.
    • (2004) Nat Med , vol.10 , pp. 602-609
    • Eichhorst, S.T.1    Krueger, A.2    Muerkoster, S.3
  • 48
    • 2942703816 scopus 로고    scopus 로고
    • Cheating death in the liver
    • Guicciardi ME, Gores GJ. Cheating death in the liver. Nat Med 2004; 10: 587-8.
    • (2004) Nat Med , vol.10 , pp. 587-588
    • Guicciardi, M.E.1    Gores, G.J.2


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