DNA-PKcs-mediated stabilization of p53 by JNK2 is involved in arsenite-induced DNA damage and apoptosis in human embryo lung fibroblast cells

Toxicology Letters

Volumn 210, Issue 3, 2012, Pages 302-310

  Li, Yuan ^a,b   Zhao, Yue ^a,b   Jiang, Rongrong ^a,b   Xu, Yuan ^a,b   Ling, Min ^a,b   Pang, Ying ^a,b   Shen, Lu ^a,b   Zhou, Yun ^c   Zhang, Jianping ^c   Zhou, Jianwei ^b   Wang, Xinru ^b   Liu, Qizhan ^a,b  

^a NANJING MEDICAL UNIVERSITY   (China)

^b Nanjing Medical University   (China)

^c THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Arsenite; C Jun N terminal kinases (JNKs); Dependent protein kinase catalytic subunit (DNA PKcs); Murine double minute 2 (mdm2); P53

Indexed keywords

ARSENIC TRIOXIDE; DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; DNA; JANUS KINASE 2; PROTEASOME; PROTEIN P53; PROTEIN SERINE THREONINE KINASE; UBIQUITIN; UNCLASSIFIED DRUG; ARSENOUS ACID DERIVATIVE; DNA DEPENDENT PROTEIN KINASE; HEAT SHOCK PROTEIN 70; HSPA9 PROTEIN, HUMAN; MDM2 PROTEIN, HUMAN; MITOCHONDRIAL PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 9; NUCLEAR PROTEIN; PRKDC PROTEIN, HUMAN; PROTEIN MDM2; TP53 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; DNA DAMAGE; EMBRYO; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LUNG FIBROBLAST; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; ACTIVE TRANSPORT; CELL CULTURE; CYTOLOGY; DRUG EFFECT; FIBROBLAST; LUNG; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

MURINAE;

ACTIVE TRANSPORT, CELL NUCLEUS; APOPTOSIS; ARSENITES; CELLS, CULTURED; DNA DAMAGE; DNA-ACTIVATED PROTEIN KINASE; FIBROBLASTS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; LUNG; MAP KINASE SIGNALING SYSTEM; MITOCHONDRIAL PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 9; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84858973975     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.02.006     Document Type: Article

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