Bone morphogenetic proteins and degenerative disk disease

Neurosurgery

Volumn 70, Issue 4, 2012, Pages 996-1002

  Than, Khoi D ^a   Rahman, Shayan U ^a   Vanaman, Monique J ^a   Wang, Anthony C ^a   Lin, Chia Ying ^a   Zhang, Huina ^a   La Marca, Frank ^a   Park, Paul ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Back pain; Bone morphogenetic protein; Degenerative disk disease; Intervertebral disk; Review

Indexed keywords

BONE MORPHOGENETIC PROTEIN 10; BONE MORPHOGENETIC PROTEIN 11; BONE MORPHOGENETIC PROTEIN 12; BONE MORPHOGENETIC PROTEIN 14; BONE MORPHOGENETIC PROTEIN 15; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN 5; BONE MORPHOGENETIC PROTEIN 8; GROWTH DIFFERENTIATION FACTOR 6; LIM MINERALIZATION PROTEIN 1; OSTEOGENIC PROTEIN 1; OSTEOGENIN; PROTEIN; SIMVASTATIN; UNCLASSIFIED DRUG;

ADENOVIRUS; AGING; APOPTOSIS; DATA BASE; DEGENERATIVE DISEASE; DEGENERATIVE DISK DISEASE; EXTRACELLULAR MATRIX; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INTERVERTEBRAL DISK DISEASE; NONHUMAN; PRIORITY JOURNAL; REVIEW; UPREGULATION;

ANIMALS; BACK PAIN; BONE MORPHOGENETIC PROTEINS; HUMANS; INTERVERTEBRAL DISC DEGENERATION;

EID: 84858748064     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1227/NEU.0b013e318235d65f     Document Type: Review

References (49)

1. Reddi AH. Bone and cartilage differentiation. Curr Opin Genet Dev. 1994;4(5): 737-744. (Pubitemid 24322911)
2. Gilbertson L, Ahn SH, Teng PN, Studer RK, Niyibizi C, Kang JD. The effects of recombinant human bone morphogenetic protein-2, recombinant human bone morphogenetic protein-12, and adenoviral bone morphogenetic protein-12 on matrix synthesis in human annulus fibrosis and nucleus pulposus cells. Spine J. 2008;8(3):449-456. (Pubitemid 351608960)
3. Majumdar MK, Wang E, Morris EA. BMP-2 and BMP-9 promotes chondrogenic differentiation of human multipotential mesenchymal cells and overcomes the inhibitory effect of IL-1. J Cell Physiol. 2001;189(3):275-284. (Pubitemid 33063295)
4. Snelling SJ, Hulley PA, Loughlin J. BMP5 activates multiple signaling pathways and promotes chondrogenic differentiation in the ATDC5 growth plate model. Growth Factors. 2010;28(4):268-279.
5. Sekiya I, Colter DC, Prockop DJ. BMP-6 enhances chondrogenesis in a sub-population of human marrow stromal cells. Biochem Biophys Res Commun. 2001; 284(2):411-418. (Pubitemid 32917992)
6. DiLeone RJ, King JA, Storm EE, Copeland NG, Jenkins NA, Kingsley DM. The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4. Genomics. 1997;40(1): 196-198. (Pubitemid 27108272)
7. Bolt P, Clerk AN, Luu HH, et al. BMP-14 gene therapy increases tendon tensile strength in a rat model of Achilles tendon injury. J Bone Joint Surg Am. 2007;89(6): 1315-1320. (Pubitemid 46898004)
8. Thawani JP, Wang AC, Than KD, Lin CY, La Marca F, Park P. Bone morphogenetic proteins and cancer: review of the literature. Neurosurgery. 2010;66 (2):233-246.
9. Takae R, Matsunaga S, Origuchi N, et al. Immunolocalization of bone morphogenetic protein and its receptors in degeneration of intervertebral disc. Spine (Phila Pa 1976). 1999;24(14):1397-1401. (Pubitemid 29331410)
10. Kim KS, Yoon ST, Park JS, Li J, Park MS, Hutton WC. Inhibition of proteoglycan and type II collagen synthesis of disc nucleus cells by nicotine. J Neurosurg. 2003;99(3 suppl):291-297.
11. Murakami H, Yoon ST, Attallah-Wasif ES, Tsai KJ, Fei Q, Hutton WC. The expression of anabolic cytokines in intervertebral discs in age-related degeneration. Spine (Phila Pa 1976). 2006;31(16):1770-1774. (Pubitemid 44079501)
12. Sowa G, Vadala G, Studer R, et al. Characterization of intervertebral disc aging: longitudinal analysis of a rabbit model by magnetic resonance imaging, histology, and gene expression. Spine (Phila Pa 1976). 2008;33(17):1821-1828.
13. Guehring T, Omlor GW, Lorenz H, et al. Stimulation of gene expression and loss of anular architecture caused by experimental disc degeneration-an in vivo animal study. Spine (Phila Pa 1976). 2005;30(22):2510-2515. (Pubitemid 41669086)
14. Omlor GW, Lorenz H, Engelleiter K, et al. Changes in gene expression and protein distribution at different stages of mechanically induced disc degeneration: an in vivo study on the New Zealand white rabbit. J Orthop Res. 2006;24(3): 385-392. (Pubitemid 43772999)
15. Anderson DG, Izzo MW, Hall DJ, et al. Comparative gene expression profiling of normal and degenerative discs: analysis of a rabbit annular laceration model. Spine (Phila Pa 1976). 2002;27(12):1291-1296. (Pubitemid 34655134)
16. Sobajima S, Shimer AL, Chadderdon RC, et al. Quantitative analysis of gene expression in a rabbit model of intervertebral disc degeneration by real-time polymerase chain reaction. Spine J. 2005;5(1):14-23. (Pubitemid 40104285)
17. Fei QM, Jiang XX, Chen TY, et al. Changes with age and the effect of recombinant human BMP-2 on proteoglycan and collagen gene expression in rabbit anulus fibrosus cells. Acta Biochim Biophys Sin (Shanghai). 2006;38(11): 773-779.
18. Zhang Y, Li Z, Thonar EJ, et al. Transduced bovine articular chondrocytes affect the metabolism of cocultured nucleus pulposus cells in vitro: implications for chondrocyte transplantation into the intervertebral disc. Spine (Phila Pa 1976). 2005;30(23):2601-2607. (Pubitemid 41780369)
19. Zhang Y, Anderson DG, Phillips FM, et al. Comparative effects of bone morphogenetic proteins and Sox9 overexpression on matrix accumulation by bovine anulus fibrosus cells: implications for anular repair. Spine (Phila Pa 1976). 2007;32(23):2515-2520. (Pubitemid 350059476)
20. Wallach CJ, Sobajima S, Watanabe Y, et al. Gene transfer of the catabolic inhibitor TIMP-1 increases measured proteoglycans in cells from degenerated human intervertebral discs. Spine (Phila Pa 1976). 2003;28(20): 2331-2337. (Pubitemid 37271328)
21. Moon SH, Nishida K, Gilbertson LG, et al. Biologic response of human intervertebral disc cells to gene therapy cocktail. Spine (Phila Pa 1976). 2008;33 (17):1850-1855.
22. Zhang Y, Phillips FM, Thonar EJ, et al. Cell therapy using articular chondrocytes overexpressing BMP-7 or BMP-10 in a rabbit disc organ culture model. Spine (Phila Pa 1976). 2008;33(8):831-838. (Pubitemid 351533849)
23. Takegami K, Thonar EJ, An HS, Kamada H, Masuda K. Osteogenic protein-1 enhances matrix replenishment by intervertebral disc cells previously exposed to interleukin-1. Spine (Phila Pa 1976). 2002;27(12):1318-1325.
24. Kawakami M, Matsumoto T, Hashizume H, Kuribayashi K, Chubinskaya S, Yoshida M. Osteogenic protein-1 (osteogenic protein-1/bone morphogenetic protein-7) inhibits degeneration and pain-related behavior induced by chronically compressed nucleus pulposus in the rat. Spine (Phila Pa 1976). 2005;30(17): 1933-1939. (Pubitemid 41292216)
25. Chubinskaya S, Kawakami M, Rappoport L, Matsumoto T, Migita N, Rueger DC. Anti-catabolic effect of OP-1 in chronically compressed intervertebral discs. J Orthop Res. 2007;25(4):517-530. (Pubitemid 46542040)
26. Wang C, Ruan DK, Zhang C, Wang DL, Xin H, Zhang Y. Effects of adeno-associated virus-2-mediated human BMP-7 gene transfection on the phenotype of nucleus pulposus cells. J Orthop Res. 2011;29(6):838-845.
27. An HS, Takegami K, Kamada H, et al. Intradiscal administration of osteogenic protein-1 increases intervertebral disc height and proteoglycan content in the nucleus pulposus in normal adolescent rabbits. Spine (Phila Pa 1976). 2005; 30(1)25-32.
28. Masuda K, Imai Y, Okuma M, et al. Osteogenic protein-1 injection into a degenerated disc induces the restoration of disc height and structural changes in the rabbit anular puncture model. Spine (Phila Pa 1976). 2006;31(7):742-754.
29. Miyamoto K, Masuda K, Kim JG, et al. Intradiscal injections of osteogenic protein-1 restore the viscoelastic properties of degenerated intervertebral discs. Spine J. 2006;6(6):692-703. (Pubitemid 44660878)
30. Imai Y, Okuma M, An HS, et al. Restoration of disc height loss by recombinant human osteogenic protein-1 injection into intervertebral discs undergoing degeneration induced by an intradiscal injection of chondroitinase ABC. Spine (Phila Pa 1976). 2007;32(11):1197-1205. (Pubitemid 46743020)
31. Wei A, Brisby H, Chung SA, Diwan AD. Bone morphogenetic protein-7 protects human intervertebral disc cells in vitro from apoptosis. Spine J. 2008;8(3):466-474.
32. Zhang H, Lin CY. Simvastatin stimulates chondrogenic phenotype of intervertebral disc cells partially through BMP-2 pathway. Spine (Phila Pa 1976). 2008;33(16):E525-E531.
33. Zhang H, Wang L, Park JB, et al. Intradiscal injection of simvastatin retards progression of intervertebral disc degeneration induced by stab injury. Arthritis Res Ther. 2009;11(6):R172.
34. Yoon ST, Park JS, Kim KS, et al. ISSLS prize winner: LMP-1 upregulates intervertebral disc cell production of proteoglycans and BMPs in vitro and in vivo. Spine (Phila Pa 1976). 2004;29(23):2603-2611. (Pubitemid 40353245)
35. Kuh SU, Zhu Y, Li J, et al. The AdLMP-1 transfection in two different cells; AF cells, chondrocytes as potential cell therapy candidates for disc degeneration. Acta Neurochir (Wien). 2008;150(8):803-810.
36. Mundy G, Garrett R, Harris S, et al. Stimulation of bone formation in vitro and in rodents by statins. Science. 1999;286(5446):1946-1949. (Pubitemid 129515901)
37. Guehring T, Omlor GW, Lorenz H, et al. Disc distraction shows evidence of regenerative potential in degenerated intervertebral discs as evaluated by protein expression, magnetic resonance imaging, and messenger ribonucleic acid expression analysis. Spine (Phila Pa 1976). 2006;31(15):1658-1665. (Pubitemid 43999961)
38. Boden SD. Biology of lumbar spine fusion and use of bone graft substitutes: present, future, and next generation. Tissue Eng. 2000;6(4):383-399. (Pubitemid 30655947)
39. Park JS, Nagata K. BMP and LMP-1 for intervertebral disc regeneration [in Japanese]. Clin Calcium. 2004;14(7):76-78.
40. Tim Yoon S, Su Kim K, Li J, et al. The effect of bone morphogenetic protein-2 on rat intervertebral disc cells in vitro. Spine (Phila Pa 1976). 2003;28(16):1773-1780. (Pubitemid 37012751)
41. Kim JS, Ellman MB, An HS, van Wijnen AJ, Borgia JA, Im HJ. Insulin-like growth factor 1 synergizes with bone morphogenetic protein 7-mediated anabolism in bovine intervertebral disc cells. Arthritis Rheum. 2010;62(12): 3706-3715.
42. Ariga K, Miyamoto S, Nakase T, et al. The relationship between apoptosis of endplate chondrocytes and aging and degeneration of the intervertebral disc. Spine (Phila Pa 1976). 2001;26(22):2414-2420. (Pubitemid 33065049)
43. Chen B, Fellenberg J, Wang H, Carstens C, Richter W. Occurrence and regional distribution of apoptosis in scoliotic discs. Spine (Phila Pa 1976). 2005;30(5): 519-524. (Pubitemid 40293838)
44. Kim KW, Kim YS, Ha KY, et al. An autocrine or paracrine Fas-mediated counterattack: a potential mechanism for apoptosis of notochordal cells in intact rat nucleus pulposus. Spine (Phila Pa 1976). 2005;30(11):1247-1251.
45. Luo X, Pietrobon R, Sun SX, Liu GG, Hey L. Estimates and patterns of direct health care expenditures among individuals with back pain in the United States. Spine (Phila Pa 1976). 2004;29(1):79-86. (Pubitemid 38040978)
46. Woolf AD, Pfleger B. Burden of major musculoskeletal conditions. Bull World Health Organ. 2003;81(9):646-656. (Pubitemid 37254686)
47. Anderson JAD. Back pain and occupation. In: Jayson MI, ed. The Lumbar Spine and Back Pain. 3rd ed. Edinburgh, Scotland: Churchill Livingstone; 1987:2-36.
48. Le Maitre CL, Richardson SM, Baird P, Freemont AJ, Hoyland JA. Expression of receptors for putative anabolic growth factors in human intervertebral disc: implications for repair and regeneration of the disc. J Pathol. 2005;207(4):445-452. (Pubitemid 43025693)
49. Attisano L, Wrana JL. Signal transduction by the TGF-beta superfamily. Science. 2002;296(5573):1646-1647.