Fluorophosphonylated nucleoside derivatives as new series of thymidine phosphorylase multisubstrate inhibitors

Journal of Medicinal Chemistry

Volumn 55, Issue 6, 2012, Pages 2758-2768

  Diab, Sonia Amel ^a   De Schutter, Coralie ^a   Muzard, Murielle ^b   Plantier Royon, Richard ^b   Pfund, Emmanuel ^a   Lequeux, Thierry ^a  

^a UNIVERSITÉ DE CAEN   (France)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1 (1 (5 DIISOPROPOXYPHOSPHONO 5,5 DIFLUOROPENTYL) 1,2,3 TRIAZOLO 4 METHYL)URACIL; 1,1 DIFLUORO 3 IODO 4 (5 METHYL 2,4 DIOXO 3,4 DIHYDROPYRIDIN 1(2H) YL)BUTYLPHOSPHONIC ACID; 1,1 DIFLUORO 4 (2 AMINO 6 HYDROXY 9H PURIN 9 YL) PENTYLPHOSPHONIC ACID; 1,1 DIFLUORO 4 (4 ((6 HYDROXY 9H PURIN 9 YL)METHYL) 1H 1,2,3 TRIAZOL 1 YL)BUTYLPHOSPHONIC ACID; 1,1 DIFLUORO 5 (2 (5 METHYL 2,4 DIHYDROPYRIMIDIN 1,3(2H) YL) 1 ETHANESULFURE)PENTYLPHOSPHONIC ACID; 1,1 DIFLUORO 5 (4 ((2,4 DIOXO 3,4 DIHYDROPYRIMIDIN 1(2H)YL)METHYL) 1H 1,2,3 TRIAZOL 1 YL)PENTYLPHOSPHONIC ACID; 1,1 DIFLUORO 5 (6 HYDROXY 9H PURIN 9 YL)PENTYLPHOSPHONIC ACID; 1,1 DIFLUORO 9 (5 METHYL 2,4 DIHYDROPYRIMIDIN 1,3(2H) YL) NONYLPHOSPHONIC ACID; 9 (1 (4 DIISOPROPOXYPHOSPHONO 4,4 DIFLUOROBUTYL) 1,2,3 TRIAZOLO 4 METHYL) 6 CHLOROPURINE; DIISOPROPYL 1,1 DIFLUORO 3 IODO 4 (5 METHYL 2,4 DIOXO 3,4 DIHYDROPYRIDIN 1(2H) YL)BUTYLPHOSPHONATE; DIISOPROPYL 1,1 DIFLUORO 5 (2 (3 BENZOYL 5 METHYL 2,4 DIHYDROPYRIMIDIN 1(2H) YL) 1 ETHANESULFURE)PENTYLPHOSPHONATE; DIISOPROPYL 1,1 DIFLUORO 5 (2 HYDROXY 1 ETHYLSULFANYL)PENTYLPHOSPHONATE; DIISOPROPYL 1,1 DIFLUORO 5 (2,4 DIOXO 3,4 DIHYDROPYRIMIDIN 1(2H) YL)PENTYLPHOSPHONATE; DIISOPROPYL 1,1 DIFLUORO 5 (5 BROMO 2,4 DIOXO 3,4 DIHYDROPYRIMIDIN 1(2H) YL)PENTYLPHOSPHONATE; DIISOPROPYL 1,1 DIFLUORO 9 (5 METHYL 2,4 DIHYDROPYRIMIDIN 1,3(2H) YL)NONYLPHOSPHONATE; DIISOPROPYL 1,1 DIFLUORO 9 BROMONONYLPHOSPHONATE; DIISOPROPYL 1,1DIFLUORO 9 (5 METHYL 2,4 DIHYDROPYRIMIDIN1,3(2H) YL)NONYLPHOSPHONATE; DIISOPROPYL 4 (2 AMINO 6 CHLORO 9H PURIN 9 YL) 1,1 DIFLUOROBUTYLPHOSPHONATE; FLUOROPHOSPHATE; FUSED CARBON NITROGEN HETEROCYCLE; GLYCOSYLTRANSFERASE INHIBITOR; NUCLEOSIDE DERIVATIVE; PHOSPHATE; PHOSPHONIC ACID DERIVATIVE; PYRIMIDINE DERIVATIVE; THYMIDINE PHOSPHORYLASE; THYMINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG CONFORMATION; DRUG SYNTHESIS; HUMAN; HUMAN CELL;

ANGIOGENESIS INHIBITORS; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; NUCLEOSIDES; PHOSPHONIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THYMIDINE PHOSPHORYLASE;

EID: 84858742379     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201694y     Document Type: Article

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