Targeting insulin-like growth factor i with 10-23 DNAzymes: 2′-O-methyl modifications in the catalytic core enhance mRNA cleavage

Biochemistry

Volumn 51, Issue 11, 2012, Pages 2181-2191

  Fokina, Alesya A ^a,b,c,d   Meschaninova, Mariya I ^c   Durfort, Tiphanie ^a,b,d   Venyaminova, Alya G ^c   François, Jean Christophe ^a,b,d  

^a INSERM   (France)

^b MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

^c INSTITUTE OF CHEMICAL BIOLOGY AND FUNDAMENTAL MEDICINE   (Russian Federation)

^d CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE; CATALYTIC CORE; CATALYTIC EFFICIENCIES; CATALYTIC PROPERTIES; CELL FUNCTIONS; CLEAVAGE RATES; DNAZYME; FLANKING SEQUENCE; GENE FUNCTION; IN-VITRO; IN-VIVO; INHIBITORY EFFECT; INHIBITORY MECHANISM; INSULIN-LIKE GROWTH FACTOR-I; MRNA TARGETS; PROTEIN-FREE; REPORTER GENE; REPORTER GENE ASSAYS; REPORTER-GENE EXPRESSION; RIBONUCLEOTIDES; RNA CLEAVAGE; RNA INTERFERENCE; SPECIFIC RECOGNITION; TARGET SEQUENCES; TUMOR GROWTH; TUMORIGENESIS;

CELLS; CYTOLOGY; GENE EXPRESSION; INSULIN; PEPTIDES; RNA;

DNA;

2' O METHYL MODIFIED DNAZYME; DEOXYRIBOZYME; MESSENGER RNA; NUCLEASE; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DNA FLANKING REGION; DNA METHYLATION; DNA MODIFICATION; DNA SEQUENCE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME KINETICS; ENZYME STABILITY; GENE ACTIVITY; GENE EXPRESSION; GENE FUNCTION; GENETIC TRANSFECTION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; RAT; REPORTER GENE; RNA CLEAVAGE; RNA TRANSCRIPTION;

ANIMALS; CATALYTIC DOMAIN; DNA, CATALYTIC; DNA, SINGLE-STRANDED; INSULIN-LIKE GROWTH FACTOR I; KINETICS; RATS; RNA CLEAVAGE; RNA INTERFERENCE; RNA, MESSENGER; TRANSFECTION;

GALIUM APARINE;

EID: 84858636357     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201532q     Document Type: Article

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