-
1
-
-
0033906634
-
Structure and function of the type 1 insulin-like growth factor receptor
-
Adams, T. E., Epa, V. C., Garrett, T. P., and Ward, C. W. (2000) Structure and function of the type 1 insulin-like growth factor receptor. Cell. Mol. Life Sci. 57, 1050-1093
-
(2000)
Cell. Mol. Life Sci.
, vol.57
, pp. 1050-1093
-
-
Adams, T.E.1
Epa, V.C.2
Garrett, T.P.3
Ward, C.W.4
-
2
-
-
0029913170
-
Overexpression of the insulin-like growth factor-1 receptor and autocrine stimulation in human cervical cancer cells
-
Steller, M. A., Delgado, C. H., Bartels, C. J., Woodworth, C. D., and Zou, Z. (1996) Overexpression of the insulin-like growth factor-1 receptor and autocrine stimulation in human cervical cancer cells. Cancer Res. 56, 1761-1765 (Pubitemid 26118210)
-
(1996)
Cancer Research
, vol.56
, Issue.8
, pp. 1761-1765
-
-
Steller, M.A.1
Delgado, C.H.2
Bartels, C.J.3
Woodworth, C.D.4
Zou, Z.5
-
3
-
-
0037092971
-
Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease
-
Hellawell, G. O., Turner, G. D., Davies, D. R., Poulsom, R., Brewster, S. F., and Macaulay, V. M. (2002) Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease. Cancer Res. 62, 2942-2950
-
(2002)
Cancer Res.
, vol.62
, pp. 2942-2950
-
-
Hellawell, G.O.1
Turner, G.D.2
Davies, D.R.3
Poulsom, R.4
Brewster, S.F.5
Macaulay, V.M.6
-
4
-
-
0032521210
-
Elevated insulin-like growth factor I receptor autophosphorylation and kinase activity in human breast cancer
-
Resnik, J. L., Reichart, D. B., Huey, K., Webster, N. J., and Seely, B. L. (1998) Elevated insulin-like growth factor I receptor autophosphorylation and kinase activity in human breast cancer. Cancer Res. 58, 1159-1164
-
(1998)
Cancer Res.
, vol.58
, pp. 1159-1164
-
-
Resnik, J.L.1
Reichart, D.B.2
Huey, K.3
Webster, N.J.4
Seely, B.L.5
-
5
-
-
60549112878
-
Insulin receptor substrate-2 mediated insulin-like growth factor-I receptor overexpression in pancreatic adenocarcinoma through protein kinase Cdelta
-
Kwon, J., Stephan, S., Mukhopadhyay, A., Muders, M. H., Dutta, S. K., Lau, J. S., and Mukhopadhyay, D. (2009) Insulin receptor substrate-2 mediated insulin-like growth factor-I receptor overexpression in pancreatic adenocarcinoma through protein kinase Cdelta. Cancer Res. 69, 1350-1357
-
(2009)
Cancer Res.
, vol.69
, pp. 1350-1357
-
-
Kwon, J.1
Stephan, S.2
Mukhopadhyay, A.3
Muders, M.H.4
Dutta, S.K.5
Lau, J.S.6
Mukhopadhyay, D.7
-
6
-
-
62449205665
-
Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition
-
Dallas, N. A., Xia, L., Fan, F., Gray, M. J., Gaur, P., van Buren, G., 2nd, Samuel, S., Kim, M. P., Lim, S. J., and Ellis, L. M. (2009) Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition. Cancer Res. 69, 1951-1957
-
(2009)
Cancer Res.
, vol.69
, pp. 1951-1957
-
-
Dallas, N.A.1
Xia, L.2
Fan, F.3
Gray, M.J.4
Gaur, P.5
Van Buren II, G.6
Samuel, S.7
Kim, M.P.8
Lim, S.J.9
Ellis, L.M.10
-
7
-
-
0037308651
-
A chimeric humanized single-chain antibody against the type I insulin-like growth factor (IGF) receptor renders breast cancer cells refractory to the mitogenic effects of IGF-I
-
Sachdev, D., Li, S. L., Hartell, J. S., Fujita-Yamaguchi, Y., Miller, J. S., and Yee, D. (2003) A chimeric humanized single-chain antibody against the type I insulin-like growth factor (IGF) receptor renders breast cancer cells refractory to the mitogenic effects of IGF-I. Cancer Res. 63, 627-635 (Pubitemid 36158140)
-
(2003)
Cancer Research
, vol.63
, Issue.3
, pp. 627-635
-
-
Sachdev, D.1
Li, S.-L.2
Hartell, J.S.3
Fujita-Yamaguchi, Y.4
Miller, J.S.5
Yee, D.6
-
8
-
-
12144285705
-
In vivo antitumor activity of NVP-AEW541 - A novel, potent, and selective inhibitor of the IGF-IR kinase
-
DOI 10.1016/S1535-6108(04)00051-0, PII S1535610804000510
-
Garcia-Echeverria, C., Pearson, M. A., Marti, A., Meyer, T., Mestan, J., Zimmermann, J., Gao, J., Brueggen, J., Capraro, H. G., Cozens, R., Evans, D. B., Fabbro, D., Furet, P., Porta, D. G., Liebetanz, J., Martiny-Baron, G., Ruetz, S., and Hofmann, F. (2004) In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell 5, 231-239 (Pubitemid 38402115)
-
(2004)
Cancer Cell
, vol.5
, Issue.3
, pp. 231-239
-
-
Garcia-Echeverria, C.1
Pearson, M.A.2
Marti, A.3
Meyer, T.4
Mestan, J.5
Zimmermann, J.6
Gao, J.7
Brueggen, J.8
Capraro, H.-G.9
Cozens, R.10
Evans, D.B.11
Fabbro, D.12
Furet, P.13
Porta, D.G.14
Liebetanz, J.15
Martiny-Baron, G.16
Ruetz, S.17
Hofmann, F.18
-
9
-
-
34548058890
-
A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo
-
Ji, Q. S., Mulvihill, M. J., Rosenfeld-Franklin, M., Cooke, A., Feng, L., Mak, G., O'Connor, M., Yao, Y., Pirritt, C., Buck, E., Eyzaguirre, A., Arnold, L. D., Gibson, N. W., and Pachter, J. A. (2007) A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo. Mol. Cancer Ther. 6, 2158-2167
-
(2007)
Mol. Cancer Ther.
, vol.6
, pp. 2158-2167
-
-
Ji, Q.S.1
Mulvihill, M.J.2
Rosenfeld-Franklin, M.3
Cooke, A.4
Feng, L.5
Mak, G.6
O'Connor, M.7
Yao, Y.8
Pirritt, C.9
Buck, E.10
Eyzaguirre, A.11
Arnold, L.D.12
Gibson, N.W.13
Pachter, J.A.14
-
10
-
-
46049100584
-
Inhibition of insulin-like growth factor-I receptor (IGF-IR) using NVP-AEW541, a small molecule kinase inhibitor, reduces orthotopic pancreatic cancer growth and angiogenesis
-
Moser, C., Schachtschneider, P., Lang, S. A., Gaumann, A., Mori, A., Zimmermann, J., Schlitt, H. J., Geissler, E. K., and Stoeltzing, O. (2008) Inhibition of insulin-like growth factor-I receptor (IGF-IR) using NVP-AEW541, a small molecule kinase inhibitor, reduces orthotopic pancreatic cancer growth and angiogenesis. Eur. J. Cancer 44, 1577-1586
-
(2008)
Eur. J. Cancer
, vol.44
, pp. 1577-1586
-
-
Moser, C.1
Schachtschneider, P.2
Lang, S.A.3
Gaumann, A.4
Mori, A.5
Zimmermann, J.6
Schlitt, H.J.7
Geissler, E.K.8
Stoeltzing, O.9
-
11
-
-
0036214015
-
Treatment of murine breast cancer cells with antisense RNA to the type I insulin-like growth factor receptor decreases the level of plasminogen activator transcripts, inhibits cell growth in vitro, and reduces tumorigenesis in vivo
-
Chernicky, C. L., Tan, H., Yi, L., Loret de Mola, J. R., and Ilan, J. (2002) Treatment of murine breast cancer cells with antisense RNA to the type I insulin-like growth factor receptor decreases the level of plasminogen activator transcripts, inhibits cell growth in vitro, and reduces tumorigenesis in vivo. Mol. Pathol. 55, 102-109
-
(2002)
Mol. Pathol.
, vol.55
, pp. 102-109
-
-
Chernicky, C.L.1
Tan, H.2
Yi, L.3
Loret De Mola, J.R.4
Ilan, J.5
-
12
-
-
34250012015
-
Antisense treatment of IGF-IR induces apoptosis and enhances chemosensitivity in central nervous system atypical teratoid/rhabdoid tumours cells
-
D'Cunja, J., Shalaby, T., Rivera, P., von Buren, A., Patti, R., Heppner, F. L., Arcaro, A., Rorke-Adams, L. B., Phillips, P. C., and Grotzer, M. A. (2007) Antisense treatment of IGF-IR induces apoptosis and enhances chemosensitivity in central nervous system atypical teratoid/rhabdoid tumours cells. Eur. J. Cancer 43, 1581-1589
-
(2007)
Eur. J. Cancer
, vol.43
, pp. 1581-1589
-
-
D'Cunja, J.1
Shalaby, T.2
Rivera, P.3
Von Buren, A.4
Patti, R.5
Heppner, F.L.6
Arcaro, A.7
Rorke-Adams, L.B.8
Phillips, P.C.9
Grotzer, M.A.10
-
13
-
-
73449103570
-
Antisense oligonucleotide targeting of insulin-like growth factor-1 receptor (IGF-1R) in prostate cancer
-
Furukawa, J., Wraight, C. J., Freier, S. M., Peralta, E., Atley, L. M., Monia, B. P., Gleave, M. E., and Cox, M. E. (2010) Antisense oligonucleotide targeting of insulin-like growth factor-1 receptor (IGF-1R) in prostate cancer. Prostate 70, 206-218
-
(2010)
Prostate
, vol.70
, pp. 206-218
-
-
Furukawa, J.1
Wraight, C.J.2
Freier, S.M.3
Peralta, E.4
Atley, L.M.5
Monia, B.P.6
Gleave, M.E.7
Cox, M.E.8
-
14
-
-
10844296820
-
Silencing of the IGF1R gene enhances sensitivity to DNA-damaging agents in both PTEN wild-type and mutant human prostate cancer
-
Rochester, M. A., Riedemann, J., Hellawell, G. O., Brewster, S. F., and Macaulay, V. M. (2005) Silencing of the IGF1R gene enhances sensitivity to DNA-damaging agents in both PTEN wild-type and mutant human prostate cancer. Cancer Gene Ther. 12, 90-100
-
(2005)
Cancer Gene Ther.
, vol.12
, pp. 90-100
-
-
Rochester, M.A.1
Riedemann, J.2
Hellawell, G.O.3
Brewster, S.F.4
Macaulay, V.M.5
-
15
-
-
33846458639
-
Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin
-
DOI 10.1158/0008-5472.CAN-06-1712
-
Zhang, H., Pelzer, A. M., Kiang, D. T., and Yee, D. (2007) Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin. Cancer Res. 67, 391-397 (Pubitemid 46142798)
-
(2007)
Cancer Research
, vol.67
, Issue.1
, pp. 391-397
-
-
Zhang, H.1
Pelzer, A.M.2
Kiang, D.T.3
Yee, D.4
-
16
-
-
77954441113
-
Sequence-specific targeting of IGF-I and IGF-IR genes by camptothecins
-
Oussedik, K., Francois, J. C., Halby, L., Senamaud-Beaufort, C., Toutirais, G., Dallavalle, S., Pommier, Y., Pisano, C., and Arimondo, P. B. (2010) Sequence-specific targeting of IGF-I and IGF-IR genes by camptothecins. FASEB J. 24, 2235-2244
-
(2010)
FASEB J.
, vol.24
, pp. 2235-2244
-
-
Oussedik, K.1
Francois, J.C.2
Halby, L.3
Senamaud-Beaufort, C.4
Toutirais, G.5
Dallavalle, S.6
Pommier, Y.7
Pisano, C.8
Arimondo, P.B.9
-
17
-
-
0033990354
-
Design of antisense and triplex-forming oligonucleotides
-
Francois, J. C., Lacoste, J., Lacroix, L., and Mergny, J. L. (2000) Design of antisense and triplex-forming oligonucleotides. Methods Enzymol. 313, 74-95
-
(2000)
Methods Enzymol.
, vol.313
, pp. 74-95
-
-
Francois, J.C.1
Lacoste, J.2
Lacroix, L.3
Mergny, J.L.4
-
18
-
-
0141988681
-
Genetic blockade of the insulin-like growth factor-I receptor: A promising strategy for human pancreatic cancer
-
Min, Y., Adachi, Y., Yamamoto, H., Ito, H., Itoh, F., Lee, C. T., Nadaf, S., Carbone, D. P., and Imai, K. (2003) Genetic blockade of the insulin-like growth factor-I receptor: a promising strategy for human pancreatic cancer. Cancer Res. 63, 6432-6441 (Pubitemid 37255193)
-
(2003)
Cancer Research
, vol.63
, Issue.19
, pp. 6432-6441
-
-
Min, Y.1
Adachi, Y.2
Yamamoto, H.3
Ito, H.4
Itoh, F.5
Lee, C.-T.6
Nadaf, S.7
Carbone, D.P.8
Imai, K.9
-
19
-
-
0036797073
-
Impact of insulin-like growth factor receptor-I function on angiogenesis, growth, and metastasis of colon
-
Reinmuth, N., Fan, F., Liu, W., Parikh, A. A., Stoeltzing, O., Jung, Y. D., Bucana, C. D., Radinsky, R., Gallick, G. E., and Ellis, L. M. (2002) Impact of insulin-like growth factor receptor-I function on angiogenesis, growth, and metastasis of colon. Cancer Lab. Invest. 82, 1377-1389
-
(2002)
Cancer Lab. Invest.
, vol.82
, pp. 1377-1389
-
-
Reinmuth, N.1
Fan, F.2
Liu, W.3
Parikh, A.A.4
Stoeltzing, O.5
Jung, Y.D.6
Bucana, C.D.7
Radinsky, R.8
Gallick, G.E.9
Ellis, L.M.10
-
20
-
-
0031785253
-
Inhibition of tumor growth by a dominant negative mutant of the insulin- like growth factor I receptor with a bystander effect
-
Reiss, K., D'Ambrosio, C., Tu, X., Tu, C., and Baserga, R. (1998) Inhibition of tumor growth by a dominant negative mutant of the insulin-like growth factor I receptor with a bystander effect. Clin. Cancer Res. 4, 2647-2655 (Pubitemid 28523490)
-
(1998)
Clinical Cancer Research
, vol.4
, Issue.11
, pp. 2647-2655
-
-
Reiss, K.1
D'Ambrosio, C.2
Tu, X.3
Tu, C.4
Baserga, R.5
-
21
-
-
69449097339
-
Emerging role of insulin-like growth factor receptor inhibitors in oncology: Early clinical trial results and future directions
-
Gualberto, A., and Pollak, M. (2009) Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions. Oncogene 28, 3009-3021
-
(2009)
Oncogene
, vol.28
, pp. 3009-3021
-
-
Gualberto, A.1
Pollak, M.2
-
22
-
-
4744373229
-
Noise amidst the silence: Off-target effects of siRNAs?
-
DOI 10.1016/j.tig.2004.08.006, PII S0168952504002409
-
Jackson, A. L., and Linsley, P. S. (2004) Noise amidst the silence: off-target effects of siRNAs? Trends Genet. 20, 521-524 (Pubitemid 39314555)
-
(2004)
Trends in Genetics
, vol.20
, Issue.11
, pp. 521-524
-
-
Jackson, A.L.1
Linsley, P.S.2
-
23
-
-
0036903132
-
Systemically delivered antisense oligomers upregulate gene expression in mouse tissues
-
DOI 10.1038/nbt759
-
Sazani, P., Gemignani, F., Kang, S. H., Maier, M. A., Manoharan, M., Persmark, M., Bortner, D., and Kole, R. (2002) Systemically delivered antisense oligomers upregulate gene expression in mouse tissues. Nat. Biotechnol. 20, 1228-1233 (Pubitemid 35462487)
-
(2002)
Nature Biotechnology
, vol.20
, Issue.12
, pp. 1228-1233
-
-
Sazani, P.1
Gemignani, F.2
Kang, S.-H.3
Maier, M.A.4
Manoharan, M.5
Persmark, M.6
Bortner, D.7
Kole, R.8
-
24
-
-
77950518145
-
Optimization of peptide nucleic acid antisense oligonucleotides for local and systemic dystrophin splice correction in the mdx mouse
-
Yin, H., Betts, C., Saleh, A. F., Ivanova, G. D., Lee, H., Seow, Y., Kim, D., Gait, M. J., and Wood, M. J. (2010) Optimization of peptide nucleic acid antisense oligonucleotides for local and systemic dystrophin splice correction in the mdx mouse. Mol. Ther. 18, 819-827
-
(2010)
Mol. Ther.
, vol.18
, pp. 819-827
-
-
Yin, H.1
Betts, C.2
Saleh, A.F.3
Ivanova, G.D.4
Lee, H.5
Seow, Y.6
Kim, D.7
Gait, M.J.8
Wood, M.J.9
-
25
-
-
0031010177
-
2′-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells
-
Baker, B. F., Lot, S. S., Condon, T. P., Cheng-Flournoy, S., Lesnik, E. A., Sasmor, H. M., and Bennett, C. F. (1997) 2′-O-(2-Methoxy)ethyl- modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells. J. Biol. Chem. 272, 11994-12000
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 11994-12000
-
-
Baker, B.F.1
Lot, S.S.2
Condon, T.P.3
Cheng-Flournoy, S.4
Lesnik, E.A.5
Sasmor, H.M.6
Bennett, C.F.7
-
26
-
-
1842412461
-
Transplatin-modified oligo(2'-o-methyl ribonucleotide)s: A new tool for selective modulation of gene expression
-
DOI 10.1021/bi962695f
-
Boudvillain, M., Guerin, M., Dalbies, R., Saison-Behmoaras, T., and Leng, M. (1997) Transplatin-modified oligo(2′-O-methyl ribonucleotide)s: a new tool for selective modulation of gene expression. Biochemistry 36, 2925-2931 (Pubitemid 27138576)
-
(1997)
Biochemistry
, vol.36
, Issue.10
, pp. 2925-2931
-
-
Boudvillain, M.1
Guerin, M.2
Dalbies, R.3
Saison-Behmoaras, T.4
Leng, M.5
-
27
-
-
0031896629
-
Assessment of high-affinity hybridization, RNase H cleavage, and covalent linkage in translation arrest by antisense oligonucleotides
-
Gee, J. E., Robbins, I., van der Laan, A. C., van Boom, J. H., Colombier, C., Leng, M., Raible, A. M., Nelson, J. S., and Lebleu, B. (1998) Assessment of high-affinity hybridization, RNase H cleavage, and covalent linkage in translation arrest by antisense oligonucleotides. Antisense Nucleic Acid Drug Dev. 8, 103-111 (Pubitemid 28223329)
-
(1998)
Antisense and Nucleic Acid Drug Development
, vol.8
, Issue.2
, pp. 103-111
-
-
Gee, J.E.1
Robbins, I.2
Van Der, L.A.C.3
Van Boom, J.H.4
Colombier, C.5
Leng, M.6
Raible, A.M.7
Nelson, J.S.8
Lebleu, B.9
-
28
-
-
34547621398
-
Cellular antisense activity of peptide nucleic acid (PNAs) targeted to HIV-1 polypurine tract (PPT) containing RNA
-
Boutimah-Hamoudi, F., Leforestier, E., Senamaud-Beaufort, C., Nielsen, P. E., Giovannangeli, C., and Saison-Behmoaras, T. E. (2007) Cellular antisense activity of peptide nucleic acid (PNAs) targeted to HIV-1 polypurine tract (PPT) containing RNA. Nucleic Acids Res. 35, 3907-3917
-
(2007)
Nucleic Acids Res.
, vol.35
, pp. 3907-3917
-
-
Boutimah-Hamoudi, F.1
Leforestier, E.2
Senamaud-Beaufort, C.3
Nielsen, P.E.4
Giovannangeli, C.5
Saison-Behmoaras, T.E.6
-
29
-
-
0036314340
-
RNA hairpin invasion and ribosome elongation arrest by mixed base PNA oligomer
-
DOI 10.1016/S0022-2836(02)00474-6
-
Dias, N., Senamaud-Beaufort, C., Forestier El, E., Auvin, C., Helene, C., and Ester Saison-Behmoaras, T. (2002) RNA hairpin invasion and ribosome elongation arrest by mixed base PNA oligomer. J. Mol. Biol. 320, 489-501 (Pubitemid 34753976)
-
(2002)
Journal of Molecular Biology
, vol.320
, Issue.3
, pp. 489-501
-
-
Dias, N.1
Senamaud-Beaufort, C.2
Forestier, E.L.3
Auvin, C.4
Helene, C.5
Ester S.-Behmoaras, T.6
-
30
-
-
0029980721
-
Antisense properties of duplex- and triplex-forming PNAs
-
Knudsen, H., and Nielsen, P. E. (1996) Antisense properties of duplex- and triplex-forming PNAs. Nucleic Acids Res. 24, 494-500
-
(1996)
Nucleic Acids Res.
, vol.24
, pp. 494-500
-
-
Knudsen, H.1
Nielsen, P.E.2
-
31
-
-
1542303763
-
Short pyrimidine stretches containing mixed base PNAs are versatile tools to induce translation elongation arrest and truncated protein synthesis
-
Senamaud-Beaufort, C., Leforestier, E., and Saison-Behmoaras, T. E. (2003) Short pyrimidine stretches containing mixed base PNAs are versatile tools to induce translation elongation arrest and truncated protein synthesis. Oligonucleotides 13, 465-478
-
(2003)
Oligonucleotides
, vol.13
, pp. 465-478
-
-
Senamaud-Beaufort, C.1
Leforestier, E.2
Saison-Behmoaras, T.E.3
-
32
-
-
0033559567
-
Automated synthesis of peptide nucleic acids and peptide nucleic acid-peptide conjugates
-
Mayfield, L. D., and Corey, D. R. (1999) Automated synthesis of peptide nucleic acids and peptide nucleic acid-peptide conjugates. Anal. Biochem. 268, 401-404
-
(1999)
Anal. Biochem.
, vol.268
, pp. 401-404
-
-
Mayfield, L.D.1
Corey, D.R.2
-
33
-
-
0034746953
-
Phosphormidate oligonucleotides as potent antisense molecules in cells and in vivo
-
DOI 10.1038/83489
-
Faria, M., Spiller, D. G., Dubertret, C., Nelson, J. S., White, M. R., Scherman, D., Helene, C., and Giovannangeli, C. (2001) Phosphoramidate oligonucleotides as potent antisense molecules in cells and in vivo. Nat. Biotechnol. 19, 40-44 (Pubitemid 32051954)
-
(2001)
Nature Biotechnology
, vol.19
, Issue.1
, pp. 40-44
-
-
Faria, M.1
Spiller, D.G.2
Dubertret, C.3
Nelson, J.S.4
White, M.R.H.5
Scherman, D.6
Helene, C.7
Giovannangeli, C.8
-
34
-
-
54449095504
-
Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer
-
Wu, B., Moulton, H. M., Iversen, P. L., Jiang, J., Li, J., Spurney, C. F., Sali, A., Guerron, A. D., Nagaraju, K., Doran, T., Lu, P., Xiao, X., and Lu, Q. L. (2008) Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer. Proc. Natl. Acad. Sci. U. S. A. 105, 14814-14819
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 14814-14819
-
-
Wu, B.1
Moulton, H.M.2
Iversen, P.L.3
Jiang, J.4
Li, J.5
Spurney, C.F.6
Sali, A.7
Guerron, A.D.8
Nagaraju, K.9
Doran, T.10
Lu, P.11
Xiao, X.12
Lu, Q.L.13
-
35
-
-
33748054317
-
Efficient and Persistent Splice Switching by Systemically Delivered LNA Oligonucleotides in Mice
-
DOI 10.1016/j.ymthe.2006.05.017, PII S1525001606002152
-
Roberts, J., Palma, E., Sazani, P., Orum, H., Cho, M., and Kole, R. (2006) Efficient and persistent splice switching by systemically delivered LNA oligonucleotides in mice. Mol. Ther. 14, 471-475 (Pubitemid 44296096)
-
(2006)
Molecular Therapy
, vol.14
, Issue.4
, pp. 471-475
-
-
Roberts, J.1
Palma, E.2
Sazani, P.3
Orum, H.4
Cho, M.5
Kole, R.6
-
36
-
-
3142762898
-
Intracellular inhibition of hepatitis C virus (HCV) internal ribosomal entry site (IRES)-dependent translation by peptide nucleic acids (PNAs) and locked nucleic acids (LNAs)
-
DOI 10.1093/nar/gkh706
-
Nulf, C. J., and Corey, D. (2004) Intracellular inhibition of hepatitis C virus (HCV) internal ribosomal entry site (IRES)-dependent translation by peptide nucleic acids (PNAs) and locked nucleic acids (LNAs). Nucleic Acids Res. 32, 3792-3798 (Pubitemid 39199071)
-
(2004)
Nucleic Acids Research
, vol.32
, Issue.13
, pp. 3792-3798
-
-
Nulf, C.J.1
Corey, D.2
-
37
-
-
6344277190
-
LNA (Locked Nucleic Acid): High-affinity targeting of complementary RNA and DNA
-
Vester, B., and Wengel, J. (2004) LNA (locked nucleic acid): high-affinity targeting of complementary RNA and DNA. Biochemistry 43, 13233-13241 (Pubitemid 39391124)
-
(2004)
Biochemistry
, vol.43
, Issue.42
, pp. 13233-13241
-
-
Vester, B.1
Wengel, J.2
-
38
-
-
0035881876
-
In vivo progression of LAPC-9 and LNCaP prostate cancer models to androgen independence is associated with increased expression of insulin-like growth factor I (IGF-I) and IGF-I receptor (IGF-IR)
-
Nickerson, T., Chang, F., Lorimer, D., Smeekens, S. P., Sawyers, C. L., and Pollak, M. (2001) In vivo progression of LAPC-9 and LNCaP prostate cancer models to androgen independence is associated with increased expression of insulin-like growth factor I (IGF-I) and IGF-I receptor (IGF-IR). Cancer Res. 61, 6276-6280 (Pubitemid 32762567)
-
(2001)
Cancer Research
, vol.61
, Issue.16
, pp. 6276-6280
-
-
Nickerson, T.1
Chang, F.2
Lorimer, D.3
Smeekens, S.P.4
Sawyers, C.L.5
Pollak, M.6
-
39
-
-
0029937307
-
Antisense RNA to the type I insulin-like growth factor receptor suppresses tumor growth and prevents invasion by rat prostate cancer cells in vivo
-
DOI 10.1073/pnas.93.14.7263
-
Burfeind, P., Chernicky, C. L., Rininsland, F., and Ilan, J. (1996) Antisense RNA to the type I insulin-like growth factor receptor suppresses tumor growth and prevents invasion by rat prostate cancer cells in vivo. Proc. Natl. Acad. Sci. U. S. A. 93, 7263-7268 (Pubitemid 26243537)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.14
, pp. 7263-7268
-
-
Burfeind, P.1
Chernicky, C.L.2
Rininsland, F.3
Ilan, J.4
Ilan, J.5
-
40
-
-
0037168667
-
Site-directed recombination via bifunctional PNA-DNA conjugates
-
Rogers, F. A., Vasquez, K. M., Egholm, M., and Glazer, P. M. (2002) Site-directed recombination via bifunctional PNA-DNA conjugates. Proc. Natl. Acad. Sci. U. S. A. 99, 16695-16700
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 16695-16700
-
-
Rogers, F.A.1
Vasquez, K.M.2
Egholm, M.3
Glazer, P.M.4
-
41
-
-
38949195105
-
Messenger RNA regulation: To translate or to degrade
-
DOI 10.1038/sj.emboj.7601977, PII 7601977
-
Shyu, A. B., Wilkinson, M. F., and van Hoof, A. (2008) Messenger RNA regulation: to translate or to degrade. EMBO J. 27, 471-481 (Pubitemid 351225677)
-
(2008)
EMBO Journal
, vol.27
, Issue.3
, pp. 471-481
-
-
Shyu, A.-B.1
Wilkinson, M.F.2
Van Hoof, A.3
-
43
-
-
33646891110
-
Induction of the interferon response by siRNA is cell type- and duplex length-dependent
-
DOI 10.1261/rna.2340906
-
Reynolds, A., Anderson, E. M., Vermeulen, A., Fedorov, Y., Robinson, K., Leake, D., Karpilow, J., Marshall, W. S., and Khvorova, A. (2006) Induction of the interferon response by siRNA is cell type- and duplex length-dependent. RNA 12, 988-993 (Pubitemid 43788117)
-
(2006)
RNA
, vol.12
, Issue.6
, pp. 988-993
-
-
Reynolds, A.1
Anderson, E.M.2
Vermeulen, A.3
Fedorov, Y.4
Robinson, K.5
Leake, D.6
Karpilow, J.7
Marshall, W.S.8
Khvorova, A.9
-
44
-
-
20144389695
-
Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7
-
DOI 10.1038/nm1191
-
Hornung, V., Guenthner-Biller, M., Bourquin, C., Ablasser, A., Schlee, M., Uematsu, S., Noronha, A., Manoharan, M., Akira, S., de Fougerolles, A., Endres, S., and Hartmann, G. (2005) Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat. Med. 11, 263-270 (Pubitemid 40460553)
-
(2005)
Nature Medicine
, vol.11
, Issue.3
, pp. 263-270
-
-
Hornung, V.1
Guenthner-Biller, M.2
Bourquin, C.3
Ablasser, A.4
Schlee, M.5
Uematsu, S.6
Noronha, A.7
Manoharan, M.8
Akira, S.9
De Fougerolles, A.10
Endres, S.11
Hartmann, G.12
-
45
-
-
33745614074
-
Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing
-
Jackson, A. L., Burchard, J., Leake, D., Reynolds, A., Schelter, J., Guo, J., Johnson, J. M., Lim, L., Karpilow, J., Nichols, K., Marshall, W., Khvorova, A., and Linsley, P. S. (2006) Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing. RNA 12, 1197-1205
-
(2006)
RNA
, vol.12
, pp. 1197-1205
-
-
Jackson, A.L.1
Burchard, J.2
Leake, D.3
Reynolds, A.4
Schelter, J.5
Guo, J.6
Johnson, J.M.7
Lim, L.8
Karpilow, J.9
Nichols, K.10
Marshall, W.11
Khvorova, A.12
Linsley, P.S.13
-
46
-
-
0029619816
-
Kinetic characteristics of Escherichia coli RNase H1: Cleavage of various antisense oligonucleotide-RNA duplexes
-
Crooke, S. T., Lemonidis, K. M., Neilson, L., Griffey, R., Lesnik, E. A., and Monia, B. P. (1995) Kinetic characteristics of Escherichia coli RNase H1: cleavage of various antisense oligonucleotide RNA duplexes. Biochem. J. 312, 599-608 (Pubitemid 26002231)
-
(1995)
Biochemical Journal
, vol.312
, Issue.2
, pp. 599-608
-
-
Crooke, S.T.1
Lemonidis, K.M.2
Neilson, L.3
Griffey, R.4
Lesnik, E.A.5
Monia, B.P.6
-
48
-
-
0033607615
-
Antisense PNA tridecamers targeted to the coding region of Ha-ras mRNA arrest polypeptide chain elongation
-
Dias, N., Dheur, S., Nielsen, P. E., Gryaznov, S., Van Aerschot, A., Herdewijn, P., Helene, C., and Saison-Behmoaras, T. E. (1999) Antisense PNA tridecamers targeted to the coding region of Ha-ras mRNA arrest polypeptide chain elongation. J. Mol. Biol. 294, 403-416
-
(1999)
J. Mol. Biol.
, vol.294
, pp. 403-416
-
-
Dias, N.1
Dheur, S.2
Nielsen, P.E.3
Gryaznov, S.4
Van Aerschot, A.5
Herdewijn, P.6
Helene, C.7
Saison-Behmoaras, T.E.8
-
49
-
-
0037335318
-
The impact of nucleic acid secondary structure on PNA hybridization
-
Armitage, B. A. (2003) The impact of nucleic acid secondary structure on PNA hybridization. Drug Discov. Today 8, 222-228
-
(2003)
Drug Discov. Today
, vol.8
, pp. 222-228
-
-
Armitage, B.A.1
-
50
-
-
33646950391
-
Evaluation of cell-penetrating peptides (CPPs) as vehicles for intracellular delivery of antisense peptide nucleic acid (PNA)
-
DOI 10.1021/bc050283q
-
Bendifallah, N., Rasmussen, F. W., Zachar, V., Ebbesen, P., Nielsen, P. E., and Koppelhus, U. (2006) Evaluation of cell-penetrating peptides (CPPs) as vehicles for intracellular delivery of antisense peptide nucleic acid (PNA). Bioconjug. Chem. 17, 750-758 (Pubitemid 43794386)
-
(2006)
Bioconjugate Chemistry
, vol.17
, Issue.3
, pp. 750-758
-
-
Bendifallah, N.1
Rasmussen, F.W.2
Zachar, V.3
Ebbesen, P.4
Nielsen, P.E.5
Koppelhus, U.6
-
51
-
-
48349109804
-
Subnanomolar antisense activity of phosphonate-peptide nucleic acid (PNA) conjugates delivered by cationic lipids to HeLa cells
-
Shiraishi, T., Hamzavi, R., and Nielsen, P. E. (2008) Subnanomolar antisense activity of phosphonate-peptide nucleic acid (PNA) conjugates delivered by cationic lipids to HeLa cells. Nucleic Acids Res. 36, 4424-4432
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. 4424-4432
-
-
Shiraishi, T.1
Hamzavi, R.2
Nielsen, P.E.3
-
52
-
-
0028928953
-
Efficient pH-independent sequence-specific DNA binding by pseudoisocytosine-containing bis-PNA
-
Egholm, M., Christensen, L., Dueholm, K. L., Buchardt, O., Coull, J., and Nielsen, P. E. (1995) Efficient pH-independent sequence-specific DNA binding by pseudoisocytosine-containing bis-PNA. Nucleic Acids Res. 23, 217-222
-
(1995)
Nucleic Acids Res.
, vol.23
, pp. 217-222
-
-
Egholm, M.1
Christensen, L.2
Dueholm, K.L.3
Buchardt, O.4
Coull, J.5
Nielsen, P.E.6
|