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Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 17, 2010, Pages 5119-5122

Introduction of guanidinium-modified deoxyuridine into the substrate binding regions of DNAzyme 10-23 to enhance target affinity: Implications for DNAzyme design

(2) Lam, Curtis H a Perrin, David M a

a UNIVERSITY OF BRITISH COLUMBIA (Canada)

Author keywords

10 23; DNAzymes; Guanidinium modified DNA; Guanidinium modified nucleoside

Indexed keywords

2 CYANOETHYL N,N' DIISOPROPY;CHLOROPHOSPHORAMIDITE; 5 (N,N' BICYANOETHOXYCARBONYL) GUANIDINOALLYL 2' DEOXYRURIDINE; DEOXYRIBOENZYME; DEOXYURIDINE; DIISOPROPYLETHYLAMIDE; DNA; GUANIDINE; MANGANESE; N,N' BIS (2 CYANOETHOXYCARBONYLOXY) 2 METHYL 2 THIOPSEUDOUREA; OLIGONUCLEOTIDE; PHOSPHORAMIDIC ACID; PHOSPHORAMIDOUS ACID; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYSIS; ENZYME STRUCTURE; MEMBRANE PERMEABILITY; PROTEIN CLEAVAGE; PROTEIN METABOLISM; PROTEIN MODIFICATION; PROTEIN TARGETING; RNA SEQUENCE; SOLID PHASE SYNTHESIS;

BIOCATALYSIS; DEOXYURIDINE; DNA, CATALYTIC; DNA, SINGLE-STRANDED; DRUG DESIGN; GUANIDINE; KINETICS; SUBSTRATE SPECIFICITY;

EID: 77955659487 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.07.027 Document Type: Article

Times cited : (24)

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