Optimisation of the 10-23 DNAzyme-substrate pairing interactions enhanced RNA cleavage activity at purine-cytosine target sites

Nucleic Acids Research

Volumn 31, Issue 11, 2003, Pages 2883-2889

  Cairns, Murray J ^a   King, Andrew ^a   Sun, Lun Quan ^a  

^a JOHNSON AND JOHNSON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; CYTOSINE; DINUCLEOTIDE; DNA; DNAZYME; GUANINE; PURINE; UNCLASSIFIED DRUG; URACIL; 2 AMINOPURINE; 2,6 DIAMINOPURINE; 2,6-DIAMINOPURINE; DEOXYRIBOZYME; DRUG DERIVATIVE; RIBOZYME; RNA; RNA CLEAVING DNA 10 23; RNA-CLEAVING DNA 10-23; SINGLE STRANDED DNA;

ARTICLE; BASE PAIRING; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME MODIFICATION; ENZYME SUBSTRATE COMPLEX; GENE SEQUENCE; GENE TARGETING; HYDROGEN BOND; MOLECULAR INTERACTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROCESS OPTIMIZATION; RNA CLEAVAGE; CATALYSIS; CHEMISTRY; CONFORMATION; ENZYME SPECIFICITY; KINETICS; METABOLISM;

2-AMINOPURINE; ADENINE; BASE PAIRING; BASE SEQUENCE; CATALYSIS; CYTOSINE; DNA, CATALYTIC; DNA, SINGLE-STRANDED; GUANINE; HYDROGEN BONDING; KINETICS; NUCLEIC ACID CONFORMATION; RNA; RNA, CATALYTIC; SUBSTRATE SPECIFICITY;

EID: 0037930729     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkg378     Document Type: Article

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