Probing the function of nucleotides in the catalytic cores of the 8-17 and 10-23 DNAzymes by abasic nucleotide and C3 spacer substitutions

Biochemistry

Volumn 49, Issue 35, 2010, Pages 7553-7562

  Wang, Bin ^a   Cao, Liqiang ^a   Chiuman, William ^b   Li, Yingfu ^b   Xi, Zhen ^a  

^a NANKAI UNIVERSITY   (China)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST ACTIVITY; CHEMICAL MODIFICATION; DNA; FUNCTIONAL GROUPS; MUTAGENESIS; OPTIMIZATION; RNA; SUGAR (SUCROSE);

CATALYTIC ACTIVITY; CATALYTIC CORE; CATALYTIC FUNCTIONS; DNAZYME; NUCLEOBASES; OPTIMAL FUNCTION; SUGAR RINGS;

NUCLEOTIDES;

DEOXYRIBOZYME; DNA; NUCLEOTIDE; OLIGONUCLEOTIDE; RNA; SPACER DNA; RNA-CLEAVING DNA 10-23; RNA-CLEAVING DNA 8-17; SINGLE STRANDED DNA;

ARTICLE; DNA SEQUENCE; ENZYME ACTIVITY; ENZYME KINETICS; MUTAGENESIS; NUCLEOTIDE SEQUENCE; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RNA CLEAVAGE; CHEMISTRY; CONFORMATION; ENZYME ACTIVE SITE; KINETICS; METABOLISM; MOLECULAR GENETICS;

BASE SEQUENCE; CATALYTIC DOMAIN; DNA, CATALYTIC; DNA, SINGLE-STRANDED; KINETICS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; NUCLEOTIDES;

EID: 77956133904     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100304b     Document Type: Article

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