Antisense insulin-like growth factor I transferred into a rat hepatoma cell line inhibits tumorigenesis by modulating major histocompatibility complex I cell surface expression

Cancer Gene Therapy

Volumn 4, Issue 5, 1997, Pages 276-285

  Lafarge Frayssinet, Christiane ^a   Duc, Huynh T ^b   Frayssinet, Charles ^a   Sarasin, Alain ^a   Anthony, Donald ^c   Guo, Yajun ^d   Trojan, Jerzy ^b  

^a CNRS   (France)

^b HÔPITAL PAUL BROUSSE   (France)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Eastern Institute of Hepatobiliary Surgery   (China)

Author keywords

Antisense ICF I; Gene therapy; Hepatoma; Major histocompatibility complex class I

Indexed keywords

B7 ANTIGEN; COMPLEMENTARY RNA; HLA ANTIGEN CLASS 1; MESSENGER RNA; SOMATOMEDIN C;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL DIVISION; CYTOCHEMISTRY; FLOW CYTOMETRY; GENE THERAPY; GENETIC TRANSFECTION; GENETICS; GLIOMA; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; LIVER TUMOR; METABOLISM; NORTHERN BLOTTING; PATHOLOGY; RAT;

ANIMALS; ANTIGENS, CD80; BLOTTING, NORTHERN; CELL DIVISION; FLOW CYTOMETRY; GENE THERAPY; GLIOMA; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; INSULIN-LIKE GROWTH FACTOR I; LIVER NEOPLASMS, EXPERIMENTAL; RATS; RNA, ANTISENSE; RNA, MESSENGER; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0031227543     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Bismuth H, Chiche L, Adam R, et al. Liver resection versus transplantation for hepatocellular carcinoma in cirrhotic patients. Ann Surg. 1993;218:145-151.
2. Han VKM, D'Ercole AJ, Lund PK. Cellular localization of somatomedin (insulin-like growth factor) messenger RNA in human fetus. Science (Wash DC). 1987;236:193-197.
3. Daughaday WH, Hall K, Raben MS, et al. Somatomedin: proposed designation for sulphation factor. Nature. 1972; 235:107.
4. Ulrich A, Gray A, Tam AW, et al. Insulin like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J. 1986;5:2503-2512.
5. White MF, Kahn CR. The insulin signaling system. J Biol Chem. 1994;269:1-4.
6. Baserga R. The insulin-like growth factor I receptor: a key to tumor growth? Cancer Res. 1995;55:249-252.
7. Johnson TR, Blossey BK, Rudin SD, et al. Regulation of IGF-I RNA transcript levels in C6 glial cells. J Cell Biol. 1991;111:505.
8. Kiess W, Lee L, Graham DE, et al. Rat C6 glial cells synthesize insulin-like growth factor I (IGF-I) and express IGF-I receptors and IGF-II/mannose-6-phosphate receptors. Endocrinology. 1989;124:1727-1736.
9. Sell C, Dumenil G, Deveaud C, et al. Effect of N cell mutation of the insulin like growth factor I receptor gene on growth and transformation of mouse embryo fibro-blasts. Mol Cell Biol. 1994;14:3604-3612.
10. Trojan J, Johnson TR, Rudin SD, et al. Treatment and prevention of rat glioblastoma by immunogenic C6 cells expressing antisense insulin like growth factor factor I. Science (Wash DC). 1993;256:94-97.
11. Resnicoff M, Sell C, Rubini M, et al. Rat glioblastoma cells expressing an antisense RNA to insulin like growth factor I (IGF-I) receptor are non tumorigenic and induce regression of wild type tumours. Cancer Res. 1994;54:2218-2222.
12. Resnicoff M, Abraham D, Yutanawibonchai W, et al. The insulin like growth factor I receptor protects tumor cells from apoptosis in vivo. Cancer Res. 1995;55:2463-2469.
13. Resnicoff M, Burgaud JL, Rotman HL, et al. Correlation between apoptosis, tumorogenesis and lack of insulin like growth factor I receptors. Cancer Res. 1995;55:3739-3741.
14. Resnicoff M, Coppola D, Sell C, et al. Growth inhibition of human melanoma cells in nude mice by antisense strategies to the type 1 Insulin like growth factor receptor. Cancer Res. 1994;54:4848-4850.
15. Trojan J, Blossey BK, Johnson TR, et al. Loss of tumorigenicity of rat glioblastoma directed by episome based antisense cDNA transcription of insulin like growth factor I. Proc Natl Acad Sci USA. 1992;89:4874-4878.
16. Trojan J, Johnson TR, Rudin SD, et al. Gene therapy of murine teratocarcinoma: separate functions for insulin like growth factors I and II in immunogenicity and differentiation. Proc Natl Acad Sci USA. 1994;91:6088-6092.
17. Hatzfeld AB, Feldman G, Guesnon J, et al. The location of aldolase A, B by immunoperoxidase technique in fast growing rat hepatomas. Cancer Res. 1978;38:16-22.
18. Lafarge-Frayssinet C, Cassingena R, Frayssinet C, et al. Polyamines content and oncogene expression in hepatoma cells in culture during methionine deprevation and refeeding. Anticancer Res. 1993;13:491-496.
19. Trojan J, Uriel J, Deugnier MA, et al. Immunocytochemical quantitive study of alphafetoprotein in normal and neoplastic development. Dev Neurosci. 1984;6:251-259.
20. Due HT, Rucay P, Righenzi S, et al. Monoclonal antibodies directed against T cells epitopes presented by class I MHC antigens. Int Immunol. 1993;5:427-431.
21. Chirgwin JM, Przybyla AE, Mac Donald RJ, et al. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochem. 1979;18:5294-5299.
22. Jansen M, van Schaik FMA, Ricker AT, et al. Sequence of cDNA encoding human insulin like growth factor I precursor. Nature (London). 1983;306:609-611.
23. Guo Y, Wu M, Chen H, et al. Effective tumor vaccine generated by fusion of hepatoma cells with lymphocytes B cells. Science (Wash DC). 1994;263:518-520.
24. Trojan J, Due TH, Upegui-Gonzalez LC, et al. Presence of MHC-I and B-7 molecules in rat and human glioma cells expressing antisense IGF-I RNA. Neurosci Lett. 1996;212: 9-13.
25. Linsley PS, Clark EA, Ledbetter JA. T-cell antigen CD28 médiats adhesion with B cells by interacting with activation antigen B7/13. Proc Natl Acad Sci USA. 1990;87:5031-5035.
26. Freeman GJ, Gray GS, Gimmi CD, et al. Structure, expression and T cell costimulatory activity of murine homologue of the human B lymphocyte activation antigen B7. J Exp Med. 1991;174:625-631.
27. Harding F, Mc Arthur JG, Gross JA, et al. CD28 mediated signaling co-stimulates murine T cells and prevents induction of anergy in T cell clones. Nature (London). 1992;356: 607-609.
28. Chen L, Ashe S, Brady WA, et al. Costimulation of anti-tumor immunity by the B7 countereceptor for the T lymphocyte molecules CD28 and CTLA-4. Cell. 1992;71: 1093-1102.
29. Townsend SE, Allison JA. Tumor rejection after direct costimulation of CDS+ T cells by B7 transfected melanoma cells. Science (Wash DC). 1993;259:368-370.
30. Saji M, Moriarty J, Ban T, et al. Major histocompatibility complex class I gene expression in rat thyroid cells is regulated by hormones, methimazole, and iodide as well as interferon. J Clin Endocrinol Metab. 1992;75:871-878.
31. Schwartz RH. Costimulation of T lymphocytes: the role of CD28, CTLA-4 and B7/BB1 in interleukin-2 production and immunotherapy. Cell. 1992;71:1065-1068.
32. Daughaday WH, Parker KA, Borowski S, et al. Measurement of somatomedin related peptides in fetal, neonatal, and maternal rat serum by insulin like growth factor (IGF) I radioimmunoassay, IGF-II radioreceptor assay (RRA), and multiplication-stimulating activity RRA after acidethanol extraction. Endocrinology. 1982;110:575-584.
33. Harrington EA, Bennet MR, Fanidi A, et al. c-myc induced apoptosis in fibroblast inhibited by specific cytokines. EMBO J. 1994;13:3286-3295.
34. Culver KW, Ram Z, Wallbridge S, et al. In vivo gene transfer with retroviral vector producer cells for treatment of experimental brain tumors. Science (Wash DC). 1992; 256:1550-1552.
35. Ridoux V, Robert JJ, Zhang X, et al. Adenoviral vectors as functional retrograde neuronal tracers. Brain Res. 1994; 648:171-175.
36. Caruso M, Panis Y, Gagandeep, et al. Regression of established macroscopic liver metastases after in situ trans-duction of a suicide gene. Proc Nail Acad Sci USA. 1993;90:7024-7028.