In vivo optical imaging in gene & cell therapy

Current Gene Therapy

Volumn 12, Issue 1, 2012, Pages 2-11

  Tangney, Mark ^a   Francis, Kevin P ^b  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b PERKINELMER INC   (United States)

Author keywords

Cancer; Fluorescence; Ivis; Luciferase; Luminescence; Lux; Reporter gene; Vector

Indexed keywords

VIRUS VECTOR;

ARTICLE; BIOLUMINESCENCE; CELL THERAPY; CONTROLLED STUDY; FLUORESCENCE IMAGING; GENE TARGETING; GENE THERAPY; NONHUMAN; PLASMID; REPORTER GENE;

ANIMALIA;

EID: 84858327204     PISSN: 15665232     EISSN: 18755631     Source Type: Journal    
DOI: 10.2174/156652312799789299     Document Type: Article

References (130)

1. Snoeks TJ, Lowik CW, Kaijzel EL. 'In vivo' optical approaches to angiogenesis imaging. Angiogenesis 2010;13(2):135-147.
2. Contag CH, Contag PR, Mullins JI, et al. Photonic detection of bacterial pathogens in living hosts. Mol Microbiol 1995;18(4):593-603.
3. Zhang Q, Yin L, Tan Y, Yuan Z, Jiang H. Quantitative bioluminescence tomography guided by diffuse optical tomography. Opt Express 2008;16(3):1481-1486.
4. Kuo C, Coquoz O, Troy TL, Xu H, Rice BW. Three-dimensional reconstruction of in vivo bioluminescent sources based on multispectral imaging. J Biomed Opt 2007;12(2):024007.
5. Leblond F, Davis SC, Valdes PA, Pogue BW. Pre-clinical whole-body fluorescence imaging: Review of instruments, methods and applications. J Photochem Photobiol B 2010;98(1):77-94.
6. Chuang K, Cheng T. Noninvasive Imaging of Reporter Gene Expression and Distribution In Vivo. Fooyin J Health Sci 2010;2(1):1-11.
7. Michelini E, Cevenini L, Mezzanotte L, Roda A. Luminescent probes and visualization of bioluminescence. Methods Mol Biol 2009;574:1-13.
8. Edinger M, Sweeney TJ, Tucker AA, et al. Noninvasive assessment of tumor cell proliferation in animal models. Neoplasia 1999;1(4):303-310.
9. Rice BW, Cable MD, Nelson MB. In vivo imaging of light-emitting probes. J Biomed Opt 2001;6(4):432-440.
10. Bhaumik S, Gambhir SS. Optical imaging of Renilla luciferase reporter gene expression in living mice. Proc Natl Acad Sci U S A 2002;99(1):377-382.
11. Tannous BA, Kim DE, Fernandez JL, Weissleder R, Breakefield XO. Codon-optimized Gaussia luciferase cDNA for mammalian gene expression in culture and in vivo. Mol Ther 2005;11(3):435-443.
12. Bhaumik S, Lewis XZ, Gambhir SS. Optical imaging of Renilla luciferase, synthetic Renilla luciferase, and firefly luciferase reporter gene expression in living mice. J Biomed Opt 2004;9(3):578-586.
13. Kimura T, Hiraoka K, Kasahara N, Logg CR. Optimization of enzyme-substrate pairing for bioluminescence imaging of gene transfer using Renilla and Gaussia luciferases. J Gene Med 2010;12(6):528-537.
14. Wurdinger T, Badr C, Pike L, et al. A secreted luciferase for ex vivo monitoring of in vivo processes. Nat Methods 2008;5(2):171-173.
15. Inoue Y, Sheng F, Kiryu S, et al. Gaussia Luciferase for Bioluminescence Tumor Monitoring in Comparison with Firefly Luciferase. Mol Imaging 2011.
16. Bloquel C, Trollet C, Pradines E, et al. Optical imaging of luminescence for in vivo quantification of gene electrotransfer in mouse muscle and knee. BMC Biotechnol 2006;6:16.
17. Miloud T, Henrich C, Hammerling GJ. Quantitative comparison of click beetle and firefly luciferases for in vivo bioluminescence imaging. J Biomed Opt 2007;12(5):054018.
18. Nakajima Y, Yamazaki T, Nishii S, et al. Enhanced beetle luciferase for high-resolution bioluminescence imaging. PLoS One 2010;5(4):e10011.
19. Chang MH, Cirillo SL, Cirillo JD. Using luciferase to image bacterial infections in mice. J Vis Exp 2011(48).
20. Morrissey D, O'Sullivan GC, Tangney M. Tumour targeting with systemically administered bacteria. Curr Gene Ther 2010;10(1):3-14.
21. Ahmad S, Casey G, Cronin M, et al. Induction of effective antitumor response after mucosal bacterial vector mediated DNA vaccination with endogenous prostate cancer specific antigen. J Urol 2011;186(2):687-693.
22. van Pijkeren JP, Morrissey D, Monk IR, et al. A novel Listeria monocytogenes-based DNA delivery system for cancer gene therapy. Hum Gene Ther 2010;21(4):405-416.
23. Tangney M, Gahan CG. Listeria monocytogenes as a vector for anti-cancer therapies. Curr Gene Ther 2010;10(1):46-55.
24. Cronin M, Morrissey D, Rajendran S, et al. Orally administered bifidobacteria as vehicles for delivery of agents to systemic tumors. Mol Ther 2010;18(7):1397-1407.
25. Belas R, Mileham A, Cohn D, et al. Bacterial bioluminescence: isolation and expression of the luciferase genes from Vibrio harveyi. Science 1982;218(4574):791-793.
26. Riedel CU, Monk IR, Casey PG, et al. Improved luciferase tagging system for Listeria monocytogenes allows real-time monitoring in vivo and in vitro. Appl Environ Microbiol 2007;73(9):3091-3094.
27. Yu YA, Shabahang S, Timiryasova TM, et al. Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emitting proteins. Nat Biotechnol 2004;22(3):313-320.
28. Baban CK, Cronin MC, O'Hanlon DM, O'Sullivan GC, Tangney M. Bacteria as vectors for gene therapy of cancer. BioEngineered Bugs 2010;1(12).
29. Close DM, Patterson SS, Ripp S, et al. Autonomous bioluminescent expression of the bacterial luciferase gene cassette (lux) in a mammalian cell line. PLoS One 2010;5(8):e12441.
30. Kong Y, Shi Y, Chang M, et al. Whole-body imaging of infection using bioluminescence. Curr Protoc Microbiol 2011;Chapter 2:Unit 2C 4.
31. Liu H, Ren G, Liu S, et al. Optical imaging of reporter gene expression using a positron-emission-tomography probe. J Biomed Opt 2010;15(6):060505.
32. Tzou SC, Roffler S, Chuang KH, et al. Micro-PET imaging of beta-glucuronidase activity by the hydrophobic conversion of a glucuronide probe. Radiology 2009;252(3):754-762.
33. Patterson GH, Knobel SM, Sharif WD, Kain SR, Piston DW. Use of the green fluorescent protein and its mutants in quantitative fluorescence microscopy. Biophys J 1997;73(5):2782-2790.
34. Kremers GJ, Gilbert SG, Cranfill PJ, Davidson MW, Piston DW. Fluorescent proteins at a glance. J Cell Sci 2011;124(Pt 2):157-160.
35. Min J-J, Nguyen V, Gambhir S. Molecular Imaging of Biological Gene Delivery Vehicles for Targeted Cancer Therapy: Beyond Viral Vectors. Nuclear Medicine and Molecular Imaging 2010;44(1):15-24.
36. Beckmann N, Kneuer R, Gremlich HU, et al. In vivo mouse imaging and spectroscopy in drug discovery. NMR Biomed 2007;20(3):154-185.
37. Ntziachristos V, Ripoll J, Wang LV, Weissleder R. Looking and listening to light: the evolution of whole-body photonic imaging. Nat Biotechnol 2005;23(3):313-320.
38. Shaner NC, Steinbach PA, Tsien RY. A guide to choosing fluorescent proteins. Nat Methods 2005;2(12):905-909.
39. Levenson RM, Lynch DT, Kobayashi H, Backer JM, Backer MV. Multiplexing with multispectral imaging: from mice to microscopy. ILAR J 2008;49(1):78-88.
40. Ntziachristos V, Tung CH, Bremer C, Weissleder R. Fluorescence molecular tomography resolves protease activity in vivo. Nat Med 2002;8(7):757-760.
41. Shah K. Current advances in molecular imaging of gene and cell therapy for cancer. Cancer Biol Ther 2005;4(5):518-523.
42. Chuang KH, Wang HE, Cheng TC, et al. Development of a universal anti-polyethylene glycol reporter gene for noninvasive imaging of PEGylated probes. J Nucl Med 2010;51(6):933-341.
43. Aswathy RG, Yoshida Y, Maekawa T, Kumar DS. Near-infrared quantum dots for deep tissue imaging. Anal Bioanal Chem 2010;397(4):1417-1435.
44. Manchester M, Singh P. Virus-based nanoparticles (VNPs): platform technologies for diagnostic imaging. Adv Drug Deliv Rev 2006;58(14):1505-1522.
45. Fukumura D, Duda DG, Munn LL, Jain RK. Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models. Microcirculation 2010;17(3):206-225.
46. Tannous BA. Gaussia luciferase reporter assay for monitoring biological processes in culture and in vivo. Nat Protoc 2009;4(4):582-591.
47. Waerzeggers Y, Monfared P, Viel T, et al. Methods to monitor gene therapy with molecular imaging. Methods 2009;48(2):146-160.
48. Kim JB, Urban K, Cochran E, et al. Non-invasive detection of a small number of bioluminescent cancer cells in vivo. PLoS One 2010;5(2):e9364.
49. Davis HL, Millan CL, Watkins SC. Immune-mediated destruction of transfected muscle fibers after direct gene transfer with antigen-expressing plasmid DNA. Gene Ther 1997;4(3):181-188.
50. Tarantal AF, Lee CC. Long-term luciferase expression monitored by bioluminescence imaging after adeno-associated virus-mediated fetal gene delivery in rhesus monkeys (Macaca mulatta). Hum Gene Ther 2009;21(2):143-148.
51. Tiffen JC, Bailey CG, Ng C, Rasko JE, Holst J. Luciferase expression and bioluminescence does not affect tumor cell growth in vitro or in vivo. Mol Cancer 2010;9:299.
52. Brutkiewicz S, Mendonca M, Stantz K, et al. The expression level of luciferase within tumour cells can alter tumour growth upon in vivo bioluminescence imaging. Luminescence 2007;22(3):221-228.
53. Massoud TF, Singh A, Gambhir SS. Noninvasive molecular neuroimaging using reporter genes: part I, principles revisited. AJNR Am J Neuroradiol 2008;29(2):229-234.
54. Wu JC, Inubushi M, Sundaresan G, Schelbert HR, Gambhir SS. Optical imaging of cardiac reporter gene expression in living rats. Circulation 2002;105(14):1631-1634.
55. Rehemtulla A, Hall DE, Stegman LD, et al. Molecular imaging of gene expression and efficacy following adenoviral-mediated brain tumor gene therapy. Mol Imaging 2002;1(1):43-55.
56. Shah K, Tang Y, Breakefield X, Weissleder R. Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivo. Oncogene 2003;22(44):6865-6872.
57. Sato M, Johnson M, Zhang L, et al. Optimization of adenoviral vectors to direct highly amplified prostate-specific expression for imaging and gene therapy. Mol Ther 2003;8(5):726-737.
58. Li HJ, Everts M, Yamamoto M, Curiel DT, Herschman HR. Combinedtransductionaluntargeting/retargeting and transcriptional restriction enhances adenovirus gene targeting and therapy for hepatic colorectal cancer tumors. Cancer Res 2009;69(2):554-564.
59. Lalani AS, Chang B, Lin J, et al. Anti-tumor efficacy of human angiostatin using liver-mediated adeno-associated virus gene therapy. Mol Ther 2004;9(1):56-66.
60. Bortolanza S, Bunuales M, Otano I, et al. Treatment of pancreatic cancer with an oncolytic adenovirus expressing interleukin-12 in Syrian hamsters. Mol Ther 2009;17(4):614-622.
61. Bremer E, van Dam GM, de Bruyn M, et al. Potent systemic anticancer activity of adenovirally expressed EGFR-selective TRAIL fusion protein. Mol Ther 2008;16(12):1919-1926.
62. Krom YD, Fallaux FJ, Que I, Lowik C, van Dijk KW. Efficient in vivo knock-down of estrogen receptor alpha: application of recombinant adenovirus vectors for delivery of short hairpin RNA. BMC Biotechnol 2006;6:11.
63. Peterson CY, Shaterian A, Borboa AK, et al. The noninvasive, quantitative, in vivo assessment of adenoviral-mediated gene delivery in skin wound biomaterials. Biomaterials 2009;30(35):6788-6793.
64. Park CY, Chuck RS, Cano M, et al. Periocular triamcinolone enhances intraocular gene expression after delivery by adenovirus. Invest Ophthalmol Vis Sci 2008;49(1):399-406.
65. Deroose CM, Reumers V, Debyser Z, Baekelandt V. Seeing genes at work in the living brain with non-invasive molecular imaging. Curr Gene Ther 2009;9(3):212-238.
66. Leo BM, Li X, Balian G, Anderson DG. In vivo bioluminescent imaging of virus-mediated gene transfer and transduced cell transplantation in the intervertebral disc. Spine (Phila Pa 1976) 2004;29(8):838-844.
67. Ranki T, Kanerva A, Ristimaki A, et al. A heparan sulfate-targeted conditionally replicative adenovirus, Ad5.pk7-Delta24, for the treatment of advanced breast cancer. Gene Ther 2007;14(1):58-67.
68. Li X, Zhang YP, Kim HS, et al. Gene therapy for prostate cancer by controlling adenovirus E1a and E4 gene expression with PSES enhancer. Cancer Res 2005;65(5):1941-1951.
69. Breitbach CJ, Paterson JM, Lemay CG, et al. Targeted inflammation during oncolytic virus therapy severely compromises tumor blood flow. Mol Ther 2007;15(9):1686-1693.
70. Qiu Z, Harms JS, Zhu J, Splitter GA. Bovine herpesvirus tegument protein VP22 enhances thymidine kinase/ganciclovir suicide gene therapy for neuroblastomas compared to herpes simplex virus VP22. J Virol 2004;78(8):4224-4233.
71. Winkeler A, Sena-Esteves M, Paulis LE, et al. Switching on the lights for gene therapy. PLoS One 2007;2(6):e528.
72. Deroose CM, Reumers V, Gijsbers R, et al. Noninvasive monitoring of long-term lentiviral vector-mediated gene expression in rodent brain with bioluminescence imaging. Mol Ther 2006;14(3):423-431.
73. Feeley BT, Conduah AH, Sugiyama O, et al. In vivo molecular imaging of adenoviral versus lentiviral gene therapy in two bone formation models. J Orthop Res 2006;24(8):1709-1721.
74. Froelich S, Ziegler L, Stroup K, Wang P. Targeted gene delivery to CD117-expressing cells in vivo with lentiviral vectors co-displaying stem cell factor and a fusogenic molecule. Biotechnol Bioeng 2009;104(1):206-215.
75. Airenne KJ, Makkonen KE, Mahonen AJ, Yla-Herttuala S. In vivo application and tracking of baculovirus. Curr Gene Ther 2010;10(3):187-194.
76. Rajendran S, Collins S, van Pijkeren JP, et al. Targeting of breast metastases using a viral gene vector with tumour selective transcription. Anticancer Res 2011.
77. Collins SA, Buhles A, Scallan MF, et al. AAV2-mediated in vivo immune gene therapy of solid tumours. Genet Vaccines Ther 2010;8:8.
78. Buhles A, Collins SA, van Pijkeren JP, et al. Anti-metastatic effects of viral and non-viral mediated Nk4 delivery to tumours. Genet Vaccines Ther 2009;7:5.
79. Lipshutz GS, Titre D, Brindle M, et al. Comparison of gene expression after intraperitoneal delivery of AAV2 or AAV5 in utero. Mol Ther 2003;8(1):90-98.
80. Lipshutz GS, Gruber CA, Cao Y, et al. In utero delivery of adeno-associated viral vectors: intraperitoneal gene transfer produces long-term expression. Mol Ther 2001;3(3):284-292.
81. Ogura T, Mizukami H, Mimuro J, et al. Utility of intraperitoneal administration as a route of AAV serotype 5 vector-mediated neonatal gene transfer. J Gene Med 2006;8(8):990-997.
82. Schwerdt A, Zintchenko A, Concia M, et al. Hyperthermia-induced targeting of thermosensitive gene carriers to tumors. Hum Gene Ther 2008;19(11):1283-1292.
83. Hildebrandt IJ, Iyer M, Wagner E, Gambhir SS. Optical imaging of transferrin targeted PEI/DNA complexes in living subjects. Gene Ther 2003;10(9):758-764.
84. Walsh M, Tangney M, O'Neill MJ, et al. Evaluation of cellular uptake and gene transfer efficiency of pegylated poly-L-lysine compacted DNA: implications for cancer gene therapy. Mol Pharm 2006;3(6):644-653.
85. Huang YH, Zugates GT, Peng W, et al. Nanoparticle-delivered suicide gene therapy effectively reduces ovarian tumor burden in mice. Cancer Res 2009;69(15):6184-6191.
86. Yurek DM, Fletcher AM, Smith GM, et al. Long-term transgene expression in the central nervous system using DNA nanoparticles. Mol Ther 2009;17(4):641-650.
87. Hauck ES, Zou S, Scarfo K, Nantz MH, Hecker JG. Whole animal in vivo imaging after transient, nonviral gene delivery to the rat central nervous system. Mol Ther 2008;16(11):1857-1864.
88. Namgung R, Nam S, Kim SK, et al. An acid-labile temperature-responsive sol-gel reversible polymer for enhanced gene delivery to the myocardium and skeletal muscle cells. Biomaterials 2009;30(28):5225-5233.
89. Iyer M, Berenji M, Templeton NS, Gambhir SS. Noninvasive imaging of cationic lipid-mediated delivery of optical and PET reporter genes in living mice. Mol Ther 2002;6(4):555-562.
90. Weng YH, Tatarov A, Bartos BP, Contag CH, Dennery PA. HO-1 expression in type II pneumocytes after transpulmonary gene delivery. Am J Physiol Lung Cell Mol Physiol 2000;278(6):L1273-L129.
91. Ahlen G, Soderholm J, Tjelle T, et al. In vivo electroporation enhances the immunogenicity of hepatitis C virus nonstructural 3/4A DNA by increased local DNA uptake, protein expression, inflammation, and infiltration of CD3+ T cells. J Immunol 2007;179(7):4741-4753.
92. Allera-Moreau C, Delluc-Clavieres A, Castano C, et al. Long term expression of bicistronic vector driven by the FGF-1 IRES in mouse muscle. BMC Biotechnol 2007;7:74.
93. Cashman JP, Larkin JO, Casey G, et al. Immune gene therapy as a neoadjuvant to surgical excision to control metastatic cancers. Cancer Lett 2008.
94. Collins CG, Tangney M, Larkin JO, et al. Local gene therapy of solid tumors with GM-CSF and B7-1 eradicates both treated and distal tumors. Cancer Gene Ther 2006;13(12):1061-1071.
95. Gould D, Yousaf N, Fatah R, Subang MC, Chernajovsky Y. Gene therapy with an improved doxycycline-regulated plasmid encoding a tumour necrosis factor-alpha inhibitor in experimental arthritis. Arthritis Res Ther 2007;9(1):R7.
96. Ahmad S, Casey G, Sweeney P, Tangney M, O'Sullivan GC. Optimised electroporation mediated DNA vaccination for treatment of prostate cancer. Genet Vaccines Ther 2010;8(1):1.
97. Ahmad S, Casey G, Sweeney P, Tangney M, O'Sullivan GC. Prostate stem cell antigen DNA vaccination breaks tolerance to self-antigen and inhibits prostate cancer growth. Mol Ther 2009;17(6):1101-1108.
98. Aoi A, Watanabe Y, Mori S, et al. Herpes simplex virus thymidine kinase-mediated suicide gene therapy using nano/microbubbles and ultrasound. Ultrasound Med Biol 2008;34(3):425-434.
99. Casey G, Cashman JP, Morrissey D, et al. Sonoporation mediated immunogene therapy of solid tumors. Ultrasound Med Biol 2010;36(3):430-440.
100. Suzuki R, Takizawa T, Negishi Y, et al. Tumor specific ultrasound enhanced gene transfer in vivo with novel liposomal bubbles. J Control Release 2008;125(2):137-144.
101. Hirata K, Nishikawa M, Kobayashi N, Takahashi Y, Takakura Y. Design of PCR-amplified DNA fragments for in vivo gene delivery: size-dependency on stability and transgene expression. J Pharm Sci 2007;96(9):2251-2261.
102. Bell JB, Aronovich EL, Schreifels JM, Beadnell TC, Hackett PB. Duration of expression and activity of Sleeping Beauty transposase in mouse liver following hydrodynamic DNA delivery. Mol Ther 2010;18(10):1796-1802.
103. Belur LR, Podetz-Pedersen K, Frandsen J, McIvor RS. Lung-directed gene therapy in mice using the nonviral Sleeping Beauty transposon system. Nat Protoc 2007;2(12):3146-3152.
104. Wilber A, Wangensteen KJ, Chen Y, et al. Messenger RNA as a source of transposase for sleeping beauty transposon-mediated correction of hereditary tyrosinemia type I. Mol Ther 2007;15(7):1280-1287.
105. Ohlfest JR, Demorest ZL, Motooka Y, et al. Combinatorial antiangiogenic gene therapy by nonviral gene transfer using the sleeping beauty transposon causes tumor regression and improves survival in mice bearing intracranial human glioblastoma. Mol Ther 2005;12(5):778-788.
106. Bertoni C, Jarrahian S, Wheeler TM, et al. Enhancement of plasmid-mediated gene therapy for muscular dystrophy by directed plasmid integration. Proc Natl Acad Sci U S A 2006;103(2):419-424.
107. Chalberg TW, Genise HL, Vollrath D, Calos MP. phiC31 integrase confers genomic integration and long-term transgene expression in rat retina. Invest Ophthalmol Vis Sci 2005;46(6):2140-2146.
108. Collins SA, Morrissey D, Rajendaran S, et al. Comparison Of DNA Delivery And Expression Using Frequently Used Delivery Methods. Gene Therapy - developments and future perspectives: InTech; 2011.
109. Rajendran S, O'Hanlon D, Morrissey D, et al. Preclinical Evaluation Of Gene Delivery Methods For The Treatment Of Loco-Regional Disease In Breast Cancer. Exp Biol Med 2011;236(4).
110. Griffin M, Greiser U, Barry F, O'Brien T, Ritter T. Genetically modified mesenchymal stem cells and their clinical potential in acute cardiovascular disease. Discov Med 2010;9(46):219-223.
111. Kanazawa H, Fujimoto Y, Teratani T, et al. Bone marrow-derived mesenchymal stem cells ameliorate hepatic ischemia reperfusion injury in a rat model. PLoS One 2011;6(4):e19195.
112. Ozawa K, Sato K, Oh I, et al. Cell and gene therapy using mesenchymal stem cells (MSCs). J Autoimmun 2008;30(3):121-127.
113. Uchibori R, Okada T, Ito T, et al. Retroviral vector-producing mesenchymal stem cells for targeted suicide cancer gene therapy. J Gene Med 2009;11(5):373-381.
114. Myers TJ, Granero-Molto F, Longobardi L, et al. Mesenchymal stem cells at the intersection of cell and gene therapy. Expert Opin Biol Ther 2010;10(12):1663-1679.
115. Schweichel D, Steitz J, Tormo D, et al. Evaluation of DNA vaccination with recombinant adenoviruses using bioluminescence imaging of antigen expression: impact of application routes and delivery with dendritic cells. J Gene Med 2006;8(10):1243-1250.
116. Birsoy K, Soukas A, Torrens J, et al. Cellular program controlling the recovery of adipose tissue mass: An in vivo imaging approach. Proc Natl Acad Sci U S A 2008;105(35):12985-12990.
117. Jeon YH, Choi Y, Yoon SO, Kim CW, Chung JK. Synergistic tumoricidal effect of combined hMUC1 vaccination and hNIS radioiodine gene therapy. Mol Cancer Ther 2008;7(7):2252-2260.
118. Fogar P, Navaglia F, Basso D, et al. Heat-induced transcription of diphtheria toxin A or its variants, CRM176 and CRM197: implications for pancreatic cancer gene therapy. Cancer Gene Ther 2009;17(1):58-68.
119. Rajendran S, Salwa S, Gao X, et al. Murine bioluminescent hepatic tumour model. J Vis Exp 2010(41).
120. Hiraoka K, Kimura T, Logg CR, et al. Therapeutic efficacy of replication-competent retrovirus vector-mediated suicide gene therapy in a multifocal colorectal cancer metastasis model. Cancer Res 2007;67(11):5345-5353.
121. Mader EK, Maeyama Y, Lin Y, et al. Mesenchymal stem cell carriers protect oncolytic measles viruses from antibody neutralization in an orthotopic ovarian cancer therapy model. Clin Cancer Res 2009;15(23):7246-7255.
122. Chu Y, Wang LX, Yang G, et al. Efficacy of GM-CSF-producing tumor vaccine after docetaxel chemotherapy in mice bearing established Lewis lung carcinoma. J Immunother 2006;29(4):367-380.
123. Chanda D, Isayeva T, Kumar S, et al. Systemic osteoprotegerin gene therapy restores tumor-induced bone loss in a therapeutic model of breast cancer bone metastasis. Mol Ther 2008;16(5):871-878.
124. Journal of Gene Medicine 2008. www.wiley.co.uk/genmed/clinical
125. Crane LM, van Oosten M, Pleijhuis RG, et al. Intraoperative imaging in ovarian cancer: fact or fiction? Mol Imaging 2011;10(4):248-257.
126. Themelis G, Harlaar NJ, Kelder W, et al. Enhancing Surgical Vision by Using Real-Time Imaging of alpha(v)beta (3)-Integrin Targeted Near-Infrared Fluorescent Agent. Ann Surg Oncol 2011.
127. van Dam GM, Themelis G, Crane LM, et al. Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-alpha targeting: first in-human results. Nat Med 2011;17(10):1315-1319.
128. Crane LM, Themelis G, Pleijhuis RG, et al. Intraoperative Multispectral Fluorescence Imaging for the Detection of the Sentinel Lymph Node in Cervical Cancer: A Novel Concept. Mol Imaging Biol 2010.
129. Crane LM, Themelis G, Buddingh T, et al. Multispectral real-time fluorescence imaging for intraoperative detection of the sentinel lymph node in gynecologic oncology. J Vis Exp 2010(44).
130. Cronin MC, Akin AR, Collins SA, et al. High Resolution In Vivo Bioluminescent Imaging For The Study Of Bacterial Tumour Targeting. PLoS One 2012;7(1):e30940.