KSHV-encoded microRNAs: Lessons for viral cancer pathogenesis and emerging concepts

International Journal of Cell Biology

Volumn , Issue , 2012, Pages

  Qin, Zhiqiang ^a,b,c   Jakymiw, Andrew ^b   Findlay, Victoria ^a   Parsons, Chris ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; MICRORNA; VIRUS RNA;

ANTIGEN RECOGNITION; CANCER GROWTH; CELL SURVIVAL; CYTOKINE RESPONSE; GENE EXPRESSION; GENETIC CODE; HERPES VIRUS; HUMAN; KAPOSI SARCOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; TUMOR MICROENVIRONMENT; VIRUS CARCINOGENESIS; VIRUS ENTRY; VIRUS EXPRESSION;

HUMAN HERPESVIRUS 8;

EID: 84858321236     PISSN: 16878876     EISSN: 16878884     Source Type: Journal    
DOI: 10.1155/2012/603961     Document Type: Review

References (103)

1. Moens U., Silencing viral MicroRNA as a novel antiviral therapy? Journal of Biomedicine and Biotechnology 2009 2009
2. Bartel D. P., MicroRNAs: genomics, biogenesis, mechanism, and function Cell 2004 116 2 281 297
3. Ambros V., The functions of animal microRNAs Nature 2004 431 7006 350 355 (Pubitemid 39265675)
4. Cullen B. R., Viral and cellular messenger RNA targets of viral microRNAs Nature 2009 457 7228 421 425
5. Schulz T. F., The pleiotropic effects of Kaposi's sarcoma herpesvirus Journal of Pathology 2006 208 2 187 198 (Pubitemid 43126112)
6. Grundhoff A., Ganem D., Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis Journal of Clinical Investigation 2004 113 1 124 136 (Pubitemid 38541639)
7. Aluigi M. G., Albini A., Carlone S., Repetto L., De Marchi R., Icardi A., Moro M., Noonan D., Benelli R., KSHV sequences in biopsies and cultured spindle cells of epidemic, iatrogenic and Mediterranean forms of Kaposi's sarcoma Research in Virology 1996 147 5 267 275 (Pubitemid 26276045)
8. Lebbé C., De Crémoux P., Millot G., Podgorniak M. P., Verola O., Berger R., Morel P., Calvo F., Characterization of in vitro culture of HIV-negative Kaposi's sarcoma-derived cells. In vitro responses to alfa interferon Archives of Dermatological Research 1997 289 7 421 428 (Pubitemid 27331337)
9. Soulier J., Grollet L., Oksenhendler E., Cacoub P., Cazals-Hatem D., Babinet P., D'Agay M. F., Clauvel J. P., Raphael M., Degos L., Sigaux F., Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease Blood 1995 86 4 1276 1280
10. Cesarman E., Chang Y., Moore P. S., Said J. W., Knowles D. M., Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS- related body-cavity-based lymphomas New England Journal of Medicine 1995 332 18 1186 1191
11. Chang Y., Cesarman E., Pessin M. S., Lee F., Culpepper J., Knowles D. M., Moore P. S., Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma Science 1994 266 5192 1865 1869
12. Pfeffer S., Sewer A., Lagos-Quintana M., Sheridan R., Sander C., Grsser F. A., van Dyk L. F., Kiong Ho C., Shuman S., Chien M., Russo J. J., Ju J., Randall G., Lindenbach B. D., Rice C. M., Simon V., Ho D. D., Zavolan M., Tuschl T., Identification of microRNAs of the herpesvirus family Nature Methods 2005 2 4 269 276 (Pubitemid 41131008)
13. Cai X., Lu S., Zhang Z., Gonzalez C. M., Damania B., Cullen B. R., Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells Proceedings of the National Academy of Sciences of the United States of America 2005 102 15 5570 5575 (Pubitemid 40530298)
14. Samols M. A., Hu J., Skalsky R. L., Renne R., Cloning and identification of a MicroRNA cluster within the latency-associated region of Kaposi's sarcoma-associated herpesvirus Journal of Virology 2005 79 14 9301 9305 (Pubitemid 40934841)
15. Gottwein E., Cai X., Cullen B. R., Expression and function of microRNAs encoded by kaposi's sarcoma-associated herpesvirus Cold Spring Harbor Symposia on Quantitative Biology 2006 71 357 364
16. Grundhoff A., Sullivan C. S., Ganem D., A combined computational and microarray-based approach identifies novel microRNAs encoded by human gamma-herpesviruses RNA 2006 12 5 733 750
17. Marshall V., Parks T., Bagni R., Wang C. D., Samols M. A., Hu J., Wyvil K. M., Aleman K., Little R. F., Yarchoan R., Renne R., Whitby D., Conservation of viraly encoded microRNAs in Kaposi sarcoma-associated herpesvirus in primary effusion lymphoma cell lines and in patients with Kaposi sarcoma or multicentric Castleman disease Journal of Infectious Diseases 2007 195 5 645 659
18. Umbach J. L., Cullen B. R., In-depth analysis of Kaposi's sarcoma-associated herpesvirus microrna expression provides insights into the mammalian microRNA-processing machinery Journal of Virology 2010 84 2 695 703
19. Marshall V., Martr E., Labo N., Ray A., Wang D., Mbisa G., Bagni R. K., Volfovsky N., Casabona J., Whitby D., Kaposi Sarcoma (KS)associated herpesvirus microRNA sequence analysis and KS risk in a European AIDS-KS case control study Journal of Infectious Diseases 2010 202 7 1126 1135
20. Qin Z., Freitas E., Sullivan R., Mohan S., Bacelieri R., Branch D., Romano M., Kearney P., Oates J., Plaisance K., Renne R., Kaleeba J., Parsons C., Upregulation of xCT by KSHV-encoded microRNAs facilitates KSHV dissemination and persistence in an environment of oxidative stress PLoS Pathogens 2010 6 1
21. Kaleeba J. A. R., Berger E. A., Kaposi's sarcoma-associated herpesvirus fusion-entry receptor: cystine transporter xCT Science 2006 311 5769 1921 1924
22. Skalsky R. L., Samols M. A., Plaisance K. B., Boss I. W., Riva A., Lopez M. C., Baker H. V., Renne R., Kaposi's sarcoma-associated herpesvirus encodes an ortholog of miR-155 Journal of Virology 2007 81 23 12836 12845 (Pubitemid 350156921)
23. Gottwein E., Mukherjee N., Sachse C., Frenzel C., Majoros W. H., Chi J. T. A., Braich R., Manoharan M., Soutschek J., Ohler U., Cullen B. R., A viral microRNA functions as an orthologue of cellular miR-155 Nature 2007 450 7172 1096 1099 (Pubitemid 350273603)
24. Hansen A., Henderson S., Lagos D., Nikitenko L., Coulter E., Roberts S., Gratrix F., Plaisance K., Renne R., Bower M., Kellam P., Boshoff C., KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming Genes and Development 2010 24 2 195 205
25. Rappocciolo G., Jenkins F. J., Hensler H. R., Piazza P., Jais M., Borowski L., Watkins S. C., Rinaldo C. R., DC-SIGN is a receptor for human herpesvirus 8 on dendritic cells and macrophages Journal of Immunology 2006 176 3 1741 1749 (Pubitemid 43134319)
26. Rappocciolo G., Hensler H. R., Jais M., Reinhart T. A., Pegu A., Jenkins F. J., Rinaldo C. R., Human herpesvirus 8 infects and replicates in primary cultures of activated B lymphocytes through DC-SIGN Journal of Virology 2008 82 10 4793 4806 (Pubitemid 351657041)
27. Kerur N., Veettil M. V., Sharma-Walia N., Sadagopan S., Bottero V., Paul A. G., Chandran B., Characterization of entry and infection of monocytic THP-1 cells by Kaposi's sarcoma associated herpesvirus (KSHV): role of heparan sulfate, DC-SIGN, integrins and signaling Virology 2010 406 1 103 116
28. Akula S. M., Pramod N. P., Wang F. Z., Chandran B., Integrin 3 1 (CD 49c/29) is a cellular receptor for Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) entry into the target cells Cell 2002 108 3 407 419 (Pubitemid 34178404)
29. Garrigues H. J., Rubinchikova Y. E., DiPersio C. M., Rose T. M., Integrin v 3 binds to the RGD motif of glycoprotein B of Kaposi's sarcoma-associated herpesvirus and functions as an RGD-dependent entry receptor Journal of Virology 2008 82 3 1570 1580
30. Gill P. S., Tsai Y. C., Rao A. P., Spruck C. H., Zheng T., Harrington W. A., Cheung T., Nathwani B., Jones P. A., Evidence for multiclonality in multicentric Kaposi's sarcoma Proceedings of the National Academy of Sciences of the United States of America 1998 95 14 8257 8261 (Pubitemid 28326100)
31. Staskus K. A., Zhong W., Gebhard K., Herndier B., Wang H., Renne R., Beneke J., Pudney J., Anderson D. J., Ganem D., Haase A. T., Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells Journal of Virology 1997 71 1 715 719 (Pubitemid 26412345)
32. Boulanger E., Duprez R., Delabesse E., Gabarre J., Macintyre E., Gessain A., Mono/oligoclonal pattern of Kaposi Sarcoma-associated herpesvirus (KSHV/HHV-8) episomes in primary effusion lymphoma cells International Journal of Cancer 2005 115 4 511 518 (Pubitemid 40656707)
33. Adang L. A., Tomescu C., Law W. K., Kedes D. H., Intracellular Kaposi's sarcoma-associated herpesvirus load determines early loss of immune synapse components Journal of Virology 2007 81 10 5079 5090 (Pubitemid 46744419)
34. Wang X., Ye L., Hou W., Zhou Y., Wang Y. J., Metzger D. S., Ho W. Z., Cellular microRNA expression correlates with susceptibility of monocytes/macrophages to HIV-1 infection Blood 2009 113 3 671 674
35. Wang X., Ye L., Zhou Y., Liu M.-Q., Zhou D.-J., Ho W.-Z., Inhibition of anti-HIV microRNA expression: a mechanism for opioid-mediated enhancement of HIV infection of monocytes American Journal of Pathology 2011 178 1 41 47
36. Ouda R., Onomoto K., Takahasi K., Edwards M. R., Kato H., Yoneyama M., Fujita T., Retinoic acid-inducible gene I-inducible miR-23b inhibits infections by minor group rhinoviruses through down-regulation of the very low density lipoprotein receptor Journal of Biological Chemistry 2011 286 29 26210 26219
37. Lin X., Liang D., He Z., Deng Q., Robertson E. S., Lan K., miR-K12-7-5p encoded by Kaposi's sarcoma-associated herpesvirus stabilizes the latent state by targeting viral ORF50/RTA PLoS One 2011 6 1
38. Bellare P., Ganem D., Regulation of KSHV lytic switch protein expression by a virus-encoded microRNA: an evolutionary adaptation that fine-tunes lytic reactivation Cell Host and Microbe 2009 6 6 570 575
39. Ziegelbauer J. M., Sullivan C. S., Ganem D., Tandem array-based expression screens identify host mRNA targets of virus-encoded microRNAs Nature Genetics 2009 41 1 130 134
40. Lu F., Stedman W., Yousef M., Renne R., Lieberman P. M., Epigenetic regulation of Kaposi's sarcoma-associated herpesvirus latency by virus-encoded microRNAs that target Rta and the cellular Rbl2-DNMT pathway Journal of Virology 2010 84 6 2697 2706
41. Lei X., Bai Z., Ye F., Xie J., Kim C. G., Huang Y., Gao S. J., Regulation of NF-B inhibitor IB and viral replication by a KSHV microRNA Nature Cell Biology 2010 12 2 193 199
42. Lu C. C., Li Z., Chu C. Y., Feng J., Feng J., Sun R., Rana T. M., MicroRNAs encoded by Kaposi's sarcoma-associated herpesvirus regulate viral life cycle EMBO Reports 2010 11 10 784 790
43. Liang D., Gao Y., Lin X., He Z., Zhao Q., Deng Q., Lan K., A human herpesvirus miRNA attenuates interferon signaling and contributes to maintenance of viral latency by targeting IKK Cell Research 2011 21 5 793 806
44. Qin Z., Kearney P., Plaisance K., Parsons C. H., Pivotal Advance: Kaposi's sarcoma-associated herpesvirus (KSHV)-encoded microRNA specifically induce IL-6 and IL-10 secretion by macrophages and monocytes Journal of Leukocyte Biology 2010 87 1 25 34
45. Boss I. W., Nadeau P. E., Abbott J. R., Yang Y., Mergia A., Renne R., A kaposi's sarcoma-associated herpesvirus-encoded ortholog of microrna mir-155 induces human splenic B-Cell expansion in NOD/ltsz-scid IL2Rnull mice Journal of Virology 2011 85 19 9877 9886
46. Abend J. R., Uldrick T., Ziegelbauer J. M., Regulation of tumor necrosis factor-like weak inducer of apoptosis receptor protein (TWEAKR) expression by Kaposi's sarcoma-associated herpesvirus microrna prevents tweak-induced apoptosis and inflammatory cytokine expression Journal of Virology 2010 84 23 12139 12151
47. Nachmani D., Stern-Ginossar N., Sarid R., Mandelboim O., Diverse herpesvirus microRNAs target the stress-induced immune ligand MICB to escape recognition by natural killer cells Cell Host and Microbe 2009 5 4 376 385
48. Gottwein E., Cullen B. R., A human herpesvirus MicroRNA inhibits p21 expression and attenuates p21-mediated cell cycle arrest Journal of Virology 2010 84 10 5229 5237
49. Mesri E. A., Cesarman E., Boshoff C., Kaposi's sarcoma and its associated herpesvirus Nature Reviews Cancer 2010 10 10 707 719
50. Jones K. D., Aoki Y., Chang Y., Moore P. S., Yarchoan R., Tosato G., Involvement of interleukin-10 (IL-10) and viral IL-6 in the spontaneous growth of Kaposi's sarcoma herpesvirus-associated infected primary effusion lymphoma cells Blood 1999 94 8 2871 2879 (Pubitemid 29477316)
51. Aoki Y., Yarchoan R., Braun J., Iwamoto A., Tosato G., Viral and cellular cytokines in AIDS-related malignant lymphomatous effusions Blood 2000 96 4 1599 1601 (Pubitemid 30658500)
52. Oksenhendler E., Carcelain G., Aoki Y., Boulanger E., Maillard A., Clauvel J. P., Agbalika F., High levels of human herpesvirus 8 viral load, human interleukin-6, interleukin-10, and C reactive protein correlate with exacerbation of multicentric Castleman disease in HIV-infected patients Blood 2000 96 6 2069 2073
53. Cirone M., Lucania G., Aleandri S., Borgia G., Trivedi P., Cuomo L., Frati L., Faggioni A., Suppression of dendritic cell differentiation through cytokines released by Primary Effusion Lymphoma cells Immunology Letters 2008 120 1-2 37 41
54. Gasperini P., Sakakibara S., Tosato G., Contribution of viral and cellular cytokines to Kaposi's sarcoma-associated herpesvirus pathogenesis Journal of Leukocyte Biology 2008 84 4 994 1000
55. Kang J.-G., Pripuzova N., Majerciak V., Kruhlak M., Le S.-Y., Zheng Z.-M., Kaposi's sarcoma-associated herpesvirus ORF57 promotes escape of viral and human interleukin-6 from microRNA-mediated suppression Journal of Virology 2011 85 6 2620 2630
56. Samols M. A., Skalsky R. L., Maldonado A. M., Riva A., Lopez M. C., Baker H. V., Renne R., Identification of cellular genes targeted by KSHV-encoded microRNAs. PLoS Pathogens 2007 3 5, article e65
57. Lagana A., Forte S., Russo F., Giugno R., Pulvirenti A., Ferro A., Prediction of human targets for viral-encoded microRNAs by thermodynamics and empirical constraints Journal of RNAi and Gene Silencing 2010 6 379 385
58. Satoh J.-I., Tabunoki H., Comprehensive analysis of human microRNA target networks BioData Mining 2011 4 1, article 17
59. Radfar M. H., Wong W., Morris Q., Computational prediction of intronic microRNA targets using host gene expression reveals novel regulatory mechanisms PLoS ONE 2011 6 6, article e19312
60. Lewis B. P., Burge C. B., Bartel D. P., Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets Cell 2005 120 1 15 20 (Pubitemid 40094598)
61. Dlken L., Malterer G., Erhard F., Kothe S., Friedel C. C., Suffert G., Marcinowski L., Motsch N., Barth S., Beitzinger M., Lieber D., Bailer S. M., Hoffmann R., Ruzsics Z., Kremmer E., Pfeffer S., Zimmer R., Koszinowski U. H., Grsser F., Meister G., Haas J., Systematic analysis of viral and cellular microRNA targets in cells latently infected with human -herpesviruses by RISC immunoprecipitation assay Cell Host and Microbe 2010 7 4 324 334
62. O'Hara A. J., Wang L., Dezube B. J., Harrington W. J., Damania B., Dittmer D. P., Tumor suppressor microRNAs are underrepresented in primary effusion lymphoma and Kaposi sarcoma Blood 2009 113 23 5938 5941
63. O'Hara A. J., Chugh P., Wang L., Netto E. M., Luz E., Harrington W. J., Dezube B. J., Damania B., Dittmer D. P., Pre-micro rna signatures delineate stages of endothelial cell transformation in kaposi sarcoma PLoS Pathogens 2009 5 4
64. Punj V., Matta H., Schamus S., Tamewitz A., Anyang B., Chaudhary P. M., Kaposi's sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 suppresses CXCR4 expression by upregulating miR-146a Oncogene 2010 29 12 1835 1844
65. Wu Y.-H., Hu T.-F., Chen Y.-C., Tsai Y. -N., Tsai Y. -H., Cheng C. -C., Wang H. -W., The manipulation of miRNA-gene regulatory networks by KSHV induces endothelial cell motility Blood 2011 118 10 2896 2905
66. Tsai Y. H., Wu M. F., Wu Y. H., Chang S. J., Lin S. F., Sharp T. V., Wang H. W., The M type K15 protein of Kaposi's sarcoma-associated herpesvirus regulates microRNA expression via its SH2-binding motif to induce cell migration and invasion Journal of Virology 2009 83 2 622 632
67. Lagos D., Pollara G., Henderson S., Gratrix F., Fabani M., Milne R. S. B., Gotch F., Boshoff C., MiR-132 regulates antiviral innate immunity through suppression of the p300 transcriptional co-activator Nature Cell Biology 2010 12 5 513 519
68. Winter J., Diederichs S., MicroRNA biogenesis and cancer Methods in Molecular Biology 2011 676 3 22
69. Schanen B. C., Li X., Transcriptional regulation of mammalian miRNA genes Genomics 2011 97 1 1 6
70. Dews M., Homayouni A., Yu D., Murphy D., Sevignani C., Wentzel E., Furth E. E., Lee W. M., Enders G. H., Mendell J. T., Thomas-Tikhonenko A., Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster Nature Genetics 2006 38 9 1060 1065 (Pubitemid 44325933)
71. He X., He L., Hannon G. J., The guardian's little helper: microRNAs in the p53 tumor suppressor network Cancer Research 2007 67 23 11099 11101 (Pubitemid 350248530)
72. Spizzo R., Nicoloso M. S., Lupini L., Lu Y., Fogarty J., Rossi S., Zagatti B., Fabbri M., Veronese A., Liu X., Davuluri R., Croce C. M., Mills G., Negrini M., Calin G. A., MiR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor- in human breast cancer cells Cell Death and Differentiation 2010 17 2 246 254
73. Huang X., Ding L., Bennewith K. L., Tong R. T., Welford S. M., Ang K. K., Story M., Le Q. T., Giaccia A. J., Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation Molecular Cell 2009 35 6 856 867
74. Cao P., Deng Z., Wan M., Huang W., Cramer S. D., Xu J., Lei M., Sui G., MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1 /HIF-1 Molecular Cancer 2010 9, article no. 108
75. Long E., Ilie M., Hofman V., Havet K., Selva E., Butori C., Lacour J. P., Nelson A. M., Cathomas G., Hofman P., LANA-1, Bcl-2, Mcl-1 and HIF-1 protein expression in HIV-associated Kaposi sarcoma Virchows Archiv 2009 455 2 159 170
76. Shin Y. C., Joo C. H., Gack M. U., Lee H. R., Jung J. U., Kaposi's sarcoma-associated herpesvirus viral IFN regulatory factor 3 stabilizes hypoxia-inducible factor-1 to induce vascular endothelial growth factor expression Cancer Research 2008 68 6 1751 1759 (Pubitemid 351416560)
77. Cai Q., Lan K., Verma S. C., Si H., Lin D., Robertson E. S., Kaposi's sarcoma-associated herpesvirus latent protein LANA interacts with HIF-1 to upregulate RTA expression during hypoxia: latency control under low oxygen conditions Journal of Virology 2006 80 16 7965 7975 (Pubitemid 44182297)
78. Cai Q., Murakami M., Si H., Robertson E. S., A potential -helix motif in the amino terminus of LANA encoded by Kaposi's sarcoma-associated herpesvirus is critical for nuclear accumulation of HIF-1 in normoxia Journal of Virology 2007 81 19 10413 10423 (Pubitemid 47463315)
79. Gregory R. I., Yan K. P., Amuthan G., Chendrimada T., Doratotaj B., Cooch N., Shiekhattar R., The Microprocessor complex mediates the genesis of microRNAs Nature 2004 432 7014 235 240 (Pubitemid 39545855)
80. Denli A. M., Tops B. B. J., Plasterk R. H. A., Ketting R. F., Hannon G. J., Processing of primary microRNAs by the Microprocessor complex Nature 2004 432 7014 231 235 (Pubitemid 39545854)
81. Han J., Lee Y., Yeom K. H., Nam J. W., Heo I., Rhee J. K., Sohn S. Y., Cho Y., Zhang B. T., Kim V. N., Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex Cell 2006 125 5 887 901 (Pubitemid 43810154)
82. Gottwein E., Cai X., Cullen B. R., A novel assay for viral microRNA function identifies a single nucleotide polymorphism that affects Drosha processing Journal of Virology 2006 80 11 5321 5326
83. Lujambio A., Esteller M., CpG island hypermethylation of tumor suppressor microRNAs in human cancer Cell Cycle 2007 6 12 1455 1459
84. Lujambio A., Calin G. A., Villanueva A., Ropero S., Snchez- Céspedes M., Blanco D., Montuenga L. M., Rossi S., Nicoloso M. S., Faller W. J., Gallagher W. M., Eccles S. A., Croce C. M., Esteller M., A microRNA DNA methylation signature for human cancer metastasis Proceedings of the National Academy of Sciences of the United States of America 2008 105 36 13556 13561
85. Brueckner B., Stresemann C., Kuner R., Mund C., Musch T., Meister M., Sltmann H., Lyko F., The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function Cancer Research 2007 67 4 1419 1423 (Pubitemid 46383365)
86. Krtzfeldt J., Rajewsky N., Braich R., Rajeev K. G., Tuschl T., Manoharan M., Stoffel M., Silencing of microRNAs in vivo with antagomirs Nature 2005 438 7068 685 689
87. Fontana L., Fiori M. E., Albini S., Cifaldi L., Giovinazzi S., Forloni M., Boldrini R., Donfrancesco A., Federici V., Giacomini P., Peschle C., Fruci D., Antagomir-17-5p abolishes the growth of therapy-resistant neuroblastoma through p21 and BIM PLoS One 2008 3 5
88. Ma L., Reinhardt F., Pan E., Soutschek J., Bhat B., Marcusson E. G., Teruya-Feldstein J., Bell G. W., Weinberg R. A., Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model Nature Biotechnology 2010 28 4 341 347
89. Morrisey E. E., The magic and mystery of miR-21 Journal of Clinical Investigation 2010 120 11 3817 3819
90. Summerton J., Morpholino antisense oligomers: the case for an RNase H-independent structural type Biochimica et Biophysica Acta 1999 1489 1 141 158
91. Choi W. Y., Giraldez A. J., Schier A. F., Target protectors reveal dampening and balancing of nodal agonist and antagonist by miR-430 Science 2007 318 5848 271 274 (Pubitemid 47574854)
92. Moulton H. M., Moulton J. D., Morpholinos and their peptide conjugates: therapeutic promise and challenge for Duchenne muscular dystrophy Biochimica et Biophysica Acta 2010 1798 12 2296 2303
93. Kinali M., Arechavala-Gomeza V., Feng L., Cirak S., Hunt D., Adkin C., Guglieri M., Ashton E., Abbs S., Nihoyannopoulos P., Garralda M. E., Rutherford M., Mcculley C., Popplewell L., Graham I. R., Dickson G., Wood M. J., Wells D. J., Wilton S. D., Kole R., Straub V., Bushby K., Sewry C., Morgan J. E., Muntoni F., Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept study The Lancet Neurology 2009 8 10 918 928
94. Lanford R. E., Hildebrandt-Eriksen E. S., Petri A., Persson R., Lindow M., Munk M. E., Kauppinen S., Rum H., Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection Science 2010 327 5962 198 201
95. Garchow B. G., Encinas O. B., Leung Y. T., Tsao P. Y., Eisenberg R. A., Caricchio R., Obad S., Petri A., Kauppinen S., Kiriakidou M., Silencing of microRNA-21 in vivo ameliorates autoimmune splenomegaly in lupus mice EMBO Molecular Medicine 2011 3 10 605 615
96. Elmén J., Lindow M., Silahtaroglu A., Bak M., Christensen M., Lind-Thomsen A., Hedtjrn M., Hansen J. B., Hansen H. F., Straarup E. M., McCullagh K., Kearney P., Kauppinen S., Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver Nucleic Acids Research 2008 36 4 1153 1162 (Pubitemid 351330933)
97. Obad S., Dos Santos C. O., Petri A., Heidenblad M., Broom O., Ruse C., Fu C., Lindow M., Stenvang J., Straarup E. M., Hansen H. F., Koch T., Pappin D., Hannon G. J., Kauppinen S., Silencing of microRNA families by seed-targeting tiny LNAs Nature Genetics 2011 43 4 371 380
98. Patrick D. M., Montgomery R. L., Qi X., Obad S., Kauppinen S., Hill J. A., Van Rooij E., Olson E. N., Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice Journal of Clinical Investigation 2010 120 11 3912 3916
99. Worm J., Stenvang J., Petri A., Frederiksen K. S., Obad S., Elmén J., Hedtjrn M., Straarup E. M., Hansen J. B., Kauppinen S., Silencing of microRNA-155 in mice during acute inflammatory response leads to derepression of c/ebp Beta and down-regulation of G-CSF Nucleic Acids Research 2009 37 17 5784 5792
100. Wiggins J. F., Ruffino L., Kelnar K., Omotola M., Patrawala L., Brown D., Bader A. G., Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34 Cancer Research 2010 70 14 5923 5930
101. Liu C., Kelnar K., Liu B., Chen X., Calhoun-Davis T., Li H., Patrawala L., Yan H., Jeter C., Honorio S., Wiggins J. F., Bader A. G., Fagin R., Brown D., Tang D. G., The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44 Nature Medicine 2011 17 2 211 216
102. Jackson D. G., Immunological functions of hyaluronan and its receptors in the lymphatics Immunological Reviews 2009 230 1 216 231
103. Qin Z., Dai L., Bratoeva M., Slomiany M. G., Toole B. P., Parsons C., Cooperative roles for emmprin and LYVE-1 in the regulation of chemoresistance for primary effusion lymphoma Leukemia 2011 25 10 1598 1609