Contribution of viral and cellular cytokines to Kaposi's sarcoma-associated herpesvirus pathogenesis

Journal of Leukocyte Biology

Volumn 84, Issue 4, 2008, Pages 994-1000

  Gasperini, Paola ^a   Sakakibara, Shuhei ^a   Tosato, Giovanna ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Angiogenesis; Cell migration; Multicentric Castleman's disease; Primary effusion lymphoma

Indexed keywords

CASPASE INHIBITOR; CHEMOKINE RECEPTOR CXCR4; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; INTERLEUKIN 6 MONOCLONAL ANTIBODY; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; NEUTRALIZING ANTIBODY; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG; VASCULOTROPIN; Z VALYLALANYLASPARTYL FLUOROMETHYLKETONE;

ANGIOFOLLICULAR LYMPH NODE HYPERPLASIA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER CELL; CANCER GROWTH; CONFERENCE PAPER; HUMAN HERPESVIRUS 8; KAPOSI SARCOMA; PATHOGENESIS; PRIMARY EFFUSION LYMPHOMA; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; SURVIVAL;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANIMALS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CELL DIVISION; CELL SURVIVAL; CYTOKINES; DISEASE MODELS, ANIMAL; HERPESVIRUS 8, HUMAN; HUMANS; INTERLEUKIN-10; INTERLEUKIN-6; MICE; MICE, INBRED NOD; MICE, SCID; SARCOMA, KAPOSI; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

HERPESVIRIDAE; HUMAN HERPESVIRUS 8;

EID: 54249142729     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1107777     Document Type: Conference Paper

References (57)

1. Chang, Y., Cesarman, E., Pessin, M. S., Lee, F., Culpepper, J., Knowles, D. M., Moore, P. S. (1994) Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266, 1865-1869.
2. Lonard, B. M., Sester, M., Sester, U., Pees, H. W., Mueller-Lantzsch, N., Kohler, H., Gartner, B. C. (2007) Estimation of human herpesvirus 8 prevalence in high-risk patients by analysis of humoral and cellular immunity. Transplantation 84, 40-45.
3. Knowles, D. M., Inghirami, G., Ubriaco, A., Dalla-Favera, R. (1989) Molecular genetic analysis of three AIDS-associated neoplasms of uncertain lineage demonstrates their B-cell derivation and the possible pathogenetic role of the Epstein-Barr virus. Blood 73, 792-799.
4. Cesarman, E., Chang, Y., Moore, P. S., Said, J. W., Knowles, D. M. (1995) Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N. Engl. J. Med. 332, 1186-1191.
5. Nador, R. G., Cesarman, E., Chadburn, A., Dawson, D. B., Ansari, M. Q., Sald, J., Knowles, D. M. (1996) Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus. Blood 88, 645-656.
6. Peterson, B. A., Frizzera, G. (1993) Multicentric Castleman's disease. Semin. Oncol. 20, 636-647.
7. Oksenhendler, E., Duarte, M., Soulier, J., Cacoub, P., Welker, Y., Cadranel, J., Cazals-Hatem, D., Autran, B., Clauvel, J. P., Raphael, M. (1996) Multicentric Castleman's disease in HIV infection: a clinical and pathological study of 20 patients. AIDS 10, 61-67.
8. Fan, W., Bubman, D., Chadburn, A., Harrington Jr., W. J., Cesarman, E., Knowles, D. M. (2005) Distinct subsets of primary effusion lymphoma can be identified based on their cellular gene expression profile and viral association. J. Virol. 79, 1244-1251.
9. Xu, D., Coleman, T., Zhang, J., Fagot, A., Kotalik, C., Zhao, L., Trivedi, P., Jones, C., Zhang, L. (2007) Epstein-Barr virus inhibits Kaposi's sarcoma-associated herpesvirus lytic replication in primary effusion lymphomas. J. Virol. 81, 6068-6078.
10. Grandadam, M., Dupin, N., Calvez, V., Gorin, I., Blum, L., Kernbaum, S., Sicard, D., Buisson, Y., Agut, H., Escande, J. P., Huraux, J. M. (1997) Exacerbations of clinical symptoms in human immunodeficiency virus type 1-infected patients with multicentric Castleman's disease are associated with a high increase in Kaposi's sarcoma herpesvirus DNA load in peripheral blood mononuclear cells. J. Infect. Dis. 175, 1198-1201.
11. Soulier, J., Grollet, L., Oksenhendler, E., Cacoub, P., Cazals-Hatem, D., Babinet, P., d'Agay, M. F., Clauvel, J. P., Raphael, M., Degos, L., Sigaux, F. (1995) Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood 86, 1276-1280.
12. Jarviluoma, A., Ojala, P. M. (2006) Cell signaling pathways engaged by KSHV. Biochim. Biophys. Acta 1766, 140-158.
13. Gaidano, G., Gloghini, A., Gattei, V., Rossi, M. F., Cilia, A. M., Godeas, C., Degan, M., Perin, T., Canzonieri, V., Aldinucci, D., Saglio, G., Carbone, A., Pinto, A. (1997) Association of Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma with expression of the CD138/syndecan-1 antigen. Blood 90, 4894-4900.
14. Carbone, A., Gaidano, G., Gloghini, A., Larocca, L. M., Capello, D., Canzonieri, V., Antinori, A., Tirelli, U., Falini, B., Dalla-Favera, R. (1998) Differential expression of BCL-6, CD138/syndecan-1, and Epstein-Barr virus-encoded latent membrane protein-1 identifies distinct histogenetic subsets of acquired immunodeficiency syndrome-related non-Hodgkin's lymphomas. Blood 91, 747-755.
15. Goedert, J. J. (2000) The epidemiology of acquired immunodeficiency syndrome malignancies. Semin. Oncol. 27, 390-401.
16. Corbellino, M., Bestetti, G., Scalamogna, C., Calattini, S., Galazzi, M., Meroni, L., Manganaro, D., Fasan, M., Moroni, M., Galli, M., Parravicini, C. (2001) Long-term remission of Kaposi sarcoma-associated herpesvirus-related multicentric Castleman disease with anti-CD20 monoclonal antibody therapy. Blood 98, 3473-3475.
17. Simonelli, C., Spina, M., Cinelli, R., Talamini, R., Tedeschi, R., Gloghini, A., Vaccher, E., Carbone, A., Tirelli, U. (2003) Clinical features and outcome of primary effusion lymphoma in HIV-infected patients: a single-institution study. J. Clin. Oncol. 21, 3948-3954.
18. Waterston, A., Bower, M. (2004) Fifty years of multicentric Castleman's disease. Acta Oncol. 43, 698-704.
19. Moore, P. S., Boshoff, C., Weiss, R. A., Chang, Y. (1996) Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV. Science 274, 1739-1744.
20. Nicholas, J., Ruvolo, V. R., Burns, W. H., Sandford, G., Wan, X., Ciufo, D., Hendrickson, S. B., Guo, H. G., Hayward, G. S., Reitz, M. S. (1997) Kaposi's sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein-1 and interleukin-6. Nat. Med. 3, 287-292.
21. Kishimoto, T., Akira, S., Narazaki, M., Taga, T. (1995) Interleukin-6 family of cytokines and gp130. Blood 86, 1243-1254.
22. Heinrich, P. C., Behrmann, I., Haan, S., Hermanns, H. M., Muller-Newen, G., Schaper, F. (2003) Principles of interleukin (IL)-6-type cytokine signaling and its regulation. Biochem. J. 374, 1-20.
23. Boulanger, M. J., Chow, D. C., Brevnova, E. E., Garcia, K. C. (2003) Hexameric structure and assembly of the interleukin-6/IL-6 α-receptor/ gp130 complex. Science 300, 2101-2104.
24. Aoki, Y., Narazaki, M., Kishimoto, T., Tosato, G. (2001) Receptor engagement by viral interleukin-6 encoded by Kaposi sarcoma-associated herpesvirus. Blood 98, 3042-3049.
25. Chen, D., Nicholas, J. (2006) Structural requirements for gp80 independence of human herpesvirus 8 interleukin-6 (vIL-6) and evidence for gp80 stabilization of gp130 signaling complexes induced by vIL-6. J. Virol. 80, 9811-9821.
26. Molden, J., Chang, Y., You, Y., Moore, P. S., Goldsmith, M. A. (1997) A Kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit. J. Biol. Chem. 272, 19625-19631.
27. Hu, F., Nicholas, J. (2006) Signal transduction by human herpesvirus 8 viral interleukin-6 (vIL-6) is modulated by the nonsignaling gp80 subunit of the IL-6 receptor complex and is distinct from signaling induced by human IL-6. J. Virol. 80, 10874-10878.
28. Meads, M. B., Medveczky, P. G. (2004) Kaposi's sarcoma-associated herpesvirus-encoded viral interleukin-6 is secreted and modified differently than human interleukin-6: evidence for a unique autocrine signaling mechanism. J. Biol. Chem. 279, 51793-51803.
29. Aoki, Y., Jaffe, E. S., Chang, Y., Jones, K., Teruya-Feldstein, J., Moore, P. S., Tosato, G. (1999) Angiogenesis and hematopoiesis induced by Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6. Blood 93, 4034-4043.
30. Vart, R. J., Nikitenko, L. L., Lagos, D., Trotter, M. W., Cannon, M., Bourboulia, D., Gratrix, F., Takeuchi, Y., Boshoff, C. (2007) Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 and G-protein-coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cells. Cancer Res. 67, 4042-4051.
31. Tosato, G., Seamon, K. B., Goldman, N. D., Sehgal, P. B., May, L. T., Washington, G. C., Jones, K. D., Pike, S. E. (1988) Monocyte-derived human B-cell growth factor identified as interferon- β 2 (BSF-2, IL-6). Science 239, 502-504.
32. Cohen, T., Nahari, D., Cerem, L. W., Neufeld, G., Levi, B. Z. (1996) Interleukin 6 induces the expression of vascular endothelial growth factor. J. Biol. Chem. 271, 736-741.
33. Aoki, Y., Tosato, G., Fonville, T. W., Pittaluga, S. (2001) Serum viral interleukin-6 in AIDS-related multicentric Castleman's disease. Blood 97, 2526-2527.
34. Aoki, Y., Tosato, G., Nambu, Y., Iwamoto, A., Yarchoan, R. (2000) Detection of vascular endothelial growth factor in AIDS-related primary effusion lymphomas. Blood 95, 1109-1110.
35. Oksenhendler, E., Carcelain, G., Aoki, Y., Boulanger, E., Maillard, A., Clauvel, J. P., Agbalika, F. (2000) High levels of human herpesvirus 8 viral load, human interleukin-6, interleukin-10, and C reactive protein correlate with exacerbation of multicentric Castleman disease in HIV-infected patients. Blood 96, 2069-2073.
36. Kluger, M. J. (1991) Fever: role of pyrogens and cryogens. Physiol. Rev. 71, 93-127.
37. Aoki, Y., Yarchoan, R., Braun, J., Iwamoto, A., Tosato, G. (2000) Viral and cellular cytokines in AIDS-related malignant lymphomatous effusions. Blood 96, 1599-1601.
38. Jones, K. D., Aoki, Y., Chang, Y., Moore, P. S., Yarchoan, R., Tosato, G. (1999) Involvement of interleukin-10 (IL-10) and viral IL-6 in the spontaneous growth of Kaposi's sarcoma herpesvirus-associated infected primary effusion lymphoma cells. Blood 94, 2871-2879.
39. Asou, H., Said, J. W., Yang, R., Munker, R., Park, D. J., Kamada, N., Koeffler, H. P. (1998) Mechanisms of growth control of Kaposi's sarcoma-associated herpes virus-associated primary effusion lymphoma cells. Blood 91, 2475-2481.
40. Sin, S. H., Roy, D., Wang, L., Staudt, M. R., Fakhari, F. D., Patel, D. D., Henry, D., Harrington Jr., W. J., Damania, B. A., Dittmer, D. P. (2007) Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signaling. Blood 109, 2165-2173.
41. Aoki, Y., Tosato, G. (1999) Role of vascular endothelial growth factor/vascular permeability factor in the pathogenesis of Kaposi's sarcoma-associated herpesvirus-infected primary effusion lymphomas. Blood 94, 4247-4254.
42. Dvorak, H. F., Sioussat, T. M., Brown, L. F., Berse, B., Nagy, J. A., Sotrel, A., Manseau, E. J., Van de Water, L., Senger, D. R. (1991) Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: concentration in tumor blood vessels. J. Exp. Med. 174, 1275-1278.
43. Mesiano, S., Ferrara, N., Jaffe, R. B. (1998) Role of vascular endothelial growth factor in ovarian cancer: inhibition of ascites formation by immunoneutralization. Am. J. Pathol. 153, 1249-1256.
44. Dvorak, H. F., Detmar, M., Claffey, K. P., Nagy, J. A., van de Water, L., Senger, D. R. (1995) Vascular permeability factor/vascular endothelial growth factor: an important mediator of angiogenesis in malignancy and inflammation. Int. Arch. Allergy Immunol. 107, 233-235.
45. Muller, A., Homey, B., Soto, H., Ge, N., Catron, D., Buchanan, M. E., McClanahan, T., Murphy, E., Yuan, W., Wagner, S. N., Barrera, J. L., Mohar, A., Verastegui, E., Zlotnik, A. (2001) Involvement of chemokine receptors in breast cancer metastasis. Nature 410, 50-56.
46. Foussat, A., Balabanian, K., Amara, A., Bouchet-Delbos, L., Durand-Gasselin, I., Baleux, F., Couderc, J., Galanaud, P., Emilie, D. (2001) Production of stromal cell-derived factor 1 by mesothelial cells and effects of this chemokine on peritoneal B lymphocytes. Eur. J. Immunol. 31, 350-359.
47. Yao, L., Salvucci, O., Cardones, A. R., Hwang, S. T., Aoki, Y., De La Luz Sierra, M., Sajewicz, A., Pittaluga, S., Yarchoan, R., Tosato, G. (2003) Selective expression of stromal-derived factor-1 in the capillary vascular endothelium plays a role in Kaposi sarcoma pathogenesis. Blood 102, 3900-3905.
48. Peled, A., Grabovsky, V., Habler, L., Sandbank, J., Arenzana-Seisdedos, F., Petit, I., Ben-Hur, H., Lapidot, T., Alon, R. (1999) The chemokine SDF-1 stimulates integrin-mediated arrest of CD34(+) cells on vascular endothelium under shear flow. J. Clin. Invest. 104, 1199-1211.
49. Grabovsky, V., Feigelson, S., Chen, C., Bleijs, D. A., Peled, A., Cinamon, G., Baleux, F., Arenzana-Seisdedos, F., Lapidot, T., van Kooyk, Y., Lobb, R. R., Alon, R. (2000) Subsecond induction of α4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions. J. Exp. Med. 192, 495-506.
50. Chow, D., He, X., Snow, A. L., Rose-John, S., Garcia, K. C. (2001) Structure of an extracellular gp130 cytokine receptor signaling complex. Science 291, 2150-2155.
51. Bartoli, M., Gu, X., Tsai, N. T., Venema, R. C., Brooks, S. E., Marrero, M. B., Caldwell, R. B. (2000) Vascular endothelial growth factor activates STAT proteins in aortic endothelial cells. J. Biol. Chem. 275, 33189-33192.
52. Mullberg, J., Geib, T., Jostock, T., Hoischen, S. H., Vollmer, P., Voltz, N., Heinz, D., Galle, P. R., Klouche, M., Rose-John, S. (2000) IL-6 receptor independent stimulation of human gp130 by viral IL-6. J. Immunol. 164, 4672-4677.
53. Takeda, K., Clausen, B. E., Kaisho, T., Tsujimura, T., Terada, N., Forster, I., Akira, S. (1999) Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10, 39-49.
54. Aoki, Y., Feldman, G. M., Tosato, G. (2003) Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. Blood 101, 1535-1542.
55. Reed, J. C. (2001) The survivin saga goes in vivo. J. Clin. Invest. 108, 965-969.
56. Song, H., Wang, R., Wang, S., Lin, J. (2005) A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. Proc. Natl. Acad. Sci. USA 102, 4700-4705.
57. Coleman IV, D. R., Ren, Z., Mandal, P. K., Cameron, A. G., Dyer, G. A., Muranjan, S., Campbell, M., Chen, X., McMurray, J. S. (2005) Investigation of the binding determinants of phosphopeptides targeted to the SRC homology 2 domain of the signal transducer and activator of transcription 3. Development of a high-affinity peptide inhibitor. J. Med. Chem. 48, 6661-6670.