miR-K12-7-5p encoded by Kaposi's sarcoma-associated herpesvirus stabilizes the latent state by targeting viral ORF50/RTA

PLoS ONE

Volumn 6, Issue 1, 2011, Pages

  Lin, Xianzhi ^a   Liang, Deguang ^a   He, Zhiheng ^a   Deng, Qiang ^a   Robertson, Erle S ^b   Lan, Ke ^a  

^a INSTITUTE PASTEUR OF SHANGHAI   (China)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MICRORNA K12 1; MICRORNA K12 10; MICRORNA K12 11; MICRORNA K12 12; MICRORNA K12 2; MICRORNA K12 3; MICRORNA K12 4; MICRORNA K12 5; MICRORNA K12 6; MICRORNA K12 7; MICRORNA K12 8; MICRORNA K12 9; UNCLASSIFIED DRUG; IMMEDIATE EARLY PROTEIN; RTA PROTEIN, HUMAN HERPESVIRUS 8; TRANSACTIVATOR PROTEIN; VIRUS RNA;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; EMBRYO; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE MUTATION; GENE TARGETING; GENETIC ANALYSIS; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; OPEN READING FRAME 50; PLASMID; POLYMERASE CHAIN REACTION; PROTEIN SYNTHESIS INHIBITION; REGULATORY MECHANISM; TRANSIENT TRANSFECTION; VIRUS LATENCY; VIRUS REPLICATION; CELL LINE; DRUG ANTAGONISM; GENETICS; PHYSIOLOGY;

HUMAN HERPESVIRUS 8;

CELL LINE; HERPESVIRUS 8, HUMAN; HUMANS; IMMEDIATE-EARLY PROTEINS; MICRORNAS; RNA, VIRAL; TRANS-ACTIVATORS; VIRUS LATENCY; VIRUS REPLICATION;

EID: 79251640100     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0016224     Document Type: Article

References (29)

1. Ambros V (2001) microRNAs: tiny regulators with great potential. Cell 107: 823-826.
2. Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297.
3. Grey F, Hook L, Nelson J (2008) The functions of herpesvirus-encoded microRNAs. Med Microbiol Immunol 197: 261-267.
4. Cai X, Lu S, Zhang Z, Gonzalez CM, Damania B, et al. (2005) Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells. Proc Natl Acad Sci U S A 102: 5570-5575.
5. Pfeffer S, Sewer A, Lagos-Quintana M, Sheridan R, Sander C, et al. (2005) Identification of microRNAs of the herpesvirus family. Nat Methods 2: 269-276.
6. Samols MA, Hu J, Skalsky RL, Renne R (2005) Cloning and identification of a microRNA cluster within the latency-associated region of Kaposi's sarcomaassociated herpesvirus. J Virol 79: 9301-9305.
7. Grundhoff A, Sullivan CS, Ganem D (2006) A combined computational and microarray-based approach identifies novel microRNAs encoded by human gamma-herpesviruses. Rna 12: 733-750.
8. Zhu FX, Cusano T, Yuan Y (1999) Identification of the immediate-early transcripts of Kaposi's sarcoma-associated herpesvirus. J Virol 73: 5556-5567.
9. Samols MA, Skalsky RL, Maldonado AM, Riva A, Lopez MC, et al. (2007) Identification of cellular genes targeted by KSHV-encoded microRNAs. PLoS Pathog 3: e65.
10. Bellare P, Ganem D (2009) Regulation of KSHV lytic switch protein expression by a virus-encoded microRNA: an evolutionary adaptation that fine-tunes lytic reactivation. Cell Host Microbe 6: 570-575.
11. Bartel DP (2009) MicroRNAs: Target Recognition and Regulatory Functions. Cell 136: 215-233.
12. Umbach JL, Cullen BR (2010) In-depth analysis of Kaposi's sarcoma-associated herpesvirus microRNA expression provides insights into the mammalian microRNA-processing machinery. J Virol 84: 695-703.
13. Lin YT, Kincaid RP, Arasappan D, Dowd SE, Hunicke-Smith SP, et al. (2010) Small RNA profiling reveals antisense transcription throughout the KSHV genome and novel small RNAs. Rna 16: 1540-1558.
14. Chang PJ, Shedd D, Gradoville L, Cho MS, Chen LW, et al. (2002) Open reading frame 50 protein of Kaposi's sarcoma-associated herpesvirus directly activates the viral PAN and K12 genes by binding to related response elements. J Virol 76: 3168-3178.
15. Chen J, Ueda K, Sakakibara S, Okuno T, Yamanishi K (2000) Transcriptional regulation of the Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor gene. J Virol 74: 8623-8634.
16. Deng H, Song MJ, Chu JT, Sun R (2002) Transcriptional regulation of the interleukin-6 gene of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus). J Virol 76: 8252-8264.
17. Liu Y, Cao Y, Liang D, Gao Y, Xia T, et al. (2008) Kaposi's sarcoma-associated herpesvirus RTA activates the processivity factor ORF59 through interaction with RBP-Jkappa and a cis-acting RTA responsive element. Virology 380: 264-275.
18. Song MJ, Brown HJ, Wu TT, Sun R (2001) Transcription activation of polyadenylated nuclear rna by rta in human herpesvirus 8/Kaposi's sarcomaassociated herpesvirus. J Virol 75: 3129-3140.
19. Zhang L, Chiu J, Lin JC (1998) Activation of human herpesvirus 8 (HHV-8) thymidine kinase (TK) TATAA-less promoter by HHV-8 ORF50 gene product is SP1 dependent. DNA Cell Biol 17: 735-742.
20. Schulz R, McCole RB, Woodfine K, Wood AJ, Chahal M, et al. (2009) Transcript- and tissue-specific imprinting of a tumour suppressor gene. Hum Mol Genet 18: 118-127.
21. Lan K, Kuppers DA, Verma SC, Robertson ES (2004) Kaposi's sarcomaassociated herpesvirus-encoded latency-associated nuclear antigen inhibits lytic replication by targeting Rta: a potential mechanism for virus-mediated control of latency. J Virol 78: 6585-6594.
22. Umbach JL, Kramer MF, Jurak I, Karnowski HW, Coen DM, et al. (2008) MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs. Nature 454: 780-783.
23. Murphy E, Vanicek J, Robins H, Shenk T, Levine AJ (2008) Suppression of immediate-early viral gene expression by herpesvirus-coded microRNAs: implications for latency. Proc Natl Acad Sci U S A 105: 5453-5458.
24. Staudt MR, Dittmer DP (2007) The Rta/Orf50 transactivator proteins of the gamma-herpesviridae. Curr Top Microbiol Immunol 312: 71-100.
25. Lei X, Bai Z, Ye F, Xie J, Kim CG, et al. (2010) Regulation of NF-kappaB inhibitor IkappaBalpha and viral replication by a KSHV microRNA. Nat Cell Biol 12: 193-199.
26. Lu F, Stedman W, Yousef M, Renne R, Lieberman PM (2010) Epigenetic regulation of Kaposi's sarcoma-associated herpesvirus latency by virus-encoded microRNAs that target Rta and the cellular Rbl2-DNMT pathway. J Virol 84: 2697-2706.
27. Izumiya Y, Izumiya C, Hsia D, Ellison TJ, Luciw PA, et al. (2009) NF-kappaB serves as a cellular sensor of Kaposi's sarcoma-associated herpesvirus latency and negatively regulates K-Rta by antagonizing the RBP-Jkappa coactivator. J Virol 83: 4435-4446.
28. Ziegelbauer JM, Sullivan CS, Ganem D (2009) Tandem array-based expression screens identify host mRNA targets of virus-encoded microRNAs. Nat Genet 41: 130-134.
29. McAllister SC, Hansen SG, Messaoudi I, Nikolich-Zugich J, Moses AV (2005) Increased efficiency of phorbol ester-induced lytic reactivation of Kaposi's sarcoma-associated herpesvirus during S phase. J Virol 79: 2626-2630.