T lymphocyte insensitivity to corticosteroids in chronic obstructive pulmonary disease

Respiratory Research

Volumn 13, Issue , 2012, Pages

  Kaur, Manminder ^a   Smyth, Lucy J C ^a,b   Cadden, Paul ^a   Grundy, Seamus ^a   Ray, David ^a   Plumb, Jonathan ^a   Singh, Dave ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF SALFORD   (United Kingdom)

Author keywords

Copd; Corticosteriods; Lymphocytes

Indexed keywords

DEXAMETHASONE; GAMMA INTERFERON; GLUCOCORTICOID RECEPTOR ALPHA; GLUCOCORTICOID RECEPTOR BETA; INTERLEUKIN 2; PHORBOL 13 ACETATE 12 MYRISTATE; PHYTOHEMAGGLUTININ; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR;

ARTICLE; BRONCHOSCOPY; CD8+ T LYMPHOCYTE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG RESPONSE; DRUG SENSITIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; LUNG LAVAGE; MALE; PROTEIN EXPRESSION; SMOKING; SUPERNATANT; AGED; BIOSYNTHESIS; CELL CULTURE; METABOLISM; MIDDLE AGED; SECRETION; T LYMPHOCYTE;

AGED; BRONCHOSCOPY; CELLS, CULTURED; DEXAMETHASONE; FEMALE; GLUCOCORTICOIDS; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-2; MALE; MIDDLE AGED; PHYTOHEMAGGLUTININS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RECEPTORS, GLUCOCORTICOID; SMOKING; T-LYMPHOCYTES; TETRADECANOYLPHORBOL ACETATE;

EID: 84858040376     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-13-20     Document Type: Article

References (48)

1. Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, Cherniack RM, Rogers RM, Sciurba FC, Coxson HO, Pare PD. The nature of small-airway obstruction in COPD. N Engl J Med 2004, 24:2645-2653.
2. Agusti A, MacNee W, Donaldson K, Cosio M. Hypothesis: Does COPD have an autoimmune component?. Thorax 2003, 58:832-834. 10.1136/thorax.58.10.832, 1746486, 14514931.
3. Lee SH, Goswami S, Grudo A, Song LZ, Bandi V, Goodnight-White S, Green L, Hacken-Bitar J, Huh J, Bakeen F, Coxson HO, Cogswell S, Storness-Bliss C, Corry DB, Kheradmand F. Antielastin autoimmunity in tobacco smoking-induced emphysema. Nat Med 2007, 5:567-569.
4. Hodge G, Nairn J, Holmes M, Reynolds PN, Hodge S. Increased intracellular T helper 1 proinflammatory cytokine production in peripheral blood, bronchoalveolar lavage and intraepithelial T cells of COPD subjects. Clin Exp Immunol 2007, 150:22-29. 10.1111/j.1365-2249.2007.03451.x, 2219288, 17614970.
5. Majori M, Corradi M, Caminati A, Cacciani G, Bertacco S, Pesci A. Predominant TH1 cytokine pattern in peripheral blood from subjects with COPD. J Allergy Clin Immunol 1999, 103:458-462. 10.1016/S0091-6749(99)70471-9, 10069880.
6. Barczyk A, Pierzchała W, Kon OM, Cosio B, Adcock IM, Barnes PJ. Cytokine production by bronchoalveolar lavage T lymphocytes in chronic obstructive pulmonary disease. J Allergy Clin Immunol 2006, 117:1484-1492. 10.1016/j.jaci.2006.02.013, 16751017.
7. Barceló B, Pons J, Fuster A, Sauleda J, Noguera A, Ferrer JM, Agusti AG. Intracellular cytokine profile of T lymphocytes in patients with chronic obstructive pulmonary disease. Clin Exp Immunol 2006, 145:474-479. 10.1111/j.1365-2249.2006.03167.x, 1809717, 16907916.
8. Di Stefano A, Caramori G, Capelli A, Gnemmi I, Ricciardolo FL, Oates T, Donner CF, Chung KF, Barnes PJ, Adcock IM. STAT4 activation in smokers and patients with chronic obstructive pulmonary disease. Eur Respir J 2004, 24:78-855. 10.1183/09031936.04.00080303, 15293608.
9. Van der Strate B, Postma D, Brandsma C, Melget B, Luinge M, Geerlings M, Hylkema M, van der Berg A, Timmens W, Kerstjens H. Cigarette smoke induced emphysema: a role for the B cell?. Am J Respir Crit Care Med 2006, 173:751-758. 10.1164/rccm.200504-594OC, 16399994.
10. Lambers C, Hacker S, Posch M, Hoetzenecker K, Pollreisz A, Lichtenauer M, Klepetko W, Ankersmit H. T cell senescence and contraction of T cell repertoire diversity in patients with chronic obstructive pulmonary disease. Clin Exp Immunol 2009, 155:466-475. 10.1111/j.1365-2249.2008.03835.x, 2669523, 19220836.
11. Leung DY, Bloom JW. Update on glucocorticoid action and resistance. J Allergy Clin Immunol 2003, 111:3-22. 10.1067/mai.2003.97, 12532089.
12. Loppow D, Schleiss MB, Kanniess F, Taube C, Jorres RA, Magnussen H. In patients with chronic bronchitis a four week trial with inhaled steroids does not attenuate airway inflammation. Respir Med 2001, 95:115-121. 10.1053/rmed.2000.0960, 11217907.
13. Culpitt SV, Maziak W, Loukidis S, Nightingale JA, Matthews JL, Barnes PJ. Effect of high dose inhaled steroid on cells, cytokines and proteases in induced sputum in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 1999, 160:1635-1639.
14. Soriano JB, Sin DD, Zhang X, Camp PG, Anderson JA, Anthonisen NR, Buist AS, Burge PS, Calverly OM, Connet JE, Petersson S, Postma DS, Szafranski W, Vestbo J. A pooled analysis of FEV1 decline in COPD patients randomized to inhaled corticosteroids or placebo. Chest 2007, 131:682-689. 10.1378/chest.06-1696, 17356080.
15. Howe LJ, Stanford MR, Edelsten C, Graham EM. The efficacy of systemic corticosteroids in sight-threatening retinal vasculitis. Eye 1994, 8:443-447. 10.1038/eye.1994.105, 7821470.
16. Corrigan CJ, Brown PH, Barnes NC, Szefler SJ, Tasi JJ, Frew AJ, Kay AB. Glucocorticoid resistance in chronic asthma: glucocorticoid pharmacokinetics, glucocorticoid receptor characteristics, and inhibition of peripheral blood T cell proliferation by glucocorticoids in vitro. Am Rev Respir 1991, 144:1016-1025.
17. Hearing SD, Norman M, Probert CS, Haslam N, Dayan CM. Predicting therapeutic outcome in severe ulcerative colitis by measuring in vitro steroid sensitivity of proliferating peripheral blood lymphocytes. Gut 1999, 45:382-388. 10.1136/gut.45.3.382, 1727659, 10446106.
18. Kirkham BW, Corkill MM, Davison SC, Panayi GS. Response to glucocorticoid treatment in rheumatoid arthritis: in vitro cell mediated immune assay predicts in vivo responses. J Rheumatol 1991, 18:821-825.
19. Global initiative for chronic Obstructive Lung Disease. , http://www.goldCOPD.com
20. Plumb J, Smyth LJ, Adams HR, Vestbo J, Bentley A, Singh SD. Increased T regulatory cells within lymphocyte follicles in moderate COPD. Eur Respir J 2009, 34:89-94. 10.1183/09031936.00100708, 19196820.
21. Schroder K, Hertzog PJ, Ravasi T, Hume DA. Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol 2004, 75:163-189.
22. Smith KA. Interleukin 2: inception, impact & implications. Science 1988, 240:1169-1176. 10.1126/science.3131876, 3131876.
23. Ito K, Ito M, Elliott WM, Cosio B, Caramori G, Kon OM, Barczyk A, Hayashi S, Adcock IM, Hogg JC, Barnes PJ. Decreased histone deacetylase activity in COPD. New Engl J Med 2005, 352:1967-1976. 10.1056/NEJMoa041892, 15888697.
24. Langhoff E, Jakobsen BK, Ryder LP, Svejgard A, Thaysen JH. Recipient lymphocyte sensitivity to methylprednisolone affects cadaver kidney graft survival. Lancet 1986, 327:1296-1297.
25. Goleva E, Kisich KO, Leung DY. A role for STAT5 in the pathogenesis of IL-2-induced glucocorticoid resistance. J Immunol 2002, 169:5934-5940.
26. Kam JC, Szefler SJ, Surs W, Sher ER, Leung DY. Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids. J Immunol 1993, 151:3460-3466.
27. Leung DY, Martin RJ, Szefler SJ, Sher ER, Ying S, Kay AB, Hamid Q. Dysregulation of interleukin 4, interleukin 5, and interferon-γ gene expression in steroid-resistant asthma. J Exp Med 1995, 181:33-40. 10.1084/jem.181.1.33, 2191836, 7807013.
28. Schoenborn JR, Wilson CB. Regulation of interferon-gamma during innate and adaptive immune responses. Adv Immunol 2007, 96:41-101.
29. Hens G, Vanaudenaerde BM, Bullens DM, Piessens M, Decramer M, Dupont LJ, Ceuppens JL, Hellings PW. Sinonasal pathology in nonallergic asthma and COPD: 'united airway disease' beyond the scope of allergy. Allergy 2008, 63:261-267.
30. Panzner P, Lafitte JJ, Tsicopoulos A, Hamid Q, Tulic MK. Marked up-regulation of T lymphocytes and expression of interleukin-9 in bronchial biopsies from patients with chronic bronchitis with obstruction. Chest 2003, 124:1909-1915. 10.1378/chest.124.5.1909, 14605067.
31. Reeves EP, Williamson M, Byrne B, Bergin DA, Smith SG, Greally P, O'Kennedy R, O'Neill SJ, McElvaney NG. IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis. J Immunol 2010, 184:1642-1652. 10.4049/jimmunol.0902605, 20026745.
32. Zhu X, Gadgil AS, Givelber R, George MP, Stoner MW, Sciurba FC, Duncan SR. Peripheral T cell functions correlate with the severity of chronic obstructive pulmonary disease. J Immunol 2009, 182:3270-3277. 10.4049/jimmunol.0802622, 19234225.
33. Singh M, Lee SH, Porter P, Xu C, Ohno A, Atmar RL, Greenberg SB, Bandi V, Gern J, Amineva S, Aminev A, Skern T, Smithwock P, Perusich S, Barrow N, Roberts L, Corry DB, Kheradmand F. Human rhinovirus proteinase 2A induces TH1 and TH2 immunity in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol 2010, 125:1369-1378. 10.1016/j.jaci.2010.02.035, 2881843, 20430426.
34. Makris D, Lazarou S, Alexandrakis M, Kourelis TV, Tzanakis N, Kyriakou D, Gourgoulianis KI. Tc2 response at the onset of COPD exacerbations. Chest 2008, 134:483-488. 10.1378/chest.07-2626, 18490406.
35. Saetta M, Stefano AD, Turato G, Facchini FM, Corbino L, Mapp CE, Maestrelli P, Ciaccia A, Fabbri L. CD8 T-Lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease. Am J Respir Cirt Care Med 1998, 157:822-826.
36. Saetta M, Baraldo S, Corbino L, Turato G, Braccioni F, Rea F, Cavallesco G, Tropeano G, Mapp CE, Maestrelli P, Ciaccia A, Fabbri LM. CD8+ve cells in the lungs of smokers with chronic obstructive pulmonary disease. Am J Respir Cirt Care Med 1999, 160:711-717.
37. Clarke D, Clifford RL, Jindarat S, Proud D, Pang I, Belvsi M, Knox AJ. TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein. J Biol Chem 2010, 285:29101-29110. 10.1074/jbc.M109.0999952, 2937941, 20833730.
38. Armstrong J, Sargent C, Singh D. Glucocorticoid sensitivity of lipopolysaccharide-stimulated chronic obstructive pulmonary disease alveolar macrophages. Clin Exp Immunol 2009, 158:74-83. 10.1111/j.1365-2249.2009.03986.x, 2759061, 19737233.
39. Kent LM, Fox SM, Farrow SN, Singh D. The effects of dexamethasone on cigarette smoke induced gene expression in COPD macrophages. Int Immunopharmacol 2010, 10:57-64. 10.1016/j.intimp.2009.09.021, 19818417.
40. Chen H, Cowan MJ, Hasday JD, Vogel SN, Medvedev AE. Tobacco smoking inhibits expression of proinflammatory cytokines and activation of IL-1R-associated kinase, p38, and NF-kappaB in alveolar macrophages stimulated with TLR2 and TLR4 agonists. J Immunol 2007, 179:6097-6106.
41. Neeck G, Klüter A, Dotzlaw H, Eggert M. Involvement of the Glucocorticoid Receptor in the pathogenesis of rheumatoid arthritis. Ann N Y Acad Sci 2002, 966:491-495. 10.1111/j.1749-6632.2002.tb04252.x, 12114309.
42. Pujols L, Mullol J, Picado C. Alpha and beta glucocorticoid receptors: relevance in airway diseases. Curr Allergy Asthma Rep 2007, 7:93-99. 10.1007/s11882-007-0005-3, 17437678.
43. Pujols L, Mullol J, Torrego A, Picado C. Glucocorticoid receptors in human airways. Allergy 2004, 59:1042-1052. 10.1111/j.1398-9995.2004.00635.x, 15355461.
44. Kraft M, Hamid Q, Chrousos GP, Martin RJ, Leung DY. Decreased steroid responsiveness at night in nocturnal asthma is the macrophage responsible?. Am J Respir Crit Care Med 2001, 163:1219-1225.
45. Adcock IM, Lane SJ, Brown CR, Lee TH, Barnes PJ. Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma. J Exp Med 1995, 182:1951-1958. 10.1084/jem.182.6.1951, 2192226, 7500041.
46. Sousa AR, Lane SJ, Cidlowski JA, Staynov DZ, Lee TH. Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor β-isoform. J Allergy Clin Immunol 2000, 105:943-950. 10.1067/mai.2000.106486, 10808175.
47. Honda M, Orii F, Ayabe T, Imai S, Ashida T, Obara T. Kohgoy: Expression of glucocorticoid receptor in lymphocytes of patients with glucocorticoid-resistant ulcerative colitis. Gastroenterology 2000, 118:859-866. 10.1016/S0016-5085(00)70172-7, 10784585.
48. Marwick JA, Gaetano C, Stevenson CS, Casolari P, Jazrawi E, Barnes PJ, Ito K, Adcock IM, Kirkham PA, Papi A. Inhibition of PI3Kd restores glucocorticoid function in smoking-induced airway inflammation in mice. Am J Respir Crit Care Med 2009, 179:542-548. 10.1164/rccm.200810-1570OC, 19164702.