Tc2 response at the onset of COPD exacerbations

Chest

Volumn 134, Issue 3, 2008, Pages 483-488

  Makris, Demosthenes ^a,c   Lazarou, Stelios ^a   Alexandrakis, Michael ^b   Kourelis, Taxiarchis V ^b   Tzanakis, Nikos ^b   Kyriakou, Despina ^a   Gourgoulianis, Kostas I ^a  

^a UNIVERSITY HOSPITAL OF LARISSA   (Greece)

^b UNIVERSITY OF CRETE   (Greece)

^c University General Hospital of Larisa   (Greece)

Author keywords

COPD; Exacerbations; Lymphocytes

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL SUBPOPULATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; DISEASE EXACERBATION; DISEASE SEVERITY; EOSINOPHIL COUNT; FEMALE; FLOW CYTOMETRY; FORCED EXPIRATORY VOLUME; HOSPITALIZATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOCYTOCHEMISTRY; INFLAMMATORY CELL; LYMPHOCYTE COUNT; MACROPHAGE; MALE; NEUTROPHIL COUNT; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SMOKING; SPUTUM; SPUTUM ANALYSIS;

EID: 51649104325     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.07-2626     Document Type: Article

References (30)

1. Pauwels RA, Buist AS, Calverley PM, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med 2001; 163:1256-1276
2. Saetta M, Turato G, Maestrelli P, et al. Cellular and structural bases of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001; 163:1304-1309
3. Saetta M, Di Stefano A, Turato G, et al. CD8+ T-lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998; 157:822-826
4. Siafakas NM. "In the beginning" of COPD: is evolution important? Am J Respir Crit Care Med 2007; 175:1-2
5. Kemeny DM, Vyas B, Vukmanovic-Stejic M, et al. CD8(+) T cell subsets and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999; 160:S33-S37
6. Tsoumakidou M, Tzanakis N, Kyriakou D, et al. Inflammatory cell profiles and T-lymphocyte subsets in chronic obstructive pulmonary disease and severe persistent asthma. Clin Exp Allergy 2004; 34:234-240
7. Seemungal T, Harper-Owen R, Bhowmik A, et al. Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001; 164:1618-1623
8. Sethi S, Murphy TF. Bacterial infection in chronic obstructive pulmonary disease in 2000: a state-of- the-art review. Clin Microbiol Rev 2001; 14:336-363
9. Vukmanovic-Stejic M, Vyas B, Goran-Stolinska P, et al. Human Tc1 and Tc2/Tc0 T cell clones display distinct cell surface and functional phenotypes. Blood 2000; 95:231-240
10. Tsoumakidou M, Tzanakis N, Chrysofakis G, et al. Changes in sputum T-lymphocyte subpopulations at the onset of severe exacerbations of chronic obstructive pulmonary disease. Respir Med 2005; 99:572-579
11. Saetta M, Di Stefano A, Maestrelli P, et al. Airway eosinophilia in chronic bronchitis during exacerbations. Am J Respir Crit Care Med 1994; 150:1646-1652
12. Makris D, Moschandreas J, Damianaki A, et al. Exacerbations and lung function decline in COPD: new insights in current and ex-smokers. Respir Med 2007; 101:1305-1312
13. Donaldson GC, Seemungal TA, Patel IS, et al. Longitudinal changes in the nature, severity and frequency of COPD exacerbations. Eur Respir J 2003; 22:931-936
14. Anthonisen NR, Manfreda J, Warren CPW, et al. Antibiotic therapy in exacerbation of chronic obstructive pulmonary disease. Ann Intern Med 1987; 106:196-200
15. American Thoracic Society. Standardization of spirometry, 1994 update. Am J Respir Crit Care Med 1995; 152:1107-1136
16. Tzanakis N, Chrysofakis G, Tsoumakidou, et al. Induced sputum CD8+ T-lymphocyte subpopulations in chronic obstructive pulmonary disease. Respir Med 2004; 98:57-65
17. Chrysofakis G, Tzanakis N, Kyriaku D, et al. Perforin expression and cytoxic activity of sputum CD8+ lymphocytes in patients with COPD. Chest 2004; 125:71-76
18. Panzner P, Lafitte JJ, Tsicopoulos A, et al. Marked upregulation of T lymphocytes and expression of interleukin-9 in bronchial biopsies from patients with chronic bronchitis with obstruction. Chest 2003; 124:1909-1915
19. Barczyk A, Pierzchala W, Kon O, et al. Cytokine production by bronchoalveolar lavage T lymphocytes in chronic obstructive pulmonary disease. J Allergy Clin Immunol 2006; 117:1484-1492
20. Majori M, Corradi M, Caminati A, et al. Predominant TH1 cytokine pattern in peripheral blood from subjects with chronic obstructive pulmonary disease. J Allergy Clin Immunol 1999; 103:458-462
21. Sad S, Mosmann TR. Interleukin (IL) 4, in the absence of antigen stimulation, induces an anergy-like state in differentiated CD8 TC1 cells: loss of IL-2 synthesis and autonomous proliferation but retention of cytotoxicity and synthesis of other cytokines. J Exp Med 1995; 182:1505-1515
22. Berke G. The binding and lysis of target cells by cytotoxic lymphocytes: molecular and cellular aspects. Annu Rev Immunol 1994; 12:735-773
23. Liu AN, Mohammed AZ, Rice WR, et al. Perforin-independent CD8+ T cell mediated cytotoxicity of alveolar epithelial cells is preferentially mediated by tumor necrosis factor-α: relative insensitivity to Fas ligand. Am J Respir Cell Mol Biol 1999; 20:849-858
24. Huang TJ, MacAry PA, Kemeny DM, et al. Effect of CD8 T-cell depletion on bronchial hyperresponsiveness and inflammation in sensitised and allergen-exposed Brown-Norway rats. Immunology 1999; 96:416-423
25. Kemeny DM, Vyas B, Vukmanovic-Stejic M, et al. CD8+T cell subsets and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999; 160:S33-S37
26. Holmes BJ, MacAry PA, Noble A, et al. Antigen-specific CD8+ T cells inhibit IgE responses and interleukin-4 production by CD4+ T cells. Eur J Immunol 1997; 27:2657-2665
27. Cannon MJ, Openshaw PJ, Askonas BA. Cytotoxic T cells clear virus but augment lung pathology in mice infected with respiratory syncytial virus. J Exp Med 1998; 168:1163-1168
28. Rabe K, Hurd S, Anzueto A, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease GOLD executive summary. Am J Respir Crit Care Med 2007; 176:532-555
29. Seemungal TA, Donaldson GC, Paul EA, et al. Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998; 157:1418-1422
30. Tsoumakidou M, Tzanakis N, Chrysofakis G, et al. Nitrosative stress, heme oxygenase-1 expression and airway inflammation during severe exacerbations of COPD. Chest 2005; 127:1911-1918