Increased T-regulatory cells within lymphocyte follicles in moderate COPD

European Respiratory Journal

Volumn 34, Issue 1, 2009, Pages 89-94

  Plumb, J ^a   Smyth, L J C ^a   Adams, H R ^a   Vestbo, J ^a,b   Bentley, A ^a   Singh, S D ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b Dept of Cardiology and Respiratory Medicine   (Denmark)

Author keywords

CD4+FOXP3+; Follicles; Smokers

Indexed keywords

L SELECTIN; TRANSCRIPTION FACTOR FOXP3;

ADULT; AGED; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; LUNG PARENCHYMA; LYMPH FOLLICLE; LYMPHOCYTE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SMOKING;

AGED; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNOHISTOCHEMISTRY; L-SELECTIN; LUNG; MALE; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; MODELS, BIOLOGICAL; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKING; T-LYMPHOCYTES, REGULATORY;

EID: 69249083645     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00100708     Document Type: Article

References (25)

1. Saetta M, Baraldo S, Corbino L, et al. CD8+ve cells in the lungs of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999; 160: 711-717.
2. Barnes PJ, Shapiro SD, Pauwels RA. Chronic obstructive pulmonary disease: molecular and cellular mechanisms. Eur Respir J 2003; 22: 672-688.
3. Gosman MM, Willemse BW, Jansen DF, et al. Increased number of B-cells in bronchial biopsies in COPD. Eur Respir J 2006; 27: 60-64.
4. Hogg JC, Chu F, Utokaparch S, et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Eng J Med 2004; 350: 2645-2652.
5. Agusti A, MacNee W, Donaldson, Et al. : Hypothesis: does COPD have an autoimmune component? Thorax 2003; 58: 832-834.
6. Lee SH, Goswami S, Grudo A, et al. Antielastin autoimmunity in tobacco smoking-induced emphysema. Nat Med 2007; 13: 567-569.
7. + regulatory T cells downregulate co-stimulatory molecules on antigen-presenting cells. Eur J Immunol 2000; 30: 1538-1543.
8. Liu H, Hu B, Xu D, et al. CD4+CD25+ regulatory T cells cure murine colitis: the role of IL-10, TGF-beta, and CTLA4. J Immunol 2003; 171: 5012-5017.
9. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057-1061.
10. Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003; 4: 330-336.
11. Fontenot JD, Jeffrey P, Rasmussen Williams LM, et al. Regulatory T cell lineage specification by the forkhead transcription factor Foxp3. Immunity 2005; 22: 329-341.
12. Roncador G, Brown PJ, Maestre L, et al. Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level. Eur J Immunol 2005; 35: 1681-1691.
13. Smyth LJC, Starkey C, Vestbo J, et al. CD4 regulatory cells in COPD patients. Chest 2007; 132: 156-163.
14. Barceló B, Pons J, Ferrer JM, et al. Phenotypic characterisation of T-lymphocytes in COPD: abnormal CD4+CD25+ regulatory Tlymphocyte response to tobacco smoking. Eur Respir J 2008; 31: 555-562.
15. Magalhães R, Stiehl P, Morawietz L, et al. Morphological and molecular pathology of the B cell response in synovitis of rheumatoid arthritis. Virchows Arch 2002; 441: 415-42.
16. Maul J, Loddenkemper C, Mundt P, et al. Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease. Gastroenterology 2005; 128: 1868-1878.
17. Van der Strate BW, Postma DS, Brandsma CA, et al. Cigarette smoke-induced emphysema: a role for the B cell? Am J Respir Crit Care Med 2006; 173: 751-758.
18. Tsoumakido M, Demedts IK, Brusselle GG, et al. Dendritic cells in chronic obstructive pulmonary disease: new players in an old game. Am J Respir Crit Care Med 2008; 177: 1180-1186.
19. Lorenz RG, Chaplin DD, McDonald KG, et al. Isolated lymphoid follicle formation is inducible and dependent upon lymphotoxin-sufficient B lymphocytes, lymphotoxin b receptor, and TNF receptor I function. J Immunol 2003; 170: 5475-5482.
20. Lim HW, Hillsamer P, Banham AH, et al. Cutting edge: direct suppression of B cells by CD4+CD25+ regulatory T cells. J Immunol 2005; 175: 4180-4183.
21. Lee JH, Kang SG, Kim CH. FoxP3+ T cells undergo conventional first switch to lymphoid tissue homing receptors in thymus but accelerated second switch to nonlymphoid tissue homing receptors in secondary lymphoid tissues. J Immunol 2007; 178: 301-311.
22. Venturi GM, Conway RM, Steeber DA, et al. CD25+CD4+ regulatory T cell migration requires L-selectin expression: L-selectin transcriptional regulation balances constitutive receptor turnover. J Immunol 2007; 178: 291-300.
23. Lim WH, Broxmeyer HE, Kim CH. Regulation of trafficking receptor expression in human forkhead box p3 regulatory T cells. J Immunol 2006; 177: 840-851.
24. Richmond I, Pritchard GE, Ashcroft T, et al. Bronchus associated lymphoid tissue (BALT) in human lung: its distribution in smokers and non-smokers. Thorax 1993; 48: 1130-1134.
25. Bosken CH, Hards J, Gatter K, et al. Characterization of the inflammatory reaction in the peripheral airways of cigarette smokers using immunocytochemistry. Am Rev Respir Dis 1992; 145: 911-917.