Loss of lysosomal ion channel transient receptor potential channel mucolipin-1 (TRPML1) leads to cathepsin B-dependent apoptosis

Journal of Biological Chemistry

Volumn 287, Issue 11, 2012, Pages 8082-8091

  Colletti, Grace A ^a   Miedel, Mark T ^b   Quinn, James ^a   Andharia, Neel ^a   Weisz, Ora A ^b   Kiselyov, Kirill ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH;

CATHEPSIN B; DEVELOPMENTAL DELAY; ION CHANNEL; MECHANISTIC LINK; PROAPOPTOTIC PROTEIN BAX; RETINAL DEGENERATIONS; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TRANSIENT RECEPTOR POTENTIALS;

TRANSIENTS;

CATHEPSIN B; PROTEIN TRPML1; SMALL INTERFERING RNA; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL MUCOLIPIN 1 PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOPLASM; CYTOSOL; HUMAN; HUMAN CELL; LYSOSOME; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN SECRETION;

EID: 84858032061     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.285536     Document Type: Article

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