A lysosomal-mitochondrial death pathway is induced by solamargine in human K562 leukemia cells

Toxicology in Vitro

Volumn 24, Issue 6, 2010, Pages 1504-1511

  Sun, Lingmei ^a   Zhao, Ying ^a   Li, Xia ^a,b   Yuan, Huiqing ^a   Cheng, Aixia ^a   Lou, Hongxiang ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

Apoptosis; Cathepsin B; Cytochrome c; Lysosome; Mitochondria

Indexed keywords

ACRIDINE ORANGE; CALCIUM; CASPASE 3; CASPASE 9; CATHEPSIN B; CYTOCHROME C; PROTEIN BAX; PROTEIN BCL 2; SOLAMARGINE;

ALKALINIZATION; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL STRAIN K 562; CELL SURVIVAL; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DOWN REGULATION; DRUG STRUCTURE; ENZYME RELEASE; HUMAN; HUMAN CELL; LYSOSOME; LYSOSOME MEMBRANE; MEMBRANE DEPOLARIZATION; MEMBRANE PERMEABILITY; MEMBRANE RUPTURE; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; OXIDATIVE STRESS; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; BCL-2-ASSOCIATED X PROTEIN; CALCIUM; CASPASES; CATHEPSIN B; CELL SURVIVAL; GENE EXPRESSION REGULATION; HUMANS; K562 CELLS; LEUKEMIA, ERYTHROBLASTIC, ACUTE; LYSOSOMES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; PERMEABILITY; PROTO-ONCOGENE PROTEINS C-BCL-2; SOLANACEOUS ALKALOIDS; TUMOR STEM CELL ASSAY;

SOLANUM NIGRUM;

EID: 77956180671     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2010.07.013     Document Type: Article

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