Lysosomal destabilization during macrophage damage induced by cholesterol oxidation products

Free Radical Biology and Medicine

Volumn 28, Issue 2, 2000, Pages 208-218

  Yuan, Xi Ming ^a   Li, Wei ^a   Brunk, Ulf T ^a   Dalen, Helge ^b   Chang, Yi Hsin ^c   Sevanian, Alex ^c  

^a LINKÖPING UNIVERSITY   (Sweden)

^b UNIVERSITY OF BERGEN   (Norway)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Apoptosis; Atherogenesis; Free radicals; LDL ; Lysosomes; Macrophages; MnSoD; Oxysterols

Indexed keywords

CASPASE 3; CHOLESTEROL; FREE RADICAL; MANGANESE SUPEROXIDE DISMUTASE; OXIDIZED LOW DENSITY LIPOPROTEIN; OXYSTEROL;

ANIMAL CELL; APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; CELL DEATH; CELL DEGENERATION; CYTOCHEMISTRY; DRUG OXIDATION; LYSOSOME; MACROPHAGE; MEMBRANE DAMAGE; NONHUMAN; NORTHERN BLOTTING; PHAGOCYTOSIS; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; APOPTOSIS; AUTOPHAGY; CATHEPSIN D; CELL LINE; CELL MEMBRANE PERMEABILITY; CHOLESTEROL; CHROMATIN; CYTOSOL; KINETICS; LYSOSOMES; MACROPHAGES; MICE; OXIDATION-REDUCTION; SUPEROXIDE DISMUTASE; TIME FACTORS; TRANSCRIPTION, GENETIC;

EID: 0033950037     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(99)00220-8     Document Type: Article

References (60)

1. Gelissen I.C., Brown A.J., Mander E.L., Kritharides L., Dean R.T., Jessup W. Sterol efflux is impaired from macrophage foam cells selectively enriched with 7-ketocholesterol. J. Biol. Chem. 271:1996;17852-17860.
2. Maor I., Aviram M. Oxidized low density lipoprotein leads to macrophage accumulation of unesterified cholesterol as a result of lysosomal trapping of the lipoprotein hydrolyzed cholesteryl ester. J. Lipid Res. 35:1994;803-819.
3. Harland W., Gilbert J.G., Steel C. Lipids of human atheroma. Atherosclerosis. 13:1971;239-246.
4. Tamamoto Y., Niki E. Presence of cholesteryl ester hydroperoxide in human blood plasma. Biochem. Biophys. Res. Commun. 165:1989;988-993.
5. Sevanian A., Hodis H.N., Hwang J., McLeod L.L., Peterson H. Characterization of endothelial cell injury by cholesterol oxidation products found in oxidized LDL. J. Lipid Res. 36:1995;1971-1986.
6. Escargueil-Blanc I., Meilhac O., Pieraggi M.T., Arnal J.F., Salvayre R., Negre-Salvayre A. Oxidized LDLs induce massive apoptosis of cultured human endothelial cells through a calcium-dependent pathway. Prevention by aurintricarboxylic acid. Arterioscler. Thromb. Vasc. Biol. 17:1997;331-339.
7. Peng S., Sevanian A., Morin R. Cytotoxicity of cholesterol oxides. Peng S., Morin R. Biological effects of cholesterol oxides. 1992;147-166 CRC Press, Boca Raton.
8. Kellner-Weibel G., Jerome W.G., Small D.M., Warner J.K., Stoltenborg M.A., Kearney M.A., Corjay M.H., Phillips M.C., Rothblat G.H. Effects of intracellular free cholesterol accumulation on macrophage viability. A model for foam cell death. Arterioscler. Thromb. Vasc. Biol. 18:1998;423-431.
9. Yuan X.M., Li W., Olsson A.G., Brunk U.T. The toxicity to macrophages of oxidized low-density lipoprotein is mediated through lysosomal damage. Atherosclerosis. 133:1997;153-161.
10. Li W., Yuan X.M., Olsson A.G., Brunk U.T. Uptake of oxidized LDL by macrophages results in partial lysosomal enzyme relocalization and inactivation. Arterioscler. Thromb. Vasc. Biol. 18:1998;177-184.
11. Sevanian A., Berliner J., Peterson H. Uptake, metabolism and cytotoxicity of isomeric cholesterol-5,6-epoxides in rabbit aortic endothelial cells. J. Lipid Res. 32:1991;147-155.
12. Sevanian A., Seraglia R., Traldi P., Rossato P., Ursini F., Hodis H.N. Analytical approaches to the measurement of plasma cholesterol oxidation products using gas- and high-performance liquid chromatography/mass spectrometry. Free Radic. Biol. Med. 17:1994;397-410.
13. Brunk U.T., Zhang H., Dalen H., Öllinger K. Exposure of cells to nonlethal concentrations of hydrogen peroxide induces degeneration-repair mechanisms involving lysosomal destabilization. Free Radic. Biol. Med. 19:1995;813-822.
14. Roberg K., Öllinger K. Oxidative stress causes relocation of the lysosomal enzyme cathepsin D with ensuing apoptosis in neonatal rat cardiomyocytes. Am. J. Pathol. 152:1998;1151-1156.
15. Frankfurt O.S., Robb J.A., Sugarbaker E.V., Villa L. Monoclonal antibody to single-stranded DNA is a specific and sensitive cellular marker of apoptosis. Exp. Cell Res. 226:1996;387-397.
16. Mancini M., Nicholson D.W., Roy S., Thornberry N.A., Peterson E.P., Casciola-Rosen L.A., Rosen A. The caspase-3 precursor has a cytosolic and mitochondrial distribution Implications for apoptotic signaling . J. Cell Biol. 140:1998;1485-1495.
17. Abok K., Cadenas E., Brunk U. An experimental model system for leishmaniasis. An ultrastructural study on cultured macrophages exposed to Leishmania parasites and sodium stibogluconate. APMIS. 96:1988;589-595.
18. Olsson G.M., Rungby J., Rundguist I., Brunk U.T. Evaluation of lysosomal stability in living cultured macrophages by cytofluorometry. Virchows Arch. 56:(B):1989;263-269.
19. - is a lipid hydroperoxide-enriched circulating lipoprotein. J. Lipid Res. 38:1997;419-428.
20. Chang Y.H., Sevanian A. Characterization of cholesterol oxidation products during the formation of oxidatively modified low density lipoprotein. Free Radic. Biol. Med. 23:1997;202-214.
21. Hughes H., Mathews B., Lenz M.L., Guyton J.R. Cytotoxicity of oxidized LDL to porcine aortic smooth muscle cells is associated with the oxysterols 7-ketocholesterol and 7-hydroxycholesterol. Arteriosclerosis. 14:1994;1177-1185.
22. Hodis H.N., Crawford D.W., Sevanian A. Identification and quantification of cholesterol oxides in normocholesterolemic and cholesterol-fed hypercholesterolemic New Zealand white rabbit plasma. Atherosclerosis. 89:1991;117-126.
23. Mattsson-Hultén L., Lindmark H., Diczfalusy U., Björkhem I., Ottosson M., Liu Y., Bondjers G., Wiklund O. Oxysterols present in atherosclerotic tissue decrease the expression of lipoprotein lipase RNA in human monocyte-derived macrophages. J. Clin. Invest. 97:1996;461-468.
24. Hessler J.R., Morel D.W., Lewis J., Chisolm G.M. Lipoprotein oxidation and lipoprotein-induced cytotoxicity. Arteriosclerosis. 3:1983;215-222.
25. Peng S.K., Tham P., Taylor C.B., Mikkelson B. Cytotoxicity of cholesterol oxidation derivatives on cultured aortic smooth muscle cells and their effect on cholesterol biosynthesis. Am. J. Clin. Nutr. 32:1979;1033-1042.
26. Naseem S.M., Heald F.P. Cytotoxicity of cholesterol oxides and their effects on cholesterol metabolism in cultured human aortic smooth muscle cells. Biochem. Int. 14:1987;71-84.
27. Baranowski A., Adams C.W.M., Bayliss High O.B., Bowyer D.B. Connective tissue responses to oxysterols. Atherosclerosis. 41:1982;255-266.
28. Sevanian, A.; Peterson, H.; Coates, T. A. Cytotoxicity of cholesterol oxidation products in bovine and rabbit aortic endothelial cells. In: The Eighth International Symposium on Atherosclerosis, CIC International edition. Rome: International Atherosclerosis Society; 1988:103-118.
29. Cox D.C., Comai K., Goldstein A.L. Effects of cholesterol and 25-hydroxycholesterol on smooth muscle cell and endothelial cell growth. Lipids. 23:1988;85-88.
30. Hu B., Hin D., Fan W., Peng S.K., Morin R.J. Effects of cholestanetriol on cytotoxicity and prostacyclin production in cultured rabbit aortic endothelial cells. Artery. 18:1991;87-98.
31. Brown A.J., Jessup W. Oxysterols and atherosclerosis. Atherosclerosis. 142:1999;1-28.
32. Morel D.W., Edgerton M.E., Warner G.E., Johnson W.J., Phillips M.C., Rothblat G.H. Comparison of the intracellular metabolism and trafficking of 25-hydroxycholesterol and cholesterol in macrophages. J. Lipid Res. 37:1996;2041-2051.
33. Verhagen J.C.D., ter Braake P., Teunissen G., van Ginkel G., Sevanian A. Physical effects of biologically formed cholesterol oxidation products on lipid membranes investigated with fluorescence depolarization sepctroscopy and electron spin resonance. J. Lipid Res. 37:1996;1488-1502.
34. Neyses L., Locher R., Streuli R., Vetter W. Stereospecific modulation of the calcium channel in human erythrocytes by cholesterol and its oxidized derivatives. Biochem. J. 227:1985;105-112.
35. Palladini G., Finardi G., Bellomo G. Disruption of actin microfilament organization by cholesterol oxides in 73/73 endothelial cells. Exp. Cell Res. 223:1996;72-82.
36. Schanne F., Kane A.B., Young E.E., Farber J.L. Calcium dependence of toxic cell death a final common pathway . Science. 206:1979;700-702.
37. Hennig B., Boissonneault G.A. Cholestan-3 beta,5 alpha,6 beta-triol decreases barrier function of cultured endothelial cell monolayers. Atherosclerosis. 68:1987;255-261.
38. Rong J.X., Rangaswamy S., Shen L., Dave R., Chang Y.H., Peterson H., Hodis H., Chisolm G.M., Sevanian A. Vascular injury by cholesterol oxidation products in an animal model of atherosclerosis. Arterioscler. Thrombos. Vasc. Biol. 18:1998;1885-1894.
39. Aupeix K., Weltin D., Mejia J.E., Christ M., Marchal J., Freyssinet J.M., Bischoff P. Oxysterol-induced apoptosis in human monocytic cell lines. Immunobiology. 194:1995;415-428.
40. Nishio E., Watanabe Y. Oxysterols induced apoptosis in cultured smooth muscle cells through CPP32 protease activation and bcl-2 protein downregulation. Biochem. Biophys. Res. Commun. 226:1996;928-934.
41. Louagie H., Cornelissen M., Philippe J., Vral A., Thierens H., De Ridder L. Flow cytometric scoring of apoptosis compared to electron microscopy in gamma irradiated lymphocytes. Cell Biol. Int. 22:1998;277-283.
42. de Duve C., Wattiaux R.V. Functions of lysosomes. Ann. Rev. Physiol. 28:1966;435-492.
43. de Duve C. The lysosome in retrospect. Dingle J.T., Fell H.B. Lysosomes in biology and pathology. 1969;13-40 North-Holland Publishing Company, Amsterdam.
44. Brunk U.T., Ericsson J.L.E. Cytochemical evidence for the leakage of acid phosphatase through ultrastructurally intact lysosomal membranes. Histochem. J. 4:1972;479-491.
45. Brunk U.T., Dalen H., Roberg K., Hellquist H.B. Photo-oxidative disruption of lysosomal membranes causes apoptosis of cultured human fibroblasts. Free Radic. Biol. Med. 23:1997;616-626.
46. Hellquist H.B., Svensson I., Brunk U.T. Oxidant-induced apoptosis a consequence of lethal lysosomal leak? Redox Report. 3:1997;65-70.
47. Brunk U.T., Svensson I. Oxidative stress, growth factor starvation, and FAS-activation may all cause apoptosis through lysosomal leak. Redox Report. 4:1999;3-11.
48. Brunk U.T., Zhang H., Roberg K., Öllinger K. Lethal hydrogen peroxide toxicity involves lysosomal iron-catalyzed reactions with membrane damage. Redox Report. 1:1995;267-277.
49. Öllinger K., Brunk U.T. Cellular injury induced by oxidative stress is mediated through lysosomal damage. Free Radic. Biol. Med. 19:1995;565-574.
50. Lennon S.V., Martin S.J., Cotter T.G. Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli. Cell Prolif. 24:1991;203-214.
51. Graham A., Angell A.D.R., Jepson C.A., Yeaman S.J., Hassall D.G. Impaired mobilization of cholesterol from stored cholesteryl esters in human (THP-1) macrophages. Artherosclerosis. 120:1996;135-145.
52. Deiss L.P., Galinka H., Berissi H., Cohen O., Kimchi A. Cathpesin D protease mediates programmed cell death induced by interferon-γ, Fas/APO-1 and TNF-α EMBO J. 15:1996;3861-3870.
53. Monney L., Olivier R., Otter I., Jansen B., Poirier G., Borner C. Role of an acidic compartment in tumor-necrosis-factor-α-induced production of ceramide, activation of caspase-3 and apoptosis. Eur. J. Biochem. 251:1998;295-303.
54. Ishisaka R., Utsumi T., Yabuki M., Kanno T., Furuno T., Inoue M., Utsumi K. Activation of caspase-3-like protease by digitonin-treated lysosomes. FEBS Lett. 435:1998;233-236.
55. Vancompernolle K., Van Herreweghe F., Pynaert G., Van de Craen M., De Vos K., Totty N., Sterling A., Fiers W., Vandenabeele P., Grooten J. Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity. FEBS Lett. 438:1998;150-158.
56. Kinscherf R., Claus R., Wagner M., Gehrke C., Kamencic H., Hou D., Nauen O., Schmiedt W., Kovacs G., Pill J., Metz J., Deigner H.P. Apoptosis caused by oxidized LDL is mangnese superoxide dismutase and p53 dependent. FASEB J. 12:1998;461-467.
57. Kinscherf R., Deiger H.P., Usinger C., Pill J., Wagner M., Claus R., Kamencic H., Hou D., Chen M., Nauen O., Schmiedt W., Schrader M., Kovacs G., Kato K., Metz J. Induction of mitochondrial manganese superoxide dismutase in macrophages by oxidised LDL its relevance in atherosclerosis of humans and heritable hyperlipdemic rabbits . FASEB J. 11:1997;1317-1328.
58. Li W., Yuan X.M., Brunk U.T. OxLDL-mediated macrophage cytotoxicity is mediated by lysosomal rupture and modified by intralysosomal iron. Free Rad. Res. 29:1998;389-398.
59. Melendez J.A., Davies K.J.A. Manganese superoxide dismutase modulates interleukin-1 levels in HT-1080 fibrosarcoma cells. J. Biol. Chem. 271:1996;18898-18903.
60. Crawford D., Lauzon R.J., Wang Y., Mazurkiewicz J.E., Schools G.P., Davies K.J.A. 16S mitochondrial ribosomal RNA degradation is associated with apoptosis. Free Radic. Biol. Med. 22:1997;551-559.