A role for the Ca2+ channel TRPML1 in gastric acid secretion, based on analysis of knockout mice

Gastroenterology

Volumn 140, Issue 3, 2011, Pages 857-867.e1

  Chandra, Manjari ^a   Zhou, Hua ^a   Li, Qin ^a   Muallem, Shmuel ^a,b   Hofmann, Sandra L ^a   Soyombo, Abigail A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

Apical Membrane Trafficking; Mucolipin 1; Stomach; Vesicles

Indexed keywords

CALCIUM CHANNEL; PROTEIN TRPML1; PROTON PUMP; UNCLASSIFIED DRUG; CALCIUM; GASTRIN; HISTAMINE; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; MCOLN1 PROTEIN, MOUSE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; CALCIUM HOMEOSTASIS; CALCIUM SIGNALING; CELL ENLARGEMENT; CELL ULTRASTRUCTURE; CELL VACUOLE; CONTROLLED STUDY; CYTOLOGY; GENE; GENE TARGETING; KNOCKOUT MOUSE; LYSOSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; STOMACH ACID SECRETION; STOMACH PARIETAL CELL; TRPML1 GENE; ACHLORHYDRIA; ANIMAL; BLOOD; C57BL MOUSE; DISEASE MODEL; GENETICS; HYPERTROPHY; LIPOYLATION; METABOLISM; MOUSE MUTANT; MUCOLIPIDOSIS; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; PROTEIN TRANSPORT; SECRETION; STOMACH ACID; TIME; ULTRASTRUCTURE;

ACHLORHYDRIA; ANIMALS; CALCIUM; DISEASE MODELS, ANIMAL; GASTRIC ACID; GASTRINS; H(+)-K(+)-EXCHANGING ATPASE; HISTAMINE; HYPERTROPHY; LIPOYLATION; LYSOSOMES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUCOLIPIDOSES; PARIETAL CELLS, GASTRIC; PHOSPHORYLATION; PROTEIN TRANSPORT; TIME FACTORS; TRPM CATION CHANNELS;

EID: 79952305319     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2010.11.040     Document Type: Article

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